Web Desc
Drugs Against Protozoan Parasites
Organizer(s): Daniel E. Goldberg, R. Kip Guy and Stephen A. Ward
Date: January 28 - February 01, 2007
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
This is a period of rapid progress for the field of anti-protozoal drug development. Genomic efforts have led to the identification of a myriad of new drug targets. Studies on the mechanisms of drug action and drug resistance have yielded new insights into how to improve on old agents. Promising development efforts span the spectrum from lead identification to clinical trials to registration. Key problems include target selection, drug development in an academia-centered environment, and performing trials in endemic areas. This meeting will bring together biologists and chemists with diverse backgrounds and scientists in academia and industry to work together towards solutions to these problems of global importance.
Scholarship Deadline: September 28 2006
Discounted Abstract Deadline: September 28 2006
Abstract Deadline: October 27 2006
Discounted Registration Deadline: November 28 2006
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome Fund
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI071682-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 28 | 3:00PM - 7:30PM
Registration
Room: Prefunction


Sunday, January 28 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 1 of 1
Peter A. Winstanley, University of Liverpool, UK
Tropical Drug Discovery - From Scientific Idea to Registered Product

Monday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 1 of 7
* James H. McKerrow, University of California, San Diego, USA

Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 2 of 7
Julio A. Urbina, Venezuelan Institute for Science Research, USA
Inhibitors of T. cruzi Lipid Biosynthesis as Specific Chemotherapeutic Agents for Chagas Disease

Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 3 of 7
Sylke Müller, University of Glasgow, UK
Antioxidant and Redox Systems of Plasmodium – Targets for Drug Design?

Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 4 of 7
R. Luise Krauth-Siegel, University of Heidelberg, Germany
Enzymes of the Trypanothione Metabolism as Antitrypanosomal Drug Targets

Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 5 of 7
Raymond Hui, University of Toronto, Canada
Short Talk: From Osteoporosis to Cryptosporidiosis: Inhibition of Cryptosporidium parvum Farnesyl Pyrophosphate Synthase by Bisphosphonates

Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 6 of 7
Silvia N. J. Moreno, University of Georgia, USA
Short Talk: A Bifunctional Enzyme in the Isoprenoid Pathway of Toxoplasma gondii is the Target for Bisphosphonates

Monday, January 29 | 8:00AM - 11:00AM
Targets
Room: Mountain/Lake Rooms

Speaker 7 of 7
Rana Nagarkatti, FDA, USA
Short Talk: Targeting the Newly Characterized Plasmodium Protein HDP that Synthesizes Hemozoin; Identification of Novel Inhibitors by High Throughput Screening

Monday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Monday, January 29 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Monday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Monday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Monday, January 29 | 5:00PM - 7:00PM
Functional Genomics/Proteomics
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Ian Street, Walter and Eliza Hall Institute of Medical Research, Australia

Monday, January 29 | 5:00PM - 7:00PM
Functional Genomics/Proteomics
Room: Mountain/Lake Rooms

Speaker 2 of 4
Joseph DeRisi, University of California, San Francisco, USA
Global Transcription Analysis for Drug Development

Monday, January 29 | 5:00PM - 7:00PM
Functional Genomics/Proteomics
Room: Mountain/Lake Rooms

Speaker 3 of 4
Maria Manuel Dias da Mota, Instituto Gulbenkian Ciência, Portugal
Identification of Host Factors Relevant for Malaria Infection

Monday, January 29 | 5:00PM - 7:00PM
Functional Genomics/Proteomics
Room: Mountain/Lake Rooms

Speaker 4 of 4
Marilyn Parsons, Seattle Biomedical Research Institute, USA
Drilling Down on the Kinome of Trypanosomatids

Monday, January 29 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay Room


Monday, January 29 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Tuesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 1 of 7
* Els Torreele, Drugs for Neglected Diseases (DNDi), Switzerland

Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 2 of 7
Norbert De Kimpe, Ghent University, Belgium
Anti-Leishmanial Natural Products from a Medicinal Plant

Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 3 of 7
Kelly Chibale, University of Cape Town, South Africa
Privileged Structures and Multi-Component Reaction Strategies in Antiprotozoal Drug Discovery

Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 4 of 7
H. Ulrich Göringer, Darmstadt University of Technology, Germany
RNA Aptamers as Anti-Trypanosomal Agents

Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 5 of 7
Dennis E. Kyle, University of Georgia, USA
Artemisinin Resistance and Recrudescence Mechanisms

Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 6 of 7
Karl A. Werbovetz, Ohio State University, USA
Short Talk: Linear and Near-linear Diamidines with Potent Antileishmanial Activity

Tuesday, January 30 | 8:00AM - 11:15AM
Compounds
Room: Mountain/Lake Rooms

Speaker 7 of 7
Wayne M. Best, Murdoch University, Australia
Short Talk: A Novel and Highly Potent Class of Compounds
for the Treatment of Trypanosomiasis


Tuesday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Tuesday, January 30 | 11:15AM - 1:00PM
Poster Setup
Room: Bay Room


Tuesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Tuesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Tuesday, January 30 | 5:00PM - 7:00PM
Screening
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Marilyn Parsons, Seattle Biomedical Research Institute, USA

Tuesday, January 30 | 5:00PM - 7:00PM
Screening
Room: Mountain/Lake Rooms

Speaker 2 of 4
Ian Street, Walter and Eliza Hall Institute of Medical Research, Australia
High Throughput Screening Based Drug Discovery: The Search for New and Effective Treatments for Tropical Diseases

Tuesday, January 30 | 5:00PM - 7:00PM
Screening
Room: Mountain/Lake Rooms

Speaker 3 of 4
James C. Sacchettini, Texas A & M University, USA
Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development

Tuesday, January 30 | 5:00PM - 7:00PM
Screening
Room: Mountain/Lake Rooms

Speaker 4 of 4
Jun O. Liu, Johns Hopkins University School of Medicine, USA
Methionine Aminopeptidases as Antimalarial Drug Targets

Tuesday, January 30 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, January 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay Room


Tuesday, January 30 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Wednesday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, January 31 | 8:00AM - 11:00AM
Lead Optimization
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Kelly Chibale, University of Cape Town, South Africa

Wednesday, January 31 | 8:00AM - 11:00AM
Lead Optimization
Room: Mountain/Lake Rooms

Speaker 2 of 5
Jay D. Keasling, University of California, Berkeley, USA
Engineering Microorganisms for Production of Artemisinin

Wednesday, January 31 | 8:00AM - 11:00AM
Lead Optimization
Room: Mountain/Lake Rooms

Speaker 3 of 5
Domingo Gargallo-Viola, GlaxoSmithKline, Spain
Animal Models for Antimalarial Development

Wednesday, January 31 | 8:00AM - 11:00AM
Lead Optimization
Room: Mountain/Lake Rooms

Speaker 4 of 5
James H. McKerrow, University of California, San Diego, USA
Developing Drugs for Parasitic Diseases in an Academic Incubator

Wednesday, January 31 | 8:00AM - 11:00AM
Lead Optimization
Room: Mountain/Lake Rooms

Speaker 5 of 5
Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Quinoline Animalarials Targeting the Parasites Achilles Heel

Wednesday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Prefunction


Wednesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Prefunction


Wednesday, January 31 | 5:00PM - 7:00PM
Drug Development
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Dennis E. Kyle, University of Georgia, USA

Wednesday, January 31 | 5:00PM - 7:00PM
Drug Development
Room: Mountain/Lake Rooms

Speaker 2 of 4
Richard R. Tidwell, University of North Carolina at Chapel Hill, USA
Development of Diamidines for Anti-protozoal Chemotherapy

Wednesday, January 31 | 5:00PM - 7:00PM
Drug Development
Room: Mountain/Lake Rooms

Speaker 3 of 4
Henri Vial, Universite Montpellier II, France
Development of Choline Inhibitors for Antimalarial Chemotherapy

Wednesday, January 31 | 5:00PM - 7:00PM
Drug Development
Room: Mountain/Lake Rooms

Speaker 4 of 4
Els Torreele, Drugs for Neglected Diseases (DNDi), Switzerland
Rediscovering Nitro-Imidazoles as Promising Drug Candidates for Human African trypanosomiasis (HAT)

Wednesday, January 31 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Wednesday, January 31 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Wednesday, January 31 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Wednesday, January 31 | 8:00PM - 11:00PM
Cash Bar
Room: Granhall


Thursday, February 01 | 10:26AM - 10:26AM
Departure


*Session Chair.