Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
B Cells at the Intersection of Innate and Adaptive Immunity (2016E3)
The Golden Anniversary of B Cell Discovery (2015X6)
Biology of B Cell Responses (2014Q4)
B Cell Development and Function (2013X1)
B Cells: New Insights into Normal versus Dysregulated Function (2011D6)
B Cells in Context (2009C3)

Web Desc
Biology of B Cells in Health and Disease Organizer(s): Mark J. Shlomchik, Cornelius Murre and Timothy W. Behrens Date: February 06 - 12, 2007 Location: Fairmont Banff Springs, Banff, AB, Canada Supported by the Director's Fund Summary of Meeting: B lymphocytes secrete antibody, present antigen and regulate immune responses. The study of B cell differentiation has revealed unexpected plasticity. B cells undergo three unique DNA rearrangement processes: V(D)J recombination, somatic hypermutation, and class switch. The latter two occur in the germinal center, where memory B cells as well as long-lived plasma cells are generated. Much research is focused on the signals that generate these cells as well as their intrinsic properties. With regard to normal and aberrant function in disease, B cells frequently undergo transformation, likely via the DNA modification processes unique to B cells. Normally, B cells are tolerant to self but this can break down, leading to autoimmunity. B cells have proven an excellent target for therapy, but the mechanisms remain unclear. The meeting will highlight these interrelated topics by focusing first on molecular events in development and normal immune responses, then covering how these go awry during transformation, autoimmunity and immunodeficiency, with an emphasis on comparing murine and human systems. Scholarship Deadline: October 6 2006 Discounted Abstract Deadline: October 6 2006 Abstract Deadline: November 6 2006 Discounted Registration Deadline: December 6 2006 We gratefully acknowledge additional support for this conference from: GlaxoSmithKline Research & Development, Ltd. We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genentech, Inc. We gratefully acknowledge the generous grant for this conference provided by: National Institute of Allergy and Infectious Diseases (NIAID) Grant No. 1R13AI072804-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Biology of B Cells in Health and Disease

Organizer(s): Mark J. Shlomchik, Cornelius Murre and Timothy W. Behrens

Date: February 06 - 12, 2007
Location: Fairmont Banff Springs, Banff, AB, Canada

Supported by the Director's Fund

Summary of Meeting:

B lymphocytes secrete antibody, present antigen and regulate immune responses. The study of B cell differentiation has revealed unexpected plasticity. B cells undergo three unique DNA rearrangement processes: V(D)J recombination, somatic hypermutation, and class switch. The latter two occur in the germinal center, where memory B cells as well as long-lived plasma cells are generated. Much research is focused on the signals that generate these cells as well as their intrinsic properties. With regard to normal and aberrant function in disease, B cells frequently undergo transformation, likely via the DNA modification processes unique to B cells. Normally, B cells are tolerant to self but this can break down, leading to autoimmunity. B cells have proven an excellent target for therapy, but the mechanisms remain unclear. The meeting will highlight these interrelated topics by focusing first on molecular events in development and normal immune responses, then covering how these go awry during transformation, autoimmunity and immunodeficiency, with an emphasis on comparing murine and human systems.

Scholarship Deadline: October 6 2006

Discounted Abstract Deadline: October 6 2006

Abstract Deadline: November 6 2006

Discounted Registration Deadline: December 6 2006

We gratefully acknowledge additional support for this conference from:

GlaxoSmithKline Research & Development, Ltd.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI072804-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Tuesday, February 06 \| 3:00PM - 7:30PM Registration Room: Van Horne Foyer
Tuesday, February 06 \| 6:30PM - 7:30PM Refreshments Room: Van Horne Foyer
Tuesday, February 06 \| 7:30PM - 8:30PM Keynote Address Room: Van Horne A-B Speaker 1 of 1 Michael S. Neuberger, Medical Research Council, UK Antibody Diversification through DNA Deamination
Wednesday, February 07 \| 7:00AM - 8:00AM Breakfast Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 1 of 7 * Cornelis Murre, University of California, San Diego, USA Regulation and Function of Helix- Loop-Helix Proteins in B Cell Development
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 2 of 7 Ana Cumano, Pasteur Institute, France Short Talk: IL-7R Signaling in B Cell Development
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 3 of 7 Ranjan Sen, National Institute of Aging, National Institutes of Health, USA Regulation of Immunoglobulin Gene Rearrangements During B Cell Development
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 4 of 7 Meinrad Busslinger, Research Institute of Molecular Pathology, Austria Transcriptional Control of B Cell Development
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 5 of 7 Harinder Singh, Cincinnati Children's Hospital Medical Center, USA Specification of the B Cell Fate and the Regulation of Immunoglobulin Gene Recombination
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 6 of 7 David M. Allman, University of Pennsylvania, USA Short Talk: Generation of Peripheral B cells Occurs via Two Spatially and Temporally Distinct Pathways
Wednesday, February 07 \| 8:00AM - 11:30AM B Development and Gene Expression Room: Van Horne A-B Speaker 7 of 7 Shiv Pillai, Massachusetts General Hospital, USA Short Talk: A Cell Surface Acetylation/Deacetylation Paradigm for the Regulation of Antigen Receptor Signaling, B Lymphocyte Development, and Humoral Autoimmunity
Wednesday, February 07 \| 9:30AM - 9:50AM Coffee Break Room: Van Horne Foyer
Wednesday, February 07 \| 11:30AM - 1:00PM Poster Setup Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Wednesday, February 07 \| 1:00PM - 10:00PM Poster Viewing Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Wednesday, February 07 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Wednesday, February 07 \| 5:00PM - 7:15PM B Cell Signaling and Activation Room: Van Horne A-B Speaker 1 of 5 * Alexander Tarakhovsky, Rockefeller University, USA Role of Argonaute 2 in B Cell Function
Wednesday, February 07 \| 5:00PM - 7:15PM B Cell Signaling and Activation Room: Van Horne A-B Speaker 2 of 5 Michael Reth, Albert-Ludwigs University Freiburg, Germany Early Events during Signal Transduction from the B Cell Antigen Receptor
Wednesday, February 07 \| 5:00PM - 7:15PM B Cell Signaling and Activation Room: Van Horne A-B Speaker 3 of 5 Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany Aspects of Tanscriptional and microRNA Cntrol in B cell Development
Wednesday, February 07 \| 5:00PM - 7:15PM B Cell Signaling and Activation Room: Van Horne A-B Speaker 4 of 5 Edward A. Clark, University of Washington, USA Short Talk: Regulation of B Cell Entry into Cell Cycle by Superoxide and CD22
Wednesday, February 07 \| 5:00PM - 7:15PM B Cell Signaling and Activation Room: Van Horne A-B Speaker 5 of 5 David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA Short Talk: Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced Signals
Wednesday, February 07 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Wednesday, February 07 \| 7:30PM - 10:00PM Poster Session 1 Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Thursday, February 08 \| 7:00AM - 8:00AM Breakfast Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 1 of 7 David G. Schatz, Yale University School of Medicine, USA Targeting of Somatic Hypermutation to the Immunoglobulin Locus
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 2 of 7 Mark S. Schlissel, University of California, Berkeley, USA Regulating V(D)J Recombination In Vivo
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 3 of 7 Yehudit Bergman, Hebrew University Medical School, Israel Epigenetic ontogeny of the Ig light chain locus during B cell development
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 4 of 7 * Frederick W. Alt, Boston Children's Hospital, USA Joining Pathways that Mediate IgH Class Switch Recombination and Suppress Oncogenic Translocations
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 5 of 7 Patricia J. Gearhart, NIA, National Institutes of Health, USA Short Talk: Deoxyuracils in Immunoglobulin Genes from Germinal Center B Cells
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 6 of 7 Janet M. Stavnezer, University of Massachusetts Medical School, USA Short Talk: DNA Breaks and DNA Repair during Antibody Class Switching
Thursday, February 08 \| 8:00AM - 11:30AM SHM/CSR/VDJ Room: Van Horne A-B Speaker 7 of 7 Amy L. Kenter, University of Illinois College of Medicine, USA Short Talk: Long Range Interactions between Germline Transcript Regulatory Elements Drives S/S Synapsis during Class Switch Recombination
Thursday, February 08 \| 9:30AM - 9:50AM Coffee Break Room: Van Horne Foyer
Thursday, February 08 \| 11:30AM - 1:00PM Poster Setup Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Thursday, February 08 \| 1:00PM - 10:00PM Poster Viewing Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 1 of 9 * David M. Allman, University of Pennsylvania, USA
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 2 of 9 * Shiv Pillai, Massachusetts General Hospital, USA
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 3 of 9 Alaitz Aranburu, Research Centre, Ospedale Bambino Gesu, Italy B Cells of Natural Mucosal Immunity Derive from Splenic Precursors
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 4 of 9 Hans-Willem E. Snoeck, Columbia University Medical Center, USA Evidence for Two Distinct B-Cell Differentiation Routes
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 5 of 9 Daniel Northrup, NHLBI, National Institutes of Health, USA Resolution of B1 B Cells in Adult Bone Marrow
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 6 of 9 Natalia V. Giltiay, Washington University, USA Act1 Regulates the Survival and Maturation of Transitional B-cells
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 7 of 9 Cynthia J. Guidos, University of Toronto and Hospital for Sick Children, Canada Lunatic and Manic Fringe Enhance Notch2/Delta-like-1 Interactions during Marginal Zone B Cell Development in Splenic Niches
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 8 of 9 Robert H. Carter, NIAMS, National Institutes of Health, USA The Role of CD19 in the Development of Marginal Zone
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1A: Development and Function of B Cell Subsets Room: Theatre Speaker 9 of 9 Frederic Sierro, Garvan Institute of Medical Research, Australia TRAF2-deficient MZ B Cells Differentiate and Survive in the Absence of BAFF
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 1 of 7 * Amy L. Kenter, University of Illinois College of Medicine, USA
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 2 of 7 * Ann J. Feeney, The Scripps Research Institute, USA Deciphering the Histone Code Controlling Immunoglobulin Gene Rearrangement
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 3 of 7 Adam G. W. Matthews, Massachusetts Institute of Technology, USA RAG2 PHD Finger Couples Histone H3 Lysine 4 Trimethylation with V(D)J Recombination
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 4 of 7 Kevin M. McBride, University of Texas MD Anderson Cancer Center, USA Regulation of CSR and Hypermutation by Multiple AID Phosphorylation Sites
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 5 of 7 Catherine T. Yan, CBR Institute for Biomedical Research, USA DNA Polymerase eta is the Sole Contributor of A-T Modifications during Immunoglobulin Gene Hypermutation in the Mouse
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 6 of 7 Jean-Claude Weill, INSERM U1151 Institut Necker-Enfants Malades, France DNA Polymerase eta is the Sole Contributor of A-T Modifications during Immunoglobulin Gene Hypermutation in the Mouse
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1B: SHM/CSR/VDJ Room: Van Horne A/B Speaker 7 of 7 Heinz Jacobs, Netherlands Cancer Institute, Netherlands Somatic Hypermutation in B Cells Lacking PCNA K164 Modifications
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 1 of 8 * Uri Hershberg, Drexel University, USA Introductory Remarks - Different View of B Cell Immunology
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 2 of 8 Michal Or-Guil, Institute for Theoretical Biology, Germany Continuous Renewal of Germinal Center Populations: The True Strategy of Affinity Maturation?
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 3 of 8 * Steven H. Kleinstein, Yale University School of Medicine, USA The Impact of Affinity on B Cell Proliferation and Death
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 4 of 8 Phillip D. Hodgkin, Walter and Eliza Hall Institute of Medical Research, Australia The Cyton Model of B Lymphocyte Growth and Regulation
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 5 of 8 Yoram Louzoun, Bar Ilan University, Israel Protein-Lipid Interactions Mediate B Cell Activation: in-silico Cell Surface Modeling
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 6 of 8 Roger Sciammas, University of California, Davis, USA Dynamics of the Gene Regulatory Network Orchestrating Isotype Switching and Plasma Cell Differentiation
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 7 of 8 Ramit Mehr, Bar-Ilan University, Israel Antigen-Driven Selection in Germinal Centers as Reflected by Shape Characteristics of Immunoglobulin Gene Lineage Trees: A Large-Scale Simulation Study
Thursday, February 08 \| 2:30PM - 4:30PM Workshop 1C: Computation and Mathematical Modeling in the St udy of B Cell Biology, Supported by the Society for Mathematical Biology Room: Shaughnessey Speaker 8 of 8 Edward J. Steele, Australian National University, Australia A-to-G Spectrum Correlates with RNA Hairpins at WA Hotspots: A Role for A-to-I RNA Editing in A-T Targeted Phase II SHM
Thursday, February 08 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Thursday, February 08 \| 5:00PM - 7:15PM B Cell Immune Responses Room: Van Horne A-B Speaker 1 of 5 * Jason G. Cyster, HHMI/University of California, San Francisco, USA Cellular Migration during the B Cell Immune Response
Thursday, February 08 \| 5:00PM - 7:15PM B Cell Immune Responses Room: Van Horne A-B Speaker 2 of 5 Frances E. Lund, University of Alabama at Birmingham, USA Regulation of Type 2 Immune Responses by Cytokine-Producing and Antigen-Presenting B cells
Thursday, February 08 \| 5:00PM - 7:15PM B Cell Immune Responses Room: Van Horne A-B Speaker 3 of 5 Elizabeth A. Leadbetter, University of Texas Long School of Medicine, USA Short Talk: CD1d-Restricted iNK T Cell Help for Lipid Antigen Specific Antibodies
Thursday, February 08 \| 5:00PM - 7:15PM B Cell Immune Responses Room: Van Horne A-B Speaker 4 of 5 Ann M. Haberman, Yale University School of Medicine, USA Short Talk: Visualization of Germinal Center (GC) B Cell Dynamics by Multi-Photon Microscopy
Thursday, February 08 \| 5:00PM - 7:15PM B Cell Immune Responses Room: Van Horne A-B Speaker 5 of 5 Peter Bergqvist, Centre for Drug Research and Development, Canada Short Talk: Gut IgA Class Switch Recombination in the Absence of CD40 does not Occur in the Lamina Propria and is Independent of Germinal Centers
Thursday, February 08 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Thursday, February 08 \| 7:30PM - 10:00PM Poster Session 2 Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Friday, February 09 \| 7:00AM - 8:00AM Breakfast Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Friday, February 09 \| 8:00AM - 11:00AM Memory B Cells/Plasma Cells Room: Van Horne A-B Speaker 1 of 6 * Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA Intrinsic Properties of Memory B Cells
Friday, February 09 \| 8:00AM - 11:00AM Memory B Cells/Plasma Cells Room: Van Horne A-B Speaker 2 of 6 Takemori Toshitada, RCAI, Riken, Japan Pathways of Memory B Cell Development
Friday, February 09 \| 8:00AM - 11:00AM Memory B Cells/Plasma Cells Room: Van Horne A-B Speaker 3 of 6 Ulf Klein, Columbia University, USA Transcriptional Control of Plasma Cell Differentiation
Friday, February 09 \| 8:00AM - 11:00AM Memory B Cells/Plasma Cells Room: Van Horne A-B Speaker 4 of 6 David M. Tarlinton, Monash University, Australia Short Talk: Plasma Cell Differentiation
Friday, February 09 \| 8:00AM - 11:00AM Memory B Cells/Plasma Cells Room: Van Horne A-B Speaker 5 of 6 Kenneth Smith, University of Cambridge, UK Short Talk: FcgammaRIIB Controls Bone Marrow Plasma Cell Persistence and Mediates Apoptosis: Implications for Plasma Cell Homeostasis, Autoimmunity and Myeloma
Friday, February 09 \| 8:00AM - 11:00AM Memory B Cells/Plasma Cells Room: Van Horne A-B Speaker 6 of 6 Rachel Ettinger, Viela Bio, USA Short Talk: Essential Role of IL-21 for Plasma Cell Generation During T Cell- B Cell or T Cell- DC- B Cell Collaboration
Friday, February 09 \| 9:30AM - 9:50AM Coffee Break Room: Van Horne Foyer
Friday, February 09 \| 11:30AM - 1:00PM Poster Setup Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Friday, February 09 \| 1:00PM - 10:00PM Poster Viewing Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 1 of 7 * Jane A. Skok, New York University School of Medicine, USA Pericentromeric Recruitment and Decontraction of the IgH Locus Depend on Different Signaling Requirements
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 2 of 7 * Patrick Matthias, Friedrich Miescher Institute for Biomed Research, Switzerland
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 3 of 7 Timothy P. Bender, University of Virginia Health System, USA c–Myb is Critical for Early B Cell Development and Maintenance of Follicular B Cells
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 4 of 7 Hart S. Dengler, Sanford-Burnham Medical Research Institute, USA A Non-redundant Role for FoxO1 in Early B Cell Differentiation
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 5 of 7 Lee Ann Garrett-Sinha, University at Buffalo, State University of New York, USA Ets-1 Regulates Plasmacytic Differentiation by Interfering with the Activity of the Transcription Factor Blimp-1
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 6 of 7 Arthur L. Shaffer III, NCI, National Institutes of Health, USA An shRNA ‘Achilles’ heel’ Screen Reveals the Requirement for IRF4 Expression in Plasma Cells and Multiple Myleoma
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2A: Transcription Factors in B Cell Development and Differentiation Room: Van Horne A/B Speaker 7 of 7 Roger Sciammas, University of California, Davis, USA Graded Expression of Irf4 Coordinates Isotype Switching with Plasma Cell Differentiation
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 1 of 8 * David M. Tarlinton, Monash University, Australia
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 2 of 8 * Stuart G. Tangye, Garvan Institute of Medical Research, Australia Interplay between IL-21 and IL-4 in Regulating isotype Switching, Ig Secretion and Differentiation of Human B-Cell Subsets
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 3 of 8 Jenni E. Crowley, University of Pennsylvania, USA Primary and Memory B Cells Occupy Independent Homeostatic Niches
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 4 of 8 Tingting Zhang, University of Manitoba, Canada Role of Bam32 in T-Cell Dependent Antibody Responses
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 5 of 8 Tanja Anke Schwickert, Rockefeller University, USA Germinal Center Imaging Reveals a Dynamic Open Structure
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 6 of 8 Isharat Yusuf, Gossamer Bio, USA Fyn is Required for Optimal Germinal Center Formation and Memory B Cell Generation
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 7 of 8 Shiang-Jong Tzeng, National Taiwan University, Taiwan FcãRIIB1 Regulates Plasma Cell Apoptosis and Differentiation through a c-Abl-dependent Pathway
Friday, February 09 \| 2:30PM - 4:30PM Workshop 2B: Germinal Centers, Plasma Cells, and Memory Cell s Room: Shaughnessey Speaker 8 of 8 Robert Brink, Garvan Institute of Medical Research, Australia Antigen Affinity Regulates Plasma Cell Differentiation
Friday, February 09 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Friday, February 09 \| 5:00PM - 7:30PM B Cell Tolerance Room: Van Horne A-B Speaker 1 of 5 Martin G. Weigert, University of Chicago, USA Anti-DNA Antibodies and Autoimmunity
Friday, February 09 \| 5:00PM - 7:30PM B Cell Tolerance Room: Van Horne A-B Speaker 2 of 5 David Nemazee, The Scripps Research Institute, USA RS Knockout Mouse: A Mutant with a Targeted Defect in Receptor Editing
Friday, February 09 \| 5:00PM - 7:30PM B Cell Tolerance Room: Van Horne A-B Speaker 3 of 5 Chandra Mohan, University of Texas Southwestern Medical Center, USA Lupus Susceptibility Loci at the Interface of Tolerance and Autoimmunity
Friday, February 09 \| 5:00PM - 7:30PM B Cell Tolerance Room: Van Horne A-B Speaker 4 of 5 * Michel C. Nussenzweig, HHMI/Rockefeller University, USA Development of Autoantibodies in Normal Humans and in Patients with SLE/GC Imaging Reveals a Dynamic Open Structure
Friday, February 09 \| 5:00PM - 7:30PM B Cell Tolerance Room: Van Horne A-B Speaker 5 of 5 Marcus R. Clark, University of Chicago, USA Short Talk: Regulation of B Cell Antigen Receptor Endocytic Trafficking in Anergy
Friday, February 09 \| 7:30PM - 8:30PM Social Hour with Lite Bites Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Friday, February 09 \| 7:30PM - 10:00PM Poster Session 3 Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Saturday, February 10 \| 7:00AM - 8:00AM Breakfast Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Saturday, February 10 \| 8:00AM - 11:00AM B Cell Transformation Room: Van Horne A-B Speaker 1 of 6 André Nussenzweig, NCI, National Institutes of Health, USA DNA Damage and Oncogenic Stress: Barriers to Chromosomal Translocations
Saturday, February 10 \| 8:00AM - 11:00AM B Cell Transformation Room: Van Horne A-B Speaker 2 of 6 Riccardo Dalla-Favera, Columbia University, USA Molecular Pathogenesis of B Cell Lymphomas
Saturday, February 10 \| 8:00AM - 11:00AM B Cell Transformation Room: Van Horne A-B Speaker 3 of 6 Nicholas Chiorazzi, Feinstein Institute for Medical Research, USA Short Talk: The Biology of Chronic Lymphocytic Leukemia B Cells
Saturday, February 10 \| 8:00AM - 11:00AM B Cell Transformation Room: Van Horne A-B Speaker 4 of 6 Robert C. Rickert, Pfizer Inc., USA Short Talk: Coordinate Suppression of B Cell Lymphoma Progression by SHIP and PTEN
Saturday, February 10 \| 8:00AM - 11:00AM B Cell Transformation Room: Van Horne A-B Speaker 5 of 6 Jayne S. Danska, Hospital for Sick Children Research Institute, Canada Short Talk: Subversion of Pre-B Cell Receptor Signaling during Progression to Pre-B Cell Leukemia in p53-/-Ptprcscid/scid mice
Saturday, February 10 \| 8:00AM - 11:00AM B Cell Transformation Room: Van Horne A-B Speaker 6 of 6 * Louis M. Staudt, NCI, National Institutes of Health, USA Loss of Function RNA Interference Screens for Molecular Targets in Lymphoid Malignancies
Saturday, February 10 \| 9:30AM - 9:50AM Coffee Break Room: Van Horne Foyer
Saturday, February 10 \| 11:00AM - 1:00PM Poster Setup Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Saturday, February 10 \| 1:00PM - 10:00PM Poster Viewing Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 1 of 8 * Qiang Pan-Hammarström, Karolinska Institutet, Sweden
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 2 of 8 * Nina Luning Prak, University of Pennsylvania, USA
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 3 of 8 Anupama Ahuja, Yale University School of Medicine, USA Amelioration of Disease in Lupus Prone MRL/lpr Mice by Depletion of B Cells
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 4 of 8 Christopher G. Mayne, University of Illinois at Urbana-Champaign, USA Systemic Autoimmunity in BAFF-R Mutant A/WySnJ Mice
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 5 of 8 Stefanie Sarantopoulos, Dana Farber Cancer Institute, USA High BAFF/Blys Results in Increased Plasmablasts in Human Chronic Graft Versus Host Disease
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 6 of 8 Laura B. Ramsey, University of Minnesota, USA Basal B Cell Receptor Signaling and Receptor Editing
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 7 of 8 Anil K. Panigrahi, Baylor College of Medicine, USA RS Recombination as a Potential Marker of Receptor Editing and Autoreactivity
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3A: Autoreactivity and Tolerance Room: Van Horne A/B Speaker 8 of 8 Nathan R. Schoettler, University of Chicago, USA V Gene Repertoires and Editing in Human Autoimmunity
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 1 of 8 * Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 2 of 8 * Cynthia J. Guidos, University of Toronto and Hospital for Sick Children, Canada
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 3 of 8 Gerald V. Denis, Boston University School of Medicine, USA Tumor-specific and Proliferation-specific Gene Expression Typifies Murine Transgenic (Tg) B Cell Lymphomagenesis
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 4 of 8 John P. Manis, Harvard Medical School, USA 53BP1 is Targeted to Sites of DNA Breaks within the Immunoglobulin Heavy Chain Locus to Promote Class Switch Recombination
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 5 of 8 Maggie M. Liu, Yale University, USA The Mutation Load Suffered by the Mouse Genome as a Consequence of Somatic Hypermutation
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 6 of 8 Van B. T. Ta, Erasmus Medical Center, Netherlands Role of V(D)J Recombination in SLP-65 Deficient Pre-B Cell Leukemia Formation
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 7 of 8 Laurence Lamy, National Cancer Institute, National Institutes of Health, USA A Loss of Function RNA Interference Screen Identifies Genes Involve in Multiple Myeloma Proliferation and Survival
Saturday, February 10 \| 2:30PM - 4:30PM Workshop 3B: B Cell Malignancy Room: Shaughnessey Speaker 8 of 8 Jing H. Wang, University of Colorado Anschutz Medical Campus, USA Aberrant Class Switch Recombination and Secondary V(D)J Recombination Lead to Oncogenic Translocations and B Cell Lymphoma
Saturday, February 10 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Saturday, February 10 \| 5:00PM - 7:15PM Autoimmunity and Immunodeficiency Room: Van Horne A-B Speaker 1 of 5 * Ann Marshak-Rothstein, University of Massachusetts Medical School, USA Toll-like Receptor Signaling in Systemic Autoimmune Disease
Saturday, February 10 \| 5:00PM - 7:15PM Autoimmunity and Immunodeficiency Room: Van Horne A-B Speaker 2 of 5 Stephen M. Anderton, University of Edinburgh, UK B Cells and the Regulation of CNS Autoimmune Disease
Saturday, February 10 \| 5:00PM - 7:15PM Autoimmunity and Immunodeficiency Room: Van Horne A-B Speaker 3 of 5 Garry P. Nolan, Stanford University, USA Single Cell Kinase Signaling for Studies of Disordered Autoimmune Signaling in Systemic Lupus Erythematosus
Saturday, February 10 \| 5:00PM - 7:15PM Autoimmunity and Immunodeficiency Room: Van Horne A-B Speaker 4 of 5 Jonathan A. Deane, Kumquat Biosciences, USA Short Talk: TLR7 Gene Dosage is Critical for Autoantibody Production and Pathology in Mouse Models of Lupus
Saturday, February 10 \| 5:00PM - 7:15PM Autoimmunity and Immunodeficiency Room: Van Horne A-B Speaker 5 of 5 Fabienne Mackay, Monash University, Australia Short Talk: The Role of BAFF in Autoimmunity is T Cell-Independent but Requires Toll-Like Receptor (TLR) Signalling
Saturday, February 10 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Saturday, February 10 \| 7:30PM - 10:00PM Poster Session 4 Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Sunday, February 11 \| 7:00AM - 8:00AM Breakfast Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Sunday, February 11 \| 8:00AM - 11:15AM Autoimmunity and Immunodeficiency in Human Room: Van Horne A-B Speaker 1 of 6 * Timothy W. Behrens, Genentech, Inc., USA The Genetics and Molecular Defects Associated with SLE
Sunday, February 11 \| 8:00AM - 11:15AM Autoimmunity and Immunodeficiency in Human Room: Van Horne A-B Speaker 2 of 6 Flavius Martin, Amgen, Inc., USA Efficacy and Mechanism of B Cell Depletion in Treatment of Autoimmune Disorders in Humans
Sunday, February 11 \| 8:00AM - 11:15AM Autoimmunity and Immunodeficiency in Human Room: Van Horne A-B Speaker 3 of 6 Anne Durandy, Institut Imagine, France Immunoglobulin Class Switch Recombination Deficiency Associated to a DNA Repair Defect
Sunday, February 11 \| 8:00AM - 11:15AM Autoimmunity and Immunodeficiency in Human Room: Van Horne A-B Speaker 4 of 6 Bodo Grimbacher, Royal Free Hospital & University College Medical School, UK Antibody Deficiencies: The Role of Costimulation
Sunday, February 11 \| 8:00AM - 11:15AM Autoimmunity and Immunodeficiency in Human Room: Van Horne A-B Speaker 5 of 6 Ignacio Sanz, Emory University, School of Medicine, USA Short Talk: Breakdown and restoration of B cell tolerance in human SLE
Sunday, February 11 \| 8:00AM - 11:15AM Autoimmunity and Immunodeficiency in Human Room: Van Horne A-B Speaker 6 of 6 Eric Meffre, Yale University School of Medicine, USA Short Talk: Defective and Alternative B Cell Tolerance Mechanisms in Rheumatoid Arthritis
Sunday, February 11 \| 9:30AM - 9:50AM Coffee Break Room: Van Horne Foyer
Sunday, February 11 \| 4:30PM - 5:00PM Coffee Available Room: Van Horne Foyer
Sunday, February 11 \| 5:00PM - 7:00PM B Cells in Pathogen Resistance Room: Van Horne A-B Speaker 1 of 4 * Rolf M. Zinkernagel, University Hospital Zurich, Switzerland Antiviral Antibody Responses
Sunday, February 11 \| 5:00PM - 7:00PM B Cells in Pathogen Resistance Room: Van Horne A-B Speaker 2 of 4 Mathias Florian Heikenwälder, German Cancer Research Center, DKFZ, Germany The Role of B Lymphocytes in Peripheral Prion Pathogenesis
Sunday, February 11 \| 5:00PM - 7:00PM B Cells in Pathogen Resistance Room: Van Horne A-B Speaker 3 of 4 John F. Kearney, University of Alabama, Birmingham, USA Marginal Zone B-lymphocytes: Development and Function.
Sunday, February 11 \| 5:00PM - 7:00PM B Cells in Pathogen Resistance Room: Van Horne A-B Speaker 4 of 4 Troy D. Randall, University of Alabama at Birmingham, USA Short Talk: Role of B Cells in Heterosubtypic Immunity to Influenza virus
Sunday, February 11 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Sunday, February 11 \| 8:00PM - 11:00PM Entertainment Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Sunday, February 11 \| 8:00PM - 11:00PM Cash Bar Room: Alberta, New Brunswick, Cascade, Conservatory, Riverview
Monday, February 12 \| 10:26AM - 10:26AM Departure *Session Chair.