Web Desc
Emerging Genomic Biomarkers: Impact on Drug Discovery and Clinical Practice
joint with The Molecular and Integrative Basis for Toxic Responses
Organizer(s): Stephen H. Friend, Lawrence J. Lesko and Daniel K. Burns
Date: May 07 - 11, 2006
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Summary of Meeting:
This conference will focus on bringing together the developers of genomic technologies with the clinicians expecting to use them, and the regulators charged with ensuring their appropriate usage. We will focus on two themes. The first theme will be to exemplify how diverse methods to track DNA, RNA, and protein changes have come to rely on sophisticated techniques of pattern recognition bringing up questions of how best to validate these methods. The second theme is to contrast the strategies needed to develop disease phenotyping marker from those needed for intermediate response markers and from other markers such as predictive markers.
Scholarship Deadline: January 5 2006
Discounted Abstract Deadline: January 5 2006
Abstract Deadline: March 17 2006
Discounted Registration Deadline: March 17 2006
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenICOS CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Bristol-Myers Squibb Company

GlaxoSmithKline

Merck Research Laboratories

PPD, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 07 | 3:00PM - 7:30PM
Registration
Room: Victoria Conference Center Foyer


Sunday, May 07 | 6:30PM - 7:30PM
Refreshments
Room: Victoria Conference Center Foyer


Sunday, May 07 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Victoria Conference Center Lecture Theatre

Speaker 1 of 1
Neil Kaplowitz, University of Shouther California Liver Transplant Program, USA
Adverse Drug Reactions in the Liver

Monday, May 08 | 7:00AM - 8:00AM
Breakfast
Room: Tea Lobby


Monday, May 08 | 8:00AM - 11:00AM
Sub-Typing Human Diseases
Room: Salon A

Speaker 1 of 3
Allen D. Roses, Duke University, Drug Discovery Institute, USA
Susceptibility Genes and Drug Development in Alzheimer's Disease and Other Complex Diseases

Monday, May 08 | 8:00AM - 11:00AM
Sub-Typing Human Diseases
Room: Salon A

Speaker 2 of 3
Eric Schadt, Mount Sinai School of Medicine, USA
An Integrative Genomics Approach to Elucidating the Genetics of Drug Response

Monday, May 08 | 8:00AM - 11:00AM
Sub-Typing Human Diseases
Room: Salon A


Speaker to be Announced

Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 1 of 4
Robert S. McCuskey, University of Arizona, USA
Hepatic Microvascular Responses to Toxicants


Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 2 of 4
Robert A. Roth, Michigan State University, USA
Influence of Inflammatory Stress on Drug Hepatotoxicity


Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 3 of 4
Peter J. O'Brien, University of Toronto, Canada
Antioxidant Prevention of Drug Induced Oxidative Stress (Inflammation Model)


Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 4 of 4
Wen Xie, University of Pittsburgh, USA
Short Talk: Orphan Nuclear Receptor-Mediated Gene Regulation in Xeno- and Endobiotic Toxic Responses


Monday, May 08 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center Foyer


Monday, May 08 | 11:00AM - 1:00PM
Poster Setup
Room: Salon B


Monday, May 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon B


Monday, May 08 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center Foyer


Monday, May 08 | 5:00PM - 7:00PM
Economic Considerations of Biomarkers
Room: Salon A

Speaker 1 of 3
Gary E. Marchant, Arizona State University, USA
Legal, Ethical and Policy Issues with Biomarkers

Monday, May 08 | 5:00PM - 7:00PM
Economic Considerations of Biomarkers
Room: Salon A

Speaker 2 of 3
M. J. Finley Austin, Hoffman-La Roche, USA
An Economic Perspective on Biomarkers and Personalized Medicine:
Regulatory and Science Policy Implications


Monday, May 08 | 5:00PM - 7:00PM
Economic Considerations of Biomarkers
Room: Salon A

Speaker 3 of 3
Phillip G. Febbo, Illumina, Inc., USA
Genomic Strategies for Individualizing Therapy in Oncology

Monday, May 08 | 5:00PM - 7:00PM
Receptors and Signaling Pathways
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 1 of 3
Frank J. Gonzalez, National Institutes of Health, USA
Role of Nuclear Receptors in Chemical Toxicity and Carcinogenicity


Monday, May 08 | 5:00PM - 7:00PM
Receptors and Signaling Pathways
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 2 of 3
Mark J. Czaja, Albert Einstein College of Medicine, USA
Regulation of Toxic Liver Injury by Cell Signaling


Monday, May 08 | 5:00PM - 7:00PM
Receptors and Signaling Pathways
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 3 of 3
Serrine S. Lau, University of Arizona, USA
Prostanoid Receptor-Mediated Cytoprotective Signaling Pathways


Monday, May 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon B


Monday, May 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Salon B


Tuesday, May 09 | 7:00AM - 8:00AM
Breakfast
Room: Tea Lobby


Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
Room: Salon A

Speaker 1 of 4
Emanuel F. Petricoin, George Mason University, USA
Diagnostics and Theranostics: Applications of Proteomics for Disease Detection and Tailored Therapy

Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
Room: Salon A

Speaker 2 of 4
Howard Schulman, Pharmaceutical Product Development, Inc., USA
Biomarker Discovery in Proteomes and Sub-Proteomes

Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
Room: Salon A

Speaker 3 of 4
Amanda Paulovich, Fred Hutchinson Cancer Research Center, USA
Evaluating Technologies for Protein Biomarker Discovery and Validation

Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
Room: Salon A

Speaker 4 of 4
Dieter Deforce, Ghent University, Belgium
Title to be Determined

Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 1 of 4
Robert P. Hanzlik, University of Kansas, USA
Tissue Injury by Reactive Metabolites: Chemistry, Proteomics and Beyond


Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 2 of 4
Daniel C. Liebler, Vanderbilt University Medical Center, USA
What are Protein Targets of Reactive Electrophiles?


Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 3 of 4
Wei Tang, Merck & Co., Inc., USA
Metabolic Bioactivation and Drug Toxicity: Managing Safety Issues Proactively in the Drug Discovery Phase


Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 4 of 4
Kiyoto Motojima, Meiji Pharmaceutical University, Japan
Short Talk: Peroxisome Proliferator-Activated Receptor á is Essential for the Induction of a Detoxification System against Plant Compounds in the Mouse Intestine and Liver


Tuesday, May 09 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center Foyer


Tuesday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center Foyer


Tuesday, May 09 | 5:00PM - 7:00PM
Identifying Drug Responders from Non-Responders
Room: Salon A

Speaker 1 of 2
John J. Sninsky, Translational Sciences, USA
Identifying Patients Responsive to Interferon

Tuesday, May 09 | 5:00PM - 7:00PM
Identifying Drug Responders from Non-Responders
Room: Salon A

Speaker 2 of 2
Nicholas C. Dracopoli, Janssen R&D Inc., USA
Predicting Drug Response: Molecular Profiles to Enrich Efficacy and Reduce Risk of Adverse Events

Tuesday, May 09 | 5:00PM - 7:00PM
Metabolic Dysfunction
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 1 of 3
Kendall B. Wallace, University of Minnesota, USA
Adriamycin-Induced Mitochondrial Cardiomyopathy and the Compensated Metabolic State


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolic Dysfunction
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 2 of 3
Greg Slatter, Amgen Inc., USA
Dose-Related Hepatic Effects of NSAIDS in Rodents: Covalent Binding Measurements and Microarray-Based Determination of Gene Expression Changes


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolic Dysfunction
This session is from Molecular and Integrative Basi
Room: Salon C

Speaker 3 of 3
Eric P. Brass, Harbor UCLA Medical Center, USA
Metabolic Basis for Drug and Nutraceutical Toxicity in Humans


Tuesday, May 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon B


Wednesday, May 10 | 7:00AM - 8:00AM
Breakfast
Room: Tea Lobby


Wednesday, May 10 | 8:00AM - 11:00AM
Biomarkers to Monitor the Safety/Toxicity of Compounds (Join
t)

Room: Victoria Conference Center Lecture Theatre

Speaker 1 of 3
Michael Lawton, Pfizer Global Research & Development, USA
A Systems Biology Approach to Identification of Candidate Biomarkers of Drug-induced Vascular Injury

Wednesday, May 10 | 8:00AM - 11:00AM
Biomarkers to Monitor the Safety/Toxicity of Compounds (Join
t)

Room: Victoria Conference Center Lecture Theatre

Speaker 2 of 3
Joseph V. Bonventre, Brigham and Women's Hospital, Harvard Medical School, USA
Mechanistic Basis and Biomarkers for Cytotoxic Renal Injury

Wednesday, May 10 | 8:00AM - 11:00AM
Biomarkers to Monitor the Safety/Toxicity of Compounds (Join
t)

Room: Victoria Conference Center Lecture Theatre

Speaker 3 of 3
Roger G. Ulrich, RUC Pharmaceutical Development Specialists, USA
Risk Factors and Differentiating Biomarkers for Liver- and Muscle-Related Adverse Drug Effects

Wednesday, May 10 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center Foyer


Wednesday, May 10 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center Foyer


Wednesday, May 10 | 5:00PM - 7:00PM
Panel Discussion: Biomarkers into Clinical Practice (Joint)
Room: Victoria Conference Center Lecture Theatre

Speaker 1 of 3
Stephen H. Friend, Sage Bionetworks, USA

Wednesday, May 10 | 5:00PM - 7:00PM
Panel Discussion: Biomarkers into Clinical Practice (Joint)
Room: Victoria Conference Center Lecture Theatre

Speaker 2 of 3
Daniel K. Burns, GlaxoSmithKline, USA

Wednesday, May 10 | 5:00PM - 7:00PM
Panel Discussion: Biomarkers into Clinical Practice (Joint)
Room: Victoria Conference Center Lecture Theatre

Speaker 3 of 3
Kate Yen, Auron Therapeutics, USA

Wednesday, May 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Palm Court & Crystal Ballroom


Wednesday, May 10 | 8:00PM - 11:00PM
Entertainment
Room: Palm Court & Crystal Ballroom


Wednesday, May 10 | 8:00PM - 11:00PM
Cash Bar
Room: Palm Court & Crystal Ballroom


Thursday, May 11 | 10:26AM - 10:26AM
Departure


*Session Chair.