Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
MicroRNAs and Human Disease (2011J6)
Mechanism and Biology of Silencing (2011C7)
RNA Silencing Mechanisms in Plants (2010B6)
RNA Silencing: Mechanism, Biology and Application (2010A7)
The Biology of RNA Silencing (2009D6)

Web Desc
MicroRNAs and siRNAs: Biological Functions and Mechanisms joint with RNAi for Target Validation and as a Therapeutic Organizer(s): David P. Bartel and Shiv I.S. Grewal Date: January 28 - February 02, 2007 Location: Keystone Resort, Keystone, CO, USA Sponsored by Novartis Institutes for BioMedical Research For important information on the coronavirus, please click here Summary of Meeting: MicroRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) act as guide RNAs to direct gene-silencing pathways in eukaryotes. These silencing pathways require related core components to process and utilize the guide RNAs. Nonetheless, they have evolved to perform different biochemical functions, mediating either transcriptional or posttranscriptional silencing important for numerous endogenous gene-regulatory programs as well as viral resistance, transposon suppression, centromere function, and programmed genome rearrangement. The aim of this meeting is to report on recent advances in understanding both the molecular mechanisms of siRNA- and miRNA-directed silencing and the biological functions of these mechanisms. Scholarship Deadline: September 28 2006 Discounted Abstract Deadline: September 28 2006 Abstract Deadline: October 27 2006 Discounted Registration Deadline: November 28 2006 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

MicroRNAs and siRNAs: Biological Functions and Mechanisms

joint with RNAi for Target Validation and as a Therapeutic

Organizer(s): David P. Bartel and Shiv I.S. Grewal

Date: January 28 - February 02, 2007
Location: Keystone Resort, Keystone, CO, USA

Sponsored by Novartis Institutes for BioMedical Research

For important information on the coronavirus, please click here

Summary of Meeting:

MicroRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) act as guide RNAs to direct gene-silencing pathways in eukaryotes. These silencing pathways require related core components to process and utilize the guide RNAs. Nonetheless, they have evolved to perform different biochemical functions, mediating either transcriptional or posttranscriptional silencing important for numerous endogenous gene-regulatory programs as well as viral resistance, transposon suppression, centromere function, and programmed genome rearrangement. The aim of this meeting is to report on recent advances in understanding both the molecular mechanisms of siRNA- and miRNA-directed silencing and the biological functions of these mechanisms.

Scholarship Deadline: September 28 2006

Discounted Abstract Deadline: September 28 2006

Abstract Deadline: October 27 2006

Discounted Registration Deadline: November 28 2006

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, January 28 \| 3:00PM - 7:30PM Registration Room: Longs Foyer
Sunday, January 28 \| 6:30PM - 7:30PM Refreshments Room: Longs Peak Foyer
Sunday, January 28 \| 7:30PM - 7:45PM Welcoming Remarks Speaker 1 of 3 David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA
Sunday, January 28 \| 7:30PM - 7:45PM Welcoming Remarks Speaker 2 of 3 John M. Maraganore, Alnylam Pharmaceuticals Inc., USA
Sunday, January 28 \| 7:30PM - 7:45PM Welcoming Remarks Speaker 3 of 3 Stephen H. Friend, Sage Bionetworks, USA
Sunday, January 28 \| 7:30PM - 10:00PM Opening Session (Joint) Room: Grays Peak/Longs Peak Speaker 1 of 3 Victor R. Ambros, University of Massachusetts, USA Functions of microRNAs in Animal Development
Sunday, January 28 \| 7:30PM - 10:00PM Opening Session (Joint) Room: Grays Peak/Longs Peak Speaker 2 of 3 Phillip A. Sharp, Massachusetts Institute of Technology, USA RNA Biology
Sunday, January 28 \| 7:30PM - 10:00PM Opening Session (Joint) Room: Grays Peak/Longs Peak Speaker 3 of 3 Gregory J. Hannon, University of Cambridge, UK Unexpected Complexity in Plant and Animal Small RNAs
Monday, January 29 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Monday, January 29 \| 8:00AM - 11:00AM siRNAs and Chromatin Silencing Room: Longs Peak Speaker 1 of 6 * James C. Carrington, Donald Danforth Plant Science Center, USA
Monday, January 29 \| 8:00AM - 11:00AM siRNAs and Chromatin Silencing Room: Longs Peak Speaker 2 of 6 Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan RNA-Directed DNA Methylation: A Versatile Pathway for Transcriptional Gene Silencing
Monday, January 29 \| 8:00AM - 11:00AM siRNAs and Chromatin Silencing Room: Longs Peak Speaker 3 of 6 Shiv I. S. Grewal, NCI, National Institutes of Health, USA RNAi and Heterochromatin Assembly in S. pombe
Monday, January 29 \| 8:00AM - 11:00AM siRNAs and Chromatin Silencing Room: Longs Peak Speaker 4 of 6 Steven E. Jacobsen, University of California, Los Angeles, USA RNAi-mediated Chromatin Silencing in Arabidopsis
Monday, January 29 \| 8:00AM - 11:00AM siRNAs and Chromatin Silencing Room: Longs Peak Speaker 5 of 6 Martin A. Gorovsky, University of Rochester, USA RNAi and Genome Rearrangements in Tetrahymena thermophila
Monday, January 29 \| 8:00AM - 11:00AM siRNAs and Chromatin Silencing Room: Longs Peak Speaker 6 of 6 Elissa P. Lei, NIDDK, National Institutes of Health, USA Short Talk: Identification of Small RNAs Associated with the Gypsy Chromatin Insulator
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 1 of 7 * Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 2 of 7 Peter S. Linsley, AVI BioPharma, USA Insights into the Design of siRNAs for Increased Specificity and Potency
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 3 of 7 Thijn Brummelkamp, Netherlands Cancer Institute, Netherlands Identification of Cancer Relevant Genes using RNAi Library Screens
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 4 of 7 William S. Marshall, miRagen Therapeutics, USA The Use of Synthetic siRNA Libraries for Target Validation
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 5 of 7 Vivek Mittal, Weill Cornell Medical College, USA Blocking Angiogenesis-Mediated Tumor Growth and Metastasis by RNAi in Mice
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 6 of 7 Peng Jin, Emory University School of Medicine, USA Short Talk: A Small Molecule Enhances RNA Interference and Promotes the Processing of microRNAs
Monday, January 29 \| 8:00AM - 11:30AM RNAi for Target Validation: Technologies and Applications I This session is from RNAi for Target Validation Room: Grays Peak Speaker 7 of 7 Christophe J. Echeverri, Cenix BioScience GmbH, Germany Short Talk: RNAi-based discovery and validation of novel anti-malarial lead compounds
Monday, January 29 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Monday, January 29 \| 11:30AM - 1:00PM Poster Setup Room: Shavano/Torreys
Monday, January 29 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Monday, January 29 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Monday, January 29 \| 5:00PM - 7:00PM Endogenous siRNAs and Silencing II Room: Longs Peak Speaker 1 of 5 * Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan
Monday, January 29 \| 5:00PM - 7:00PM Endogenous siRNAs and Silencing II Room: Longs Peak Speaker 2 of 5 Andrew Fire, Stanford University, USA Roles of RdRPs in Amplifying the RNAi Response and Distinct Modes of Primary and Secondary siRNA Biogenesis in C. elegans
Monday, January 29 \| 5:00PM - 7:00PM Endogenous siRNAs and Silencing II Room: Longs Peak Speaker 3 of 5 Sarah C.R. Elgin, Washington University, USA Heterochromatin Formation and Gene Silencing in Drosophila Melanogaster
Monday, January 29 \| 5:00PM - 7:00PM Endogenous siRNAs and Silencing II Room: Longs Peak Speaker 4 of 5 Ramin Shiekhattar, University of Miami, USA Biochemistry of RNAi Effector Complexes
Monday, January 29 \| 5:00PM - 7:00PM Endogenous siRNAs and Silencing II Room: Longs Peak Speaker 5 of 5 Christophe Antoniewski, Institut Pasteur, France Short Talk: Using Viral Suppressors of RNA Silencing to Explore the Diversity and Functions of Small RNAs in Drosophila
Monday, January 29 \| 5:00PM - 7:00PM RNAi for Target Validation: Technologies and Applications II This session is from RNAi for Target Validation Room: Grays Peak Speaker 1 of 5 * Peter S. Linsley, AVI BioPharma, USA
Monday, January 29 \| 5:00PM - 7:00PM RNAi for Target Validation: Technologies and Applications II This session is from RNAi for Target Validation Room: Grays Peak Speaker 2 of 5 Stephen W. Fesik, Vanderbilt University School of Medicine, USA Cancer Target Identification and Validation with RNAi
Monday, January 29 \| 5:00PM - 7:00PM RNAi for Target Validation: Technologies and Applications II This session is from RNAi for Target Validation Room: Grays Peak Speaker 3 of 5 Jonathan Hall, Eth Zurich, Switzerland RNAi in Target Discovery and Validation
Monday, January 29 \| 5:00PM - 7:00PM RNAi for Target Validation: Technologies and Applications II This session is from RNAi for Target Validation Room: Grays Peak Speaker 4 of 5 Klaus Giese, Silence Therapeutics plc, Germany AtuPLEX a Novel RNAi-Based Delivery System for Cancer Therapies
Monday, January 29 \| 5:00PM - 7:00PM RNAi for Target Validation: Technologies and Applications II This session is from RNAi for Target Validation Room: Grays Peak Speaker 5 of 5 Jost Seibler, TaconicArtemis, Germany Short Talk: Reversible Gene Knockdown in Mice using a Tight, Inducible shRNA Expression System
Monday, January 29 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys
Monday, January 29 \| 7:30PM - 10:00PM Poster Session 1 Room: Shavano/Torreys
Tuesday, January 30 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 1 of 7 * Thomas Tuschl, HHMI/Rockefeller University, USA
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 2 of 7 V. Narry Kim, Institute for Basic Science, South Korea Primary microRNA Processing: When Does It Take Place and How Are the Processing Factors Regulated?
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 3 of 7 James C. Carrington, Donald Danforth Plant Science Center, USA Small RNA-Directed Pathways in Plants
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 4 of 7 Richard W. Carthew, Northwestern University, USA MicroRNAs in Drosophila
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 5 of 7 Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland Forward Genetic Approach of miRNA Biogenesis and Function in Arabidopsis
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 6 of 7 Mikiko C. Siomi, University of Tokyo, Japan Piwi Subfamily Proteins and their Associated Small RNAs in Drosophila Germlines
Tuesday, January 30 \| 8:00AM - 11:30AM MicroRNA Biogenesis and Function Room: Longs Peak Speaker 7 of 7 Eric C. Lai, Sloan Kettering Institute, USA Short Talk: Drosophila miR-315 Regulates Wingless Signaling by Inhibiting Axin and Notum
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 1 of 8 * John J. Rossi, Beckman Research Institute of the City of Hope, USA
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 2 of 8 Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania, USA The use of Expression-based RNAi to Treat Neurological Disease
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 3 of 8 Neil Aronin, University of Massachusetts Medical School, USA Advances in the use of Synthetic siRNAs in the Treatment of Huntington's Disease Models
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 4 of 8 Ralph A. Tripp, University of Georgia, USA RNAi as a Therapeutic Strategy for the Treatment of Viral Respiratory Disease
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 5 of 8 Josephine Lai, University of Arizona, USA Treating Neuropathic Pain with RNA Interference
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 6 of 8 Joerg F. Rippmann, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany Short Talk: LXR Alpha Knock Down in an Obese Mouse Model Results in Improved Lipid Parameters but Organ Toxicity
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 7 of 8 Xavier J. de Mollerat du Jeu, Life Techonologies, USA Short Talk: Targeting APP with Chemically Modified siRNA (stealthRNAi™) Ameliorates Alzheimer’s Disease Neuropathology in a Transgenic Mouse Model
Tuesday, January 30 \| 8:00AM - 11:30AM Therapeutic RNAi: Direct Delivery This session is from RNAi for Target Validation Room: Grays Peak Speaker 8 of 8 Daniel G. Anderson, Massachusetts Institute of Technology, USA Short Talk: Combinatorial Libraries of Lipidoids for Systemic siRNA Delivery
Tuesday, January 30 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Tuesday, January 30 \| 11:30AM - 1:00PM Poster Setup Room: Shavano/Torreys
Tuesday, January 30 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Tuesday, January 30 \| 2:30PM - 4:30PM Workshop 1: miRNA and piRNA Function Room: Longs Peak Speaker 1 of 6 * Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Tuesday, January 30 \| 2:30PM - 4:30PM Workshop 1: miRNA and piRNA Function Room: Longs Peak Speaker 2 of 6 Antonio J. Giraldez, Yale University School of Medicine, USA Sex, Fish and MicroRNAs: the Regulation of the Germ Line
Tuesday, January 30 \| 2:30PM - 4:30PM Workshop 1: miRNA and piRNA Function Room: Longs Peak Speaker 3 of 6 Chang-Zheng Chen, Stanford University, USA MiR-181a As a T Cell Sensitivity Rheostat
Tuesday, January 30 \| 2:30PM - 4:30PM Workshop 1: miRNA and piRNA Function Room: Longs Peak Speaker 4 of 6 Trinna Lee Cuellar, Genentech, USA Development of a Mouse Model to Study Dicer Function in the Brain
Tuesday, January 30 \| 2:30PM - 4:30PM Workshop 1: miRNA and piRNA Function Room: Longs Peak Speaker 5 of 6 Anindya Dutta, University of Virginia, USA Muscle-Differentiation-Induced MicroRNA miR-206 Promotes Muscle Differentiation and Cell Quiescence by Post-Transcriptional Degradation of Target by mRNAs.
Tuesday, January 30 \| 2:30PM - 4:30PM Workshop 1: miRNA and piRNA Function Room: Longs Peak Speaker 6 of 6 Sergey G. Shpiz, Institute of Molecular Genetics, Russia RNAi in the Functioning of Drosophila Telomeres
Tuesday, January 30 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Tuesday, January 30 \| 5:00PM - 7:00PM Posttranscriptional Silencing Mechanism I Room: Longs Peak Speaker 1 of 5 * Phillip D. Zamore, University of Massachusetts Medical School, USA
Tuesday, January 30 \| 5:00PM - 7:00PM Posttranscriptional Silencing Mechanism I Room: Longs Peak Speaker 2 of 5 Craig C. Mello, University of Massachusetts Medical School, USA RNAi and Related Pathways in C. elegans
Tuesday, January 30 \| 5:00PM - 7:00PM Posttranscriptional Silencing Mechanism I Room: Longs Peak Speaker 3 of 5 David C. Baulcombe, University of Cambridge, UK ARGONOMICS: The Roles of Argonaute Proteins in RNA Silencing
Tuesday, January 30 \| 5:00PM - 7:00PM Posttranscriptional Silencing Mechanism I Room: Longs Peak Speaker 4 of 5 Xuemei Chen, University of California, Riverside, USA Role of Methlation in microRNA Metabolism in Plants
Tuesday, January 30 \| 5:00PM - 7:00PM Posttranscriptional Silencing Mechanism I Room: Longs Peak Speaker 5 of 5 Raul Andino, University of California, San Francisco, USA Short Talk: Characterization of the Drosophila RNAi-based Antiviral Defense Mechanism
Tuesday, January 30 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery I This session is from RNAi for Target Validation Room: Grays Peak Speaker 1 of 5 * Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania, USA
Tuesday, January 30 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery I This session is from RNAi for Target Validation Room: Grays Peak Speaker 2 of 5 Mark A. Kay, Stanford University, USA Making Viruses to Attack Other Viruses
Tuesday, January 30 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery I This session is from RNAi for Target Validation Room: Grays Peak Speaker 3 of 5 John J. Rossi, Beckman Research Institute of the City of Hope, USA RNAi Based Gene Therapy and the Treatment of HIV Infection
Tuesday, January 30 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery I This session is from RNAi for Target Validation Room: Grays Peak Speaker 4 of 5 Tracy Zimmermann, Alnylam Pharmaceuticals Inc., USA Achieving Therapeutic Gene Silencing in vivo with RNAi
Tuesday, January 30 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery I This session is from RNAi for Target Validation Room: Grays Peak Speaker 5 of 5 Matthew C. Catley, AstraZeneca, Sweden Short Talk: Developing siRNA for Target Validation in the Rat lung: A Rational Approach
Tuesday, January 30 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys
Tuesday, January 30 \| 7:30PM - 10:00PM Poster Session 2 Room: Shavano/Torreys
Wednesday, January 31 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Wednesday, January 31 \| 8:00AM - 11:30AM Posttrancriptional Silencing Mechanism II (Joint) Room: Grays Peak/Longs Peak Speaker 1 of 6 * V. Narry Kim, Institute for Basic Science, South Korea
Wednesday, January 31 \| 8:00AM - 11:30AM Posttrancriptional Silencing Mechanism II (Joint) Room: Grays Peak/Longs Peak Speaker 2 of 6 Phillip D. Zamore, University of Massachusetts Medical School, USA RNAi and other Ancient Pathways Programmed by Small RNA
Wednesday, January 31 \| 8:00AM - 11:30AM Posttrancriptional Silencing Mechanism II (Joint) Room: Grays Peak/Longs Peak Speaker 3 of 6 Thomas Tuschl, HHMI/Rockefeller University, USA Mechanisms of Small RNA Mediated Mammalian Gene Silencing
Wednesday, January 31 \| 8:00AM - 11:30AM Posttrancriptional Silencing Mechanism II (Joint) Room: Grays Peak/Longs Peak Speaker 4 of 6 Erik Sontheimer, University of Massachusetts Medical School, USA Biochemical Analysis of RNAi
Wednesday, January 31 \| 8:00AM - 11:30AM Posttrancriptional Silencing Mechanism II (Joint) Room: Grays Peak/Longs Peak Speaker 5 of 6 Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland Role of Dicer in RNAi/miRNA Pathways and Regulation of miRNA Repression in Mammalian Cells
Wednesday, January 31 \| 8:00AM - 11:30AM Posttrancriptional Silencing Mechanism II (Joint) Room: Grays Peak/Longs Peak Speaker 6 of 6 David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA MicroRNA Target Recognition
Wednesday, January 31 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Wednesday, January 31 \| 11:30AM - 1:00PM Poster Setup Room: Shavano/Torreys
Wednesday, January 31 \| 1:00PM - 10:00PM Poster Viewing Room: Shavano/Torreys
Wednesday, January 31 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Wednesday, January 31 \| 5:00PM - 7:00PM Structural Biology of RNAi Machinery Room: Longs Peak Speaker 1 of 6 * Xuemei Chen, University of California, Riverside, USA
Wednesday, January 31 \| 5:00PM - 7:00PM Structural Biology of RNAi Machinery Room: Longs Peak Speaker 2 of 6 Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA Structural Biology of RNA Silencing
Wednesday, January 31 \| 5:00PM - 7:00PM Structural Biology of RNAi Machinery Room: Longs Peak Speaker 3 of 6 Marianthi Kiriakidou, University of Pennsylvania School of Medicine, USA Short Talk: An mRNA m7G cap Binding Motif within Human Argonaute2 Represses Translation
Wednesday, January 31 \| 5:00PM - 7:00PM Structural Biology of RNAi Machinery Room: Longs Peak Speaker 4 of 6 † Javier A. Martinez, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria Short Talk: hClp1 is a Novel Human RNA-Kinase that Phosphorylates siRNAs and 3' exons during tRNA Splicing
Wednesday, January 31 \| 5:00PM - 7:00PM Structural Biology of RNAi Machinery Room: Longs Peak Speaker 5 of 6 Renée Schroeder, Max F. Perutz Laboratories, University of Vienna, Austria Short Talk: Mechanism of Risc-Mediated RNA Recognition and Cleavage is Revealed by Target RNA Requirements
Wednesday, January 31 \| 5:00PM - 7:00PM Structural Biology of RNAi Machinery Room: Longs Peak Speaker 6 of 6 Chris B. Burge, Massachusetts Institute of Technology, USA Short Talk: Determinants of Targeting by Endogenous and Exogenous MicroRNAs
Wednesday, January 31 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery II This session is from RNAi for Target Validation Room: Grays Peak Speaker 1 of 5 * Judy Lieberman, Harvard University, USA
Wednesday, January 31 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery II This session is from RNAi for Target Validation Room: Grays Peak Speaker 2 of 5 Akshay Vaishnaw, Alnylam Pharmaceuticals Inc., USA Clinical Opportunities for RNAi Therapeutics
Wednesday, January 31 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery II This session is from RNAi for Target Validation Room: Grays Peak Speaker 3 of 5 Barry A. Polisky, Sirna Therapeutics, Inc., USA Advancing RNAi Drugs in the Clinic
Wednesday, January 31 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery II This session is from RNAi for Target Validation Room: Grays Peak Speaker 4 of 5 C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA Oligonucleotide-Based Therapeutics: Oligonucleotides as Drugs
Wednesday, January 31 \| 5:00PM - 7:00PM Therapeutic RNAi: Systemic Delivery II This session is from RNAi for Target Validation Room: Grays Peak Speaker 5 of 5 Isidore Rigoutsos, International Business Machines Corporation, USA Short Talk: Revisiting the Topics of MicroRNA Target Detection and MicroRNA Precursor Discovery
Wednesday, January 31 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys
Wednesday, January 31 \| 7:30PM - 10:00PM Poster Session 3 Room: Shavano/Torreys
Thursday, February 01 \| 7:00AM - 8:00AM Breakfast Room: Shavano/Torreys
Thursday, February 01 \| 8:00AM - 11:00AM MicroRNAs in Development and Disease (Joint) Room: Grays Peak/Longs Peak Speaker 1 of 6 * Phillip A. Sharp, Massachusetts Institute of Technology, USA
Thursday, February 01 \| 8:00AM - 11:00AM MicroRNAs in Development and Disease (Joint) Room: Grays Peak/Longs Peak Speaker 2 of 6 Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany Short Talk: Mechanisms of miRNA-Mediated Gene Silencing
Thursday, February 01 \| 8:00AM - 11:00AM MicroRNAs in Development and Disease (Joint) Room: Grays Peak/Longs Peak Speaker 3 of 6 Carlo M. Croce, Ohio State University, USA MicroRNAs in Cancer
Thursday, February 01 \| 8:00AM - 11:00AM MicroRNAs in Development and Disease (Joint) Room: Grays Peak/Longs Peak Speaker 4 of 6 Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands MicroRNAs in Animal Development
Thursday, February 01 \| 8:00AM - 11:00AM MicroRNAs in Development and Disease (Joint) Room: Grays Peak/Longs Peak Speaker 5 of 6 Jan Krützfeldt, ETH-Zurich, Switzerland Therapeutic Strategies using the microRNA Pathway
Thursday, February 01 \| 8:00AM - 11:00AM MicroRNAs in Development and Disease (Joint) Room: Grays Peak/Longs Peak Speaker 6 of 6 Anna M. Krichevsky, Brigham and Women's Hospital, Harvard Medical School, USA MicroRNA in Brain and Brain Tumors
Thursday, February 01 \| 9:20AM - 9:40AM Coffee Break Room: Longs Peak Foyer
Thursday, February 01 \| 4:30PM - 5:00PM Coffee Available Room: Longs Peak Foyer
Thursday, February 01 \| 5:00PM - 7:00PM Silencing RNAs in Genetic Pathways Room: Longs Peak Speaker 1 of 4 * Craig C. Mello, University of Massachusetts Medical School, USA
Thursday, February 01 \| 5:00PM - 7:00PM Silencing RNAs in Genetic Pathways Room: Longs Peak Speaker 2 of 4 Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany Natural Selection on microRNA Targets, and Some Other Stories
Thursday, February 01 \| 5:00PM - 7:00PM Silencing RNAs in Genetic Pathways Room: Longs Peak Speaker 3 of 4 Jian-Kang Zhu, Purdue University and Shanghai Center for Plant Stress Biology, CAS, USA Stress Regulated Small RNAs and DNA Demethylation in Plants
Thursday, February 01 \| 5:00PM - 7:00PM Silencing RNAs in Genetic Pathways Room: Longs Peak Speaker 4 of 4 Kathryn N. Ivey, Tenaya Therapeutics, USA Short Talk: MicroRNAs Regulate Cardiomyocyte Differentiation from Embryonic Stem Cells
Thursday, February 01 \| 5:00PM - 7:00PM Therapeutic RNAi: Delivery Technologies This session is from RNAi for Target Validation Room: Grays Peak Speaker 1 of 5 * C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Thursday, February 01 \| 5:00PM - 7:00PM Therapeutic RNAi: Delivery Technologies This session is from RNAi for Target Validation Room: Grays Peak Speaker 2 of 5 Judy Lieberman, Harvard University, USA Delivering RNA Interference: Appliations to Viral Infection and Cancer
Thursday, February 01 \| 5:00PM - 7:00PM Therapeutic RNAi: Delivery Technologies This session is from RNAi for Target Validation Room: Grays Peak Speaker 3 of 5 Dan McCallus, Nucleonics, USA Gene-Expressed RNAi for Hepatitis B Virus
Thursday, February 01 \| 5:00PM - 7:00PM Therapeutic RNAi: Delivery Technologies This session is from RNAi for Target Validation Room: Grays Peak Speaker 4 of 5 Patrick Lu, Intradigm Corporation, USA Nanoparticle Delivery of siRNA for Targeted Therapeutics
Thursday, February 01 \| 5:00PM - 7:00PM Therapeutic RNAi: Delivery Technologies This session is from RNAi for Target Validation Room: Grays Peak Speaker 5 of 5 Stephen Isaac Rudnick, Fox Chase Cancer Center, USA Short Talk: Effects of Secondary Structure on Short Interfering RNA and Antisense Oligonucleotide Mediated mRNA Cleavage
Thursday, February 01 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Shavano/Torreys
Thursday, February 01 \| 8:00PM - 11:00PM Entertainment Room: Shavano/Torreys
Thursday, February 01 \| 8:00PM - 11:00PM Cash Bar Room: Shavano/Torreys
Friday, February 02 \| 10:21AM - 10:21AM Departure *Session Chair †Invited, not yet responded.