Web Desc
Bioactive Lipids in the Lipidomics Era
Organizer(s): Sarah Spiegel, Alfred H. Merrill and H. Alex Brown
Date: February 20 - 25, 2007
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Director's Fund
Summary of Meeting:
The identification of many receptors and targets of bioactive lipid mediators has led to research uncovering their roles in regulating many important normal and pathophysiological processes. It has become evident that the biological activities and functions of lipid signaling molecules are dependent on both their molecular structures and complex cell-specific interactions among the different pathways involved in their biosynthesis and metabolism. The growing complexity of these interactions and the thousands of cellular lipids, together with genomics and proteomics technology already in place, has emphasized the need for development of complementary lipidomics technology. The goal of this meeting is to bring investigators studying signaling and metabolism of bioactive lipids together with researchers who are now developing lipidomics methods for exhaustive characterization and systematic measurement by mass spectrometry of the lipidome, ie cellular lipids, their precursors and their metabolites. The program of this meeting has been designed to foster and synergize research in these areas.
Scholarship Deadline: October 20 2006
Discounted Abstract Deadline: October 20 2006
Abstract Deadline: November 20 2006
Discounted Registration Deadline: December 20 2006
We gratefully acknowledge additional support for this conference from:
Advion BioSciences, Inc.Avanti Polar Lipids, Inc.
Cayman Chemical Company, Inc.
Matreya LLC
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM080134-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 20 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, February 20 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Tuesday, February 20 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Tuesday, February 20 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
Edward A. Dennis, University of California, San Diego, USA
LIPID MAPS and Eicosanoid Lipidomics

Wednesday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Dennis R. Voelker, National Jewish Health, USA

Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 2 of 7
Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Lipid Rafts

Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 3 of 7
Takao Shimizu, University of Tokyo, Japan
Profiling Lipid Mediators and Membrane Lipids in Various Disease Models

Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 4 of 7
H. Alex Brown, Vanderbilt University, USA
Phospholipids and Signaling Networks

Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 5 of 7
Michael J.O. Wakelam, Babraham Institute, UK
The Importance of Lipidomic Analysis in Signalling Research

Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 6 of 7
Maria Fuller, SA Pathology, University of Adelaide, Australia
Short Talk: Lipid Composition of Microdomains is Altered in a Cell Model of Gaucher Disease

Wednesday, February 21 | 8:00AM - 11:15AM
Lipidomics Across the MAP
Room: Chamisa Ballroom 1

Speaker 7 of 7
Alan N. Hunt, University of Southampton, UK
Short Talk: Dissecting the Topological Dynamics of the Lipidome

Wednesday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 21 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, February 21 | 4:30PM - 4:45PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 21 | 4:45PM - 7:00PM
Bioactive Lipids Functions
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA

Wednesday, February 21 | 4:45PM - 7:00PM
Bioactive Lipids Functions
Room: Chamisa Ballroom 1

Speaker 2 of 6
Jerold J. Chun, The Scripps Research Institute, USA
New Roles for Lysophospholipid Signaling

Wednesday, February 21 | 4:45PM - 7:00PM
Bioactive Lipids Functions
Room: Chamisa Ballroom 1

Speaker 3 of 6
Andrew J. Morris, University of Kentucky, USA
New Lipid Phosphatases and Unexpected Functions

Wednesday, February 21 | 4:45PM - 7:00PM
Bioactive Lipids Functions
Room: Chamisa Ballroom 1

Speaker 4 of 6
Suzanne E. Barbour, Virginia Commonwealth University, USA
Platelet-Activating Factor Acetylhydrolase (PAFAH) in Aggressive Periodontitis and Cardiovascular Disease

Wednesday, February 21 | 4:45PM - 7:00PM
Bioactive Lipids Functions
Room: Chamisa Ballroom 1

Speaker 5 of 6
Andrew D. Renault, MPI of Developmental Biology, Germany
Short Talk: Lipid Phosphate Phosphatases are Necessary for the Trans-Epithelial Migration of Germ Cells

Wednesday, February 21 | 4:45PM - 7:00PM
Bioactive Lipids Functions
Room: Chamisa Ballroom 1

Speaker 6 of 6
Reinhard Sebastian Bauer, LIMES, Germany
Short Talk: Novel Functions for the Drosophila Dihydroceramide Synthase DLAG1 in Growth Regulation and Lipid Homeostasis

Wednesday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Lina M. Obeid, Stony Brook Medicine, USA

Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 2 of 7
Sarah Spiegel, Virginia Commonwealth University, USA
The Role of ABC Transporters in Sphingosine-1-Phosphate Secretion

Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 3 of 7
Hugh Rosen, ActivX Biosciences, USA
S1P Receptor Immunopharmacology

Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 4 of 7
Julie D. Saba, University of California, San Francisco, USA
S1P Lyase in Cell Fate and Intestinal Tumorigenesis

Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 5 of 7
Richard L. Proia, National Institutes of Health, USA
Physiologic Functions of Lipids as Revealed by Knockout Mice

Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 6 of 7
Petra Keul, University of Duisburg, Essen, Germany
Short Talk: The Sphingosine-1-Phosphate Analogue and Immunosuppressant FTY720 Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

Thursday, February 22 | 8:00AM - 11:15AM
Bioactive Sphingolipids: New Frontiers
Room: Chamisa Ballroom 1

Speaker 7 of 7
M. Cameron Sullards, Georgia Institute of Technology, USA
Short Talk: Identification and Structure Determination of Sphingolipids From Sphingoid Bases to Sulfatides Using Q-Trap and Chip-Based Nanoelectrospray Ionization With Hybrid Q-TOF Tandem Mass Spectrometry

Thursday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 22 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, February 22 | 4:30PM - 4:45PM
Coffee Available
Room: Chamisa Lobby


Thursday, February 22 | 4:45PM - 7:00PM
Bioactive Lipids and Human Disease
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Jerold J. Chun, The Scripps Research Institute, USA

Thursday, February 22 | 4:45PM - 7:00PM
Bioactive Lipids and Human Disease
Room: Chamisa Ballroom 1

Speaker 2 of 6
Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
Lysophospholipids in Cancer

Thursday, February 22 | 4:45PM - 7:00PM
Bioactive Lipids and Human Disease
Room: Chamisa Ballroom 1

Speaker 3 of 6
Lina M. Obeid, Stony Brook Medicine, USA
Sphingosine Kinase and Cancer

Thursday, February 22 | 4:45PM - 7:00PM
Bioactive Lipids and Human Disease
Room: Chamisa Ballroom 1

Speaker 4 of 6
Susan A. Henry, Cornell University, USA
Phospholipid Mediated Signaling in Yeast: New Roles for Phosphatidic Acid and Diacylglycerol

Thursday, February 22 | 4:45PM - 7:00PM
Bioactive Lipids and Human Disease
Room: Chamisa Ballroom 1

Speaker 5 of 6
Robert V. Stahelin, Purdue University, USA
Short Talk: Disparate Membrane Targeting Mechanisms of Matrix Proteins From Retroviruses and Filoviruses

Thursday, February 22 | 4:45PM - 7:00PM
Bioactive Lipids and Human Disease
Room: Chamisa Ballroom 1

Speaker 6 of 6
Greger Orädd, Umeå University, Sweden
Short Talk: NMR Studies of Oriented Domain-Forming Model Membranes

Thursday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, February 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 23 | 8:00AM - 11:00AM
Lipid Partners and Microenviroments
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Yusuf A. Hannun, Stony Brook Cancer Center, USA

Friday, February 23 | 8:00AM - 11:00AM
Lipid Partners and Microenviroments
Room: Chamisa Ballroom 1

Speaker 2 of 6
Gordon Tollin, University of Arizona, Tucson, USA
Plasmon-Waveguide Resonance Studies of Lateral Segregation of Lipids and Proteins Into Microdomains (Rafts): Effects of Microenvironment on GPCR Distribution and Function

Friday, February 23 | 8:00AM - 11:00AM
Lipid Partners and Microenviroments
Room: Chamisa Ballroom 1

Speaker 3 of 6
Dennis R. Voelker, National Jewish Health, USA
Macromolecular Assemblies of Lipids and Proteins Regulate Non-Vesicular Phospholipid Traffic

Friday, February 23 | 8:00AM - 11:00AM
Lipid Partners and Microenviroments
Room: Chamisa Ballroom 1

Speaker 4 of 6
William Dowhan, University of Texas Medical School, USA
Lipid Dependent Organization of Polytopic Membrane Proteins

Friday, February 23 | 8:00AM - 11:00AM
Lipid Partners and Microenviroments
Room: Chamisa Ballroom 1

Speaker 5 of 6
John D. York, Vanderbilt University, USA
Inositol Polyphosphate Regulation of Nuclear Processes and Development

Friday, February 23 | 8:00AM - 11:00AM
Lipid Partners and Microenviroments
Room: Chamisa Ballroom 1

Speaker 6 of 6
Banafshé Larijani, Cancer Research, London Research Institute, UK
Short Talk: Role of Phosphoinositide Signaling in Nuclear Envelope Assembly

Friday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 23 | 4:30PM - 4:45PM
Coffee Available
Room: Chamisa Lobby


Friday, February 23 | 4:45PM - 7:00PM
New Lipid Functions
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Wonhwa Cho, University of Illinois at Chicago, USA

Friday, February 23 | 4:45PM - 7:00PM
New Lipid Functions
Room: Chamisa Ballroom 1

Speaker 2 of 6
Christian R.H. Raetz, Duke University Medical Center, USA
Structure and Inhibition of Enzymes that Assemble Endotoxins

Friday, February 23 | 4:45PM - 7:00PM
New Lipid Functions
Room: Chamisa Ballroom 1

Speaker 3 of 6
Charles E. Chalfant, Virginia Commonwealth University, School of Medicine, USA
Ceramide 1-Phosphate, A Novel Activator of cPLA2

Friday, February 23 | 4:45PM - 7:00PM
New Lipid Functions
Room: Chamisa Ballroom 1

Speaker 4 of 6
Courtney Frasch, National Jewish Medical and Research Center, USA
Short Talk: Lysophosphatidylserine (Lyso-PS), a Signaling Phospholipid, is Made by Activated Neutrophils in a NADPH-Dependent Manner

Friday, February 23 | 4:45PM - 7:00PM
New Lipid Functions
Room: Chamisa Ballroom 1

Speaker 5 of 6
Josef Ecker, University of Regensburg, Germany
Short Talk: Isomer Specific Effects of Conjugated Linoleic Acid on Macrophage ABCG1 Transcription by a SREBP-1c Dependent Mechanism

Friday, February 23 | 4:45PM - 7:00PM
New Lipid Functions
Room: Chamisa Ballroom 1

Speaker 6 of 6
Bogdan G. Gugiu, University of California, Los Angeles, USA
Short Talk: Receptors of Biotinylated Oxidized Phospholipids in Human Aortic Endothelial Cells

Friday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, February 24 | 8:00AM - 11:00AM
Lipidomics Technologies and Opportunities for New Paradigms
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Edward A. Dennis, University of California, San Diego, USA

Saturday, February 24 | 8:00AM - 11:00AM
Lipidomics Technologies and Opportunities for New Paradigms
Room: Chamisa Ballroom 1

Speaker 2 of 6
Alfred H. Merrill, Jr., Georgia Institute of Technology, USA
SphinGOMAP

Saturday, February 24 | 8:00AM - 11:00AM
Lipidomics Technologies and Opportunities for New Paradigms
Room: Chamisa Ballroom 1

Speaker 3 of 6
Robert C. Murphy, University of Colorado Denver, USA
Neutral Lipid Analysis by Mass Spectrometry

Saturday, February 24 | 8:00AM - 11:00AM
Lipidomics Technologies and Opportunities for New Paradigms
Room: Chamisa Ballroom 1

Speaker 4 of 6
Vytas A. Bankaitis, Texas A&M University, USA
Functional Anatomy of the Sec14 Superfamily of Lipid Binding Proteins

Saturday, February 24 | 8:00AM - 11:00AM
Lipidomics Technologies and Opportunities for New Paradigms
Room: Chamisa Ballroom 1

Speaker 5 of 6
Wonhwa Cho, University of Illinois at Chicago, USA
Lipid-Protein Interactions in Cell Signaling and Real-Time Monitoring of Lipid Mediators

Saturday, February 24 | 8:00AM - 11:00AM
Lipidomics Technologies and Opportunities for New Paradigms
Room: Chamisa Ballroom 1

Speaker 6 of 6
Peter Sjövall, SP Swedish National Testing and Research Institute, Sweden
Short Talk: Imaging TOF-SIMS Analysis of Tissue Sections From Kidney Patients and Controls

Saturday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 24 | 11:00AM - 12:00PM
Workshop on Lipidomics Technologies
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Alfred H. Merrill, Jr., Georgia Institute of Technology, USA

Saturday, February 24 | 11:00AM - 12:00PM
Workshop on Lipidomics Technologies
Room: Chamisa Ballroom 1

Speaker 2 of 2
* H. Alex Brown, Vanderbilt University, USA

Saturday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, February 24 | 5:00PM - 7:00PM
Computation and Visualization in Lipidomics
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Robert C. Murphy, University of Colorado Denver, USA

Saturday, February 24 | 5:00PM - 7:00PM
Computation and Visualization in Lipidomics
Room: Chamisa Ballroom 1

Speaker 2 of 4
Yusuf A. Hannun, Stony Brook Cancer Center, USA
Sphingolipid Metabolism and Function in Yeast, Analysis and Simulation

Saturday, February 24 | 5:00PM - 7:00PM
Computation and Visualization in Lipidomics
Room: Chamisa Ballroom 1

Speaker 3 of 4
Jens Nielsen, Chalmers University of Technology, Sweden
Systems Biology of Lipid Metabolism in Saccharomyces cerevisiae: Mapping of Global Regulatory Structures

Saturday, February 24 | 5:00PM - 7:00PM
Computation and Visualization in Lipidomics
Room: Chamisa Ballroom 1

Speaker 4 of 4
Carissa L. Perez, Fred Hutchinson Cancer Research Center, USA
Short Talk: Metabolic Labeling Assays of Fatty Acid Synthesis and Turnover in C. elegans

Saturday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 24 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, February 24 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, February 25 | 10:26AM - 10:26AM
Departure


*Session Chair.