Web Desc
Genome Instability and Repair
Organizer(s): Nancy Maizels, Ian D. Hickson and David B. Roth
Date: January 17 - 22, 2007
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Genentech, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
Genomic instability is a key event in aging, cancer and some heritable diseases. Highly conserved pathways have evolved to detect the presence of genome damage and to effect its repair. This meeting will explore recent advances in our understanding of the nature and causes of genomic instability, the mechanisms of DNA repair, and the consequences of failure in DNA repair with regard to human health and disease. The program will emphasize advances that provide mechanistic understanding of pathways that maintain genomic integrity, and the intersection of these pathways with normal cellular development, aging, and tumorigenesis. The molecular and mechanistic emphasis is designed to attract a broad cross-section of researchers. The goals of this meeting are to identify new avenues for investigation, to define therapeutic strategies for maintenance of genomic integrity, to stimulate collaborations, and to foster the long-term development of this rapidly emerging research area by encouraging participation of young investigators.
Scholarship Deadline: September 18 2006
Discounted Abstract Deadline: September 18 2006
Abstract Deadline: October 20 2006
Discounted Registration Deadline: November 17 2006
We gratefully acknowledge additional support for this conference from:
Genentech, Inc.Novus Biologicals, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

KuDOS Pharmaceuticals Ltd.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA124284-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, January 17 | 3:00PM - 7:30PM
Registration
Room: Foyer


Wednesday, January 17 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Wednesday, January 17 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
Frederick W. Alt, Boston Children's Hospital, USA
NHEJ and the Double-strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma

Thursday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Thursday, January 18 | 8:00AM - 11:15AM
Avoiding DNA Damage
Room: Peaks 1-5

Speaker 1 of 5
* Curtis C. Harris, NCI, National Institutes of Health, USA
p53 Biological Network: Inflammation, microRNA and Cancer

Thursday, January 18 | 8:00AM - 11:15AM
Avoiding DNA Damage
Room: Peaks 1-5

Speaker 2 of 5
Simon J. Boulton, Francis Crick Institute, UK
Short Talk: HCLK2 is Essential for the Mammalian S-Phase Checkpoint and Impacts on Chk1Stability

Thursday, January 18 | 8:00AM - 11:15AM
Avoiding DNA Damage
Room: Peaks 1-5

Speaker 3 of 5
Gregory L. Verdine, Harvard University, USA
The Lesion-Search Mechanism of DNA Glycosylases

Thursday, January 18 | 8:00AM - 11:15AM
Avoiding DNA Damage
Room: Peaks 1-5

Speaker 4 of 5
Dipanjan Chowdhury, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Role of phosphatases in removal of Gamma-H2AX

Thursday, January 18 | 8:00AM - 11:15AM
Avoiding DNA Damage
Room: Peaks 1-5

Speaker 5 of 5
Keith W. Caldecott, University of Sussex, UK
DNA Single-Strand Breaks and Neurodegeneration

Thursday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 18 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Thursday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Thursday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 18 | 5:00PM - 7:00PM
Chromatin, DNA Damage and Repair
Room: Peaks 1-5

Speaker 1 of 4
* Michael J. Lichten, National Cancer Institute, National Institutes of Health, USA
Controlling the Outcome of Meiotic Double-Strand Break Repair

Thursday, January 18 | 5:00PM - 7:00PM
Chromatin, DNA Damage and Repair
Room: Peaks 1-5

Speaker 2 of 4
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin Assembly Factors, Histone H3 Variants and Cell Cycle

Thursday, January 18 | 5:00PM - 7:00PM
Chromatin, DNA Damage and Repair
Room: Peaks 1-5

Speaker 3 of 4
Jac A. Nickoloff, Colorado State University, USA
Short Talk: INO80-Dependent Chromatin Remodeling Regulates the Kinetics and Efficiency of DSB Repair by Homologous Recombination

Thursday, January 18 | 5:00PM - 7:00PM
Chromatin, DNA Damage and Repair
Room: Peaks 1-5

Speaker 4 of 4
Andrés Aguilera, University of Seville, CABIMER, Spain
Mechanisms of Transcription-Associated Genetic Instability

Thursday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Thursday, January 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 14-17


Friday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, January 19 | 8:00AM - 11:15AM
Intersection of Damage, Repair and the Cell Cycle
Room: Peaks 1-5

Speaker 1 of 6
* Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
DNA Damage and Cell Death

Friday, January 19 | 8:00AM - 11:15AM
Intersection of Damage, Repair and the Cell Cycle
Room: Peaks 1-5

Speaker 2 of 6
XiaoZhe Wang, Dana-Farber Cancer Institute, USA
Short Talk: The role of Chk1 in the Fanconi Anemia/BRCA Pathway

Friday, January 19 | 8:00AM - 11:15AM
Intersection of Damage, Repair and the Cell Cycle
Room: Peaks 1-5

Speaker 3 of 6
Michael B. Kastan, St. Jude Children's Research Hospital, USA
Roles of ATM and NBS1 in Modulating Chromatin Structure Changes and Repair of DNA Breaks

Friday, January 19 | 8:00AM - 11:15AM
Intersection of Damage, Repair and the Cell Cycle
Room: Peaks 1-5

Speaker 4 of 6
Sandy Chang, University of Texas MD Anderson Cancer Center, USA
Telomere End Protection in Senescence and Cancer



Friday, January 19 | 8:00AM - 11:15AM
Intersection of Damage, Repair and the Cell Cycle
Room: Peaks 1-5

Speaker 5 of 6
Travis H. Stracker, IRB Barcelona, Spain
Short Talk: The Apoptotic Functions of Chk2 Suppress Tumorigenesis in Mre11 Deficient Mice

Friday, January 19 | 8:00AM - 11:15AM
Intersection of Damage, Repair and the Cell Cycle
Room: Peaks 1-5

Speaker 6 of 6
Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
p53 Cell Cycle Control and Maintenance of Chromosomal Stability

Friday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, January 19 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Friday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 1 of 10
* Raymond J. Monnat Jr., University of Washington, USA

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 2 of 10
Prasad Tekkatte Krishnamurthy, Columbia University, USA
Visualizing Dynamics of Rdh54 on Single Double-Stranded DNA Molecule

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 3 of 10
Lisa Postow, Rockefeller University, USA
Damage-Dependent Ubiquitination and Degradation of Ku80

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 4 of 10
Eric T. Larson, University of Washington, USA
MutSalpha and UNG Direct Redundant Pathways for Faithful as well as Mutagenic Repair of U/G Mismatches

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 5 of 10
Marie Dutreix, Center National Scientific Research, Institut Curie, France
Baiting Double-Strand Break Repair Complex by Short Inhibitory DNA (siDNA)

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 6 of 10
David O. Ferguson, University of Michigan Medical School, USA
TPP1 and Mre11: Two Tales of Genomic Instability

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 7 of 10
Jillian L. Youds, University of British Columbia, Canada
Characterization of BRIP1/FANCJ Homologs in ICL Repair in C. elegans

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 8 of 10
Yannick Doyon, Laval University, Canada
High-Efficiency Targeted Integration in Human Cells using Designed Zinc Finger Nucleases

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 9 of 10
Wojciech Niedzwiedz, Institute of Cancer Research, UK
The Possible Role for FANCM in DNA Cross-Links Repair

Friday, January 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Peaks 1-5

Speaker 10 of 10
Sachin Katyal, St. Jude Children's Research Hospital, USA
Defective DNA Damage Responses in Mice Lacking TDP1

Friday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, January 19 | 5:00PM - 7:30PM
Mechanisms of Processing Repair Intermediates
Room: Peaks 1-5

Speaker 1 of 5
* Ian D. Hickson, University of Copenhagen, Denmark
Functions of the BLM Protein at Damaged Replication Forks

Friday, January 19 | 5:00PM - 7:30PM
Mechanisms of Processing Repair Intermediates
Room: Peaks 1-5

Speaker 2 of 5
Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Choosing a Pathway for Break Repair

Friday, January 19 | 5:00PM - 7:30PM
Mechanisms of Processing Repair Intermediates
Room: Peaks 1-5

Speaker 3 of 5
Bernard S. Lopez, Institut Gustave Roussy, France
Short Talk: PKBĄ/AKT1 Inhibits Homologous Recombination by Cytoplasmic Retention of BRCA1 and Rad51, Mediated by FOXO1a

Friday, January 19 | 5:00PM - 7:30PM
Mechanisms of Processing Repair Intermediates
Room: Peaks 1-5

Speaker 4 of 5
Tanya T. Paull, University of Texas at Austin, USA
DNA Repair Activities of Mre11/Rad50 Complexes

Friday, January 19 | 5:00PM - 7:30PM
Mechanisms of Processing Repair Intermediates
Room: Peaks 1-5

Speaker 5 of 5
Stephen C. West, Francis Crick Institute, UK
Resolution of Abortive DNA Ligation Intermediates by Aprataxin

Friday, January 19 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Peaks 14-17


Friday, January 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 14-17


Saturday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, January 20 | 8:00AM - 11:15AM
Pathways of Break Repair
Room: Peaks 1-5

Speaker 1 of 6
* David B. Roth, New York University School of Medicine, USA
The Recombinase as Gatekeeper: Linking V(D)J Recombination to DNA Repair

Saturday, January 20 | 8:00AM - 11:15AM
Pathways of Break Repair
Room: Peaks 1-5

Speaker 2 of 6
Piero R. Bianco, University at Buffalo, State University of New York, USA
Short Talk: Rad54 Protein Translocates and Cross-Bridges dsDNA to Stimulate the Synapsis Stage of Homologous Recombination

Saturday, January 20 | 8:00AM - 11:15AM
Pathways of Break Repair
Room: Peaks 1-5

Speaker 3 of 6
Minoru Takata, Radiation Biology Center, Japan
Interplay Between FANCD2, the Fanconi Anemia Core Complex, and FancJ in DNA Repair

Saturday, January 20 | 8:00AM - 11:15AM
Pathways of Break Repair
Room: Peaks 1-5

Speaker 4 of 6
John A. Tainer, The Scripps Research Institute, USA
The Double-Strand Break Repair Machinery

Saturday, January 20 | 8:00AM - 11:15AM
Pathways of Break Repair
Room: Peaks 1-5

Speaker 5 of 6
Les A. Hanakahi, University of Illinois at Chicago, Rockford Campus, USA
Short Talk: Inhibition of Non-Homologous End-Joining by Adenoviral Oncoproteins: Inactivation of DNA Repair Protein XRCC4

Saturday, January 20 | 8:00AM - 11:15AM
Pathways of Break Repair
Room: Peaks 1-5

Speaker 6 of 6
Graeme C. M. Smith, KuDOS Pharmaceuticals Ltd., UK
DNA Repair Pathways as Targets for Cancer Therapeutics

Saturday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, January 20 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Saturday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 1 of 10
* Judith Campisi, Buck Institute for Research on Aging, USA

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 2 of 10
Shan Zha, Columbia University Medical Center, USA

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 3 of 10
Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Positional Stability of Single Double Strand Breaks in Living Mammalian Cells


Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 4 of 10
Kok Lung Chan, Weatherall Institute of Molecular Medicine, UK
The Localization of BLM Defines a Novel Class of Anaphase Bridges

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 5 of 10
Bin Wang, University of Texas MD Anderson Cancer Center, USA
Identification of a Novel Brca1 Associated Protein Complex that is Involved in the DNA Damage Response

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 6 of 10
Ciaran G. Morrison, National University of Ireland, Galway, Ireland
Distinct BRCT Domains in Mcph1/Brit1 Mediate Gamma-H2AX Interaction and Centrosomal Localisation

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 7 of 10
Patrick Ryan Potts, University of Texas Southwestern Medical Center, USA
Human SMC5/6 Complex Is Required for Telomere Recombination and Maintenance in ALT Cells

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 8 of 10
Susanna Maxwell Lewis, Harvard Medical School, USA
Coming and Going: Controlling Palindromy in Mammalian Genomes

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 9 of 10
Robert Hromas, University of New Mexico, USA
The Human Transposase Metnase Mediates NHEJ repair, HIV Integration, and Progression Through the Decatenation Cell Cycle Checkpoint

Saturday, January 20 | 2:30PM - 4:30PM
Workshop 2: Genomic Instability in Aging, Cancer and Genetic
Disease
Room: Peaks 1-5

Speaker 10 of 10
Patricia L. Opresko, University of Pittsburgh, USA
Processing of Telomere Ends by the Werner Syndrome Protein and Telomeric POT1 Protein

Saturday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, January 20 | 5:00PM - 7:00PM
Aging
Room: Peaks 1-5

Speaker 1 of 5
* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Human Premature Aging and DNA Repair

Saturday, January 20 | 5:00PM - 7:00PM
Aging
Room: Peaks 1-5

Speaker 2 of 5
Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Repair in Cancer and Aging

Saturday, January 20 | 5:00PM - 7:00PM
Aging
Room: Peaks 1-5

Speaker 3 of 5
Jung-Hyun Min, Memorial Sloan-Kettering Cancer Center, USA

Saturday, January 20 | 5:00PM - 7:00PM
Aging
Room: Peaks 1-5

Speaker 4 of 5
JoAnn M. Sekiguchi, University of Michigan, USA
Short Talk: Dysfunctional Nuclease Activity Leads to Partial Immunodeficiency and Genomic Instability

Saturday, January 20 | 5:00PM - 7:00PM
Aging
Room: Peaks 1-5

Speaker 5 of 5
Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Substantial Overlap in Acquired Chromosomal Aberrations in a Murine Model of Genomic Instability and Human Cancer

Saturday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Saturday, January 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 14-17


Sunday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Sunday, January 21 | 8:00AM - 11:15AM
Programmed Genomic Instability in the Immune Response
Room: Peaks 1-5

Speaker 1 of 6
* Nancy Maizels, University of Washington School of Medicine, USA
Molecular Mechanisms of Immunoglobulin Gene Diversification

Sunday, January 21 | 8:00AM - 11:15AM
Programmed Genomic Instability in the Immune Response
Room: Peaks 1-5

Speaker 2 of 6
Ronald Chalmers, University of Nottingham Medical School, UK
Short Talk: The Mechanism of Base Flipping and DNA Bending in V(D)J Recombination and DNA Transposition

Sunday, January 21 | 8:00AM - 11:15AM
Programmed Genomic Instability in the Immune Response
Room: Peaks 1-5

Speaker 3 of 6
Michael S. Neuberger, Medical Research Council, UK
Immunity through DNA Deamination

Sunday, January 21 | 8:00AM - 11:15AM
Programmed Genomic Instability in the Immune Response
Room: Peaks 1-5

Speaker 4 of 6
Myron F. Goodman, University of Southern California, USA
Biochemical Scanning Mechanisms of DNA Cytidine Deaminases AID and Apo3G

Sunday, January 21 | 8:00AM - 11:15AM
Programmed Genomic Instability in the Immune Response
Room: Peaks 1-5

Speaker 5 of 6
Katheryn D. Meek, Michigan State University, USA
Short Talk: The RAG Complex Physically Directs DSBs into the NHEJ Pathway

Sunday, January 21 | 8:00AM - 11:15AM
Programmed Genomic Instability in the Immune Response
Room: Peaks 1-5

Speaker 6 of 6
Bertrand Nadel, CNRS-INSERM - Universite de la Medditerranee, France
Reactive DNA Ends as Byproducts of Lymphocyte Receptor Construction

Sunday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, January 21 | 5:00PM - 7:00PM
Outcomes of Genomic Instability
Room: Peaks 1-5

Speaker 1 of 4
* André Nussenzweig, NCI, National Institutes of Health, USA
Relationship between DNA Damage Detection and Signaling in Vivo

Sunday, January 21 | 5:00PM - 7:00PM
Outcomes of Genomic Instability
Room: Peaks 1-5

Speaker 2 of 4
Jiri Bartek, Danish Cancer Society, Denmark
Coordination of DNA Repair with DNA Damage Checkpoints and Their Role in Cancer Pathogenesis

Sunday, January 21 | 5:00PM - 7:00PM
Outcomes of Genomic Instability
Room: Peaks 1-5

Speaker 3 of 4
Chengming (Ben) Zhu, University of Texas MD Anderson Cancer Center, USA
Short Talk: Role of p53-Dependent Cell Cycle Arrest in Tumor Suppression

Sunday, January 21 | 5:00PM - 7:00PM
Outcomes of Genomic Instability
Room: Peaks 1-5

Speaker 4 of 4
Peter J. McKinnon, St. Jude Children's Research Hospital, USA
Linking DNA Damage, Neurodegeneration and Brain Tumors

Sunday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Sunday, January 21 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 14-17


Sunday, January 21 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 14-17


Monday, January 22 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.