Web Desc
Tuberculosis: From Lab Research to Field Trials
Organizer(s): Stefan H.E. Kaufmann, Issar Smith and Carl F. Nathan
Date: March 20 - 25, 2007
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Tuberculosis remains one of the major infectious disease killers in the world. This is in spite of the fact that, in most cases, the host response is capable of controlling Mycobacterium tuberculosis infection efficiently: only a minority of infected individuals develops active tuberculosis. The situation is exacerbated by increasing incidences of multi-drug-resistant strains and the dangerous liaison between tuberculosis and AIDS. Recent accomplishments in molecular genetics, cell biology, structural biology and immunology have provided the clues to an in-depth understanding of the crosstalk between pathogen and host which leads to latency, resuscitation, disease outbreak, susceptibility and protective immunity. Application of state-of-the-art technologies will help in elucidating underlying molecular mechanisms and in identifying the responsible gene products both on the side of the invader and its host. Based on such insights, novel vaccination strategies can be pursued and new drug candidates developed. This meeting will discuss the most recent findings in the broad field of research activities relevant to a better understanding of tuberculosis and provide a forum for intensive discussions and collaborations for scientists ranging from basic research to field studies. The meeting, therefore, will also promote exchange between and amalgamation of highly sophisticated research approaches and fundamental issues of disease control.
Scholarship Deadline: November 20 2006
Discounted Abstract Deadline: November 20 2006
Abstract Deadline: December 20 2006
Discounted Registration Deadline: January 22 2007
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome FundGlaxoSmithKline UKIntercell AGNovartis Pharma AG
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

Intercell AG

Novartis Institute for Tropical Diseases Pte Ltd
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 U13 AI60000-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI072803-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 20 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Tuesday, March 20 | 6:30PM - 7:30PM
Refreshments
Room: Pacific Ballroom


Tuesday, March 20 | 7:30PM - 8:30PM
Keynote Address
Room: British Columbia Ballroom

Speaker 1 of 1
Gerald H. Friedland, Yale University, USA
Extensively Drug Resistant TB (XDR-TB) in Rural South Africa - Tip of the Iceberg?

Wednesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Saturna/ Vancouver Island/ Pacific Ballroom


Wednesday, March 21 | 8:00AM - 11:00AM
Bacterial Metabolism and Biochemistry
Room: British Columbia Ballroom

Speaker 5 of 5
Carlos Martin, University of Zaragoza, Spain
Short Talk: Live Vaccines Based on phoP Mutants: A Step Toward Clinical Trials

Wednesday, March 21 | 8:00AM - 11:00AM
Bacterial Metabolism and Biochemistry
Room: British Columbia Ballroom

Speaker 4 of 5
David R. Sherman, University of Washington, USA
Environmental Sensing and TB Metabolism

Wednesday, March 21 | 8:00AM - 11:00AM
Bacterial Metabolism and Biochemistry
Room: British Columbia Ballroom

Speaker 3 of 5
* Rajesh S. Gokhale, National Institute of Immunology, India
Versatile Polyketide Enzymatic Machinery for Biosynthesis of Complex Mycobacterial Lipids

Wednesday, March 21 | 8:00AM - 11:00AM
Bacterial Metabolism and Biochemistry
Room: British Columbia Ballroom

Speaker 2 of 5
Mamadou Daffé, Centre National de la Recherche Scientifique, France
Biosynthesis and Function of Mycobacteria Cell Wall Components

Wednesday, March 21 | 8:00AM - 11:00AM
Bacterial Metabolism and Biochemistry
Room: British Columbia Ballroom

Speaker 1 of 5
Carl F. Nathan, Weill Cornell Medical College, USA
Selective Killing of Non-Replicating Mycobacteria by Inhibitors of Dihydrolipoamide Acyl Transferase

Wednesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Drugs against Tuberculosis
Room: British Columbia Ballroom

Speaker 5 of 5
Douglas B. Young, Imperial College London, UK
Drugs for Treatment of Latent TB: a Grand Challenge in Global Health

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Drugs against Tuberculosis
Room: British Columbia Ballroom

Speaker 4 of 5
Jacques H. Grosset, Johns Hopkins School of Medicine, USA
Current Problems and Possible Solutions for the Chemotherapy of Tuberculosis

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Drugs against Tuberculosis
Room: British Columbia Ballroom

Speaker 3 of 5
Vasan Sambandamurthy, Novartis Institute for Tropical Diseases, Singapore
A Chemical Genetics Approach to Identify Essential Targets in Mycobacterium tuberculosis

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Drugs against Tuberculosis
Room: British Columbia Ballroom

Speaker 2 of 5
Barrington J. A. Furr, AstraZeneca, UK
Validated Targets and Antituberculosis Drug Discovery

Wednesday, March 21 | 2:30PM - 4:30PM
Workshop 1: Drugs against Tuberculosis
Room: British Columbia Ballroom

Speaker 1 of 5
* Ann M. Ginsberg, BMGF, USA
Recent Advances in TB Drug Development

Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Wednesday, March 21 | 5:00PM - 7:00PM
Latency and Novel Intervention Strategies
Room: British Columbia Ballroom

Speaker 4 of 4
William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Modeling TB Pathogenesis: Have We Been Mouse Led?

Wednesday, March 21 | 5:00PM - 7:00PM
Latency and Novel Intervention Strategies
Room: British Columbia Ballroom

Speaker 3 of 4
Nicole Kruh-Garcia, Colorado State University, USA
Short Talk: A Novel Interaction Between the FAS-II and PDIM Biosynthetic Pathways

Wednesday, March 21 | 5:00PM - 7:00PM
Latency and Novel Intervention Strategies
Room: British Columbia Ballroom

Speaker 2 of 4
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Requirements for Mycobacterial Growth in vitro and in vivo

Wednesday, March 21 | 5:00PM - 7:00PM
Latency and Novel Intervention Strategies
Room: British Columbia Ballroom

Speaker 1 of 4
Helena I. M. Boshoff, NIAID, National Institutes of Health, USA
Metabolism in Latent Tuberculosis

Wednesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Wednesday, March 21 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Saturna/ Vancouver Island/ Pacific Ballroom


Thursday, March 22 | 8:00AM - 11:00AM
Functional and Structural Analysis on a Global Level
Room: British Columbia Ballroom

Speaker 1 of 5
Issar Smith, Public Health Research Institute/ICPH, USA
Global Response of M. tuberculosis to the Environment

Thursday, March 22 | 8:00AM - 11:00AM
Functional and Structural Analysis on a Global Level
Room: British Columbia Ballroom

Speaker 2 of 5
* William R. Jacobs, Jr., HHMI/Albert Einstein College of Medicine, USA
Eradicating Tuberculosis, A War on Two Fronts: Chemotherapy and Immune Evasion Mechanisms

Thursday, March 22 | 8:00AM - 11:00AM
Functional and Structural Analysis on a Global Level
Room: British Columbia Ballroom

Speaker 3 of 5
Lindsay D. Eltis, University of British Columbia, Canada
Short Talk: Characterization of Cholesterol-Degrading Enzymes Critical for the Survival of Mycobacterium Tuberculosis in the Macrophage

Thursday, March 22 | 8:00AM - 11:00AM
Functional and Structural Analysis on a Global Level
Room: British Columbia Ballroom

Speaker 4 of 5
Brian D. Robertson, Imperial College London, UK
Look Global, Focus Local

Thursday, March 22 | 8:00AM - 11:00AM
Functional and Structural Analysis on a Global Level
Room: British Columbia Ballroom

Speaker 5 of 5
Matthias Wilmanns, European Molecular Biology Laboratory Hamburg, Germany
Towards the Proteome of Mycobacterium Tuberculosis in 3D

Thursday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Thursday, March 22 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Thursday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 1 of 7
* Camille Locht, Institut Pasteur de Lille, France
From Extrapulmonary Dissemination to Diagnosis of Latent M. tuberculosis Infection and Novel Vaccine Development

Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 2 of 7
Marc Jacobsen, University Hospital Duesseldorf, Germany
Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis

Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 3 of 7
J. Muse Davis, University of Washington, USA
Mechanisms of Mycobacterial Dissemination Within and From Early Tuberculous Granulomas Revealed by Long-Term Live Imaging of Mycobacterium Marinum-Infected Zebrafish Embryos

Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 4 of 7
Anthony J. Hickey, University of North Carolina at Chapel Hill, USA
Needle-Free Vaccination by BCG-LPP Aerosols in the Guinea Pig

Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 5 of 7
Kari Ann Sweeney, Albert Einstein College of Medicine, USA
A M. Tuberculosis Gene Cluster that Prevents IL-12 Induction and Innate Immune Killing

Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 6 of 7
Jeff E. Grotzke, Oregon Health & Science University, USA
The Mycobacterium Tuberculosis Phagosome: Evidence for ER-derived HLA-I Antigen Processing and Presentation

Thursday, March 22 | 2:30PM - 4:30PM
Workhop 2: Oral Abstract Presentations
Room: British Columbia Ballroom

Speaker 7 of 7
Sandhya S. Visweswariah, Indian Institute of Science, India
Cyclic AMP and Mycobacteria: Roles of Nucleotide Cyclases and Phosphodiesterases

Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Thursday, March 22 | 5:00PM - 7:00PM
Cell and Tissue Response
Room: British Columbia Ballroom

Speaker 1 of 4
Sabine Ehrt, Weill Cornell Medical College, USA
Host Defense and Mycobacterial Virulence

Thursday, March 22 | 5:00PM - 7:00PM
Cell and Tissue Response
Room: British Columbia Ballroom

Speaker 2 of 4
* Alan Sher, NIAID, National Institutes of Health, USA
Cellular Dynamics of Granuloma Formation and Maintenance Revealed by Intravital Imaging

Thursday, March 22 | 5:00PM - 7:00PM
Cell and Tissue Response
Room: British Columbia Ballroom

Speaker 3 of 4
Hardy Kornfeld, University of Massachusetts Medical School, USA
Short Talk: Multiple Death Modes of M. tuberculosis-Infected Macrophages

Thursday, March 22 | 5:00PM - 7:00PM
Cell and Tissue Response
Room: British Columbia Ballroom

Speaker 4 of 4
John D. MacMicking, Yale University, USA
Immunity-Related GTPases (IRGs) in Host Defense against Tuberculosis

Thursday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Thursday, March 22 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Friday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Saturna/ Vancouver Island/ Pacific Ballroom


Friday, March 23 | 8:00AM - 11:00AM
Genetic Determinants of Disease (Host and Pathogen)
Room: British Columbia Ballroom

Speaker 1 of 6
* Peter M. Small, Bill & Melinda Gates Foundation, USA

Friday, March 23 | 8:00AM - 11:00AM
Genetic Determinants of Disease (Host and Pathogen)
Room: British Columbia Ballroom

Speaker 2 of 6
Igor B. Kramnik, Boston University, USA
Experimental Mouse Model of Pulmonary Tuberculosis: Genetic Perspectives

Friday, March 23 | 8:00AM - 11:00AM
Genetic Determinants of Disease (Host and Pathogen)
Room: British Columbia Ballroom

Speaker 3 of 6
Laurent Abel, INSERM U550, Necker Medical School, France
Human Genetics of Tuberculosis: A Continuous Spectrum of Predisposition

Friday, March 23 | 8:00AM - 11:00AM
Genetic Determinants of Disease (Host and Pathogen)
Room: British Columbia Ballroom

Speaker 4 of 6
Pedro O. Flores-Villanueva, Methodist Hospital Research Institute, USA
MCP-1 Gene, Host Determinant of Progression from Infection to Disease

Friday, March 23 | 8:00AM - 11:00AM
Genetic Determinants of Disease (Host and Pathogen)
Room: British Columbia Ballroom

Speaker 5 of 6
Diane Houben, Netherlands Cancer Institute, Netherlands
Short Talk: M. tuberculosis and M. leprae Translocate From the Phagolysosome to the Cytosol in Myeloid Cells

Friday, March 23 | 8:00AM - 11:00AM
Genetic Determinants of Disease (Host and Pathogen)
Room: British Columbia Ballroom

Speaker 6 of 6
Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolution of Mycobacterium tuberculosis

Friday, March 23 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, March 23 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Friday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 1 of 7
Uli Fruth, World Health Organization, Switzerland
What is Role of the World Health Organization in TB Vaccine Development?

Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 2 of 7
* Christine F. Sizemore, NIAID, National Institutes of Health, USA
NIAID's Extramural TB Program - Contributions to TB Science and Vaccine Development

Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 3 of 7
Alexander von Gabain, Valneva SE, France
Characterization of IC31TM, a Novel Multipurpose Adjuvant with a Profile Matching the Need of TB Vaccines

Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 4 of 7
Pascal Mettens, GlaxoSmithKline, Belgium
Prospects For Tuberculosis Vaccine Based On The Mtb72F/AS02A

Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 5 of 7
Francois Spertini, Centre Hospitalier Universitaire Vaudois, Switzerland
Safety and Immunogenicity of the Mtb72F/AS02A Tuberculosis Vaccine in PPD-Positive Swiss Adults

Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 6 of 7
Albrecht Läufer, Corvay GmbH, Germany
Developing a TB Vaccine for Human Use

Friday, March 23 | 2:30PM - 4:30PM
Workshop 3: Vaccines against Tuberculosis
Room: British Columbia Ballroom

Speaker 7 of 7
Jerald C. Sadoff, Crucell Vaccine Institute, Janssen Pharmaceutical Companies of Johnson & Johnson, Netherlands
Aeras TB Vaccine Development

Friday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Friday, March 23 | 5:00PM - 7:30PM
Immune Response and Correlates of Protection
Room: British Columbia Ballroom

Speaker 1 of 5
* Gilla Kaplan, University of Cape Town, South Africa
Immunologic Correlates of Protective Immunity against TB in BCG-Vaccinated Neonates

Friday, March 23 | 5:00PM - 7:30PM
Immune Response and Correlates of Protection
Room: British Columbia Ballroom

Speaker 2 of 5
Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
Human Inflammatory Response Against M. tuberculosis

Friday, March 23 | 5:00PM - 7:30PM
Immune Response and Correlates of Protection
Room: British Columbia Ballroom

Speaker 3 of 5
Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Immunoregulation and Suppression in Human Tuberculosis

Friday, March 23 | 5:00PM - 7:30PM
Immune Response and Correlates of Protection
Room: British Columbia Ballroom

Speaker 4 of 5
David M. Lewinsohn, Oregon Health & Science University, USA
Short Talk: Defining Immunodominance in the Human CD8+ T Cell Response to Mtb

Friday, March 23 | 5:00PM - 7:30PM
Immune Response and Correlates of Protection
Room: British Columbia Ballroom

Speaker 5 of 5
Larry S. Schlesinger, Texas Biomedical Research Institute, USA
Regulation of Lung Inflammation by Macrophages: Impact of the Alveolar Microenvironment on Tuberculosis Pathogenesis

Friday, March 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Friday, March 23 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Saturday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Saturna/ Vancouver Island/ Pacific Ballroom


Saturday, March 24 | 8:00AM - 11:00AM
Vaccines
Room: British Columbia Ballroom
World TB Day. 125 Years after the Discovery of the Etiology of Tuberculosis
Speaker 1 of 4
Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Recombinant BCG with Improved Immunogenicity

Saturday, March 24 | 8:00AM - 11:00AM
Vaccines
Room: British Columbia Ballroom
World TB Day. 125 Years after the Discovery of the Etiology of Tuberculosis
Speaker 2 of 4
Peter L. Andersen, Statens Serum Institut, Denmark
Subunit Vaccines Against Tuberculosis

Saturday, March 24 | 8:00AM - 11:00AM
Vaccines
Room: British Columbia Ballroom
World TB Day. 125 Years after the Discovery of the Etiology of Tuberculosis
Speaker 3 of 4
* Marcus A. Horwitz, University of California, Los Angeles, USA
New More Potent and Safer Recombinant BCG Vaccines Against Tuberculosis

Saturday, March 24 | 8:00AM - 11:00AM
Vaccines
Room: British Columbia Ballroom
World TB Day. 125 Years after the Discovery of the Etiology of Tuberculosis
Speaker 4 of 4
Helen McShane, Jenner Institute, UK
Boosting BCG with MVA85A - Results from Clinical Trials

Saturday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, March 24 | 11:00AM - 12:00PM
Poster Setup
Room: Pacific Ballroom


Saturday, March 24 | 12:00PM - 1:00PM
Lunch
Room: Pacific Ballroom/ Saturna/ Vancouver Island


Saturday, March 24 | 1:00PM - 5:00PM
Poster Session 4
Room: Pacific Ballroom/ Saturna/ Vancouver Island


Saturday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, March 24 | 5:00PM - 7:00PM
Beyond the Wet Lab - Clinical Experience and Trials
Room: British Columbia Ballroom

Speaker 1 of 3
Michael Levin, Imperial College London, UK
Insights into the Immunological Basis of Susceptibility and Resistance to Mycobacteria from Studies on Patients

Saturday, March 24 | 5:00PM - 7:00PM
Beyond the Wet Lab - Clinical Experience and Trials
Room: British Columbia Ballroom

Speaker 2 of 3
* Neil W. Schluger, Columbia University College of Physicians and Surgeons, USA
Tuberculosis Clinical Trials: Past, Present and Future

Saturday, March 24 | 5:00PM - 7:00PM
Beyond the Wet Lab - Clinical Experience and Trials
Room: British Columbia Ballroom

Speaker 3 of 3
Greg D. Hussey, University of Cape Town, South Africa
Development of a Tuberculosis Vaccine Trial Site in South Africa: Challenges and Lessons Learned



Saturday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, March 24 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Saturday, March 24 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Sunday, March 25 | 10:26AM - 10:26AM
Departure


*Session Chair.