Web Desc
Epigenetics: Regulation of Chromatin Structure in Development and Disease
Organizer(s): Barbara Panning and Hiten D. Madhani
Date: April 11 - 16, 2007
Location: Beaver Run Resort, Breckenridge, CO, USA
Summary of Meeting:
Epigenetic regulatory mechanisms provide cells with transcriptional memory, allowing cells to stably maintain expression patterns for many divisions, and developmental flexibility, facilitating programmed alterations in gene expression during embryogenesis. Recent developments indicate that surprisingly dynamic modifications in chromatin structure are employed to regulate gene expression and have far-reaching consequences for cell fate decisions and normal and pathological development. Significant progress has been made in understanding the role of epigenetics in topics as diverse as cloning, cancer biology, genomic imprinting, development in plants and animals, and DNA repair. Similar molecules are employed by different organisms to affect chromatin structure and achieve epigenetic regulation. However the molecular mechanisms by which the changes in chromatin structure modulate gene expression remain mysterious. This Keystone Symposium on ‘Chromatin Structure in Development and Disease’ will bring together diverse fields, from basic studies in model organisms to medical research to biotechnology. The primary aim of the meeting will be to promote communication between diverse groups of epigenetic and chromatin researchers, facilitating cross dissemination of approaches to understanding these fascinating and medically important processes.
Scholarship Deadline: December 11 2006
Discounted Abstract Deadline: December 11 2006
Abstract Deadline: January 15 2007
Discounted Registration Deadline: February 12 2007
We gratefully acknowledge additional support for this conference from:
CellCentric Ltd.EMD MilliporeRett Syndrome Research Foundation
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA124284-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Wednesday, April 11 | 3:00PM - 7:30PM
Registration
Room: Foyer


Wednesday, April 11 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Wednesday, April 11 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 1 - 5

Speaker 1 of 1
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Epigenetics and Nuclear Reprogramming

Thursday, April 12 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6 - 12


Thursday, April 12 | 8:00AM - 11:15AM
Histone Modifications 1: Making the Marks
Room: Peaks 1 - 5

Speaker 1 of 6
Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Dynamic Regulation of Histone Methylation by Demethylases

Thursday, April 12 | 8:00AM - 11:15AM
Histone Modifications 1: Making the Marks
Room: Peaks 1 - 5

Speaker 2 of 6
Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Histone Demethylation by the JmjC Domain-Containing Proteins

Thursday, April 12 | 8:00AM - 11:15AM
Histone Modifications 1: Making the Marks
Room: Peaks 1 - 5

Speaker 3 of 6
* Brian D. Strahl, University of North Carolina at Chapel Hill, USA
Histone Modifications in RNA Polymerase II Transcription

Thursday, April 12 | 8:00AM - 11:15AM
Histone Modifications 1: Making the Marks
Room: Peaks 1 - 5

Speaker 4 of 6
Yifan Liu, Rockefeller University, USA
Short Talk: RNAi-Dependent H3 K27 Methylation is Required for Heterochromatin Formation and DNA Elimination in Tetrahymena

Thursday, April 12 | 8:00AM - 11:15AM
Histone Modifications 1: Making the Marks
Room: Peaks 1 - 5

Speaker 5 of 6
Alexander Tarakhovsky, Rockefeller University, USA
Histone Mimicry by Histone Methyltransferase G9a

Thursday, April 12 | 8:00AM - 11:15AM
Histone Modifications 1: Making the Marks
Room: Peaks 1 - 5

Speaker 6 of 6
Hengbin Wang, University of Alabama, Birmingham, USA
Short Talk: Regulation of Cell Cycle Progression and Gene Expression by H2A Deubiquitination

Thursday, April 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 12 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 14 - 17


Thursday, April 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14 - 17


Thursday, April 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, April 12 | 5:00PM - 7:00PM
Histone Modifications 2: The Effectors
Room: Peaks 1 - 5

Speaker 1 of 5
Robert E. Kingston, Massachusetts General Hospital, USA
Possible Roles in Silencing for piRNAs

Thursday, April 12 | 5:00PM - 7:00PM
Histone Modifications 2: The Effectors
Room: Peaks 1 - 5

Speaker 2 of 5
Sarah C.R. Elgin, Washington University, USA
Heterochromatin Formation and Gene Silencing in Drosophila

Thursday, April 12 | 5:00PM - 7:00PM
Histone Modifications 2: The Effectors
Room: Peaks 1 - 5

Speaker 3 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Combinatorial Readout of Histone Epigenetics Marks

Thursday, April 12 | 5:00PM - 7:00PM
Histone Modifications 2: The Effectors
Room: Peaks 1 - 5

Speaker 4 of 5
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Heterochromatin: A Versatile Platform of the Genome

Thursday, April 12 | 5:00PM - 7:00PM
Histone Modifications 2: The Effectors
Room: Peaks 1 - 5

Speaker 5 of 5
Masami Horikoshi, University of Tokyo, Japan
Short Talk: Structure and Functional Basis of the Histone Chaperone CIA/ASF1-Histone H3-H4 Complex

Thursday, April 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14 - 17


Thursday, April 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 14 - 17


Friday, April 13 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6 - 12


Friday, April 13 | 8:00AM - 11:15AM
Non Coding RNAs
Room: Peaks 1 - 5

Speaker 1 of 6
Danesh Moazed, Harvard Medical School, USA
Transcription and RNAi in Heterochromatin

Friday, April 13 | 8:00AM - 11:15AM
Non Coding RNAs
Room: Peaks 1 - 5

Speaker 2 of 6
Sundeep Kalantry, University of Michigan Medical School, USA
Short Talk: Xist RNA-Independent Initiation of Mouse Imprinted X-Chromosome Inactivation

Friday, April 13 | 8:00AM - 11:15AM
Non Coding RNAs
Room: Peaks 1 - 5

Speaker 3 of 6
Takashi Nagano, Babraham Institute, UK
Short Talk: The Air Non-Coding RNA Epigenetically Silences Transcription by Interacting with Chromatin at Specific Regions

Friday, April 13 | 8:00AM - 11:15AM
Non Coding RNAs
Room: Peaks 1 - 5

Speaker 4 of 6
John L. Rinn, University of Colorado Boulder, USA
Short Talk: Epigenetic Regulation of the Human HOX Loci by Non-coding RNAs


Friday, April 13 | 8:00AM - 11:15AM
Non Coding RNAs
Room: Peaks 1 - 5

Speaker 5 of 6
Yota Murakami, Institute for Virus Research, Kyoto University, Japan
Short Talk: Determinants of the Fate of Non-Coding RNA Transcribed from RNAi-Dependent Heterochromatin in Fission Yeast

Friday, April 13 | 8:00AM - 11:15AM
Non Coding RNAs
Room: Peaks 1 - 5

Speaker 6 of 6
* Barbara Panning, University of California, San Francisco, USA
Xist RNA and Randomness

Friday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 13 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 14 - 17


Friday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14 - 17


Friday, April 13 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, April 13 | 5:00PM - 7:00PM
DNA Methylation
Room: Peaks 1 - 5

Speaker 1 of 4
Steven E. Jacobsen, University of California, Los Angeles, USA
DNA Methylation in Arabidopsis

Friday, April 13 | 5:00PM - 7:00PM
DNA Methylation
Room: Peaks 1 - 5

Speaker 2 of 4
* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA
Epigenetic Regulation of H19 and Igf2 Imprinting

Friday, April 13 | 5:00PM - 7:00PM
DNA Methylation
Room: Peaks 1 - 5

Speaker 3 of 4
Timothy H. Bestor, Columbia University College of Physicians and Surgeons, USA
An Epigenetic Machine Interprets Histone H3K4 Methylation to Guide DNA Methylation

Friday, April 13 | 5:00PM - 7:00PM
DNA Methylation
Room: Peaks 1 - 5

Speaker 4 of 4
Matthew C. Lorincz, University of British Columbia, Canada
Short Talk: An Unmethylated 3’ Promoter-Proximan Region is Required for Efficient Transcription Initiation

Friday, April 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14 - 17


Friday, April 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 14 - 17


Saturday, April 14 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6 - 12


Saturday, April 14 | 8:00AM - 11:15AM
Histone Variants
Room: Peaks 1 - 5

Speaker 1 of 6
Ralph Scully, Beth Israel Deaconess Medical Center, USA
Histone H2AX-Associated Proteins MDC1, 53BP1 and BRCA1 in Recombination Control

Saturday, April 14 | 8:00AM - 11:15AM
Histone Variants
Room: Peaks 1 - 5

Speaker 2 of 6
Elizabeth M. Duncan, Stowers Institute for Medical Research, USA
Short Talk: Chromatin Remodeling during Murine ES Cell Differentiation

Saturday, April 14 | 8:00AM - 11:15AM
Histone Variants
Room: Peaks 1 - 5

Speaker 3 of 6
* Hiten D. Madhani, University of California, San Francisco, USA
Determinants of Promoter Chromatin Architecture

Saturday, April 14 | 8:00AM - 11:15AM
Histone Variants
Room: Peaks 1 - 5

Speaker 4 of 6
Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Epigenetic Patterns Generated by Histone Replacement

Saturday, April 14 | 8:00AM - 11:15AM
Histone Variants
Room: Peaks 1 - 5

Speaker 5 of 6
Karolin Luger, University of Colorado Boulder, USA
Histone Chaperones and Scavengers

Saturday, April 14 | 8:00AM - 11:15AM
Histone Variants
Room: Peaks 1 - 5

Speaker 6 of 6
Jason H. Brickner, Northwestern University, USA
Short Talk: Gene Recruitment to the Nuclear Periphery Confers Memory of Past Transcription

Saturday, April 14 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 14 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 14 - 17


Saturday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14 - 17


Saturday, April 14 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, April 14 | 5:00PM - 7:15PM
Epigenetics and Disease 1
Room: Peaks 1 - 5

Speaker 1 of 5
Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
Genome Organizer SATB1 in Breast Carcinogenesis

Saturday, April 14 | 5:00PM - 7:15PM
Epigenetics and Disease 1
Room: Peaks 1 - 5

Speaker 2 of 5
* Douglas Higgs, MRC Molecular Haematology Unit, UK
Progress Towards Understanding the Role of the ATRX Protein

Saturday, April 14 | 5:00PM - 7:15PM
Epigenetics and Disease 1
Room: Peaks 1 - 5

Speaker 3 of 5
Dennis R. Grayson, University of Illinois at Chicago, USA
Methylation and the Regulation of Reelin and GAD67 in Schizophrenia

Saturday, April 14 | 5:00PM - 7:15PM
Epigenetics and Disease 1
Room: Peaks 1 - 5

Speaker 4 of 5
Raman Nagarajan, GlaxoSmithKline, USA
Short Talk: Defects in MECP2 Expression and Epigenetic Regulation are Common in Autism Brain

Saturday, April 14 | 5:00PM - 7:15PM
Epigenetics and Disease 1
Room: Peaks 1 - 5

Speaker 5 of 5
Kyoko Yokomori, University of California, Irvine, USA
Short Talk: Specific Loss of Heterochromatin at D4Z4 Repeats in Facioscapulohumeral Dystrophy

Saturday, April 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Peaks 14 - 17


Saturday, April 14 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 14 - 17


Sunday, April 15 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6 - 12


Sunday, April 15 | 8:00AM - 11:00AM
Genomic Approaches
Room: Peaks 1 - 5

Speaker 1 of 6
* Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Silent Running: RNA Interference and Heterochromatin in Plants and
Fission Yeast


Sunday, April 15 | 8:00AM - 11:00AM
Genomic Approaches
Room: Peaks 1 - 5

Speaker 2 of 6
Jeffrey A. Jeddeloh, Roche NimbleGen, USA
Short Talk: Comparative Epigenetic Profiling Reveals Novel Cancer Biomarkers

Sunday, April 15 | 8:00AM - 11:00AM
Genomic Approaches
Room: Peaks 1 - 5

Speaker 3 of 6
Richard A. Young, Whitehead Institute for Biomedical Research, USA
TrxG and PcG Proteins in Vertebrate Development


Sunday, April 15 | 8:00AM - 11:00AM
Genomic Approaches
Room: Peaks 1 - 5

Speaker 4 of 6
Chia-Lin Wei, Genome Institute of Singapore, Singapore
Short Talk: Global Mapping of Histone K4 and K27 Trimethylation Patterns Reveal Distinct Compartments and Utilization of Human ESC Genome

Sunday, April 15 | 8:00AM - 11:00AM
Genomic Approaches
Room: Peaks 1 - 5

Speaker 5 of 6
Thomas G. Fazzio, University of Massachusetts Medical School, USA
Short Talk: Identification of Chromatin Regulators Required for Embryonic Stem Cell Self-Renewal using RNA Interference

Sunday, April 15 | 8:00AM - 11:00AM
Genomic Approaches
Room: Peaks 1 - 5

Speaker 6 of 6
Nevan J. Krogan, University of California, San Francisco, USA
E-MAP Analysis of Chromatin in S. cerevisiae

Sunday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, April 15 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, April 15 | 5:00PM - 7:00PM
Epigenetics and Disease 2
Room: Peaks 1 - 5

Speaker 1 of 4
* Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development

Sunday, April 15 | 5:00PM - 7:00PM
Epigenetics and Disease 2
Room: Peaks 1 - 5

Speaker 2 of 4
Moshe Szyf, McGill University, Canada
DNA Demethylation and Cancer; Therapeutic Implications

Sunday, April 15 | 5:00PM - 7:00PM
Epigenetics and Disease 2
Room: Peaks 1 - 5

Speaker 3 of 4
Harriet Karimi Kinyamu, NIEHS, National Institutes of Health, USA
Short Talk: Proteasome Inhibition Alters HIstone H3 Lysine Methylation Landscape to Modulate Hormone Regulated Gene Expression

Sunday, April 15 | 5:00PM - 7:00PM
Epigenetics and Disease 2
Room: Peaks 1 - 5

Speaker 4 of 4
Amar J. S. Klar, NCI, National Institutes of Health, USA
Regulation of DNA Strand/Chromatid Segregation in Mouse Cell Divisions

Sunday, April 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14 - 17


Sunday, April 15 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 14 - 17


Sunday, April 15 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 14 - 17


Monday, April 16 | 10:26AM - 10:26AM
Departure


*Session Chair.