Web Desc
Host Cell Interaction and Response to the Cancer Cell
Organizer(s): David A. Cheresh and Nicholas P. Restifo
Date: January 21 - 26, 2007
Location: Keystone Resort, Keystone, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Tumor growth and invasion depends on the ability of tumor cells to respond to a wide range of host cells. However, it is clear that host cells also respond to the presence of the tumor. In fact it is the outcome of these cellular interactions that may well predict the clinical course of a wide variety of cancers. During growth at the primary site, tumor cells interact locally with fibroblasts and their extracellular matrix. Tumors often produce an inflammatory response causing immune cell recruitment to the tumor; the ability of a tumor cell to evade this immune recognition is a critical determinant of the tumor’s capacity to spread. Tumor cell invasion and metastasis also depend on the ability of tumor cells to recruit a blood supply to nourish the tumor. The resulting blood vessels often serve as a conduit for metastasis. While in the circulation, interactions between tumor cells and platelets can further facilitate tumor metastasis. Ultimately, tumors respond to a variety of cells and microenvironments in a wide range of organs including the lymph node, lung, liver, brain, and bone. Given the critical role of tumor cell-host cell interactions in tumor growth and metatasis as well as the therapeutic potential offered by intervening in these interactions, developing a better understanding of the molecular basis for these cellular interactions is imperative. In addition, it is critical to determine how these cell-cell interactions directly influence the cancer cell and its gene expression, proliferation rate, and capacity to evade recognition by host immune cells. The goal of this meeting is to bring together experts in areas such as tumor immunology, angiogenesis and tumor cell biology to begin to define the host cellular response to the tumor and to identify new molecular pathways leading to a better understanding of tumor invasion and metastasis.
Scholarship Deadline: September 21 2006
Discounted Abstract Deadline: September 21 2006
Abstract Deadline: October 24 2006
Discounted Registration Deadline: November 21 2006
We gratefully acknowledge additional support for this conference from:
UCB Celltech
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 21 | 3:00PM - 7:30PM
Registration
Room: Shavano Foyer


Sunday, January 21 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Foyer


Sunday, January 21 | 7:30PM - 8:30PM
Keynote Address: Cancer and the Inflammatory Response
Room: Red Cloud/Shavano

Speaker 1 of 1
Michael Karin, University of California, San Diego, USA
Inflammation and Cancer

Monday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Torreys


Monday, January 22 | 8:00AM - 11:00AM
Tumor Response to Host Cells
Room: Red Cloud/Shavano

Speaker 1 of 5
* Harold L. Moses, Vanderbilt University, USA
TGF-beta Regulation of Stromal Cells in Cancer Initiation and Progression

Monday, January 22 | 8:00AM - 11:00AM
Tumor Response to Host Cells
Room: Red Cloud/Shavano

Speaker 2 of 5
Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
FoxOs in Cancer and Aging

Monday, January 22 | 8:00AM - 11:00AM
Tumor Response to Host Cells
Room: Red Cloud/Shavano

Speaker 3 of 5
Filippo G. Giancotti, Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Integrin Signaling during Breast Tumorigenesis

Monday, January 22 | 8:00AM - 11:00AM
Tumor Response to Host Cells
Room: Red Cloud/Shavano

Speaker 4 of 5
Yves A. DeClerck, Children's Hospital Los Angeles, USA
Bone Marrow Microenvironment and Tumor Progression

Monday, January 22 | 8:00AM - 11:00AM
Tumor Response to Host Cells
Room: Red Cloud/Shavano

Speaker 5 of 5
Marina Bacac, University of Lausanne, Switzerland
Short Talk: A Mouse Stromal Response to Tumor Invasion Predicts Prostate and Breast Cancer Patient Survival

Monday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Foyer


Monday, January 22 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys


Monday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys


Monday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Foyer


Monday, January 22 | 5:00PM - 7:00PM
Tumor Response to Host Cells II
Room: Red Cloud/Shavano

Speaker 1 of 4
* Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Site-Specific Metastasis Genes and Functions

Monday, January 22 | 5:00PM - 7:00PM
Tumor Response to Host Cells II
Room: Red Cloud/Shavano

Speaker 2 of 4
Brunhilde Felding-Habermann, The Scripps Research Institute, USA
Platelet Adhesive Interactions with Tumor Cells

Monday, January 22 | 5:00PM - 7:00PM
Tumor Response to Host Cells II
Room: Red Cloud/Shavano

Speaker 3 of 4
Ruth J. Muschel, John Radcliffe Hospital, UK
Coagulation, Blood Vessels and Pulmonary Metastasis

Monday, January 22 | 5:00PM - 7:00PM
Tumor Response to Host Cells II
Room: Red Cloud/Shavano

Speaker 4 of 4
Jennifer Kirstein, University of Western Ontario, Canada
Short Talk: Effect of Coagulation on Melanoma Metastasis in Aprotinin Treated Animals

Monday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano Foyer


Monday, January 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys


Tuesday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Torreys


Tuesday, January 23 | 8:00AM - 11:15AM
Vascular Response to the Tumor
Room: Red Cloud/Shavano

Speaker 1 of 5
* Gabriele A.I. Bergers, University of Leuven, Belgium
Hypoxia-Dependent Mechanisms of Blood Vessel Formation in Tumors

Tuesday, January 23 | 8:00AM - 11:15AM
Vascular Response to the Tumor
Room: Red Cloud/Shavano

Speaker 2 of 5
Donald M. McDonald, University of California, San Francisco, USA
Imaging the Vascular Compartment in Tumors: Effects of Angiogenesis Inhibitors

Tuesday, January 23 | 8:00AM - 11:15AM
Vascular Response to the Tumor
Room: Red Cloud/Shavano

Speaker 3 of 5
Harold F. Dvorak, Beth Israel Deaconess Medical Center, USA
Building Tumor Blood Vessels

Tuesday, January 23 | 8:00AM - 11:15AM
Vascular Response to the Tumor
Room: Red Cloud/Shavano

Speaker 4 of 5
Bruce R. Zetter, Children's Hospital Boston, USA
Microenvironmental Control of Prostate Cancer Growth via Protein Degradation

Tuesday, January 23 | 8:00AM - 11:15AM
Vascular Response to the Tumor
Room: Red Cloud/Shavano

Speaker 5 of 5
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Matrix and Tumor Microenvironment in Cancer Progression and Metastasis

Tuesday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Foyer


Tuesday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys


Tuesday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys


Tuesday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Foyer


Tuesday, January 23 | 5:00PM - 7:00PM
Vascular Response to the Tumor II
Room: Red Cloud/Shavano

Speaker 1 of 4
* Judith A. Varner, University of California, San Diego, USA
Integrin Roles in Tumor Angiogenesis and Lymphangiogenesis

Tuesday, January 23 | 5:00PM - 7:00PM
Vascular Response to the Tumor II
Room: Red Cloud/Shavano

Speaker 2 of 4
Elisabetta Dejana, Uppsala University, Sweden
Cadherins in Cancer and Tumor Vasculature

Tuesday, January 23 | 5:00PM - 7:00PM
Vascular Response to the Tumor II
Room: Red Cloud/Shavano

Speaker 3 of 4
Alireza Alavi, Autolus Inc, USA
Short Talk: Chemoresistance of Endothelial Cells Induced by bFGF Depends on Raf-1-Mediated Inhibition of the Pro-Apoptotic Kinase, ASK1

Tuesday, January 23 | 5:00PM - 7:00PM
Vascular Response to the Tumor II
Room: Red Cloud/Shavano

Speaker 4 of 4
Carmen Z. Cantemir-Stone, Ohio State University, USA
Short Talk: Critical Role of Ets2 in Regulating Fibroblasts Survival and Activity in the Breast Cancer Microenvironment

Tuesday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano Foyer


Tuesday, January 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys


Wednesday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Torreys


Wednesday, January 24 | 8:00AM - 11:00AM
Vascular and Lymphatic Invasion
Room: Red Cloud/Shavano

Speaker 1 of 5
* David A. Cheresh, University of California, San Diego, USA
Angiogenesis Inhibition by Stabilizing the DFG/P-Loop Interaction in Raf

Wednesday, January 24 | 8:00AM - 11:00AM
Vascular and Lymphatic Invasion
Room: Red Cloud/Shavano

Speaker 2 of 5
Carlos Bais, Genentech, Inc., USA
Targeting VEGF to Attack Pathological Blood Supply

Wednesday, January 24 | 8:00AM - 11:00AM
Vascular and Lymphatic Invasion
Room: Red Cloud/Shavano

Speaker 3 of 5
Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
Targeting the Plasticity of Metastatic Tumor Cells

Wednesday, January 24 | 8:00AM - 11:00AM
Vascular and Lymphatic Invasion
Room: Red Cloud/Shavano

Speaker 4 of 5
Michael C. Schmid, University of Liverpool, UK
Short Talk: SDF-1alpha and IL-1beta Activate Integrin alpha4beta1 to Promote Homing of Bone Marrow Derived Cells to Tumor Vasculature

Wednesday, January 24 | 8:00AM - 11:00AM
Vascular and Lymphatic Invasion
Room: Red Cloud/Shavano

Speaker 5 of 5
Young Chul Kim, University of Wisconsin, Madison, USA
Short Talk: Wnt1 Activates Stromal Cells and Mobilizes Endothelial Precursor Cells During Mouse Mammary Tumor Development

Wednesday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Foyer


Wednesday, January 24 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Foyer


Wednesday, January 24 | 5:00PM - 7:00PM
Recognition of the Cancer Cell
Room: Red Cloud/Shavano

Speaker 1 of 4
* Ulf R. Rapp, University of Wurzburg, Germany
Role of Angiogenic Switch Induction and Tumor Stem Cells in Progression of Raf-Induced Lung Tumors to Metastasis

Wednesday, January 24 | 5:00PM - 7:00PM
Recognition of the Cancer Cell
Room: Red Cloud/Shavano

Speaker 2 of 4
Masataka Majima, Kitasato University School of Medicine, Japan
Inflammatory Response to Cancer. Role of Prostaglandins in Tumor-associated Angiogenesis

Wednesday, January 24 | 5:00PM - 7:00PM
Recognition of the Cancer Cell
Room: Red Cloud/Shavano

Speaker 3 of 4
Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany
Transgenic Mice with Sporadic Immunogenic Tumors

Wednesday, January 24 | 5:00PM - 7:00PM
Recognition of the Cancer Cell
Room: Red Cloud/Shavano

Speaker 4 of 4
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Short Talk: Dynamic Imaging in Living Mice Reveals Effects of the Tumor Microenvironment on Leukocyte Behavior

Wednesday, January 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano Foyer


Thursday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Torreys


Thursday, January 25 | 8:00AM - 11:30AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / St
romal Barriers

Room: Red Cloud/Shavano

Speaker 1 of 6
* Judith Campisi, Buck Institute for Research on Aging, USA
Stromal-Epithelial Interactions in Aging and Cancer

Thursday, January 25 | 8:00AM - 11:30AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / St
romal Barriers

Room: Red Cloud/Shavano

Speaker 2 of 6
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Protease Requirements in Cancer Invasion in vitro and in Vivo: From Individual to Collective Cell Migration

Thursday, January 25 | 8:00AM - 11:30AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / St
romal Barriers

Room: Red Cloud/Shavano

Speaker 3 of 6
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Tumor-Educated Macrophages as Promoters of Tumor Progression

Thursday, January 25 | 8:00AM - 11:30AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / St
romal Barriers

Room: Red Cloud/Shavano

Speaker 4 of 6
Alberto Mantovani, Humanitas University, Italy
Smoldering Inflammation in the Initiation and Promotion of Malignant Disease

Thursday, January 25 | 8:00AM - 11:30AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / St
romal Barriers

Room: Red Cloud/Shavano

Speaker 5 of 6
Michael Bouvet, University of California, San Diego, USA
Short Talk: In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver Metastases

Thursday, January 25 | 8:00AM - 11:30AM
How Tumor Cells Exploit Host Immune Defenses and Tissue / St
romal Barriers

Room: Red Cloud/Shavano

Speaker 6 of 6
Shahin Rafii, Weill Cornell Medical College, USA
Contribution of Bone Marrow's Vascular Microenvironment to Tumor Angiogenesis

Thursday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Foyer


Thursday, January 25 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Foyer


Thursday, January 25 | 5:00PM - 7:00PM
New Therapies Based on Host Interactions with the Cancer Cel
l

Room: Red Cloud/Shavano

Speaker 1 of 3
* Hans Schreiber, University of Chicago, USA
New Strategies of Cancer Therapy by Targeting Antigens Resulting from Tumor-Specific
Mutations


Thursday, January 25 | 5:00PM - 7:00PM
New Therapies Based on Host Interactions with the Cancer Cel
l

Room: Red Cloud/Shavano

Speaker 2 of 3
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
How Suppression of Stat3 Activation Potentiates Innate and Adaptive Anti-Tumor Immunity


Thursday, January 25 | 5:00PM - 7:00PM
New Therapies Based on Host Interactions with the Cancer Cel
l

Room: Red Cloud/Shavano

Speaker 3 of 3
Nicholas P. Restifo, Lyell, USA
Adoptive Immunotherapy: Building on Success

Thursday, January 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano Foyer


Thursday, January 25 | 8:00PM - 11:00PM
Entertainment
Room: Castle Peaks


Thursday, January 25 | 8:00PM - 11:00PM
Cash Bar
Room: Castle Peaks


Friday, January 26 | 10:26AM - 10:26AM
Departure


*Session Chair.