Web Desc
RNAi for Target Validation and as a Therapeutic
joint with MicroRNAs and siRNAs: Biological Functions and Mechanisms
Organizer(s): John M. Maraganore and Stephen H. Friend
Date: January 28 - February 02, 2007
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Alnylam Pharmaceuticals, Inc.
For important information on the coronavirus, please click here
Summary of Meeting:
RNA Interference (RNAi) remains a promising new approach for gene silencing both in the context of post-genomic research on target validation and for potential therapeutic applications. As a tool for target validation, synthetic and DNA-based RNAi strategies have been applied in both academia and industry, with significant recent advances in understanding selection of siRNA sequences, optimization for potency and specificity, mechanisms for activation of innate immunity, and vector-based methods for whole-genome siRNA libraries. Several applications of these technologies will be presented. As a therapeutic strategy, synthetic and DNA-based RNAi strategies have advanced to pre-clinical animal models and early clinical testing. These approaches have explored multiple strategies to address the delivery hurdle, and include both local and systemic administration opportunities. The goals of the meeting are to discuss the latest advances in RNAi technology as both a research tool and therapeutic strategy.
Scholarship Deadline: September 28 2006
Discounted Abstract Deadline: September 28 2006
Abstract Deadline: October 27 2006
Discounted Registration Deadline: November 28 2006
We gratefully acknowledge additional support for this conference from:
Alnylam Pharmaceuticals, Inc.EMD MilliporeIntegrated DNA TechnologiesIsis Pharmaceuticals, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Abbott Laboratories

Isis Pharmaceuticals, Inc.

Thermo Fisher Scientific, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 28 | 3:00PM - 7:30PM
Registration
Room: Longs Foyer


Sunday, January 28 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, January 28 | 7:30PM - 7:45PM
Welcoming Remarks

Speaker 1 of 3
David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA

Sunday, January 28 | 7:30PM - 7:45PM
Welcoming Remarks

Speaker 2 of 3
John M. Maraganore, Alnylam Pharmaceuticals Inc., USA

Sunday, January 28 | 7:30PM - 7:45PM
Welcoming Remarks

Speaker 3 of 3
Stephen H. Friend, Sage Bionetworks, USA

Sunday, January 28 | 7:30PM - 10:00PM
Opening Session (Joint)
Room: Grays Peak/Longs Peak

Speaker 1 of 3
Victor R. Ambros, University of Massachusetts, USA
Functions of microRNAs in Animal Development

Sunday, January 28 | 7:30PM - 10:00PM
Opening Session (Joint)
Room: Grays Peak/Longs Peak

Speaker 2 of 3
Phillip A. Sharp, Massachusetts Institute of Technology, USA
RNA Biology

Sunday, January 28 | 7:30PM - 10:00PM
Opening Session (Joint)
Room: Grays Peak/Longs Peak

Speaker 3 of 3
Gregory J. Hannon, University of Cambridge, UK
Unexpected Complexity in Plant and Animal Small RNAs

Monday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 1 of 7
* Stephen W. Fesik, Vanderbilt University School of Medicine, USA

Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 2 of 7
Peter S. Linsley, AVI BioPharma, USA
Insights into the Design of siRNAs for Increased Specificity and Potency

Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 3 of 7
Thijn Brummelkamp, Netherlands Cancer Institute, Netherlands
Identification of Cancer Relevant Genes using RNAi Library Screens

Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 4 of 7
William S. Marshall, miRagen Therapeutics, USA
The Use of Synthetic siRNA Libraries for Target Validation

Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 5 of 7
Vivek Mittal, Weill Cornell Medical College, USA
Blocking Angiogenesis-Mediated Tumor Growth and Metastasis by RNAi in Mice

Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 6 of 7
Peng Jin, Emory University School of Medicine, USA
Short Talk: A Small Molecule Enhances RNA Interference and Promotes the Processing of microRNAs

Monday, January 29 | 8:00AM - 11:30AM
RNAi for Target Validation: Technologies and Applications I
Room: Grays Peak

Speaker 7 of 7
Christophe J. Echeverri, Cenix BioScience GmbH, Germany
Short Talk: RNAi-based discovery and validation of novel anti-malarial lead compounds

Monday, January 29 | 8:00AM - 11:00AM
siRNAs and Chromatin Silencing
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 6
* James C. Carrington, Donald Danforth Plant Science Center, USA


Monday, January 29 | 8:00AM - 11:00AM
siRNAs and Chromatin Silencing
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 6
Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan
RNA-Directed DNA Methylation: A Versatile Pathway for Transcriptional Gene Silencing


Monday, January 29 | 8:00AM - 11:00AM
siRNAs and Chromatin Silencing
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 6
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi and Heterochromatin Assembly in S. pombe


Monday, January 29 | 8:00AM - 11:00AM
siRNAs and Chromatin Silencing
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 6
Steven E. Jacobsen, University of California, Los Angeles, USA
RNAi-mediated Chromatin Silencing in Arabidopsis


Monday, January 29 | 8:00AM - 11:00AM
siRNAs and Chromatin Silencing
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 5 of 6
Martin A. Gorovsky, University of Rochester, USA
RNAi and Genome Rearrangements in Tetrahymena thermophila


Monday, January 29 | 8:00AM - 11:00AM
siRNAs and Chromatin Silencing
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 6 of 6
Elissa P. Lei, NIDDK, National Institutes of Health, USA
Short Talk: Identification of Small RNAs Associated with the Gypsy Chromatin Insulator


Monday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 29 | 11:45AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, January 29 | 5:00PM - 7:00PM
RNAi for Target Validation: Technologies and Applications II
Room: Grays Peak

Speaker 1 of 5
* Peter S. Linsley, AVI BioPharma, USA

Monday, January 29 | 5:00PM - 7:00PM
RNAi for Target Validation: Technologies and Applications II
Room: Grays Peak

Speaker 2 of 5
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Cancer Target Identification and Validation with RNAi

Monday, January 29 | 5:00PM - 7:00PM
RNAi for Target Validation: Technologies and Applications II
Room: Grays Peak

Speaker 3 of 5
Jonathan Hall, Eth Zurich, Switzerland
RNAi in Target Discovery and Validation

Monday, January 29 | 5:00PM - 7:00PM
RNAi for Target Validation: Technologies and Applications II
Room: Grays Peak

Speaker 4 of 5
Klaus Giese, Silence Therapeutics plc, Germany
AtuPLEX a Novel RNAi-Based Delivery System for Cancer Therapies

Monday, January 29 | 5:00PM - 7:00PM
RNAi for Target Validation: Technologies and Applications II
Room: Grays Peak

Speaker 5 of 5
Jost Seibler, TaconicArtemis, Germany
Short Talk: Reversible Gene Knockdown in Mice using a Tight, Inducible shRNA Expression System

Monday, January 29 | 5:00PM - 7:00PM
Endogenous siRNAs and Silencing II
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 5
* Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan


Monday, January 29 | 5:00PM - 7:00PM
Endogenous siRNAs and Silencing II
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 5
Andrew Fire, Stanford University, USA
Roles of RdRPs in Amplifying the RNAi Response and Distinct Modes of Primary and Secondary siRNA Biogenesis in C. elegans


Monday, January 29 | 5:00PM - 7:00PM
Endogenous siRNAs and Silencing II
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 5
Sarah C.R. Elgin, Washington University, USA
Heterochromatin Formation and Gene Silencing in Drosophila Melanogaster


Monday, January 29 | 5:00PM - 7:00PM
Endogenous siRNAs and Silencing II
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 5
Ramin Shiekhattar, University of Miami, USA
Biochemistry of RNAi Effector Complexes


Monday, January 29 | 5:00PM - 7:00PM
Endogenous siRNAs and Silencing II
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 5 of 5
Christophe Antoniewski, Institut Pasteur, France
Short Talk: Using Viral Suppressors of RNA Silencing to Explore the Diversity and Functions of Small RNAs in Drosophila


Monday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Monday, January 29 | 7:30PM - 10:00PM
Poster Session 1: RNAi Therapeutic Discovery and Development
Room: Shavano/Torreys


Tuesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 1 of 8
* John J. Rossi, Beckman Research Institute of the City of Hope, USA

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 2 of 8
Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania, USA
The use of Expression-based RNAi to Treat Neurological Disease

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 3 of 8
Neil Aronin, University of Massachusetts Medical School, USA
Advances in the use of Synthetic siRNAs in the Treatment of Huntington's Disease Models

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 4 of 8
Ralph A. Tripp, University of Georgia, USA
RNAi as a Therapeutic Strategy for the Treatment of Viral Respiratory Disease

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 5 of 8
Josephine Lai, University of Arizona, USA
Treating Neuropathic Pain with RNA Interference

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 6 of 8
Joerg F. Rippmann, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany
Short Talk: LXR Alpha Knock Down in an Obese Mouse Model Results in Improved Lipid Parameters but Organ Toxicity

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 7 of 8
Xavier J. de Mollerat du Jeu, Life Techonologies, USA
Short Talk: Targeting APP with Chemically Modified siRNA (stealthRNAi™) Ameliorates Alzheimer’s Disease Neuropathology in a Transgenic Mouse Model

Tuesday, January 30 | 8:00AM - 11:30AM
Therapeutic RNAi: Direct Delivery
Room: Grays Peak

Speaker 8 of 8
Daniel G. Anderson, Massachusetts Institute of Technology, USA
Short Talk: Combinatorial Libraries of Lipidoids for Systemic siRNA Delivery

Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 7
* Thomas Tuschl, HHMI/Rockefeller University, USA


Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 7
V. Narry Kim, Institute for Basic Science, South Korea
Primary microRNA Processing: When Does It Take Place and How Are the Processing Factors Regulated?


Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 7
James C. Carrington, Donald Danforth Plant Science Center, USA
Small RNA-Directed Pathways in Plants


Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 7
Richard W. Carthew, Northwestern University, USA
MicroRNAs in Drosophila


Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 5 of 7
Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
Forward Genetic Approach of miRNA Biogenesis and Function in Arabidopsis


Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 6 of 7
Mikiko C. Siomi, University of Tokyo, Japan
Piwi Subfamily Proteins and their Associated Small RNAs in Drosophila Germlines


Tuesday, January 30 | 8:00AM - 11:30AM
MicroRNA Biogenesis and Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 7 of 7
Eric C. Lai, Sloan Kettering Institute, USA
Short Talk: Drosophila miR-315 Regulates Wingless Signaling by Inhibiting Axin and Notum


Tuesday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, January 30 | 11:30AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Tuesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Tuesday, January 30 | 2:30PM - 4:30PM
Workshop 1: miRNA and piRNA Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 6
* Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany


Tuesday, January 30 | 2:30PM - 4:30PM
Workshop 1: miRNA and piRNA Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 6
Antonio J. Giraldez, Yale University School of Medicine, USA
Sex, Fish and MicroRNAs: the Regulation of the Germ Line


Tuesday, January 30 | 2:30PM - 4:30PM
Workshop 1: miRNA and piRNA Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 6
Chang-Zheng Chen, Stanford University, USA
MiR-181a As a T Cell Sensitivity Rheostat


Tuesday, January 30 | 2:30PM - 4:30PM
Workshop 1: miRNA and piRNA Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 6
Trinna Lee Cuellar, Genentech, USA
Development of a Mouse Model to Study Dicer Function in the Brain


Tuesday, January 30 | 2:30PM - 4:30PM
Workshop 1: miRNA and piRNA Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 5 of 6
Anindya Dutta, University of Virginia, USA
Muscle-Differentiation-Induced MicroRNA miR-206 Promotes Muscle Differentiation and Cell Quiescence by Post-Transcriptional Degradation of Target by mRNAs.


Tuesday, January 30 | 2:30PM - 4:30PM
Workshop 1: miRNA and piRNA Function
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 6 of 6
Sergey G. Shpiz, Institute of Molecular Genetics, Russia
RNAi in the Functioning of Drosophila Telomeres


Tuesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, January 30 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery I
Room: Grays Peak

Speaker 1 of 5
* Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania, USA

Tuesday, January 30 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery I
Room: Grays Peak

Speaker 2 of 5
Mark A. Kay, Stanford University, USA
Making Viruses to Attack Other Viruses

Tuesday, January 30 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery I
Room: Grays Peak

Speaker 3 of 5
John J. Rossi, Beckman Research Institute of the City of Hope, USA
RNAi Based Gene Therapy and the Treatment of HIV Infection

Tuesday, January 30 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery I
Room: Grays Peak

Speaker 4 of 5
Tracy Zimmermann, Alnylam Pharmaceuticals Inc., USA
Achieving Therapeutic Gene Silencing in vivo with RNAi

Tuesday, January 30 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery I
Room: Grays Peak

Speaker 5 of 5
Matthew C. Catley, AstraZeneca, Sweden
Short Talk: Developing siRNA for Target Validation in the Rat lung: A Rational Approach

Tuesday, January 30 | 5:00PM - 7:00PM
Posttranscriptional Silencing Mechanism I
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 5
* Phillip D. Zamore, University of Massachusetts Medical School, USA


Tuesday, January 30 | 5:00PM - 7:00PM
Posttranscriptional Silencing Mechanism I
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 5
Craig C. Mello, University of Massachusetts Medical School, USA
RNAi and Related Pathways in C. elegans


Tuesday, January 30 | 5:00PM - 7:00PM
Posttranscriptional Silencing Mechanism I
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 5
David C. Baulcombe, University of Cambridge, UK
ARGONOMICS: The Roles of Argonaute Proteins in RNA Silencing


Tuesday, January 30 | 5:00PM - 7:00PM
Posttranscriptional Silencing Mechanism I
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 5
Xuemei Chen, University of California, Riverside, USA
Role of Methlation in microRNA Metabolism in Plants


Tuesday, January 30 | 5:00PM - 7:00PM
Posttranscriptional Silencing Mechanism I
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 5 of 5
Raul Andino, University of California, San Francisco, USA
Short Talk: Characterization of the Drosophila RNAi-based Antiviral Defense Mechanism


Tuesday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Tuesday, January 30 | 7:30PM - 10:00PM
Poster Session 2: RNAi Toolkit: Sreening, Viral Vectors, and
Delivery Technologies
Room: Shavano/Torreys


Wednesday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Wednesday, January 31 | 8:00AM - 11:30AM
Posttrancriptional Silencing Mechanism II (Joint)
Room: Grays Peak/Longs Peak

Speaker 1 of 6
* V. Narry Kim, Institute for Basic Science, South Korea

Wednesday, January 31 | 8:00AM - 11:30AM
Posttrancriptional Silencing Mechanism II (Joint)
Room: Grays Peak/Longs Peak

Speaker 2 of 6
Phillip D. Zamore, University of Massachusetts Medical School, USA
RNAi and other Ancient Pathways
Programmed by Small RNA


Wednesday, January 31 | 8:00AM - 11:30AM
Posttrancriptional Silencing Mechanism II (Joint)
Room: Grays Peak/Longs Peak

Speaker 3 of 6
Thomas Tuschl, HHMI/Rockefeller University, USA
Mechanisms of Small RNA Mediated Mammalian Gene Silencing

Wednesday, January 31 | 8:00AM - 11:30AM
Posttrancriptional Silencing Mechanism II (Joint)
Room: Grays Peak/Longs Peak

Speaker 4 of 6
Erik Sontheimer, University of Massachusetts Medical School, USA
Biochemical Analysis of RNAi

Wednesday, January 31 | 8:00AM - 11:30AM
Posttrancriptional Silencing Mechanism II (Joint)
Room: Grays Peak/Longs Peak

Speaker 5 of 6
Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Role of Dicer in RNAi/miRNA Pathways and Regulation of miRNA Repression in Mammalian Cells

Wednesday, January 31 | 8:00AM - 11:30AM
Posttrancriptional Silencing Mechanism II (Joint)
Room: Grays Peak/Longs Peak

Speaker 6 of 6
David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA
MicroRNA Target Recognition

Wednesday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, January 31 | 11:30AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Wednesday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Wednesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, January 31 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery II
Room: Grays Peak

Speaker 1 of 5
* Judy Lieberman, Harvard University, USA

Wednesday, January 31 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery II
Room: Grays Peak

Speaker 2 of 5
Akshay Vaishnaw, Alnylam Pharmaceuticals Inc., USA
Clinical Opportunities for RNAi Therapeutics

Wednesday, January 31 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery II
Room: Grays Peak

Speaker 3 of 5
Barry A. Polisky, Sirna Therapeutics, Inc., USA
Advancing RNAi Drugs in the Clinic

Wednesday, January 31 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery II
Room: Grays Peak

Speaker 4 of 5
C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA
Oligonucleotide-Based Therapeutics: Oligonucleotides as Drugs

Wednesday, January 31 | 5:00PM - 7:00PM
Therapeutic RNAi: Systemic Delivery II
Room: Grays Peak

Speaker 5 of 5
Isidore Rigoutsos, International Business Machines Corporation, USA
Short Talk: Revisiting the Topics of MicroRNA Target Detection and MicroRNA Precursor Discovery

Wednesday, January 31 | 5:00PM - 7:00PM
Structural Biology of RNAi Machinery
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 6
* Xuemei Chen, University of California, Riverside, USA


Wednesday, January 31 | 5:00PM - 7:00PM
Structural Biology of RNAi Machinery
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 6
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Structural Biology of RNA Silencing


Wednesday, January 31 | 5:00PM - 7:00PM
Structural Biology of RNAi Machinery
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 6
Marianthi Kiriakidou, University of Pennsylvania School of Medicine, USA
Short Talk: An mRNA m7G cap Binding Motif within Human Argonaute2 Represses Translation


Wednesday, January 31 | 5:00PM - 7:00PM
Structural Biology of RNAi Machinery
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 6
† Javier A. Martinez, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria
Short Talk: hClp1 is a Novel Human RNA-Kinase that Phosphorylates siRNAs and 3' exons during tRNA Splicing


Wednesday, January 31 | 5:00PM - 7:00PM
Structural Biology of RNAi Machinery
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 5 of 6
Renée Schroeder, Max F. Perutz Laboratories, University of Vienna, Austria
Short Talk: Mechanism of Risc-Mediated RNA Recognition and Cleavage is Revealed by Target RNA Requirements


Wednesday, January 31 | 5:00PM - 7:00PM
Structural Biology of RNAi Machinery
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 6 of 6
Chris B. Burge, Massachusetts Institute of Technology, USA
Short Talk: Determinants of Targeting by Endogenous and Exogenous MicroRNAs


Wednesday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Wednesday, January 31 | 7:30PM - 10:00PM
Poster Session 3: RNAi Biology: Mechanism of Action, Structu
re-Activity Relationship, and Other Topics
Room: Shavano/Torreys


Thursday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Thursday, February 01 | 8:00AM - 11:00AM
MicroRNAs in Development and Disease (Joint)
Room: Grays Peak/Longs Peak

Speaker 1 of 6
* Phillip A. Sharp, Massachusetts Institute of Technology, USA

Thursday, February 01 | 8:00AM - 11:00AM
MicroRNAs in Development and Disease (Joint)
Room: Grays Peak/Longs Peak

Speaker 2 of 6
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Short Talk: Mechanisms of miRNA-Mediated Gene Silencing

Thursday, February 01 | 8:00AM - 11:00AM
MicroRNAs in Development and Disease (Joint)
Room: Grays Peak/Longs Peak

Speaker 3 of 6
Carlo M. Croce, Ohio State University, USA
MicroRNAs in Cancer

Thursday, February 01 | 8:00AM - 11:00AM
MicroRNAs in Development and Disease (Joint)
Room: Grays Peak/Longs Peak

Speaker 4 of 6
Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands
MicroRNAs in Animal Development

Thursday, February 01 | 8:00AM - 11:00AM
MicroRNAs in Development and Disease (Joint)
Room: Grays Peak/Longs Peak

Speaker 5 of 6
Jan Krützfeldt, ETH-Zurich, Switzerland
Therapeutic Strategies using the microRNA Pathway

Thursday, February 01 | 8:00AM - 11:00AM
MicroRNAs in Development and Disease (Joint)
Room: Grays Peak/Longs Peak

Speaker 6 of 6
Anna M. Krichevsky, Brigham and Women's Hospital, Harvard Medical School, USA
MicroRNA in Brain and Brain Tumors

Thursday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 01 | 5:00PM - 7:00PM
Therapeutic RNAi: Delivery Technologies
Room: Grays Peak

Speaker 1 of 5
* C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA

Thursday, February 01 | 5:00PM - 7:00PM
Therapeutic RNAi: Delivery Technologies
Room: Grays Peak

Speaker 2 of 5
Judy Lieberman, Harvard University, USA
Delivering RNA Interference: Appliations to Viral Infection and Cancer

Thursday, February 01 | 5:00PM - 7:00PM
Therapeutic RNAi: Delivery Technologies
Room: Grays Peak

Speaker 3 of 5
Dan McCallus, Nucleonics, USA
Gene-Expressed RNAi for Hepatitis B Virus

Thursday, February 01 | 5:00PM - 7:00PM
Therapeutic RNAi: Delivery Technologies
Room: Grays Peak

Speaker 4 of 5
Patrick Lu, Intradigm Corporation, USA
Nanoparticle Delivery of siRNA for Targeted Therapeutics

Thursday, February 01 | 5:00PM - 7:00PM
Therapeutic RNAi: Delivery Technologies
Room: Grays Peak

Speaker 5 of 5
Stephen Isaac Rudnick, Fox Chase Cancer Center, USA
Short Talk: Effects of Secondary Structure on Short Interfering RNA and Antisense Oligonucleotide Mediated mRNA Cleavage

Thursday, February 01 | 5:00PM - 7:00PM
Silencing RNAs in Genetic Pathways
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 1 of 4
* Craig C. Mello, University of Massachusetts Medical School, USA


Thursday, February 01 | 5:00PM - 7:00PM
Silencing RNAs in Genetic Pathways
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 2 of 4
Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
Natural Selection on microRNA Targets, and Some Other Stories


Thursday, February 01 | 5:00PM - 7:00PM
Silencing RNAs in Genetic Pathways
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 3 of 4
Jian-Kang Zhu, Purdue University and Shanghai Center for Plant Stress Biology, CAS, USA
Stress Regulated Small RNAs and DNA Demethylation in Plants


Thursday, February 01 | 5:00PM - 7:00PM
Silencing RNAs in Genetic Pathways
This session is from Regulatory RNAs
Room: Longs Peak

Speaker 4 of 4
Kathryn N. Ivey, Tenaya Therapeutics, USA
Short Talk: MicroRNAs Regulate Cardiomyocyte Differentiation from Embryonic Stem Cells


Thursday, February 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Shavano/Torreys


Thursday, February 01 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Thursday, February 01 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Friday, February 02 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.