Web Desc
Mechanisms Linking Inflammation and Cancer
Organizer(s): Lisa M. Coussens, Frances R. Balkwill and Glenn Dranoff
Date: February 10 - 15, 2007
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by the Director's Fund
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Summary of Meeting:
Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of tumors as entities that can hijack and exploit various normal physiologic processes of the host. The frequent presence of inflammatory cell infiltrates and chemical mediators of inflammation in tumors has been recognized for over a century, although an understanding of their role during cancer development has been elusive. Leukocytic infiltrates and cytokine/chemokine networks in premalignant tissues and tumors can be distinct, depending upon the stage of malignant development and organ microenvironment. Current thinking is that activated immune cells provide both anti- and pro-tumorigenic signals, thus representing targets to be harnessed or attacked for therapeutic advantage depending upon environmental and/or cellular context. T lymphocytes are being exploited for their ability to induce tumor regression, as are strategies that disable innate immune cells or neutralize immunosuppressive or pro-inflammatory microenvironments. Such approaches may also provide clinical benefit for at-risk cancer patients and those with pre-malignant lesions. This meeting will link innate and adaptive immune regulatory mechanisms with cancer development and cancer treatment by focusing on relevant basic research, preclinical, translational and clinical studies.
Scholarship Deadline: October 10 2006
Discounted Abstract Deadline: October 10 2006
Abstract Deadline: November 9 2006
Discounted Registration Deadline: December 11 2006
We gratefully acknowledge additional support for this conference from:
Celgene CorporationEntreMed, Inc.UCB Celltech
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA124284-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 10 | 3:00PM - 7:30PM
Registration
Room: Promenade


Saturday, February 10 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Saturday, February 10 | 7:30PM - 8:30PM
Keynote Session: Cancer as an Evolving Organ: A Central Role
for Inflammation and the Microenviroment
Room: Mesa A-B

Speaker 1 of 1
Zena Werb, University of California, San Francisco, USA
The Co-Evolution of Neoplastic Cells and Their Microenvironment During Tumor
Progression


Sunday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Sunday, February 11 | 8:00AM - 11:00AM
Infection, Persistent Inflammation and Epidemiology: Linking
Inflammation and Cancer

Room: Mesa A-B

Speaker 1 of 5
Martin J. Blaser, New York University School of Medicine, USA
Genomic Plasticity of Persistent Microbial Colonizers Affects Host Cell Phenotypes: A Model for Carcinogenesis

Sunday, February 11 | 8:00AM - 11:00AM
Infection, Persistent Inflammation and Epidemiology: Linking
Inflammation and Cancer

Room: Mesa A-B

Speaker 2 of 5
* Richard M. Peek, Jr., Vanderbilt University, USA
Pathogenesis of H. pylori-Induced Carcinogenesis

Sunday, February 11 | 8:00AM - 11:00AM
Infection, Persistent Inflammation and Epidemiology: Linking
Inflammation and Cancer

Room: Mesa A-B

Speaker 3 of 5
Hui Xiao, Institut Pasteur of Shanghai, China
Short Talk: The Regulatory Role of SIGIRR in Colonic Epithelial Homeostasis, Inflammation and Tumorigenesis

Sunday, February 11 | 8:00AM - 11:00AM
Infection, Persistent Inflammation and Epidemiology: Linking
Inflammation and Cancer

Room: Mesa A-B

Speaker 4 of 5
Khashayarsha Khazaie, Northwestern University, USA
Short Talk: Inflammation is an Inherent and Essential Component of Colon Cancer.

Sunday, February 11 | 8:00AM - 11:00AM
Infection, Persistent Inflammation and Epidemiology: Linking
Inflammation and Cancer

Room: Mesa A-B

Speaker 5 of 5
Mirna Perez-Moreno, University of Copenhagen, Denmark
Links Between Cell Adhesion, Inflammation and Cancer

Sunday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Sunday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Sunday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Sunday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Sunday, February 11 | 5:00PM - 7:15PM
INITIATION: Mechanisms Linking Inflammation and Cancer - A
Room: Mesa A-B

Speaker 1 of 4
Anil K. Sood, University of Texas MD Anderson Cancer Center, USA
Influence of Biobehavioral Factors on Tumor Biology: Pathways and Mechanisms

Sunday, February 11 | 5:00PM - 7:15PM
INITIATION: Mechanisms Linking Inflammation and Cancer - A
Room: Mesa A-B

Speaker 2 of 4
Sonia Vallet, Dana Farber Cancer Institute, USA
The Role of MIP1alpha/CCR1 in the Pathogenesis of Osteolytic Bone Lesions in Multiple Myeloma

Sunday, February 11 | 5:00PM - 7:15PM
INITIATION: Mechanisms Linking Inflammation and Cancer - A
Room: Mesa A-B

Speaker 3 of 4
* Dafna Bar-Sagi, New York University School of Medicine, USA
Assessing the Link Between Chronic Pancreatitis and the Evolution of Pancreatic Cancer

Sunday, February 11 | 5:00PM - 7:15PM
INITIATION: Mechanisms Linking Inflammation and Cancer - A
Room: Mesa A-B

Speaker 4 of 4
David H. Raulet, University of California, Berkeley, USA
Natural Killer Cells, DNA Damage and Cancer

Sunday, February 11 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Ortiz/Chamisa


Sunday, February 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Ortiz/Chamisa


Monday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 12 | 8:00AM - 11:00AM
PROMOTION: Mechanisms Linking Inflammation and Cancer - B
Room: Mesa A-B

Speaker 1 of 5
* Alberto Mantovani, Humanitas University, Italy
Tumor-Associated Macrophages in Extrinsic and Intrinsic Pathways of Tumor Promotion

Monday, February 12 | 8:00AM - 11:00AM
PROMOTION: Mechanisms Linking Inflammation and Cancer - B
Room: Mesa A-B

Speaker 2 of 5
Merav Darash-Yahana, NIAID, National Institutes of Health, USA
Short Talk: A Possible Role for the Transmembrane Chemokine CXCL16 in Inflammation-Associated Cancers

Monday, February 12 | 8:00AM - 11:00AM
PROMOTION: Mechanisms Linking Inflammation and Cancer - B
Room: Mesa A-B

Speaker 3 of 5
Michael Karin, University of California, San Diego, USA
Crosstalk Between Inflammation Cells and Carcinomas

Monday, February 12 | 8:00AM - 11:00AM
PROMOTION: Mechanisms Linking Inflammation and Cancer - B
Room: Mesa A-B

Speaker 4 of 5
Barrett J. Rollins, Dana Farber Cancer Institute, USA
Chemokines as Soluble Mediators


Monday, February 12 | 8:00AM - 11:00AM
PROMOTION: Mechanisms Linking Inflammation and Cancer - B
Room: Mesa A-B

Speaker 5 of 5
Roberta B. Ness, University of Texas, USA
Inflammation and Ovarian Cancer: An Epidemiologist’s Perspective

Monday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Monday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Monday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 12 | 5:00PM - 7:15PM
PROGRESSION: Mechanisms Linking Inflammation and Cancer
Room: Mesa A-B

Speaker 1 of 5
* Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation, Proteolysis and Cancer Development

Monday, February 12 | 5:00PM - 7:15PM
PROGRESSION: Mechanisms Linking Inflammation and Cancer
Room: Mesa A-B

Speaker 2 of 5
Sung Hee Baek, Seoul National University, South Korea
Short Talk: Macrophage and Hormone-Dependent Cancer

Monday, February 12 | 5:00PM - 7:15PM
PROGRESSION: Mechanisms Linking Inflammation and Cancer
Room: Mesa A-B

Speaker 3 of 5
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages: A Cellular Toolbox Used by Tumors to Promote Progression and Metastasis

Monday, February 12 | 5:00PM - 7:15PM
PROGRESSION: Mechanisms Linking Inflammation and Cancer
Room: Mesa A-B

Speaker 4 of 5
Dmitry I. Gabrilovich, Wistar Institute, USA
Dendritic Cells Inflammation and Cancer

Monday, February 12 | 5:00PM - 7:15PM
PROGRESSION: Mechanisms Linking Inflammation and Cancer
Room: Mesa A-B

Speaker 5 of 5
Laura Soucek, University of California, San Francisco, USA
Short Talk: Mast Cells Are Required for Expansion of Myc-Dependent Tumors

Monday, February 12 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Ortiz/Chamisa


Monday, February 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Ortiz/Chamisa


Tuesday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Tuesday, February 13 | 8:00AM - 11:00AM
Balancing Pro- and Anti-Tumor Responses
Room: Mesa A-B

Speaker 1 of 5
* Suzanne Ostrand-Rosenberg, University of Maryland, USA
Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

Tuesday, February 13 | 8:00AM - 11:00AM
Balancing Pro- and Anti-Tumor Responses
Room: Mesa A-B

Speaker 2 of 5
Martin Oft, ARMO BioSciences, USA
IL-23 Subverts Immunesurveilance and Promotes Tumor Growth

Tuesday, February 13 | 8:00AM - 11:00AM
Balancing Pro- and Anti-Tumor Responses
Room: Mesa A-B

Speaker 3 of 5
Christoffer Gebhardt, German Cancer Research Center, Germany
Short Talk: The Receptor for Advanced Glycation End-Products (RAGE) Drives Tumor Development by Sustaining Inflammation

Tuesday, February 13 | 8:00AM - 11:00AM
Balancing Pro- and Anti-Tumor Responses
Room: Mesa A-B

Speaker 4 of 5
Randall S. Johnson, University of Cambridge, UK
Inflammatory Cell Production of HIF1alpha and VEGF During Cancer Development

Tuesday, February 13 | 8:00AM - 11:00AM
Balancing Pro- and Anti-Tumor Responses
Room: Mesa A-B

Speaker 5 of 5
Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Tie2-Expressing Monocytes: A Novel Lineage of Proangiogenic Cells

Tuesday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Tuesday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Tuesday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 13 | 5:00PM - 7:00PM
Immune Resistance and Cancer
Room: Mesa A-B

Speaker 1 of 4
Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Host Immune Resistance and Regulation in Cancer

Tuesday, February 13 | 5:00PM - 7:00PM
Immune Resistance and Cancer
Room: Mesa A-B

Speaker 2 of 4
Susan E. Erdman, Massachusetts Institute of Technology, USA
Protective Role of Regulatory T Cells in Inhibiting Inflammation-Induced Cancer

Tuesday, February 13 | 5:00PM - 7:00PM
Immune Resistance and Cancer
Room: Mesa A-B

Speaker 3 of 4
George C. Prendergast, Lankenau Institute for Medical Research, USA
Short Talk: BAR Adapters and IDO in Tumoral Immune Escape

Tuesday, February 13 | 5:00PM - 7:00PM
Immune Resistance and Cancer
Room: Mesa A-B

Speaker 4 of 4
* Robert D. Schreiber, Washington University School of Medicine, USA
The Role of Immunity in Cancer Protection, Persistence and Progression

Tuesday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz/Chamisa


Tuesday, February 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Ortiz/Chamisa


Wednesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Wednesday, February 14 | 8:00AM - 11:00AM
Mechanisms-Based Therapies for Innate Responses
Room: Mesa A-B

Speaker 1 of 5
Raymond N. DuBois, Arizona State University, USA
Inflammation and Cancer: The PGE2—COX-2—Wnt Pathway

Wednesday, February 14 | 8:00AM - 11:00AM
Mechanisms-Based Therapies for Innate Responses
Room: Mesa A-B

Speaker 2 of 5
* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Inflammation and Cancer: The TNF-alpha Connection

Wednesday, February 14 | 8:00AM - 11:00AM
Mechanisms-Based Therapies for Innate Responses
Room: Mesa A-B

Speaker 3 of 5
Anuradha Budhu, NCI, National Institutes of Health, USA
Short Talk: A Predominant Th2 Cytokine Profile in the Hepatic Microenvironment of Metastatic Hepatocellular Carcinoma Patients May be Promoted by Colony Stimulating Factor 1/osteopontin

Wednesday, February 14 | 8:00AM - 11:00AM
Mechanisms-Based Therapies for Innate Responses
Room: Mesa A-B

Speaker 4 of 5
Olivera J. Finn, University of Pittsburgh School of Medicine, USA
MUC1, Inflammation and Cancer

Wednesday, February 14 | 8:00AM - 11:00AM
Mechanisms-Based Therapies for Innate Responses
Room: Mesa A-B

Speaker 5 of 5
Claire E. Lewis, University of Sheffield Medical School, UK
Hypoxic Macrophages in Tumors: Targets and Vehicles for Anti-Cancer Therapy

Wednesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 1 of 8
* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 2 of 8
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 3 of 8
* Lisa M. Coussens, Oregon Health & Science University, USA

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 4 of 8
Sharon S. Evans, Roswell Park Memorial Institute, USA
Role of Interleukin-6 Trans-Signaling in Overcoming Hurdles to T Lymphocyte Trafficking in the Tumor Microenvironment

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 5 of 8
Jennifer K.L. Colby, University of Texas M.D. Anderson Cancer Center Science Park, USA
Inflammatory Cell Infiltrate and Tumor Immune Tolerance in the BK5.COX-2 Mouse Model of Pancreatitis and Pancreatic Tumorigenesis

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 6 of 8
Michael Girardi, Yale University School of Medicine, USA
Characterizing Tumor-Promoting T Cells in Chemically-Induced Cutaneous Carcinogenesis

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 7 of 8
Lillian Maggio-Price, University of Washington, USA
Helicobacter-Infected Smad3-Deficient Mice with Impaired TGF-beta Signaling: A Model to Study Inflammation Associated Colon Cancer

Wednesday, February 14 | 2:30PM - 4:30PM
Workshop: Lymphocyte Responses to Cancer
Room: Mesa A-B

Speaker 8 of 8
Jacqueline S. Papkoff, JSP3 Consulting, USA
Discovery and Validation of a Promising New Target for Therapeutic Monoclonal Antibodies: The Immuno-Modulatory Protein B7-H4 is Overexpressed in Human Breast and Ovarian Cancers

Wednesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 14 | 5:00PM - 7:00PM
Mechanisms-Based Therapies for Adaptive Responses
Room: Mesa A-B

Speaker 1 of 3
Marcin T. Kortylewski, Beckman Research Institute, City of Hope, USA
Targeting Stat3 Enhances CpG Based Therapy

Wednesday, February 14 | 5:00PM - 7:00PM
Mechanisms-Based Therapies for Adaptive Responses
Room: Mesa A-B

Speaker 2 of 3
James P. Allison, University of Texas MD Anderson Cancer Center, USA
Progress with CTLA4-based Strategies


Wednesday, February 14 | 5:00PM - 7:00PM
Mechanisms-Based Therapies for Adaptive Responses
Room: Mesa A-B

Speaker 3 of 3
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
The Interplay of Inflammation and Cancer.
Meeting Summary


Wednesday, February 14 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Mesa C


Wednesday, February 14 | 9:00PM - 11:00PM
Entertainment
Room: Mesa C


Wednesday, February 14 | 9:00PM - 11:00PM
Cash Bar
Room: Mesa C


Thursday, February 15 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.