Web Desc
Regulatory T Cells
Organizer(s): Ethan M. Shevach, Fiona M. Powrie and Alexander Y. Rudensky
Date: February 01 - 06, 2007
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Although immune regulation by T suppressor cells was first proposed more than 30 years ago, recent studies in both man and experimental animals now provide a solid basis for the role of T cells in immune regulation. It is now widely accepted that the major T effector functions are mediated by two distinct subpopulations of T cells -- Th1 and Th2 -- cells which produce distinct cytokine profiles. In addition, both naturally occurring and adaptive T suppressor/regulatory T cells have been shown to play major roles in the control of all immune responses. This meeting will review the molecular basis for the differentiation of Th1/Th2 cells from naive precursors. The second goal is to present the most up to date information on the development, function, mechanism of action, and homeostasis of regulatory T cells. Modulation of both Th1/Th2 differentiation and regulatory T cell function are about to be translated to the clinic. Several presentations will address the approaches used and the results of preclincal and clinical trials involving manipulation of regulatory T cell function.
Scholarship Deadline: October 2 2006
Discounted Abstract Deadline: October 2 2006
Abstract Deadline: November 1 2006
Discounted Registration Deadline: December 1 2006
We gratefully acknowledge additional support for this conference from:
JDRFNational Multiple Sclerosis SocietyUCB Celltech
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 U13 AI60000-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI072874-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, February 01 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Thursday, February 01 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Thursday, February 01 | 7:30PM - 8:30PM
Keynote Address
Room: British Columbia Ballroom

Speaker 1 of 2
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Thursday, February 01 | 7:30PM - 8:30PM
Keynote Address
Room: British Columbia Ballroom

Speaker 2 of 2
Shimon Sakaguchi, Osaka University, Japan
The Rebirth of Suppressor/Regulatory T Cells

Friday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, February 02 | 8:00AM - 11:00AM
Molecular Determinants of T Cell Differentiation
Room: British Columbia Ballroom

Speaker 1 of 4
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Genetic and Epigenetic Mechanisms Influencing T Cell Differentiation

Friday, February 02 | 8:00AM - 11:00AM
Molecular Determinants of T Cell Differentiation
Room: British Columbia Ballroom

Speaker 2 of 4
Mark I. Greene, University of Pennsylvania, USA
FOXP3 Interactions with Histone Acetyltransferase and Class II Histone Deacetylases are Required for Repression

Friday, February 02 | 8:00AM - 11:00AM
Molecular Determinants of T Cell Differentiation
Room: British Columbia Ballroom

Speaker 3 of 4
Shohei Hori, RIKEN Research Center for Allergy and Immunology, Japan
How Foxp3 Controls Dominant Tolerance: Lessons Learned from Naturally Occurring foxp3 Gene Mutations

Friday, February 02 | 8:00AM - 11:00AM
Molecular Determinants of T Cell Differentiation
Room: British Columbia Ballroom

Speaker 4 of 4
Ming O. Li, Memorial Sloan Kettering Cancer Center, USA
Regulatory T Cells, TGF-beta and Immune Suppression

Friday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, February 02 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Friday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 1 of 9
* Fiona M. Powrie, University of Oxford, UK

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 2 of 9
Allison L. Bayer, University of Miami School of Medicine, USA
Dominant Role for IL-2 in the Thymic Production and Peripheral Maintenance of CD4+CD25+ FoxP3+ T Regulatory Cells

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 3 of 9
Rosa Bacchetta, Stanford University, USA
Influence of Human FOXP3 Mutations on Effector T Cell Functions and on the In Vitro Differentiation of IL-10 Producing Tr1 Cells

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 4 of 9
Tobias Bopp, University Medical Center of the Johannes Gutenberg-University, Germany
cAMP is Crucial for Regulatory T Cell-Mediated Suppression

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 5 of 9
Talal A. Chatila, University of California, Los Angeles, USA
Development and Differentiated Functions of Regulatory T cell Precursors in the Absence of a Functional Foxp3 Protein

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 6 of 9
Michael A. Farrar, University of Minnesota, USA
Gamma c Receptor-dependent Cytokines in Regulatory T Cell Development

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 7 of 9
Deborah J. Fowell, University of Rochester, USA
Rapid Shutdown of the CD4 T Cell Activation Program by Naturally Occurring CD4+CD25+ Tregs

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 8 of 9
Christian W. Grant, NINDS, National Institutes of Health, USA
Impairment of Treg-Specific Foxp3 Expression by Virus-Induced Dysregulation of TGF-beta Signaling

Friday, February 02 | 2:30PM - 4:30PM
Workshop 1
Room: British/Columbia Ballroom

Speaker 9 of 9
Stacey N. Walters, Garvan Institute of Medical Research, Australia
BAFF Promotes the Expansion of FoxP3+ T Regulatory Cells

Friday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Friday, February 02 | 5:00PM - 7:00PM
Development of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 1 of 4
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Foxp3 as the Regulatory T Cell Lineage Specification Factor

Friday, February 02 | 5:00PM - 7:00PM
Development of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 2 of 4
* Harald von Boehmer, Harvard Medical School, USA
Positive Selection of Regulatory T cells

Friday, February 02 | 5:00PM - 7:00PM
Development of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 3 of 4
Christophe Benoist, Harvard Medical School, USA
Cells on Regulatory T Cell Repertoire and FoxP3 as a Master Regulator of Regulatory T Cells

Friday, February 02 | 5:00PM - 7:00PM
Development of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 4 of 4
Leszek Ignatowicz, Georgia Regents University, USA
Short Talk: On the origin and self-reactivity of CD4+CD25+Foxp3+ T cells.

Friday, February 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Friday, February 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Saturday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, February 03 | 8:00AM - 11:00AM
Mechanism of Action of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 1 of 5
Ethan M. Shevach, NIAID, National Institutes of Health, USA
Mechanisms of Action of T Regulatory Cells in vivo

Saturday, February 03 | 8:00AM - 11:00AM
Mechanism of Action of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 2 of 5
Haruhiko Suzuki, Nagoya University Graduate School of Medicine, Japan
Essential Roles of CD8+CD122+ Regulatory T Cells in Immune Homeostasis and Their Application to Disease

Saturday, February 03 | 8:00AM - 11:00AM
Mechanism of Action of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 3 of 5
* Juan J. Lafaille, New York University School of Medicine, USA
Regulatory T Cells Control T Cell Homeostasid

Saturday, February 03 | 8:00AM - 11:00AM
Mechanism of Action of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 4 of 5
Lauren W. Collison, St. Jude Children's Research Hospital, USA
Short Talk: IL-34, A Novel Inhibitory Cytokine, Is Specifically Made By Regulatory T Cells And Is Required For Their Suppressive Activity

Saturday, February 03 | 8:00AM - 11:00AM
Mechanism of Action of Regulatory T Cells
Room: British Columbia Ballroom

Speaker 5 of 5
Stephanie K. Lathrop, Rocky Mountain Laboratories, USA
Short Talk: Antigen Specific Peripheral Generation of “Natural” Regulatory T Cells

Saturday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, February 03 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Saturday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 1 of 8
* Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA

Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 2 of 8
Ana M. Izcue, Max Planck Institute of Immunobiology and Epigenetics, Germany
Regulatory T Cell Function, But Not Persistense, Depends on CTLA-4

Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 3 of 8
Shuo Li, MacFarlane Burnet Institute, Australia
Defining Target Antigen for CD25+FOXP3+IFN-Gamma- Regulatory T Cells in Chronic Hepatitis C Virus Infection

Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 4 of 8
Wendy P. Loomis, Harvard Medical School, USA
Reduced T cell Activation During Chlamydia Trachomatis Infection

Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 5 of 8
Lara Myers, Rocky Mountain Laboratories, USA
Tissue Specific Localization of Virus-Induced Regulatory T Cells Correlates with CD8+ T Cell Dysfunction

Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 6 of 8
Stephen D. Miller, Northwestern University Medical School, USA
Regulation of Susceptibility/Resistance to the Theiler’s Virus-Induced Demyelinating Disease Model of MS by CD4+CD25+ Regulatory T Cells

Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 7 of 8
Ciriaco A. Piccirillo, McGill University, Canada
Impact of Idd3 Alleles on the Function of CD4+ Foxp3+ Treg Cells and Resistance to Autoimmune Diabetes


Saturday, February 03 | 2:30PM - 4:30PM
Workshop 2
Room: British Columbia Ballroom

Speaker 8 of 8
Francisco J. Quintana, Harvard Medical School, USA
FoxP3-Mediated Immunoregulation in Zebrafish

Saturday, February 03 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, February 03 | 5:00PM - 7:00PM
Immune Regulation by Unconventional T Cells
Room: British Columbia Ballroom

Speaker 1 of 4
* Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Regulatory T cells:Therapeutic Aspects

Saturday, February 03 | 5:00PM - 7:00PM
Immune Regulation by Unconventional T Cells
Room: British Columbia Ballroom

Speaker 2 of 4
Albert S. Bendelac, University of Chicago, USA
NKT cell Development

Saturday, February 03 | 5:00PM - 7:00PM
Immune Regulation by Unconventional T Cells
Room: British Columbia Ballroom

Speaker 3 of 4
Adrian C. Hayday, King's College London School of Medicine, UK
The Phenotype and the Development of TCRgammadelta+ and TCRalphbeta+ Regulatory T Cells

Saturday, February 03 | 5:00PM - 7:00PM
Immune Regulation by Unconventional T Cells
Room: British Columbia Ballroom

Speaker 4 of 4
Craig L. Maynard, University of Alabama at Birmingham, USA
Short Talk: On the in Vivo Development of Adaptive/Induced IL-10-producing Regulatory T Cells

Saturday, February 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, February 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Sunday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Sunday, February 04 | 8:00AM - 11:00AM
Immune Regulation of Infectious Diseases
Room: British Columbia Ballroom

Speaker 1 of 4
Kingston H.G. Mills, Trinity College Dublin, Ireland
The Balance Between Regulatory and Effector/Pathogenic Cells in Infection – Implications for Autoimmunity and Cancer

Sunday, February 04 | 8:00AM - 11:00AM
Immune Regulation of Infectious Diseases
Room: British Columbia Ballroom

Speaker 2 of 4
Yasmine Belkaid, NIAID, National Institutes of Health, USA
Antigen Specificity and Origin of Foxp3+Treg during Parasitic Infections

Sunday, February 04 | 8:00AM - 11:00AM
Immune Regulation of Infectious Diseases
Room: British Columbia Ballroom

Speaker 3 of 4
* Kim J. Hasenkrug, NIAID, National Institutes of Health, USA
Enabling the CTL Response in the Presence of Virus-Induced Regulatory T Cells

Sunday, February 04 | 8:00AM - 11:00AM
Immune Regulation of Infectious Diseases
Room: British Columbia Ballroom

Speaker 4 of 4
Christophe M. Filippi, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Viral infection enables CD4+CD25+ regulatory T cells to protect from autoimmune diabetes

Sunday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, February 04 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Sunday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 1 of 8
* Ethan M. Shevach, NIAID, National Institutes of Health, USA

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 2 of 8
Silvia Deaglio, University of Turin, Italy
T Regulatory Cells Co-Express CD39 and CD73 Ecto-Nucleotidases and Generate Adenosine to Catalyze Immunoregulation

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 3 of 8
Fu-Dong Shi, St. Joseph's Hospital - CHW, USA
Critical Role of IL-21 on Homeostasis of CD4+CD25+ Regulatory T Cell During Autoimmunity

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 4 of 8
Machteld Tiemessen, Janssen Vaccines & Prevention, Netherlands
Monocytes/Macrophages as Targets for CD4+CD25+ Treg-Mediated Suppression

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 5 of 8
Michael S. Turner, Bristol-Myers Squibb, USA
Differential Induction of MUC1-Specific Helper and Regulatory CD4+ T Cells by Mature and Immature DC Populations

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 6 of 8
Maitee Urbieta, University of Miami, USA
Regulation of Hematopoietic Colony Forming Cells by CD4+CD25+ T Cells: A Role for T Regulatory Cells in Hematopoiesis

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 7 of 8
Elizabeth A. Wohlfert, NIAID, National Institutes of Health, USA
How PPARγ Mediates Immunoregulation: An Integral Role for PPARγ in Regulatory T Cells

Sunday, February 04 | 2:30PM - 4:30PM
Workshop 3
Room: British Columbia Ballroom

Speaker 8 of 8
Scott Snapper, Children`s Hospital Boston, USA
The Wiskott-Aldrich Syndrome Protein is Required for the Function of CD4+CD25+Foxp3+ Regulatory T cells

Sunday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Sunday, February 04 | 5:00PM - 7:00PM
T Cell Mediated Control of Regional Immune Responses
Room: British Columbia Ballroom

Speaker 1 of 4
Fiona M. Powrie, University of Oxford, UK
Immune Regulation in the Intestine: A Balancing Act Between Effector and Regulatory T Cells

Sunday, February 04 | 5:00PM - 7:00PM
T Cell Mediated Control of Regional Immune Responses
Room: British Columbia Ballroom

Speaker 2 of 4
* Dale T. Umetsu, Genentech, Inc., USA
The Regulation of Immune Responses in the Lung by CD4+ T Cells

Sunday, February 04 | 5:00PM - 7:00PM
T Cell Mediated Control of Regional Immune Responses
Room: British Columbia Ballroom

Speaker 3 of 4
Alf Hamann, Charité University Medicine Berlin, Germany
Migration of Regulatory T Cells

Sunday, February 04 | 5:00PM - 7:00PM
T Cell Mediated Control of Regional Immune Responses
Room: British Columbia Ballroom

Speaker 4 of 4
Nancy A. Hosken, University of Washington, USA
Short Talk: Il27-Transgenic Mice Lack Cd4+Foxp3+ Regulatory T Cells And Develop Lethal Multi-Organ Inflammation But Not Lymphoproliferative Syndrome

Sunday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Sunday, February 04 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Monday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Monday, February 05 | 8:00AM - 11:00AM
Regulatory T Cells and Autoimmunity/Tumor Immunity
Room: British Columbia Ballroom

Speaker 1 of 5
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Expanded Regulatory T Cells for the Treatment of Autoimmunity

Monday, February 05 | 8:00AM - 11:00AM
Regulatory T Cells and Autoimmunity/Tumor Immunity
Room: British Columbia Ballroom

Speaker 2 of 5
Kenneth S. Tung, University of Virginia, USA
Regulatory T Cells Excel in Preventing but not Deterring Ongoing Autoimmune Disease

Monday, February 05 | 8:00AM - 11:00AM
Regulatory T Cells and Autoimmunity/Tumor Immunity
Room: British Columbia Ballroom

Speaker 3 of 5
Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Enhancement of Regulatory T Cell Function in Man

Monday, February 05 | 8:00AM - 11:00AM
Regulatory T Cells and Autoimmunity/Tumor Immunity
Room: British Columbia Ballroom

Speaker 4 of 5
Weiping Zou, University of Michigan, USA
B7-H4, IL-10 and Regulatory T Cells in Human Tumor Immunity

Monday, February 05 | 8:00AM - 11:00AM
Regulatory T Cells and Autoimmunity/Tumor Immunity
Room: British Columbia Ballroom

Speaker 5 of 5
Omar Duramad, University of Texas, MD Anderson Cancer Center, USA
Short Talk: Origin and Dynamics of Tumor-Associated Foxp3+ Regulatory T Cells

Monday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, February 05 | 5:00PM - 7:00PM
Immune Regulation of Transplantation
Room: British Columbia Ballroom

Speaker 1 of 4
Bruce R. Blazar, University of Minnesota, USA
Rapid Expansion of Functional Human CD4+25+ T Regulatory Cells (Tregs) Using Cell-Based Artificial Antigen Presenting Cells (aAPCs)

Monday, February 05 | 5:00PM - 7:00PM
Immune Regulation of Transplantation
Room: British Columbia Ballroom

Speaker 2 of 4
* Herman Waldmann, University of Oxford, UK
Explaining Infectious Tolerance

Monday, February 05 | 5:00PM - 7:00PM
Immune Regulation of Transplantation
Room: British Columbia Ballroom

Speaker 3 of 4
David C. Gondek, Harvard Medical School, USA
Granzyme B is Pivotal in T-Regulatory Contact-Mediated Immunosuppression in Transplantation Tolerance

Monday, February 05 | 5:00PM - 7:00PM
Immune Regulation of Transplantation
Room: British Columbia Ballroom

Speaker 4 of 4
Petra Hoffmann, University Hospital Regensburg, Germany
Short Talk: Only the CD45RA+ Subpopulation of CD4+CD25high T Cells Gives Rise to Homogeneous Regulatory T Cell Lines

Monday, February 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Monday, February 05 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Monday, February 05 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Tuesday, February 06 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.