Web Desc
Antibodies as Drugs: From Basic Biology to the Clinic
Organizer(s): Jochen G. Salfeld and Karl Dane Wittrup
Date: February 01 - 06, 2007
Location: Fairmont Chateau Lake Louise, Lake Louise, AB, Canada
Sponsored by Abbott Laboratories
For important information on the coronavirus, please click here
Summary of Meeting:
Therapeutic antibodies have become important components of standard care in some areas of clinical practice, but lag behind in others. What can be learned from prior successes and failures of antibody drug development? Interdisciplinary discussions spanning immunobiology, protein engineering, bioprocess development, pharmacokinetics, and clinical medicine for neurological disease, infectious diseases, immunological diseases, and cancer should help identify crosscutting themes and general approaches.
Scholarship Deadline: October 2 2006
Discounted Abstract Deadline: October 2 2006
Abstract Deadline: November 1 2006
Discounted Registration Deadline: December 1 2006
We gratefully acknowledge additional support for this conference from:
Abbott LaboratoriesUCB CelltechVarian, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Abbott Bioresearch Center

Biogen Idec

Bristol-Myers Squibb Company

Domantis Limited

UCB Celltech
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA124284-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 U13 AI60000-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 01 | 3:00PM - 7:30PM
Registration
Room: Mt. Temple Foyer


Thursday, February 01 | 6:30PM - 7:30PM
Refreshments
Room: Mt. Temple Foyer


Thursday, February 01 | 7:30PM - 7:45PM
Opening Remarks
Room: Mt. Temple A-B

Speaker 1 of 1
* Jochen G. Salfeld, Abbott, USA

Thursday, February 01 | 7:45PM - 8:45PM
Keynote Address
Room: Mt. Temple A-B

Speaker 1 of 1
Jeffrey V. Ravetch, Rockefeller University, USA
Mechanism of Therapeutic Antibodies

Friday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Victoria Dining Room


Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 1 of 7
* Jochen G. Salfeld, Abbott, USA

Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 2 of 7
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Natural IgM as a Mediator of Innate Autoimmunity

Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 3 of 7
Birgitta Heyman, Uppsala University, Sweden
Regulation of Antibody Responses via Antibodies, Fc Receptors and Complement

Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 4 of 7
P. Mark Hogarth, Burnet Institute, Australia
Short Talk: Structural and in vivo Analyses of FcgammaRIIa to Define Unique Approaches for the Development of Therapeutic Antibodies and Anti-Inflammatory Compounds

Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 5 of 7
Eugenia Corrales-Aguilar, Heinrich-Heine-University, Düsseldorf, Germany
Short Talk: Receptor-selective Inhibition of IgG-mediated Effector Functions through Herpesviral FcgammaReceptors

Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 6 of 7
Shigeru Iida, Kyowa Hakko Chemical Co., Japan
Short Talk: Non-Fucosylated Therapeutic IgG1 Antibody can Evade the Inhibitory Effect of Serum IgG on Antibody-Dependent Cellular Cytotoxicity Through its High Binding to FcgammaRIIIa

Friday, February 02 | 8:00AM - 11:00AM
Therapeutic Antibody Effector Functions
Room: Mt. Temple A-B

Speaker 7 of 7
Phil Hammond, Zymeworks, USA
Beyond ADCC: Fc Engineered Antibodies with Broadly Improved Function Including Enhanced Phagocytosis

Friday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Mt. Temple Foyer


Friday, February 02 | 11:15AM - 1:00PM
Poster Setup
Room: Mt. Temple C


Friday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Mt. Temple C


Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 1 of 8
* E. Sally Ward, University of Texas Southwestern Medical Center, USA

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 2 of 8
* Eric V. Shusta, University of Wisconsin-Madison, USA

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 3 of 8
Greg Thurber, Massachusetts Institute of Technology, USA
Internalization and Clearance Limit Antibody Uptake – An Experimental and Theoretical Analysis

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 4 of 8
Paul A. Ramsland, RMIT University, Australia
Structural Studies in Antibody Recognition of Type 2 Lewis Carbohydrates and Implications for Cancer Immunotherapy

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 5 of 8
Michael M. Schmidt, Compass Therapeutics, USA
Engineering Antibody Fragments for Improved Targeting of Solid Tumors and Micrometastases

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 6 of 8
Gerard Zurawski, Baylor Institute for Immunology Research, USA
Anti-Dendritic Cell Receptor Recombinant Antibodies Fused to Cancer and Viral Antigens Effectively Target the Antigens to Human Dendritic Cells and Elicit Potent Immune Responses

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 7 of 8
Esther Breij, Genmab, Netherlands
Chimeric Surfactant Protein D/anti-Fc Receptor Proteins as a Tool to Enhance Host Defense Against Infections

Friday, February 02 | 2:30PM - 4:30PM
Workshop: Targeting of Therapeutic Antibodies
Room: Mt. Temple A-B

Speaker 8 of 8
Liming Liu, Merck, USA
Amelioration of Experimental Autoimmune Myasthenia Gravis (EAMG) in Rats by FcRn Blockade

Friday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Mt. Temple Foyer


Friday, February 02 | 5:00PM - 7:00PM
New Antibody Engineering Technologies
Room: Mt. Temple A-B

Speaker 1 of 5
* Karl Dane Wittrup, Massachusetts Institute of Technology, USA

Friday, February 02 | 5:00PM - 7:00PM
New Antibody Engineering Technologies
Room: Mt. Temple A-B

Speaker 2 of 5
Andreas G. Plückthun, University of Zürich, Switzerland
Tumor Tagerting with Ankyrin Repeat Proteins

Friday, February 02 | 5:00PM - 7:00PM
New Antibody Engineering Technologies
Room: Mt. Temple A-B

Speaker 3 of 5
Ian M. Tomlinson, GlaxoSmithKline, UK
Domain Antibodies: Half-Life Extension and Dual Targeting Antibodies

Friday, February 02 | 5:00PM - 7:00PM
New Antibody Engineering Technologies
Room: Mt. Temple A-B

Speaker 4 of 5
John Löfblom, Royal Institute of Technology, School of Biotechnology, Sweden
Short Talk: Staphylococcal Surface Display in Combinatorial Bioengineering

Friday, February 02 | 5:00PM - 7:00PM
New Antibody Engineering Technologies
Room: Mt. Temple A-B

Speaker 5 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Human Monoclonal Antibodies from Memory B Cells

Friday, February 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mt. Temple C


Friday, February 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Mt. Temple C


Saturday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Victoria Dining Room


Saturday, February 03 | 8:00AM - 11:00AM
Antibody Manufacturing and Formulation
Room: Mt. Temple A-B

Speaker 1 of 5
* George C. Avgerinos, Fortress Biotech, Inc., USA
Trends in Large-Scale Antibody Manufacture

Saturday, February 03 | 8:00AM - 11:00AM
Antibody Manufacturing and Formulation
Room: Mt. Temple A-B

Speaker 2 of 5
Alexis T. Henry, Diosynth Biotechnology, USA
Short Talk: Development of Antibody Producing Chinese Hamster Ovary Cell Lines by Traditional and Non-Traditional Methods

Saturday, February 03 | 8:00AM - 11:00AM
Antibody Manufacturing and Formulation
Room: Mt. Temple A-B

Speaker 3 of 5
David P. Humphreys, UCB Pharma, UK, UK
Antibody Fab’ Fragments: Expression and Purification from E. coli, PEGylation and Clinical Uses.

Saturday, February 03 | 8:00AM - 11:00AM
Antibody Manufacturing and Formulation
Room: Mt. Temple A-B

Speaker 4 of 5
Yi Wang, Alexion Pharmaceuticals, Inc., USA
Short Talk: Nebulization administration of anti-C5 mAb on the Development of Airway Hyperresponsiveness (AHR)

Saturday, February 03 | 8:00AM - 11:00AM
Antibody Manufacturing and Formulation
Room: Mt. Temple A-B

Speaker 5 of 5
Jun Liu, Genentech, Inc., USA
Challenges and Issues in the Development of High Concentration Monoclonal Antibody Formulations

Saturday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: Mt. Temple Foyer


Saturday, February 03 | 11:00AM - 1:00PM
Poster Setup
Room: Mt. Temple C


Saturday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Mt. Temple C


Saturday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: Mt. Temple Foyer


Saturday, February 03 | 5:00PM - 7:00PM
Antibody Pharmacokinetics
Room: Mt. Temple A-B

Speaker 1 of 4
* E. Sally Ward, University of Texas Southwestern Medical Center, USA
Molecular Mechanisms of IgG Homeostasis: Implications for Modulating Pharmacokinetics of Therapeutic Antibodies

Saturday, February 03 | 5:00PM - 7:00PM
Antibody Pharmacokinetics
Room: Mt. Temple A-B

Speaker 2 of 4
Inger Sandlie, University of Olso, Norway
Short Talk: The Conserved H166 Residue of Human FcRn Heavy Chain is Critical for the pH Dependent Binding to Albumin that Occurs Independently of IgG Binding

Saturday, February 03 | 5:00PM - 7:00PM
Antibody Pharmacokinetics
Room: Mt. Temple A-B

Speaker 3 of 4
Steven M. Larson, Memorial Sloan-Kettering Cancer Center, USA
Imaging and Therapy with Radiolabeled Antibodies

Saturday, February 03 | 5:00PM - 7:00PM
Antibody Pharmacokinetics
Room: Mt. Temple A-B

Speaker 4 of 4
David J. King, aTyr Pharma, Inc., USA
Human Antibody Alkylating Agent Conjugates for Cancer Therapy

Saturday, February 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mt. Temple C


Saturday, February 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Mt. Temple C


Sunday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Victoria Dining Room


Sunday, February 04 | 8:00AM - 11:15AM
Cancer
Room: Mt. Temple A-B

Speaker 1 of 6
Richard H.J. Begent, University College London, UK
Lessons from Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

Sunday, February 04 | 8:00AM - 11:15AM
Cancer
Room: Mt. Temple A-B

Speaker 2 of 6
Ling Liu, Eli Lilly and Company, USA
Short Talk: Antagonist Antibodies to Interleukin 17 Reduces Plasma KC and Tumor Growth

Sunday, February 04 | 8:00AM - 11:15AM
Cancer
Room: Mt. Temple A-B

Speaker 3 of 6
Dario Neri, ETH Zürich, Switzerland
Vascular Targeting with Recombinant Antibody Derivatives


Sunday, February 04 | 8:00AM - 11:15AM
Cancer
Room: Mt. Temple A-B

Speaker 4 of 6
Andrew M. Scott, Ludwig Institute for Cancer Research, Australia
Targeting a Tumor Specific Epitope of the Epidermal Growth Factor Receptor

Sunday, February 04 | 8:00AM - 11:15AM
Cancer
Room: Mt. Temple A-B

Speaker 5 of 6
William M. Siders, Genzyme Corporation, USA
Short Talk: In Vitro and in Vivo Analysis of the Mechanism of Action of Campath (Alemtuzumab)

Sunday, February 04 | 8:00AM - 11:15AM
Cancer
Room: Mt. Temple A-B

Speaker 6 of 6
* Louis M. Weiner, Georgetown University Medical Center, USA
Influence of Antibody Structure on Tumor Targeting and Immune Mediated Tumor Lysis

Sunday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Mt. Temple Foyer


Sunday, February 04 | 1:00PM - 2:30PM
Panel Discussion: Lessons from TGN1412 Phase I Trial
Room: Mt. Temple A-B

Speaker 1 of 4
* Lars Klareskog, Karolinska Institutet, Sweden
Panelists will be selected from symposium attendees prior to the meeting.

Sunday, February 04 | 1:00PM - 2:30PM
Panel Discussion: Lessons from TGN1412 Phase I Trial
Room: Mt. Temple A-B

Speaker 2 of 4
Richard H.J. Begent, University College London, UK

Sunday, February 04 | 1:00PM - 2:30PM
Panel Discussion: Lessons from TGN1412 Phase I Trial
Room: Mt. Temple A-B

Speaker 3 of 4
† Steven M. Larson, Memorial Sloan-Kettering Cancer Center, USA

Sunday, February 04 | 1:00PM - 2:30PM
Panel Discussion: Lessons from TGN1412 Phase I Trial
Room: Mt. Temple A-B

Speaker 4 of 4
Jochen G. Salfeld, Abbott, USA

Sunday, February 04 | 2:30PM - 3:00PM
Coffee Available
Room: Mt. Temple Foyer


Sunday, February 04 | 3:00PM - 5:00PM
Neuroscience
Room: Mt. Temple A-B

Speaker 1 of 4
Eric V. Shusta, University of Wisconsin-Madison, USA
Blood-Brain Barrier Models and New Transporter Discovery

Sunday, February 04 | 3:00PM - 5:00PM
Neuroscience
Room: Mt. Temple A-B

Speaker 2 of 4
Eliezer Masliah, University of California, San Diego, USA
Novel Approaches to Alzheimer Therapy

Sunday, February 04 | 3:00PM - 5:00PM
Neuroscience
Room: Mt. Temple A-B

Speaker 3 of 4
Joseph F. Poduslo, Mayo Clinic, USA
Short Talk: In Vivo Targeting of Antibody Fragments to the Nervous System for Alzheimer’s Disease Immunotherapy and Molecular Imaging of Amyloid Plaques

Sunday, February 04 | 3:00PM - 5:00PM
Neuroscience
Room: Mt. Temple A-B

Speaker 4 of 4
* Arnon Rosenthal, Alector, USA
Experience with Therapeutic Antibodies for Pain

Monday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Victoria Dining Room


Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 1 of 7
* Paul P. Tak, GlaxoSmithKline, UK
Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Disease

Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 2 of 7
Cornelia M. Weyand, Emory University School of Medicine, USA
Mechanisms of B cell-targeted Therapeutic Approaches in Rheumatoid Arthritis

Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 3 of 7
Michael Panzara, Biogen Idec, Inc., USA
Development of Natalizumab: A Case Study

Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 4 of 7
Steven G. Nadler, Aro Biotherapeutics, USA
Treating Autoimmune Disease with Co-Stimulation Inhibitors

Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 5 of 7
Csaba C. Pazmany, Dyax Corporation, USA
Short Talk: Role of Tissue Kallikrein 1 in Airway Inflammation

Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 6 of 7
Helena Persson, Lund University, Sweden
Short Talk: The IgE Repertoire in Grass Pollen Allergy – Specificity and Diversity

Monday, February 05 | 8:00AM - 11:45AM
Autoimmunity, Allergy and Asthma
Room: Mt. Temple A-B

Speaker 7 of 7
Lars Klareskog, Karolinska Institutet, Sweden
Assessment of Long Term Effectiveness and Safety of Therapeutic Antibodies

Monday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Mt. Temple Foyer


Monday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Mt. Temple Foyer


Monday, February 05 | 5:00PM - 6:45PM
Infectious Disease
Room: Mt. Temple A-B

Speaker 1 of 3
* James D. Marks, University of California, San Francisco, USA
Anti-Botulism Toxin Antibody Engineering

Monday, February 05 | 5:00PM - 6:45PM
Infectious Disease
Room: Mt. Temple A-B

Speaker 2 of 3
Michael S. Diamond, Washington University School of Medicine, USA
The Molecular Basis of Antibody-Mediated Neutralization of West Nile Virus

Monday, February 05 | 5:00PM - 6:45PM
Infectious Disease
Room: Mt. Temple A-B

Speaker 3 of 3
Dennis R. Burton, The Scripps Research Institute, USA
Antibodies in Antiviral Vaccine Development

Monday, February 05 | 6:45PM - 7:00PM
Closing Remarks and Summary
Room: Mt. Temple A-B

Speaker 1 of 1
Karl Dane Wittrup, Massachusetts Institute of Technology, USA

Monday, February 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Victoria


Monday, February 05 | 8:00PM - 11:00PM
Entertainment
Room: Victoria


Monday, February 05 | 8:00PM - 11:00PM
Cash Bar
Room: Victoria


Tuesday, February 06 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.