Web Desc
Ubiquitin and Signaling
Organizer(s): Brenda A. Schulman, Tony Hunter, Mark W. Hochstrasser and Claudio A.P. Joazeiro
Date: February 04 - 09, 2007
Location: Big Sky Resort, Big Sky, MT, USA
Supported by the Director's Fund
Summary of Meeting:
Our understanding of how ubiquitin regulates cellular functions has greatly expanded in the past several years, spurred by discoveries of protein families involved in ubiquitin conjugation and deconjugation, and of nonproteasomal signaling functions for ubiquitin and ubiquitin-related proteins. The first Keystone meeting on Ubiquitin and Signaling, in February 2005, was highly successful, based on both strong attendance and feedback from the participants. The significance and timely nature of the ubiquitination problem is highlighted by the 2004 Nobel Prize in Chemistry honoring pioneers in the field. We anticipate a further explosion in our understanding of ubiquitination over the next few years, and propose a meeting that captures this momentum. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in numerous diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins, presenting the challenge to determine their functions and mechanistic links to the ubiquitin system. In addition, the ubiquitin system is now widely recognized as a target for pharmacological intervention in various diseases. The goal of the meeting is to bring together experts from different areas of ubiquitin research as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.
Scholarship Deadline: October 4 2006
Discounted Abstract Deadline: October 4 2006
Abstract Deadline: November 2 2006
Discounted Registration Deadline: December 4 2006
We gratefully acknowledge additional support for this conference from:
Boston Biochem, an R&D Systems CompanyEducational donation provided by AmgenENZO LIFE SCIENCES INTERNATIONAL, INC.Invitrogen CorporationMerck Research Laboratories
Proteome Resources LLC
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 04 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Sunday, February 04 | 7:00PM - 8:00PM
Refreshments
Room: Lower Atrium


Sunday, February 04 | 8:00PM - 9:00PM
Keynote Address: The Cecile Pickart Memorial Lecture
Room: Gallatin

Speaker 1 of 1
Alfred L. Goldberg, Harvard Medical School, USA
What We've Learned and What We Haven't Learned About Protein Degradation


Monday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/ Lake/ Canyon Rooms


Monday, February 05 | 8:00AM - 11:15AM
Regulation by E3 Ubiquitin Ligases
Room: Gallatin/ Madison

Speaker 1 of 6
* Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA

Monday, February 05 | 8:00AM - 11:15AM
Regulation by E3 Ubiquitin Ligases
Room: Gallatin/ Madison

Speaker 2 of 6
Michael Karin, University of California, San Diego, USA
Crosstalk Between Inflammation Cells and Carcinomas

Monday, February 05 | 8:00AM - 11:15AM
Regulation by E3 Ubiquitin Ligases
Room: Gallatin/ Madison

Speaker 3 of 6
J. Wade Harper, Harvard Medical School, USA
Genetic Discovery in the Ubiquitin Proteasome Pathway

Monday, February 05 | 8:00AM - 11:15AM
Regulation by E3 Ubiquitin Ligases
Room: Gallatin/ Madison

Speaker 4 of 6
Claudio A. P. Joazeiro, University of Heidelberg, Germany
Functional Genomic Analyses of Ubiquitin Ligases

Monday, February 05 | 8:00AM - 11:15AM
Regulation by E3 Ubiquitin Ligases
Room: Gallatin/ Madison

Speaker 5 of 6
Mark A. Estelle, University of California, San Diego, USA
The F-box Protein TIR1 is a Receptor for the Plant Hormone Auxin

Monday, February 05 | 8:00AM - 11:15AM
Regulation by E3 Ubiquitin Ligases
Room: Gallatin/ Madison

Speaker 6 of 6
Bruce E. Clurman, Fred Hutchinson Cancer Research Center, USA
Fbw7 at the Crossroads of Cell Division, Growth, and Differentiation

Monday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, February 05 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/ Lake/ Canyon Rooms


Monday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/ Lake/ Canyon Rooms


Monday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, February 05 | 5:00PM - 7:00PM
Signal Transduction by Ubiquitin Conjugation and Deconjugati
on

Room: Gallatin/ Madison

Speaker 1 of 5
* J. Wade Harper, Harvard Medical School, USA

Monday, February 05 | 5:00PM - 7:00PM
Signal Transduction by Ubiquitin Conjugation and Deconjugati
on

Room: Gallatin/ Madison

Speaker 2 of 5
Vishva M. Dixit, Genentech, Inc., USA
ATM Mediated Auto-Degradation of the E3 Ubiquitin Ligase COP1 After DNA Damage

Monday, February 05 | 5:00PM - 7:00PM
Signal Transduction by Ubiquitin Conjugation and Deconjugati
on

Room: Gallatin/ Madison

Speaker 3 of 5
René Bernards, Netherlands Cancer Institute, Netherlands
RNAi Screens to Identify Functions of DUBs

Monday, February 05 | 5:00PM - 7:00PM
Signal Transduction by Ubiquitin Conjugation and Deconjugati
on

Room: Gallatin/ Madison

Speaker 4 of 5
Christian D. Schlieker, Whitehead Institute for Biomedical Research, USA
Short Talk: Structure of a Herpesvirus-Encoded Deubiquitinating Enzyme Reveals a New Class of Ubiquitin-Specific Proteases

Monday, February 05 | 5:00PM - 7:00PM
Signal Transduction by Ubiquitin Conjugation and Deconjugati
on

Room: Gallatin/ Madison

Speaker 5 of 5
Paul J. Lehner, Cambridge Institute for Medical Research, UK
Short Talk: Lysine-63 Linked Ubiquitination is Required for Efficient Internalization and Endolysosomal Degradation of Critical Immunoreceptors

Monday, February 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin/Lake/Canyon Rooms


Monday, February 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson/ Lake/ Canyon Rooms


Tuesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/ Lake/ Canyon Rooms


Tuesday, February 06 | 8:00AM - 11:00AM
Ubiquitin-Like Protein Pathways
Room: Gallatin/ Madison

Speaker 1 of 6
* Daniel J. Finley, Harvard University, USA

Tuesday, February 06 | 8:00AM - 11:00AM
Ubiquitin-Like Protein Pathways
Room: Gallatin/ Madison

Speaker 2 of 6
Ronald T. Hay, University of Dundee, UK
Role of SUMO Modification in the Control of Gene Expression

Tuesday, February 06 | 8:00AM - 11:00AM
Ubiquitin-Like Protein Pathways
Room: Gallatin/ Madison

Speaker 3 of 6
Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
SUMO: Insights into Ubiquitin and Ubiquitin-Like Protein Conjugation

Tuesday, February 06 | 8:00AM - 11:00AM
Ubiquitin-Like Protein Pathways
Room: Gallatin/ Madison

Speaker 4 of 6
Frauke Melchior, Universität Heidelberg, Germany
Functions and Regulation of SUMOylation

Tuesday, February 06 | 8:00AM - 11:00AM
Ubiquitin-Like Protein Pathways
Room: Gallatin/ Madison

Speaker 5 of 6
Jorge A. Iñiguez-Lluhi, University of Michigan, USA
Short Talk: SUMO Modification Regulates Inactivation of the voltage-Gated Potassium Channel KV1.5

Tuesday, February 06 | 8:00AM - 11:00AM
Ubiquitin-Like Protein Pathways
Room: Gallatin/ Madison

Speaker 6 of 6
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Structural Insights into Ubiquitin-like Protein Activation

Tuesday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/ Lake/ Canyon Rooms


Tuesday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/ Lake/ Canyon Rooms


Tuesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, February 06 | 5:00PM - 7:00PM
Regulation of and by the Proteasome and Signalosome
Room: Gallatin/ Madison

Speaker 1 of 5
* Alfred L. Goldberg, Harvard Medical School, USA

Tuesday, February 06 | 5:00PM - 7:00PM
Regulation of and by the Proteasome and Signalosome
Room: Gallatin/ Madison

Speaker 2 of 5
Xing Wang Deng, Yale University, USA
Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Cullin3-based E3 ligases

Tuesday, February 06 | 5:00PM - 7:00PM
Regulation of and by the Proteasome and Signalosome
Room: Gallatin/ Madison

Speaker 3 of 5
Ning Zheng, University of Washington, USA
Mechanism of Auxin Perception by the TIR1 F-box Protein

Tuesday, February 06 | 5:00PM - 7:00PM
Regulation of and by the Proteasome and Signalosome
Room: Gallatin/ Madison

Speaker 4 of 5
Daniel J. Finley, Harvard University, USA
Regulation of Proteasome Function

Tuesday, February 06 | 5:00PM - 7:00PM
Regulation of and by the Proteasome and Signalosome
Room: Gallatin/ Madison

Speaker 5 of 5
Rina Rosenzweig, Weizmann Institute of Science, Israel
Short Talk: A Mason's Approach to the 19S Proteasome Regulator

Tuesday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin/Lake/Canyon Rooms


Tuesday, February 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson/ Lake/ Canyon Rooms


Wednesday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/ Lake/ Canyon Rooms


Wednesday, February 07 | 8:00AM - 11:00AM
Ubiquitin and Subcellular Compartments
Room: Gallatin/ Madison

Speaker 1 of 6
* Frauke Melchior, Universität Heidelberg, Germany

Wednesday, February 07 | 8:00AM - 11:00AM
Ubiquitin and Subcellular Compartments
Room: Gallatin/ Madison

Speaker 2 of 6
Simona Polo, FIRC Institute of Molecular Oncology, Italy
Molecular Mechanisms of Coupled Monoubiquitination

Wednesday, February 07 | 8:00AM - 11:00AM
Ubiquitin and Subcellular Compartments
Room: Gallatin/ Madison

Speaker 3 of 6
Thomas Sommer, Max Delbrück Center for Molecular Medicine, Germany
Protein Quality Control by the HRD-Ligase Complex

Wednesday, February 07 | 8:00AM - 11:00AM
Ubiquitin and Subcellular Compartments
Room: Gallatin/ Madison

Speaker 4 of 6
Mary Ann Osley, University of New Mexico School of Medicine, USA
Interplay between H2B Ubiquitylation and Histone Chaperones during Transcription Elongation

Wednesday, February 07 | 8:00AM - 11:00AM
Ubiquitin and Subcellular Compartments
Room: Gallatin/ Madison

Speaker 5 of 6
Sylvie Urbé, University of Liverpool, UK
Control of Growth Factor Receptor Dynamics by Reversible Ubiquitination

Wednesday, February 07 | 8:00AM - 11:00AM
Ubiquitin and Subcellular Compartments
Room: Gallatin/ Madison

Speaker 6 of 6
Vincent Chau, Pennsylvania State University College of Medicine, USA
Short Talk: The Crystal Structure of a RING-Ubc7 Fusion Reveals a Mechanism for the Activation of a Ubiquitin-Conjugating Enzyme

Wednesday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson/ Lake/ Canyon Rooms


Wednesday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson/ Lake/ Canyon Rooms


Wednesday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, February 07 | 5:00PM - 7:00PM
Novel Functions of Ubiquitin
Room: Gallatin/ Madison

Speaker 1 of 5
* Simona Polo, FIRC Institute of Molecular Oncology, Italy

Wednesday, February 07 | 5:00PM - 7:00PM
Novel Functions of Ubiquitin
Room: Gallatin/ Madison

Speaker 2 of 5
Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Ubiquitination and Degradation of the Cholesterol Biosynthetic Enzyme, HMG CoA Reductase

Wednesday, February 07 | 5:00PM - 7:00PM
Novel Functions of Ubiquitin
Room: Gallatin/ Madison

Speaker 3 of 5
Mark W. Hochstrasser, Yale University, USA
Regulation of Ubiquitin Enzymes at the Endoplasmic Reticulum and Nuclear Envelope

Wednesday, February 07 | 5:00PM - 7:00PM
Novel Functions of Ubiquitin
Room: Gallatin/ Madison

Speaker 4 of 5
Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Cell-Polarity Control of Protein Degradation in Intestinal Epithelial Cells

Wednesday, February 07 | 5:00PM - 7:00PM
Novel Functions of Ubiquitin
Room: Gallatin/ Madison

Speaker 5 of 5
Peter Kaiser, University of California, Irvine, USA
Short Talk: Proteolysis-Independent Regulation by Poly-Ubiquitination

Wednesday, February 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Gallatin/Lake/Canyon Rooms


Wednesday, February 07 | 7:30PM - 10:00PM
Poster Session 3
Room: Jefferson/ Lake/ Canyon Rooms


Thursday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/ Lake/ Canyon Rooms


Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 1 of 7
* Thomas Sommer, Max Delbrück Center for Molecular Medicine, Germany

Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 2 of 7
Tony Hunter, The Salk Institute for Biological Sciences, USA
Crosstalk Between Phosphorylation and Sumoylation Pathways and Ubiquitination

Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 3 of 7
Gentry N. Patrick, University of California, San Diego, USA
UPS and Mammalian CNS Synapses

Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 4 of 7
Ron R. Kopito, Stanford University, USA
Protein Aggregation and Neurodegeneration

Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 5 of 7
Laurent Coscoy, University of California, Berkeley, USA
Ubiquitination on Non-lysine Residues

Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 6 of 7
Agata Smogorzewska, Rockefeller University, USA
Short Talk: Cloning and Characterization of FANCI, a Novel Component of the Fanconi Anemia Pathway

Thursday, February 08 | 8:00AM - 11:15AM
The Ubiquitin System: Disease and Drug Targets
Room: Gallatin/ Madison

Speaker 7 of 7
Frédéric Colland, Hybrigenics, France
Short Talk: Identification and Characterization of Small Molecule Inhibitors of Ubiquitin-Specific Protease 8, a Newly Validated Cancer Target

Thursday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, February 08 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, February 08 | 5:00PM - 7:00PM
Proteomics and Other Technology Trends
Room: Gallatin/ Madison

Speaker 1 of 4
* William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Pharmacodynamic Imaging with Degron-Containing Luciferase Fusion Proteins

Thursday, February 08 | 5:00PM - 7:00PM
Proteomics and Other Technology Trends
Room: Gallatin/ Madison

Speaker 2 of 4
Steven P. Gygi, Harvard Medical School, USA
Mass Spectrometry Based Methods for Analysis of Site Specific Ubiquitination

Thursday, February 08 | 5:00PM - 7:00PM
Proteomics and Other Technology Trends
Room: Gallatin/ Madison

Speaker 3 of 4
Dieter A. Wolf, Harvard School of Public Health, USA
Systematic Screening for Ubiquitylation Substrates


Thursday, February 08 | 5:00PM - 7:00PM
Proteomics and Other Technology Trends
Room: Gallatin/ Madison

Speaker 4 of 4
Benjamin Nicholson, Merck Research Laboratories, USA
Short Talk: Mining the Deubiquitinase Space with a Novel Reporter Assay

Thursday, February 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/ Madison


Thursday, February 08 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson/ Madison


Thursday, February 08 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson/ Madison


Friday, February 09 | 10:26AM - 10:26AM
Departure


*Session Chair.