Web Desc
The Molecular and Integrative Basis for Toxic Responses
joint with Emerging Genomic Biomarkers: Impact on Drug Discovery and Clinical Practice
Organizer(s): Roger G. Ulrich and Robert A. Roth
Date: May 07 - 11, 2006
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Sponsored by ICOS Corporation
Summary of Meeting:
Drug toxicity continues to be an important human health problem and a major economic issue for the pharmaceutical industry, since it results in many failed candidates and drug recalls. It is widely recognized that knowledge of toxic mechanisms can aid in the design of safer drugs, and recent advances in molecular and genomic biology hold promise for increasing such mechanistic understanding. Determining untoward effects of drug exposure on cellular signaling pathways that result in altered RNA transcription, protein expression and activity along with the consequent impact on cell and tissue function has become an intense focus in toxicological research. This conference will bring together key scientists to discuss important organ targets for drug toxicity, emphasizing pathways and mediators of cell and tissue injury and the contribution of environmental and genetic factors that determine individual susceptibility.
Scholarship Deadline: January 5 2006
Discounted Abstract Deadline: January 5 2006
Abstract Deadline: March 17 2006
Discounted Registration Deadline: March 17 2006
We gratefully acknowledge additional support for this conference from:
ICOS CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Environmental Health Sciences (NIEHS)
Grant No. 1R13 ES014763-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, May 07 | 3:00PM - 7:30PM
Registration
Room: Victoria Conference Center Foyer


Sunday, May 07 | 6:30PM - 7:30PM
Refreshments
Room: Victoria Conference Center Foyer


Sunday, May 07 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Victoria Conference Center Lecture Theatre

Speaker 1 of 1
Neil Kaplowitz, University of Shouther California Liver Transplant Program, USA
Adverse Drug Reactions in the Liver

Monday, May 08 | 7:00AM - 8:00AM
Breakfast
Room: Tea Lobby


Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
Room: Salon C

Speaker 1 of 4
Robert S. McCuskey, University of Arizona, USA
Hepatic Microvascular Responses to Toxicants

Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
Room: Salon C

Speaker 2 of 4
Robert A. Roth, Michigan State University, USA
Influence of Inflammatory Stress on Drug Hepatotoxicity

Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
Room: Salon C

Speaker 3 of 4
Peter J. O'Brien, University of Toronto, Canada
Antioxidant Prevention of Drug Induced Oxidative Stress (Inflammation Model)

Monday, May 08 | 8:00AM - 11:00AM
Endogenous Susceptibility Factors in Toxic Responses
Room: Salon C

Speaker 4 of 4
Wen Xie, University of Pittsburgh, USA
Short Talk: Orphan Nuclear Receptor-Mediated Gene Regulation in Xeno- and Endobiotic Toxic Responses

Monday, May 08 | 8:00AM - 11:00AM
Sub-Typing Human Diseases
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 1 of 3
Allen D. Roses, Duke University, Drug Discovery Institute, USA
Susceptibility Genes and Drug Development in Alzheimer's Disease and Other Complex Diseases


Monday, May 08 | 8:00AM - 11:00AM
Sub-Typing Human Diseases
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 2 of 3
Eric Schadt, Mount Sinai School of Medicine, USA
An Integrative Genomics Approach to Elucidating the Genetics of Drug Response


Monday, May 08 | 8:00AM - 11:00AM
Sub-Typing Human Diseases
This session is from Emerging Genomic Biomarkers
Room: Salon A


Speaker to be Announced


Monday, May 08 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center Foyer


Monday, May 08 | 11:00AM - 1:00PM
Poster Setup
Room: Salon B


Monday, May 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon B


Monday, May 08 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center Foyer


Monday, May 08 | 5:00PM - 7:00PM
Receptors and Signaling Pathways
Room: Salon C

Speaker 1 of 3
Frank J. Gonzalez, National Institutes of Health, USA
Role of Nuclear Receptors in Chemical Toxicity and Carcinogenicity

Monday, May 08 | 5:00PM - 7:00PM
Receptors and Signaling Pathways
Room: Salon C

Speaker 2 of 3
Mark J. Czaja, Albert Einstein College of Medicine, USA
Regulation of Toxic Liver Injury by Cell Signaling

Monday, May 08 | 5:00PM - 7:00PM
Receptors and Signaling Pathways
Room: Salon C

Speaker 3 of 3
Serrine S. Lau, University of Arizona, USA
Prostanoid Receptor-Mediated Cytoprotective Signaling Pathways

Monday, May 08 | 5:00PM - 7:00PM
Economic Considerations of Biomarkers
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 1 of 3
Gary E. Marchant, Arizona State University, USA
Legal, Ethical and Policy Issues with Biomarkers


Monday, May 08 | 5:00PM - 7:00PM
Economic Considerations of Biomarkers
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 2 of 3
M. J. Finley Austin, Hoffman-La Roche, USA
An Economic Perspective on Biomarkers and Personalized Medicine:
Regulatory and Science Policy Implications


Monday, May 08 | 5:00PM - 7:00PM
Economic Considerations of Biomarkers
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 3 of 3
Phillip G. Febbo, Illumina, Inc., USA
Genomic Strategies for Individualizing Therapy in Oncology


Monday, May 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon B


Monday, May 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Salon B


Tuesday, May 09 | 7:00AM - 8:00AM
Breakfast
Room: Tea Lobby


Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
Room: Salon C

Speaker 1 of 4
Robert P. Hanzlik, University of Kansas, USA
Tissue Injury by Reactive Metabolites: Chemistry, Proteomics and Beyond

Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
Room: Salon C

Speaker 2 of 4
Daniel C. Liebler, Vanderbilt University Medical Center, USA
What are Protein Targets of Reactive Electrophiles?

Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
Room: Salon C

Speaker 3 of 4
Wei Tang, Merck & Co., Inc., USA
Metabolic Bioactivation and Drug Toxicity: Managing Safety Issues Proactively in the Drug Discovery Phase

Tuesday, May 09 | 8:00AM - 11:00AM
Bioactivation and Macromolecular Adducts
Room: Salon C

Speaker 4 of 4
Kiyoto Motojima, Meiji Pharmaceutical University, Japan
Short Talk: Peroxisome Proliferator-Activated Receptor á is Essential for the Induction of a Detoxification System against Plant Compounds in the Mouse Intestine and Liver

Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 1 of 4
Emanuel F. Petricoin, George Mason University, USA
Diagnostics and Theranostics: Applications of Proteomics for Disease Detection and Tailored Therapy


Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 2 of 4
Howard Schulman, Pharmaceutical Product Development, Inc., USA
Biomarker Discovery in Proteomes and Sub-Proteomes


Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 3 of 4
Amanda Paulovich, Fred Hutchinson Cancer Research Center, USA
Evaluating Technologies for Protein Biomarker Discovery and Validation


Tuesday, May 09 | 8:00AM - 11:00AM
Detection of Early Disease
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 4 of 4
Dieter Deforce, Ghent University, Belgium
Title to be Determined


Tuesday, May 09 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center Foyer


Tuesday, May 09 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center Foyer


Tuesday, May 09 | 5:00PM - 7:00PM
Metabolic Dysfunction
Room: Salon C

Speaker 1 of 3
Kendall B. Wallace, University of Minnesota, USA
Adriamycin-Induced Mitochondrial Cardiomyopathy and the Compensated Metabolic State

Tuesday, May 09 | 5:00PM - 7:00PM
Metabolic Dysfunction
Room: Salon C

Speaker 2 of 3
Greg Slatter, Amgen Inc., USA
Dose-Related Hepatic Effects of NSAIDS in Rodents: Covalent Binding Measurements and Microarray-Based Determination of Gene Expression Changes

Tuesday, May 09 | 5:00PM - 7:00PM
Metabolic Dysfunction
Room: Salon C

Speaker 3 of 3
Eric P. Brass, Harbor UCLA Medical Center, USA
Metabolic Basis for Drug and Nutraceutical Toxicity in Humans

Tuesday, May 09 | 5:00PM - 7:00PM
Identifying Drug Responders from Non-Responders
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 1 of 2
John J. Sninsky, Translational Sciences, USA
Identifying Patients Responsive to Interferon


Tuesday, May 09 | 5:00PM - 7:00PM
Identifying Drug Responders from Non-Responders
This session is from Emerging Genomic Biomarkers
Room: Salon A

Speaker 2 of 2
Nicholas C. Dracopoli, Janssen R&D Inc., USA
Predicting Drug Response: Molecular Profiles to Enrich Efficacy and Reduce Risk of Adverse Events


Tuesday, May 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon B


Wednesday, May 10 | 7:00AM - 8:00AM
Breakfast
Room: Tea Lobby


Wednesday, May 10 | 8:00AM - 11:00AM
Biomarkers to Monitor the Safety/Toxicity of Compounds (Join
t)

Room: Victoria Conference Center Lecture Theatre

Speaker 1 of 3
Michael Lawton, Pfizer Global Research & Development, USA
A Systems Biology Approach to Identification of Candidate Biomarkers of Drug-induced Vascular Injury

Wednesday, May 10 | 8:00AM - 11:00AM
Biomarkers to Monitor the Safety/Toxicity of Compounds (Join
t)

Room: Victoria Conference Center Lecture Theatre

Speaker 2 of 3
Joseph V. Bonventre, Brigham and Women's Hospital, Harvard Medical School, USA
Mechanistic Basis and Biomarkers for Cytotoxic Renal Injury

Wednesday, May 10 | 8:00AM - 11:00AM
Biomarkers to Monitor the Safety/Toxicity of Compounds (Join
t)

Room: Victoria Conference Center Lecture Theatre

Speaker 3 of 3
Roger G. Ulrich, RUC Pharmaceutical Development Specialists, USA
Risk Factors and Differentiating Biomarkers for Liver- and Muscle-Related Adverse Drug Effects

Wednesday, May 10 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center Foyer


Wednesday, May 10 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center Foyer


Wednesday, May 10 | 5:00PM - 7:00PM
Panel Discussion: Biomarkers into Clinical Practice (JOINT)
Room: Victoria Conference Center Lecture Theatre
Discuss the paradigm shift on how biomarkers can be used by a consortium of industry, govenment and acedemic scientist to solve toxicology/health issues.
Speaker 1 of 3
Stephen H. Friend, Sage Bionetworks, USA

Wednesday, May 10 | 5:00PM - 7:00PM
Panel Discussion: Biomarkers into Clinical Practice (JOINT)
Room: Victoria Conference Center Lecture Theatre
Discuss the paradigm shift on how biomarkers can be used by a consortium of industry, govenment and acedemic scientist to solve toxicology/health issues.
Speaker 2 of 3
Daniel K. Burns, GlaxoSmithKline, USA

Wednesday, May 10 | 5:00PM - 7:00PM
Panel Discussion: Biomarkers into Clinical Practice (JOINT)
Room: Victoria Conference Center Lecture Theatre
Discuss the paradigm shift on how biomarkers can be used by a consortium of industry, govenment and acedemic scientist to solve toxicology/health issues.
Speaker 3 of 3
Kate Yen, Auron Therapeutics, USA

Wednesday, May 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Palm Court & Crystal Ballroom


Wednesday, May 10 | 8:00PM - 11:00PM
Entertainment
Room: Palm Court & Crystal Ballroom


Wednesday, May 10 | 8:00PM - 11:00PM
Cash Bar
Room: Palm Court & Crystal Ballroom


Thursday, May 11 | 10:26AM - 10:26AM
Departure


*Session Chair.