Web Desc
Atherothrombosis
joint with Molecular Biology of the Vasculature
Organizer(s): Peter Libby and Shaun R. Coughlin
Date: April 02 - 07, 2006
Location: Keystone Resort, Keystone, CO, USA
Summary of Meeting:
The field of atherothrombosis is poised for advances in basic science and novel therapeutics, yet faces considerable challenges to clinical translation due to 1) the very success of current therapies (rendering event rates low and hence clinical trials large and lengthy) and 2) the lack of validated predictors of clinical outcomes to evaluate new therapies short of endpoint trials and to target cost-effective preventive therapies to asymptomatic individuals nonetheless at high risk, as well as to those with established disease. Bringing basic science discoveries to the bedside with minimum delay will require major advances. This meeting will bring together investigators of various disciplines to confront these issues. Emerging science of genetics, lipid metabolism, metabolic syndrome, stem cell biology, thrombosis will be coupled with discussions of emerging biomarkers and rapidly evolving imaging technologies. This conjunction should spur progress in confronting these challenges and reducing the rapidly advancing ravages of atherothrombosis worldwide.
Scholarship Deadline: December 1 2005
Discounted Abstract Deadline: December 1 2005
Abstract Deadline: December 28 2005
Discounted Registration Deadline: February 2 2006
We gratefully acknowledge additional support for this conference from:
Boehringer Ingelheim Pharmaceuticals, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational grant from Lilly USA, LLC

Esperion Therapeutics, a Division of Pfizer Global Research & Development

Portola Pharmaceuticals Inc.

Schering-Plough Research Institute
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13 HL083692-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 02 | 3:00PM - 7:30PM
Registration
Room: Columbine Foyer


Sunday, April 02 | 6:30PM - 7:30PM
Refreshments
Room: Columbine Foyer


Sunday, April 02 | 7:30PM - 7:45PM
Opening Remarks
Room: Grays/Long

Speaker 1 of 4
Michael E. Mendelsohn, USA

Sunday, April 02 | 7:30PM - 7:45PM
Opening Remarks
Room: Grays/Long

Speaker 2 of 4
Bradford C. Berk, University of Rochester Medical Center, USA

Sunday, April 02 | 7:30PM - 7:45PM
Opening Remarks
Room: Grays/Long

Speaker 3 of 4
Peter Libby, Brigham and Women's Hospital, USA

Sunday, April 02 | 7:30PM - 7:45PM
Opening Remarks
Room: Grays/Long

Speaker 4 of 4
Shaun R. Coughlin, University of California, San Francisco, USA

Sunday, April 02 | 7:45PM - 8:45PM
Keynote Address (Joint)
Room: Grays/Long

Speaker 1 of 1
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
7TM Receptors: Brief History and New Signaling Paradigms

Monday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, April 03 | 8:00AM - 11:00AM
Vascular Genetics and Genomics (Joint)
Room: Grays/Long

Speaker 1 of 3
Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Comparative Genomics at the Extremes

Monday, April 03 | 8:00AM - 11:00AM
Vascular Genetics and Genomics (Joint)
Room: Grays/Long

Speaker 2 of 3
Peter F. Carmeliet, University of Leuven, VIB, Belgium
Functional Angiogenomics

Monday, April 03 | 8:00AM - 11:00AM
Vascular Genetics and Genomics (Joint)
Room: Grays/Long

Speaker 3 of 3
* Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Genetic Protection from Coronary Atherosclerosis

Monday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, April 03 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, April 03 | 5:00PM - 7:00PM
Oxidative Stress
Room: Grays

Speaker 1 of 3
* Kathy K. Griendling, Emory University School of Medicine, USA
Physiology and Pathophysiology of Vascular NADPH Oxidases

Monday, April 03 | 5:00PM - 7:00PM
Oxidative Stress
Room: Grays

Speaker 2 of 3
Jay W. Heinecke, University of Washington School of Medicine, USA
Production of Dysfunctional HDL by Myeloperoxidase

Monday, April 03 | 5:00PM - 7:00PM
Oxidative Stress
Room: Grays

Speaker 3 of 3
Anders Gabrielsen, Karolinska Institute, Sweden
Short Talk

Monday, April 03 | 5:00PM - 7:00PM
Vascular Function in Health and Disease
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 1 of 3
Thomas P. Stossel, Brigham and Women's Hospital, USA
Molecular Mechanisms of Vascular Cell Motility


Monday, April 03 | 5:00PM - 7:00PM
Vascular Function in Health and Disease
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 2 of 3
Richard O. Hynes, Massachusetts Institute of Technology, USA
Contributions of Fibronectins to Vascular Development


Monday, April 03 | 5:00PM - 7:00PM
Vascular Function in Health and Disease
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 3 of 3
* Monty Krieger, Massachusetts Institute of Technology, USA
The HDL Receptor SR-BI and a Model of Fatal Occlusive Coronary Heart Disease


Monday, April 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Monday, April 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Tuesday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, April 04 | 8:00AM - 11:00AM
New Pathways and Targets in Lipid Metabolism
Room: Grays

Speaker 1 of 4
Jorge Plutzky, Brigham and Women's Hospital, USA
Lipolytic Mechanisms of PPAR Activation

Tuesday, April 04 | 8:00AM - 11:00AM
New Pathways and Targets in Lipid Metabolism
Room: Grays

Speaker 2 of 4
* Daniel J. Rader, University of Pennsylvania, USA
Molecular Regulation of Reverse Cholesterol Transport

Tuesday, April 04 | 8:00AM - 11:00AM
New Pathways and Targets in Lipid Metabolism
Room: Grays

Speaker 3 of 4
Robert V. Farese Jr., Harvard School of Public Health, USA
The Enzymes of Neutral Lipid Synthesis: Sources of Some Fat Problems

Tuesday, April 04 | 8:00AM - 11:00AM
New Pathways and Targets in Lipid Metabolism
Room: Grays

Speaker 4 of 4
Scott W. Altmann, Schering-Plough Research Institute, USA
Molecular Mechanisms of Intestinal Cholesterol Transport

Tuesday, April 04 | 8:00AM - 11:00AM
Vascular Cell Biology I: Vascular Endothelium
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 1 of 5
Guillermo Garcia-Cardena, Harvard Medical School, USA
Short Talk: KLF2: A Mechano-Activated Transcription Factor that Acts as an Integrator of Multiple Endothelial Functions


Tuesday, April 04 | 8:00AM - 11:00AM
Vascular Cell Biology I: Vascular Endothelium
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 2 of 5
Mark L. Kahn, University of Pennsylvania, USA
Short Talk: Role of KLF2 in Cardiovascular Development and Function


Tuesday, April 04 | 8:00AM - 11:00AM
Vascular Cell Biology I: Vascular Endothelium
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 3 of 5
Philip W. Shaul, University of Texas Southwestern Medical Center, USA
Atheroslerosis Risk Factors and Signaling Modules in Endothelial Cell Caveolae


Tuesday, April 04 | 8:00AM - 11:00AM
Vascular Cell Biology I: Vascular Endothelium
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 4 of 5
William C. Sessa, Yale University School of Medicine, USA
Dynamics of Caveolae Function and eNOS Regulation


Tuesday, April 04 | 8:00AM - 11:00AM
Vascular Cell Biology I: Vascular Endothelium
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 5 of 5
* Peter F. Davies, University of Pennsylvania, USA
Site-Specific Phenotype Mapping of Endothelium from Patho-Susceptible and Resistant Locations in Vivo


Tuesday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, April 04 | 2:30PM - 4:30PM
Roundtable Workshop on Development of Therapeutics
Room: Grays

Speaker 1 of 5
* Peter Libby, Brigham and Women's Hospital, USA

Tuesday, April 04 | 2:30PM - 4:30PM
Roundtable Workshop on Development of Therapeutics
Room: Grays

Speaker 2 of 5
* Shaun R. Coughlin, University of California, San Francisco, USA

Tuesday, April 04 | 2:30PM - 4:30PM
Roundtable Workshop on Development of Therapeutics
Room: Grays

Speaker 3 of 5
J. Anthony Ware, Eli Lilly and Company, USA
Development of Novel Drugs for Atherothrombotics

Tuesday, April 04 | 2:30PM - 4:30PM
Roundtable Workshop on Development of Therapeutics
Room: Grays

Speaker 4 of 5
David R. Phillips, Portola Pharmaceuticals Inc., USA
Platelet Adhesion and Activation in Atherothrombosis

Tuesday, April 04 | 2:30PM - 4:30PM
Roundtable Workshop on Development of Therapeutics
Room: Grays

Speaker 5 of 5
Roger S. Newton, Esperion Therapeutics, Inc., USA
Cholesterol Acceptors

Tuesday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, April 04 | 5:00PM - 7:00PM
Cardiovascular Aspects of the Metabolic Syndrome/Diabetes
Room: Grays

Speaker 1 of 4
* Jorge Plutzky, Brigham and Women's Hospital, USA

Tuesday, April 04 | 5:00PM - 7:00PM
Cardiovascular Aspects of the Metabolic Syndrome/Diabetes
Room: Grays

Speaker 2 of 4
Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Mutations in Mitochondrial DNA and Metabolic Syndrome

Tuesday, April 04 | 5:00PM - 7:00PM
Cardiovascular Aspects of the Metabolic Syndrome/Diabetes
Room: Grays

Speaker 3 of 4
Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Inflammatory Signaling & Atherosclerosis in Diabetes and Beyond

Tuesday, April 04 | 5:00PM - 7:00PM
Cardiovascular Aspects of the Metabolic Syndrome/Diabetes
Room: Grays

Speaker 4 of 4
Douglas E. Vaughan, Vanderbilt University, USA
PAI-1, Obesity and Diabetes

Tuesday, April 04 | 5:00PM - 7:00PM
Vascular Cell Biology II: Vascular Smooth Muscle
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 1 of 3
Peter Oettgen, Harvard Institutes of Medicine, USA
The Role of Ets-1 in Vascular Inflammation and Remodeling


Tuesday, April 04 | 5:00PM - 7:00PM
Vascular Cell Biology II: Vascular Smooth Muscle
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 2 of 3
Joachim Herz, University of Texas Southwestern Medical Center, USA
LRP1 and Vascular Wall Integrity


Tuesday, April 04 | 5:00PM - 7:00PM
Vascular Cell Biology II: Vascular Smooth Muscle
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 3 of 3
* Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Vascular Proliferation and Inflammation: Lessons Learned from Genetic Diseases


Tuesday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Tuesday, April 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Wednesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, April 05 | 8:00AM - 11:00AM
Biomarkers/Imaging
Room: Grays

Speaker 1 of 6
Thomas Hatsukami, University of Washington, USA
Magnetic Resonance Imaging of Atherosclerosis

Wednesday, April 05 | 8:00AM - 11:00AM
Biomarkers/Imaging
Room: Grays

Speaker 2 of 6
João A.C. Lima, Johns Hopkins Medical Institutions, USA
Cardiovascular CT in Coronary Artery Disease

Wednesday, April 05 | 8:00AM - 11:00AM
Biomarkers/Imaging
Room: Grays

Speaker 3 of 6
* Ralph Weissleder, Massachusetts General Hospital, USA
Molecular Imaging of Atherosclerosis

Wednesday, April 05 | 8:00AM - 11:00AM
Biomarkers/Imaging
Room: Grays

Speaker 4 of 6
Jorge L. Durand, Albert Einstein College of Medicine, USA
Short Talk: A Novel Integration of Magnetic Resonance Imaging and Raman Spectroscopy of Atherosclerotic Mouse Aortas

Wednesday, April 05 | 8:00AM - 11:00AM
Biomarkers/Imaging
Room: Grays

Speaker 5 of 6
Andreas Kalmes, Amgen Inc., USA
Short Talk: Use of Near-Infrared Protease-Activated Probes to Measure
Anti-Inflammatory Treatment in a Mouse Model of Arterial Injury


Wednesday, April 05 | 8:00AM - 11:00AM
Biomarkers/Imaging
Room: Grays

Speaker 6 of 6
Sander Leonard Wolters, Maastricht University and Hospital, Netherlands
Short Talk: Noninvasive Imaging of Inflammation/Apoptosis with 99mTc-Annexin A5 Reveals Plaque Instability in Patients with Significant Carotid Artery Stenosis

Wednesday, April 05 | 8:00AM - 11:00AM
Control of Vascular Tone I: Cyclic GMP
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 1 of 5
Thomas M. Lincoln, University of South Alabama, USA
Cyclic GMP-Dependent Protein Kinases in Vascular Smooth Muscle: From the Regulation of Tone to Gene Expression


Wednesday, April 05 | 8:00AM - 11:00AM
Control of Vascular Tone I: Cyclic GMP
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 2 of 5
Joseph A. Beavo, University of Washington, USA
CGMP Phosphodiesterase in Vascular Smooth Muscle Cell Function


Wednesday, April 05 | 8:00AM - 11:00AM
Control of Vascular Tone I: Cyclic GMP
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 3 of 5
† Chen Yan, University of Rochester, USA
Short Talk: PDEIA in Vascular Smooth Muscle Function


Wednesday, April 05 | 8:00AM - 11:00AM
Control of Vascular Tone I: Cyclic GMP
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 4 of 5
Franz Hofmann, Technische Universität München, Germany
Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System: Insights from Genetically Modified Mice


Wednesday, April 05 | 8:00AM - 11:00AM
Control of Vascular Tone I: Cyclic GMP
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 5 of 5
* Michael E. Mendelsohn, USA
Regulation of Vascular Smooth Muscle Cell Phenotype, Vascular Function and Blood Pressure by Cyclic GMP-dependent Protein Kinase Ialpha


Wednesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, April 05 | 11:00AM - 12:00PM
Optional Session: How to Navigate NIH Study Section and Prog
ram
Room: Grays

Speaker 1 of 2
Lawrence M. Pinkus, NIH, USA
What You Need to Know about NIH Grant Applications

Wednesday, April 05 | 11:00AM - 12:00PM
Optional Session: How to Navigate NIH Study Section and Prog
ram
Room: Grays

Speaker 2 of 2
Eser Tolunay, NHLBI, National Institutes of Health, USA

Wednesday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, April 05 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Grays

Speaker 1 of 3
Peter Libby, Brigham and Women's Hospital, USA
Innate Immunity and Atherothrombosis

Wednesday, April 05 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Grays

Speaker 2 of 3
* Göran K. Hansson, Karolinska University Hospital, Sweden
Atherosclerosis – An Autoimmune Disease?

Wednesday, April 05 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Grays

Speaker 3 of 3
Cornelia M. Weyand, Stanford University, USA
Mechanisms of Vasculitis

Wednesday, April 05 | 5:00PM - 7:00PM
Control of Vascular Tone II: EDHF and Ion Channels
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 1 of 3
* Rudi Busse, Klinikum der J.W. Goethe-Universität, Germany
Endothelial Hyperpolarization: CYP’s, Trp’s, Gaps and the Rest


Wednesday, April 05 | 5:00PM - 7:00PM
Control of Vascular Tone II: EDHF and Ion Channels
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 2 of 3
Michael J. Davis, University of Missouri-Columbia, USA
Signaling Mechanisms Underlying the Vascular Myogenic Response


Wednesday, April 05 | 5:00PM - 7:00PM
Control of Vascular Tone II: EDHF and Ion Channels
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 3 of 3
Mark T. Nelson, University of Vermont, USA
Local Potassium Signaling Couples Astrocytic Activity to Cerebrovascular Function.


Wednesday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Thursday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, April 06 | 8:00AM - 11:00AM
Platelets/Thrombosis
Room: Grays

Speaker 1 of 3
Kenneth G. Mann, University of Vermont, USA
Quantitative Modeling of the Tissue Factor Pathway of Coagulation

Thursday, April 06 | 8:00AM - 11:00AM
Platelets/Thrombosis
Room: Grays

Speaker 2 of 3
* Shaun R. Coughlin, University of California, San Francisco, USA
Thrombin signaling in hemostasis and thrombosis

Thursday, April 06 | 8:00AM - 11:00AM
Platelets/Thrombosis
Room: Grays

Speaker 3 of 3
Yale Nemerson, Mt. Sinai Medical School, USA
The Role of Phospholipid in Regulating Tissue Factor Activity: A Different Role for Lipid Surfaces in the Initiation of Coagulation.

Thursday, April 06 | 8:00AM - 11:00AM
Vascular Pathobiology in Disease I
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 1 of 3
* Bradford C. Berk, University of Rochester Medical Center, USA
Vascular Pathobiology of Oxidative Stress


Thursday, April 06 | 8:00AM - 11:00AM
Vascular Pathobiology in Disease I
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 2 of 3
Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Role of WNK Kinases in Human Hypertension


Thursday, April 06 | 8:00AM - 11:00AM
Vascular Pathobiology in Disease I
This session is from Molecular Biology of the Vascu
Room: Longs

Speaker 3 of 3
Marlene Rabinovitch, Stanford University, USA
Bone Morphogenetic Protein Mediated Signaling in the Pathobiology of Pulmonary Vascular Disease


Thursday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, April 06 | 5:00PM - 6:45PM
Intimal Cell Origins and Regulation/Vascular Pathobiology in
Disease II (Joint)

Room: Grays/Long

Speaker 1 of 3
Ryozo Nagai, University of Tokyo, Japan
Significance of Krüppel-Like Transcription Factor 5 in Cardiovascular Disease

Thursday, April 06 | 5:00PM - 6:45PM
Intimal Cell Origins and Regulation/Vascular Pathobiology in
Disease II (Joint)

Room: Grays/Long

Speaker 2 of 3
* Douglas W. Losordo, Caladrius Biosciences, Inc., USA
Autologous CD34+ Cells for Ischemic Tissue Repair: Scientific Basis and Early Results of Human Clinical Trials

Thursday, April 06 | 5:00PM - 6:45PM
Intimal Cell Origins and Regulation/Vascular Pathobiology in
Disease II (Joint)

Room: Grays/Long

Speaker 3 of 3
Bruce Furie, Beth Israel Deaconess Medical Center, USA
Dynamics of Thrombus Formation in vivo

Thursday, April 06 | 6:45PM - 7:00PM
Concluding Remarks
Room: Grays/Long

Speaker 1 of 4
Michael E. Mendelsohn, USA

Thursday, April 06 | 6:45PM - 7:00PM
Concluding Remarks
Room: Grays/Long

Speaker 2 of 4
Bradford C. Berk, University of Rochester Medical Center, USA

Thursday, April 06 | 6:45PM - 7:00PM
Concluding Remarks
Room: Grays/Long

Speaker 3 of 4
Peter Libby, Brigham and Women's Hospital, USA

Thursday, April 06 | 6:45PM - 7:00PM
Concluding Remarks
Room: Grays/Long

Speaker 4 of 4
Shaun R. Coughlin, University of California, San Francisco, USA

Thursday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Thursday, April 06 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Thursday, April 06 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, April 07 | 10:26AM - 10:26AM
Departure


*Session Chair.