Web Desc
PI 3-Kinase Signaling Pathways in Disease
Organizer(s): Peter M. Finan and Lewis C. Cantley
Date: February 15 - 20, 2007
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by Merck Research Laboratories
Summary of Meeting:
The PI 3-kinase signaling pathway is emerging as a promising therapeutic target in a number of human diseases including cancer, inflammation and heart disease. Mutations in the PIK3CA gene and the deletion of lipid phosphatase, PTEN, are widespread in many tumors. Mouse models which target individual PI 3-kinase isoforms have shed light on the roles of these enzymes in immune cell function, mast cell degranulation and leukocyte migration. One of the most exciting developments in this field is the discovery of new PI 3-kinase inhibitors. However, identifying the indications that will provide the best opportunity to develop these inhibitors is the subject of intense debate. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI 3-kinase pathway in disease, drawing on human pathophysiology and genetics, mouse models and preclinical data with new PI 3-kinase inhibitors.
Scholarship Deadline: October 16 2006
Discounted Abstract Deadline: October 16 2006
Abstract Deadline: November 15 2006
Discounted Registration Deadline: December 15 2006
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Educational donation provided by AmgenEMD MilliporeGenentech, Inc.GlaxoSmithKline OncologyMerck Research LaboratoriesNovartis Institutes for BioMedical ResearchUCB Celltech
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Abbott Laboratories

Novartis Pharma AG

TargeGen, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK076500-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 15 | 3:00PM - 7:30PM
Registration
Room: Promenade


Thursday, February 15 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Thursday, February 15 | 7:30PM - 8:30PM
Keynote Address: Targeting the PI3K Pathway
Room: Mesa A-B

Speaker 1 of 1
Lewis C. Cantley, Weill Cornell Medicine, USA
Control of Cell Growth by LKB1/AMPK versus PI3K/AKT: Implications for Cancer and Diabetes

Friday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Friday, February 16 | 8:00AM - 11:00AM
PI 3-Kinase Signaling I
Room: Mesa A-B

Speaker 1 of 6
* Peter M. Finan, Epidarex Capital, UK

Friday, February 16 | 8:00AM - 11:00AM
PI 3-Kinase Signaling I
Room: Mesa A-B

Speaker 2 of 6
Len R. Stephens, Babraham Institute, UK
Signaling via PI3Ks

Friday, February 16 | 8:00AM - 11:00AM
PI 3-Kinase Signaling I
Room: Mesa A-B

Speaker 3 of 6
Jan Domin, Imperial College London, UK
Activation and Function of Class II Phosphoinositide 3-Kinase Enzymes

Friday, February 16 | 8:00AM - 11:00AM
PI 3-Kinase Signaling I
Room: Mesa A-B

Speaker 4 of 6
Emilio Hirsch, Fondazione per la Ricerca Biomedica – ONLUS, Italy
What Function for PI3Kbeta?

Friday, February 16 | 8:00AM - 11:00AM
PI 3-Kinase Signaling I
Room: Mesa A-B

Speaker 5 of 6
Marco Falasca, Curtin University, Australia
Short Talk: Emerging Roles of Phosphatidylinositol-3-Phosphate as a Dynamic Intracellular Second Messenger

Friday, February 16 | 8:00AM - 11:00AM
PI 3-Kinase Signaling I
Room: Mesa A-B

Speaker 6 of 6
Takehiko Sasaki, Tokyo Medical and Dental University, Japan
Short Talk: Control of Chemotaxis by PI3Ks and PtdIns(3,4,5)P3 Phosphatases

Friday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Friday, February 16 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Friday, February 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Friday, February 16 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Friday, February 16 | 5:00PM - 7:00PM
PI 3-Kinase Signaling II
Room: Mesa A-B

Speaker 1 of 5
* Len R. Stephens, Babraham Institute, UK

Friday, February 16 | 5:00PM - 7:00PM
PI 3-Kinase Signaling II
Room: Mesa A-B

Speaker 2 of 5
Dario Alessi, University of Dundee, UK
PDK1 Signaling

Friday, February 16 | 5:00PM - 7:00PM
PI 3-Kinase Signaling II
Room: Mesa A-B

Speaker 3 of 5
Brendan D. Manning, Harvard School of Public Health, USA
Signal Integration and Feedback Inhibition Within the TSC-mTORC1 Signaling Network

Friday, February 16 | 5:00PM - 7:00PM
PI 3-Kinase Signaling II
Room: Mesa A-B

Speaker 4 of 5
Bruno D. Fonseca, University of British Columbia, Life Sciences Institute, Canada
Short Talk: PRAS40, a Novel Raptor Binding Partner, is Essential for the Function of the mTORC1 Complex

Friday, February 16 | 5:00PM - 7:00PM
PI 3-Kinase Signaling II
Room: Mesa A-B

Speaker 5 of 5
Andreas Androutsellis-Theotokis, NINDS, National Institutes of Health, USA
Short Talk: STAT3-Ser727: A Stem Cell Target for Cancer and Regeneration, Downstream of PI3 Kinase

Friday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz/Chamisa


Friday, February 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Ortiz/Chamisa


Saturday, February 17 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Saturday, February 17 | 8:00AM - 11:00AM
Dissecting PI 3-Kinase Isoform Specificity
Room: Mesa A-B

Speaker 1 of 6
* Matthias P. Wymann, University of Basel, Switzerland

Saturday, February 17 | 8:00AM - 11:00AM
Dissecting PI 3-Kinase Isoform Specificity
Room: Mesa A-B

Speaker 2 of 6
Bart Vanhaesebroeck, University College London, Cancer Institute, UK
Dissecting PI 3-kinase Function Using Genetically Modified Mice

Saturday, February 17 | 8:00AM - 11:00AM
Dissecting PI 3-Kinase Isoform Specificity
Room: Mesa A-B

Speaker 3 of 6
Kevan M. Shokat, University of California, San Francisco, USA
PI3K Target Validation Using a Matrix of Selective Small Molecule PI3K Inhibitors

Saturday, February 17 | 8:00AM - 11:00AM
Dissecting PI 3-Kinase Isoform Specificity
Room: Mesa A-B

Speaker 4 of 6
John Doukas, Vical Incorporated, USA
PI3K gamma/delta Inhibitors as Therapeutics for Inflammatory-Based Diseases

Saturday, February 17 | 8:00AM - 11:00AM
Dissecting PI 3-Kinase Isoform Specificity
Room: Mesa A-B

Speaker 5 of 6
Christian Rommel, F. Hoffmann-La Roche Ltd, Switzerland
PI 3-kinase gamma Inhibitors

Saturday, February 17 | 8:00AM - 11:00AM
Dissecting PI 3-Kinase Isoform Specificity
Room: Mesa A-B

Speaker 6 of 6
Peter Lamb, Exelixis, USA
Short Talk: Characterization of Selective Inhibitors of Class I and Class III PI3 Kinases

Saturday, February 17 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Saturday, February 17 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Saturday, February 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Saturday, February 17 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Saturday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Signaling in the Immune System
Room: Mesa A-B

Speaker 1 of 5
* Bart Vanhaesebroeck, University College London, Cancer Institute, UK

Saturday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Signaling in the Immune System
Room: Mesa A-B

Speaker 2 of 5
Matthias P. Wymann, University of Basel, Switzerland
PI3K - Context-dependent Signaling

Saturday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Signaling in the Immune System
Room: Mesa A-B

Speaker 3 of 5
David A. Fruman, University of California, Irvine, USA
Role of Class IA PI3K in T Cell Function and Autoimmunity

Saturday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Signaling in the Immune System
Room: Mesa A-B

Speaker 4 of 5
Klaus Okkenhaug, University of Cambridge, UK
The PI3K p110delta Regulates T Cell Differentiation and Regulation

Saturday, February 17 | 5:00PM - 7:00PM
PI 3-Kinase Signaling in the Immune System
Room: Mesa A-B

Speaker 5 of 5
Subha Krishnan, Indiana University School of Medicine, USA
Short Talk: Differential Role of p85á and p85â Regulatory Subunits of Class IA PI-3Kinase in Mast Cell Growth and Differentiation

Saturday, February 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz/Chamisa


Saturday, February 17 | 7:30PM - 10:00PM
Poster Session 2
Room: Ortiz/Chamisa


Sunday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Sunday, February 18 | 8:00AM - 11:00AM
Crosstalk to Other Pathways
Room: Mesa A-B

Speaker 1 of 5
* George Thomas, University of Cincinnati, USA

Sunday, February 18 | 8:00AM - 11:00AM
Crosstalk to Other Pathways
Room: Mesa A-B

Speaker 2 of 5
Brian A. Hemmings, Friedrich Miescher Institute, Switzerland
Effectors Downstream of PI 3-Kinase: AKT/PKB

Sunday, February 18 | 8:00AM - 11:00AM
Crosstalk to Other Pathways
Room: Mesa A-B

Speaker 3 of 5
Yan Luo, Abbott Laboratories, USA
Potent and Selective Inhibitors of Akt Delay Tumor Growth and Sensitize Tumors to Chemotherapy in vivo

Sunday, February 18 | 8:00AM - 11:00AM
Crosstalk to Other Pathways
Room: Mesa A-B

Speaker 4 of 5
Heidi A. Lane, Basilea Pharmaceutica International Ltd., Switzerland
The mTOR Inhibitor RAD001 (Everolimus): A Promising Therapeutic for the Treatment of Human Cancers

Sunday, February 18 | 8:00AM - 11:00AM
Crosstalk to Other Pathways
Room: Mesa A-B

Speaker 5 of 5
Igor Vivanco, Institute of Cancer Research, UK
Short Talk: Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN

Sunday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Sunday, February 18 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Sunday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Sunday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Sunday, February 18 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Control of Metabolism
Room: Mesa A-B

Speaker 1 of 5
* Lewis C. Cantley, Weill Cornell Medicine, USA

Sunday, February 18 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Control of Metabolism
Room: Mesa A-B

Speaker 2 of 5
George Thomas, University of Cincinnati, USA
The Role of the Nutrient Input in TSC1/2-Rheb Mediated mTOR signaling

Sunday, February 18 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Control of Metabolism
Room: Mesa A-B

Speaker 3 of 5
Morris J. Birnbaum, Pfizer Inc., USA
Regulation of Glucose and Lipid Metabolism by Akt/PKB

Sunday, February 18 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Control of Metabolism
Room: Mesa A-B

Speaker 4 of 5
Takashi Kadowaki, University of Tokyo, Japan
Insulin Signaling

Sunday, February 18 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Control of Metabolism
Room: Mesa A-B

Speaker 5 of 5
Cheryl L. Walker, Baylor College of Medicine, USA
Short Talk: Activation of AMPK Signaling in TSC2-Deficient Cells Regulates p27 Localization and Function

Sunday, February 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz/Chamisa


Sunday, February 18 | 7:30PM - 10:00PM
Poster Session 3
Room: Ortiz/Chamisa


Monday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 19 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer I
Room: Mesa A-B

Speaker 1 of 6
* Paul Workman, Institute of Cancer Research, UK

Monday, February 19 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer I
Room: Mesa A-B

Speaker 2 of 6
Thomas M. Roberts, Dana-Farber Cancer Institute, USA
Targeting PI3 Kinase Isoforms in Cancer

Monday, February 19 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer I
Room: Mesa A-B

Speaker 3 of 6
Paul S. Mischel, University of California, San Diego, USA
mTOR Inhibitors in Glioblastoma

Monday, February 19 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer I
Room: Mesa A-B

Speaker 4 of 6
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
PTEN and Tumorigensis

Monday, February 19 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer I
Room: Mesa A-B

Speaker 5 of 6
Levi A. Garraway, Genentech, Inc, USA
Somatic Alterations of PTEN and PIK3CA Elicit Distinct Cancer Phenotypes

Monday, February 19 | 8:00AM - 11:00AM
PI 3-Kinase Signaling and Cancer I
Room: Mesa A-B

Speaker 6 of 6
Surbhi Gupta, UK
Short Talk: The Interaction of Ras with p110alpha is Required for Ras-Driven Tumorigenesis and for Normal Lymphatic Development

Monday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 19 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Cancer II
Room: Mesa A-B

Speaker 1 of 5
* Peter M. Finan, Epidarex Capital, UK

Monday, February 19 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Cancer II
Room: Mesa A-B

Speaker 2 of 5
Jonathan M. Backer, Albert Einstein College of Medicine, USA
Mechanism of Oncogenic Deregulation of Class IA PI 3-Kinases

Monday, February 19 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Cancer II
Room: Mesa A-B

Speaker 3 of 5
Paul Workman, Institute of Cancer Research, UK
Drugging the PI3 Kinome for Cancer Treatment

Monday, February 19 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Cancer II
Room: Mesa A-B

Speaker 4 of 5
Carlos García-Echeverría, Sanofi-Aventis, France
Blocking the PI3K/PKB Signaling Pathway in Tumor Cells: A Challenging and Ardous Drug Discovery Enterprise

Monday, February 19 | 5:00PM - 7:00PM
PI 3-Kinase Signaling and Cancer II
Room: Mesa A-B

Speaker 5 of 5
Lewis C. Cantley, Weill Cornell Medicine, USA
Closing Statement

Monday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Mesa C


Monday, February 19 | 8:00PM - 11:00PM
Entertainment
Room: Mesa C


Monday, February 19 | 8:00PM - 11:00PM
Cash Bar
Room: Mesa C


Tuesday, February 20 | 10:26AM - 10:26AM
Departure


*Session Chair.