Web Desc
Mast Cells, Basophils, and IgE: Host Defense and Disease
Organizer(s): Joshua A. Boyce, K. Frank Austen, Jean S. Marshall and William E. Paul
Date: January 20 - 24, 2007
Location: Copper Mountain Resort, Copper Mountain, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Mast cells, basophils, and IgE form a strongly conserved interface between innate and adaptive mucosal immune systems. Each cell is a sensitive detector of environmental perturbations, to which they respond by generating and releasing a distinctive profile of mediators. The development of progressively more sophisticated experimental models has permitted the recognition of clear-cut and novel functions for mast cells and basophils in mediating effector cell recruitment, facilitating antigen presentation, inducing and amplifying immune responses, and modulating host responses in disease models. This program will focus on new aspects of development and trafficking of both cell lineages, homeostatic controls of cell activation, in-depth examination of mast cell and basophil-derived mediators, the roles of these cells in both allergic (IgE-mediated) and non-allergic disease, and therapeutic modulation of their roles in both mouse models and human disease.
Scholarship Deadline: September 20 2006
Discounted Abstract Deadline: September 20 2006
Abstract Deadline: October 23 2006
Discounted Registration Deadline: November 20 2006
We gratefully acknowledge additional support for this conference from:
UCB Celltech
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI071684-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 20 | 3:00PM - 7:30PM
Registration
Room: Kokopelli's


Saturday, January 20 | 6:30PM - 7:30PM
Refreshments
Room: Kokopelli's


Saturday, January 20 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn B

Speaker 1 of 1
William E. Paul, NIAID, National Institutes of Health, USA
Searching for IL-4 or How I Came to Love the Basophil

Sunday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Sunday, January 21 | 8:00AM - 11:00AM
Development and Trafficking
Room: Bighorn B

Speaker 1 of 6
* Dean D. Metcalfe, NIAID, National Institutes of Health, USA

Sunday, January 21 | 8:00AM - 11:00AM
Development and Trafficking
Room: Bighorn B

Speaker 2 of 6
Koichi Akashi, Kyushu University, Japan
The Origin and Developmental Mechanism of Mast Cells, Basophils and Eosinophils

Sunday, January 21 | 8:00AM - 11:00AM
Development and Trafficking
Room: Bighorn B

Speaker 3 of 6
Constance Oliver, Faculty of Medicine at Ribeirão Preto, University of São Paulo, Brazil
Recruitment and Homing of Mast Cell Precursors, Immature and Mature Mast Cells

Sunday, January 21 | 8:00AM - 11:00AM
Development and Trafficking
Room: Bighorn B

Speaker 4 of 6
Charlie Weller, Wellcome Trust, UK
Activated Mature Mast Cells can Recruit Progenitors that Express the BLT1 Receptor

Sunday, January 21 | 8:00AM - 11:00AM
Development and Trafficking
Room: Bighorn B

Speaker 5 of 6
Michael F. Gurish, Brigham and Women's Hospital, Harvard Medical School, USA
Defining the Mechanisms Controlling Basal Homing and Inflammatory Recruitment of Committed Mast Cell Progenitors to the Intestine and Lung

Sunday, January 21 | 8:00AM - 11:00AM
Development and Trafficking
Room: Bighorn B

Speaker 6 of 6
Scott Byrne, University of Sydney, Australia
Short Talk: CXCR4-Mediated Mast Cell Migration to Lymph Nodes is Essential for UV-Induced Immune Suppression

Sunday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Sunday, January 21 | 11:00AM - 1:00PM
Poster Setup
Room: Bighorn C


Sunday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 1 of 8
* Gunnar Pejler, Swedish University of Agricultural Sciences, Sweden

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 2 of 8
* Richard L. Stevens, Brigham and Women's Hospital, USA
Ancient Origin of Connective Tissue Mast Cells and their Granule and Lipid Mediators

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 3 of 8
Magnus Åbrink, Uppsala University, Sweden
Serglycin-Deficiency in Ageing Mice Leads to Splenomegaly, Enlarged Peyer’s Patches and Bronchus-Associated Lymphoid Tissues (BALTs)

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 4 of 8
Tiago Braga Moreira de Campos Carlos, Swedish University of Agricultural Sciences, Sweden
Serglycin Proteoglycan is Required for Secretory Granule Integrity in Mucosal Mast Cells

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 5 of 8
Hans-Reimer Rodewald, Ulm University, Germany
A Single Mast Cell Enzyme, Carboxypeptidase A, is Essential for Protection against Snake Venom Sarafotoxin

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 6 of 8
Shakeel M. Thakurdas, University of Texas, MD Anderson Cancer Center, USA
Mouse Mast Cell Protease 6 is Essential in Defense against Gram- Negative Bacterial Infection

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 7 of 8
Katherine R. Groschwitz, Cincinnati Children's Hospital Medical Center, USA
Intestinal Expression of Interleukin 9 (IL-9) Induces Mast Cell-Mediated Intestinal Permeability

Sunday, January 21 | 2:30PM - 4:30PM
Workshop 1: Novel Functions of Mast Cell Proteases
Room: Bighorn B

Speaker 8 of 8
Kichul Shin, Seoul National University Hospital, South Korea
Mast Cell Tryptase mMCP-6 Enhances Skeletal Muscle Larvae Necrosis and Tissue Eosinophilia in Trichinella spiralis Infection

Sunday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Sunday, January 21 | 5:00PM - 7:15PM
What's New in Signal Transduction and Transcription
Room: Bighorn B

Speaker 1 of 4
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Contrasting Mechanisms of Transcriptional Control in Mast Cells and Th2 Cells

Sunday, January 21 | 5:00PM - 7:15PM
What's New in Signal Transduction and Transcription
Room: Bighorn B

Speaker 2 of 4
Tatsuki R. Kataoka, Osaka University, Japan
STAT4 Expression and Th1-Polarizing Characteristics of Connective Tissue Type Mast Cells

Sunday, January 21 | 5:00PM - 7:15PM
What's New in Signal Transduction and Transcription
Room: Bighorn B

Speaker 3 of 4
Christine Tkaczyk, Nabi Biopharmaceuticals, USA
Role of the Transmembrane Adaptor Protein (TRAP) NTAL/LAB/LAT2 (NTAL) in Mast Cell Activation

Sunday, January 21 | 5:00PM - 7:15PM
What's New in Signal Transduction and Transcription
Room: Bighorn B

Speaker 4 of 4
Ehud Razin, Hebrew University, Hadassah Medical School, Israel
Lysyl tRNA Synthetase is an Intracellular, Immunologically Activated Signaling Molecule in Mast Cells

Sunday, January 21 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Bighorn C


Sunday, January 21 | 7:15PM - 10:00PM
Poster Session 1
Room: Bighorn C


Monday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Monday, January 22 | 8:00AM - 11:15AM
Innate Immunity
Room: Bighorn B

Speaker 1 of 6
* Jean S. Marshall, Dalhousie University, Canada
Selective Mast Cell Responses to Pathogen Products

Monday, January 22 | 8:00AM - 11:15AM
Innate Immunity
Room: Bighorn B

Speaker 2 of 6
Matthias Mack, University of Regensburg, Germany
Basophils as Antigen Capturing Cells and their Role in Immune Regulation

Monday, January 22 | 8:00AM - 11:15AM
Innate Immunity
Room: Bighorn B

Speaker 3 of 6
Marcus Maurer, Charité - Universitätsmedizin Berlin, Germany
Mast Cell-Dependent Homeostasis in Sepsis- The Role of Endothelin 1

Monday, January 22 | 8:00AM - 11:15AM
Innate Immunity
Room: Bighorn B

Speaker 4 of 6
John T. Schroeder, Johns Hopkins Asthma and Allergy Center, USA
Innate Immunity in Modulating Basophil Responses

Monday, January 22 | 8:00AM - 11:15AM
Innate Immunity
Room: Bighorn B

Speaker 5 of 6
Marc Becker, Institute for Immunology, Germany
Short Talk: Murine Mast Cells Prime the Development of Cytotoxic T Cell Responses by Epicutaneous Peptide Vaccination with TLR7 Ligand as Adjuvant

Monday, January 22 | 8:00AM - 11:15AM
Innate Immunity
Room: Bighorn B

Speaker 6 of 6
Jared M. Brown, University of Colorado Anshutz Medical Campus, USA
Short Talk: Preservation of Innate and Acquired Immune Function in Mast Cells Following Radiation Exposure

Monday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, January 22 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn C


Monday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn C


Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 1 of 9
* Melissa A. Brown, Northwestern University, USA

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 2 of 9
* A. Dean Befus, University of Alberta, Canada

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 3 of 9
Jeoung-Sook Shin, University of California, San Francisco, USA
Harboring of Particulate Allergens within Secretory Compartments by Mast Cells Following IgE/FcepsilonRI-Lipid Raft Mediated Phagocytosis

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 4 of 9
Clinton B. Mathias, Children's Hospital, Harvard Medical School, USA
Allergen-Driven Mast Cell Expansion in the Airways is Driven by IgE Antibodies

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 5 of 9
Duraisamy Kempuraj, Tufts University School of Medicine, USA
Myelin Basic Protein Stimulates Human Mast Cells and Together they Activate T Cells: Inhibition by Luteolin and Implications for Multiple Sclerosis

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 6 of 9
Guy J.T. Delespesse, Centre de Recherche du CHUM, Canada
Thymic Stromal Lymphopoietin (TSLP) is a Potent Activator of Human Mast Cells

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 7 of 9
Michael Stassen, Johannes Gutenberg University, Germany
p38 MAP Kinase and GATA-1 are Part of a Mast Cell-Specific Signaling Network which Drives the Expression of the Th2-Type Cytokine IL-9

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 8 of 9
J. Bruce Sundstrom, NIAID, National Institutes of Health, USA
IgE Enhances CXCR4 Expression and Susceptibility to Infection with CXCR4-Tropic HIV-1 During Ontogeny of Human Mast Cells

Monday, January 22 | 2:30PM - 4:30PM
Workshop 2: Mast Cells in Acquired Immunity
Room: Bighorn B

Speaker 9 of 9
Anna Erdei, Eötvös University, Hungary
The Effect of Complement-Derived Inhibitory Peptides on FcepsiloneRI-Clustering Induced Mast Cell Signaling

Monday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Monday, January 22 | 5:00PM - 7:00PM
Novel Aspects of Mast Cell and Basophil Function in Inflamma
tion and Disease

Room: Bighorn B

Speaker 1 of 4
* Erwin W. Gelfand, National Jewish Medical and Research Center, USA
Mast Cell-T Cell Interactions: A New Paradigm

Monday, January 22 | 5:00PM - 7:00PM
Novel Aspects of Mast Cell and Basophil Function in Inflamma
tion and Disease

Room: Bighorn B

Speaker 2 of 4
David R. Beier, Brigham and Women's Hospital, Harvard Medical School, USA
Mast Cells in the Regulation of Naive Airway Responsiveness; Lessons from A/J Mice

Monday, January 22 | 5:00PM - 7:00PM
Novel Aspects of Mast Cell and Basophil Function in Inflamma
tion and Disease

Room: Bighorn B

Speaker 3 of 4
Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Basophils Regulate Chronic Allergic Inflammation

Monday, January 22 | 5:00PM - 7:00PM
Novel Aspects of Mast Cell and Basophil Function in Inflamma
tion and Disease

Room: Bighorn B

Speaker 4 of 4
Silvana Balzar, University of Pittsburgh, USA
Short Talk: Mast Cell Phenotypes in Large Airway Smooth Muscle and Submucosa of Normal Subjects and Subjects with Asthma do not Correlate with Lung Function

Monday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Bighorn C


Monday, January 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Bighorn C


Tuesday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Tuesday, January 23 | 8:00AM - 11:00AM
Negative Regulation of Mast Cell and Basophil Activation
Room: Bighorn B

Speaker 1 of 4
* Juan Rivera, USA
Lipid Regulators of IgE/Fc Epsilon Homeostasis and Function

Tuesday, January 23 | 8:00AM - 11:00AM
Negative Regulation of Mast Cell and Basophil Activation
Room: Bighorn B

Speaker 2 of 4
Marc Daëron, Institut Pasteur, France
Modulation of Mast Cell and Basophil Activation by FcgammaRIIB

Tuesday, January 23 | 8:00AM - 11:00AM
Negative Regulation of Mast Cell and Basophil Activation
Room: Bighorn B

Speaker 3 of 4
Jean-Pierre Kinet, Beth Israel Deaconess Medical Center and Harvard Medical School, USA
Calcium Signaling in Mast Cells

Tuesday, January 23 | 8:00AM - 11:00AM
Negative Regulation of Mast Cell and Basophil Activation
Room: Bighorn B

Speaker 4 of 4
See-ying Tam, Stanford University, USA
Regulation of Mast Cell Activation by RabGEF1/Rabex-5

Tuesday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 1 of 9
* K. Frank Austen, Harvard Medical School, USA

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 2 of 9
* George H. Caughey, University of California, San Francisco, USA
W/W-v Versus W-sh Mast Cell-Deficient Mice: Pros, Cons and Challenges

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 3 of 9
Michele Grimbaldeston, Centre for Cancer Biology, Australia
Comparative Studies of Mast Cell Biology in vivo Using C57BL/6-KitW-sh/W-sh versus WB x C57BL/6 F1 (WBB6F1)-KitW/W-v Mice

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 4 of 9
Howard R. Katz, Brigham and Women's Hospital, Harvard Medical School, USA
Inflammatory Arthritis is Intact in KitW-sh/W-sh Mice and is Exacerbated by LILRB4 Deficiency

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 5 of 9
Wojciech Dawicki, University of Saskatchewan, Canada
Mast Cell Activation Selectively Promotes the Recruitment of Multiple Dendritic Cell Subpopulations to the Lymph Node

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 6 of 9
Ernestina Melicoff, University of Texas MD Anderson Cancer Center, USA
Selective Defect in Mast Cell Regulated Exocytosis: Its Importance in Allergy and Infection

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 7 of 9
Guo-Ping Shi, Brigham and Women's Hospital, USA
Mast Cell, a Novel Aortic Cell Type, Controls the Pathogenesis of Abdominal Aortic Aneurysms

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 8 of 9
Barry K. Wershil, Albert Einstein College of Medicine, USA
Substance P-Induced Gastric Inflammation Requires Mast Cell Production of Leukotrienes but not Tumor Necrosis Factor alpha

Tuesday, January 23 | 2:30PM - 4:30PM
Workshop 3: Differences in Biologic Outcomes between the Two
Strains of Mast Cell-Deficient Mice (Wsh and W/Wv)
Room: Bighorn B

Speaker 9 of 9
Paul Wolters, University of California, San Francisco, USA
Mast Cell IL-6 Improves Survival Following Klebsiella Pneumonia and Sepsis by Enhancing Neutrophil Killing

Tuesday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Tuesday, January 23 | 5:00PM - 7:15PM
Regulation of Activation by Lysophospholipids and Lipids
Room: Bighorn B

Speaker 1 of 5
Sarah Spiegel, Virginia Commonwealth University, USA
Sphingosine-1-Phosphate in Mast Cell Activation

Tuesday, January 23 | 5:00PM - 7:15PM
Regulation of Activation by Lysophospholipids and Lipids
Room: Bighorn B

Speaker 2 of 5
Ana Olivera, NIAMS, National Institutes of Health, USA
Sphingosine Kinases are Determinants of Mast Cell Function and Anaphylaxis

Tuesday, January 23 | 5:00PM - 7:15PM
Regulation of Activation by Lysophospholipids and Lipids
Room: Bighorn B

Speaker 3 of 5
* Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Cysteinyl Leukotrienes as Regulators of Mast Cell Function

Tuesday, January 23 | 5:00PM - 7:15PM
Regulation of Activation by Lysophospholipids and Lipids
Room: Bighorn B

Speaker 4 of 5
Stefen A. Boehme, Actimis Pharmaceuticals, USA
Short Talk: Murine Bone Marrow Derived Mast Cells Express the CRTH2 Receptor

Tuesday, January 23 | 5:00PM - 7:15PM
Regulation of Activation by Lysophospholipids and Lipids
Room: Bighorn B

Speaker 5 of 5
Tae Chul Moon, University of Alberta, Canada
Short Talk: Exogenous Nitric Oxide Regulates Cyclooxygenase-2 Expression and Prostaglandin D2 Generation In Mouse Bone Marrow-Derived Mast Cells

Tuesday, January 23 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Bighorn C


Tuesday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Bighorn C


Tuesday, January 23 | 8:00PM - 11:00PM
Cash Bar
Room: Bighorn C


Wednesday, January 24 | 10:26AM - 10:26AM
Departure


*Session Chair.