Web Desc
Imaging Immune Responses
joint with Intracellular and Intercellular Signaling in Dendritic Cell Function
Organizer(s): Ronald N. Germain and Ellen A. Robey
Date: February 25 - March 01, 2007
Location: Keystone Resort, Keystone, CO, USA
Supported by the Director's Fund
Summary of Meeting:
The cellular events leading to host defense and immunopathology are dynamic in nature and involve the migration, transient arrest, and redistribution of various hematopoietic cells types between blood, secondary lymphoid organs, and peripheral tissues. For this reason, a great deal of excitement has been generated by the recent application of miniaturized versions of clinical imaging tools such as PET scanning and MRI, confocal and especially multiphoton microscopy, and luminescence imaging to living animals, permitting direct spatiotemporal analysis of immune cells within complex tissue environments. However, standards for data analysis and interpretation are just emerging, as are improved methods that bridge the resolution and time gaps between the various methods, allowing analyses to begin with initiation of a response and to follow it through to pathogen/tumor clearance or induction of autoimmune pathology. This meeting will bring together experts who will describe ongoing and future applications of these new imaging methods and provide the attendees with an understanding of the new biological paradigms that are emerging from such investigations. Speakers will discuss both basic and clinically-related advances, including cell-cell interactions in the development of humoral and cell-mediated immune responses, the events underlying autoimmune pathology in models of rheumatoid arthritis and diabetes, the trafficking of hematopoietic stem cells following grafting, signaling events in the thymus, bone marrow, and secondary lymphoid tissues, the sites of Treg activity, and the interplay between tumor cell growth and immune cell effector activity following anti-cancer vaccination.
Scholarship Deadline: October 25 2006
Discounted Abstract Deadline: October 25 2006
Abstract Deadline: November 27 2006
Discounted Registration Deadline: December 26 2006
We gratefully acknowledge additional support for this conference from:
JDRFUCB Celltech
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI074292-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 25 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Sunday, February 25 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Sunday, February 25 | 7:30PM - 8:30PM
Keynote Address
Room: Grays Peak 2-3

Speaker 1 of 1
Scott E. Fraser, University of Southern California, USA
Observing Dynamic Cell Behavior in Complex Tissues

Monday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Monday, February 26 | 8:00AM - 11:00AM
Antigen Presentation and the Initiation of T Cell Responses
Room: Grays Peak 2-3

Speaker 1 of 4
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Directed Cell-Cell Interactions in the Development of Adaptive Immunity

Monday, February 26 | 8:00AM - 11:00AM
Antigen Presentation and the Initiation of T Cell Responses
Room: Grays Peak 2-3

Speaker 2 of 4
Jean M. Davoust, Hôpital Saint-Vincent-de-Paul, France
Langerhans Cell Trafficking and Antigen Capture in the Skin

Monday, February 26 | 8:00AM - 11:00AM
Antigen Presentation and the Initiation of T Cell Responses
Room: Grays Peak 2-3

Speaker 3 of 4
Ulrich H. Von Andrian, Harvard Medical School, USA
Cell Entry and Interaction within Lymphoid Tissues

Monday, February 26 | 8:00AM - 11:00AM
Antigen Presentation and the Initiation of T Cell Responses
Room: Grays Peak 2-3

Speaker 4 of 4
Marc K. Jenkins, University of Minnesota Medical School, USA
Imaging Peptide:MHC II Production During the Primary Immune Response

Monday, February 26 | 8:00AM - 11:15AM
Pathogen Recognition Pathways
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 6
* Takashi Fujita, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Triggering Antiviral Responses and Cell Regulation by the Cytoplasmic RNA Helicase RIG-I


Monday, February 26 | 8:00AM - 11:15AM
Pathogen Recognition Pathways
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 6
Akira Shizuo, Osaka University, Japan
TLR-Dependent and Independent Anti-Viral Responses


Monday, February 26 | 8:00AM - 11:15AM
Pathogen Recognition Pathways
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 6
Michel Gilliet, University Hospital of Lausanne, Switzerland
Short Talk: Activation of Plasmacytoid Dendritic Cell Precursors by an Endogenous Peptide


Monday, February 26 | 8:00AM - 11:15AM
Pathogen Recognition Pathways
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 6
Dana Philpott, University of Toronto, Canada
NOD Pathway for Pathogen Sensing


Monday, February 26 | 8:00AM - 11:15AM
Pathogen Recognition Pathways
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 6
Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Short Talk: DC-SIGN Modulates TLR-Induced Immune Responses in Dendritic Cells through Acetylation of NF-kappaB-Subunit p65


Monday, February 26 | 8:00AM - 11:15AM
Pathogen Recognition Pathways
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 6
Caetano Reis e Sousa, Francis Crick Institute, UK
Activation of DC by Yeast


Monday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, February 26 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud


Monday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud


Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 1 of 8
* Mark J. Miller, Washington University School of Medicine, USA
Multi-photon Imaging of Antigen Presentation During Listeria monocytogenes Infection

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 2 of 8
* Philippe Bousso, Institute Pasteur, France
Cellular Orchestration of T Cell Priming In Vivo

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 3 of 8
Ann M. Haberman, Yale University School of Medicine, USA
Visualization of Germinal Center B Cell Dynamics In Vivo

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 4 of 8
Sarah E. Henrickson, Children's Hospital of Philadelphia, USA
T Cell Sensing of Antigen Avidity Determines the Kinetics and Character of T Cell-Dendritic Cell Interactions in Lymph Nodes

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 5 of 8
Reinhold Förster, Hannover Medical School, Germany
CCR7-Ligands Stimulate the Intranodal Motility of T Lymphocytes in vivo

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 6 of 8
Joost B. Beltman, Leiden University, Netherlands
Lymph Node Topology Dictates T Cell Migration Behavior

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 7 of 8
Thorsten R. Mempel, Massachusetts General Hospital, USA
Conduits Mediate Antigen Transport to Follicular Dendritic Cells in Lymph Nodes

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Intravital Multiphoton Imaging
Room: Grays Peak 2-3

Speaker 8 of 8
Michio Tomura, Kyoto University Graduate School of Medicine, Japan
Following Cells In Vivo Using Photoconverting Protein KAEDE

Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 6
* Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan
Critical Involvement of IkappaB kinase-alpha in TLR7/9-Induced Type I IFN Production


Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 6
Emmanuel Derudder, CBR Institute for Biomedical Research, USA
Roles for Canonical and Alternative NF-kappaB Activation Pathways in Dendritic Cells


Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 6
Esther C. de Jong, Academic Medical Center, Netherlands
Non-Canonical NF-kappaB Signaling in Dendritic Cells is Required for Indoleamine 2,3-Dioxygenase (IDO) Induction and Immune Regulation


Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 6
Ranjeny Thomas, University of Queensland, Australia
RelB-Competent Dendritic Cells Suppress Autoimmune Inflammatory Disease


Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 6
Hiromitsu Hara, Saga University, Japan
CARD9 is Essential for Myeloid Cell Activation
through ITAM-bearing Receptors


Monday, February 26 | 2:30PM - 4:30PM
Workshop 1: Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 6
Yen-Michael S. Hsu, University of Texas MD Anderson Cancer Center, USA
CARD9 is Required for Innate Immune Responses Against Intracellular Pathogens


Monday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, February 26 | 5:00PM - 7:00PM
Intracellular Signaling by Lymphoid Cells Analyzed in situ
Room: Grays Peak 2-3

Speaker 1 of 3
Mark M. Davis, Stanford University School of Medicine, USA
The Role of Endogenous Peptides in T Cell Activation and Thymic Selection

Monday, February 26 | 5:00PM - 7:00PM
Intracellular Signaling by Lymphoid Cells Analyzed in situ
Room: Grays Peak 2-3

Speaker 2 of 3
Richard S. Lewis, Stanford University School of Medicine, USA
A Molecular Mechanism for Sustained Calcium Signaling During T Cell Activation

Monday, February 26 | 5:00PM - 7:00PM
Intracellular Signaling by Lymphoid Cells Analyzed in situ
Room: Grays Peak 2-3

Speaker 3 of 3
* Doreen A. Cantrell, University of Dundee, UK
Spatial/Temporal Analysis of Inositol Lipid Metabolism During T Lymphocyte Activation

Monday, February 26 | 5:00PM - 7:00PM
Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 4
Marco Colonna, Washington University School of Medicine, USA
Cross Talks between TLRs and ITAM-Dependent Receptors in DC


Monday, February 26 | 5:00PM - 7:00PM
Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 4
Jürg Tschopp, University of Lausanne, Switzerland
NLRs and the Inflammasome: Danger Sensing Complexes Involved in Inflammatory Diseases


Monday, February 26 | 5:00PM - 7:00PM
Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 4
You-Me Kim, KAIST, South Korea
Short Talk: the Interaction Between the ER Membrane Protein UNC93B and Toll-like Receptors 3, 7, and 9 is Crucial for TLR Signaling


Monday, February 26 | 5:00PM - 7:00PM
Signaling in Pathogen Recognition
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 4
* Anne O'Garra, Francis Crick Institute, UK
Molecular Mechanisms for the Regulation of IL-10 Expression in Dendritic Cells, Macrophages and T Cells


Monday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Monday, February 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone/Red Cloud


Tuesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Tuesday, February 27 | 8:00AM - 11:00AM
B Cell Migration and the Induction of Humoral Immune Respons
es

Room: Grays Peak 2-3

Speaker 1 of 4
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
Cell Migration Dynamics During the B Cell Immune Response

Tuesday, February 27 | 8:00AM - 11:00AM
B Cell Migration and the Induction of Humoral Immune Respons
es

Room: Grays Peak 2-3

Speaker 2 of 4
Philippa C. Marrack, HHMI/National Jewish Health, USA
The Effects of Adjuvants on B and T Cells

Tuesday, February 27 | 8:00AM - 11:00AM
B Cell Migration and the Induction of Humoral Immune Respons
es

Room: Grays Peak 2-3

Speaker 3 of 4
John H. Kehrl, NIAID, National Institutes of Health, USA
Regulation of B Cell Motility in Lymph Nodes

Tuesday, February 27 | 8:00AM - 11:00AM
B Cell Migration and the Induction of Humoral Immune Respons
es

Room: Grays Peak 2-3

Speaker 4 of 4
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Imaging Germinal Centers

Tuesday, February 27 | 8:00AM - 11:15AM
Cross-Talk with Other Cells
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 6
* Kenneth L. Rock, University of Massachusetts Medical School, USA
How Dying Cells Alert the Immune System to Danger


Tuesday, February 27 | 8:00AM - 11:15AM
Cross-Talk with Other Cells
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 6
Laurence Zitvogel, Institut Gustave Roussy, France
DC and NK Cells


Tuesday, February 27 | 8:00AM - 11:15AM
Cross-Talk with Other Cells
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 6
Vincenzo Cerundolo, University of Oxford, UK
DC and NKT cells


Tuesday, February 27 | 8:00AM - 11:15AM
Cross-Talk with Other Cells
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 6
Anna M. Keller, Netherlands Cancer Institute, Netherlands
Short Talk: Costimulatory Ligand CD70 is Delivered to the Immunological Synapse by Shared Intracellular Trafficking with MHC Class II


Tuesday, February 27 | 8:00AM - 11:15AM
Cross-Talk with Other Cells
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 6
Yatin M. Vyas, Children's Hospital of Pittsburgh, USA
Short Talk: Antiparallel Segregation of Notch Components in the Immunological Synapse Directs Reciprocal Signaling in Allogeneic Th:DC Conjugates


Tuesday, February 27 | 8:00AM - 11:15AM
Cross-Talk with Other Cells
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 6
Yvette van Kooyk, Vrije University Medical Center, Netherlands
Regulation of DC Cross Talk with other Immune Cells by C-Type Lectins and Carbohydrates


Tuesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, February 27 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud


Tuesday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 1 of 7
* Bridget S. Wilson, University of New Mexico Health Science Center, USA
High Resolution Imaging Methods to Probe Fc[epsilon]RI Membrane Organization and Behavior

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 2 of 7
Pavel Tolar, Francis Crick Institute, UK
Imaging the B-Cell Receptor Signaling in the Immunological Synapse

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 3 of 7
Carles Rentero, University of Barcelona, Spain
Membrane Organization at T Cell Activation Sites and Immunological Synapse

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 4 of 7
Valarie A. Barr, NCI, National Institutes of Health, USA
Cbl-Dependent Internalization of TCR-Induced, LAT-Nucleated Signaling Complexes

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 5 of 7
Aaron K. Neumann, University of New Mexico, USA
Distribution and Lateral Mobility of DC-SIGN on Immature Dendritic Cells

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 6 of 7
David M. Haaland, Sandia National Laboratories, USA
Hyperspectral Confocal Imaging of Live Cell Immune Response to Cytokines

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Functional, High Resolution
Imaging
Room: Grays Peak 2-3

Speaker 7 of 7
Matthias Gunzer, Helmholtz Centre for Infection Research, Germany
The Power of Single- and Multibeam 2-Photon Microscopy for High-Resolution and High-Speed Deep Tissue and Intravital Imaging

Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 7
* Shannon J. Turley, Genentech, Inc., USA
Presentation of Intestinal Self by Dendritic Cells and Lymph Node Stroma


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 7
Ena Ladi, University of California, Berkeley, USA
Visualizing Dendritic Cell Interactions of Migrating Thymocytes in Real-time Using Two-Photon Microscopy


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 7
John P. Driver, The Jackson Laboratory, USA
Activated NKT Cells Inhibit Autoimmune Diabetes Through Tolerogenic Maturation of Dendritic Cells


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 7
Flavio A. Salazar Onfray, Institute of Biomedical Sciences, Chile
Functional Gap Junctions Facilitate Melanoma Antigen Cross-Presentation in Human Dendritic Cells and are Recruited to the Immunological Synapses Contributing to T Cell Activation


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 7
Lesley Ann Smyth, Kings College London, UK
A Novel Pathway of Antigen Presentation by Dendritic Cells; Implications for Infectious Diseases


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 7
Payal Watchmaker, University of Pittsburgh, USA
Memory CD8+ T Cells Protect Dendritic Cells from CTL-Mediated Killing: Helper Function of Memory CD8+ T Cells


Tuesday, February 27 | 2:30PM - 4:30PM
Workshop 2: Intercellular Interactions Regulating DC Functio
n
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 7 of 7
Fabienne Brilot, Rockefeller University, USA
NK Cell Survival Mediated Through the Regulatory Synapse With Dendritic Cells Requires IL-15Ralpha


Tuesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, February 27 | 5:00PM - 7:00PM
Lymphocyte Behavior Outside the Lymph Node
Room: Grays Peak 2-3

Speaker 1 of 4
* Ellen A. Robey, University of California, Berkeley, USA
Cell Interactions and Migration in the Thymus

Tuesday, February 27 | 5:00PM - 7:00PM
Lymphocyte Behavior Outside the Lymph Node
Room: Grays Peak 2-3

Speaker 2 of 4
Matthew F. Krummel, University of California, San Francisco, USA
Visualizing Cellular Decision-Making in Lymphocytes

Tuesday, February 27 | 5:00PM - 7:00PM
Lymphocyte Behavior Outside the Lymph Node
Room: Grays Peak 2-3

Speaker 3 of 4
Ute Frevert, New York University School of Medicine, USA
Intravital Imaging of the Liver Phase of a Malaria Infection

Tuesday, February 27 | 5:00PM - 7:00PM
Lymphocyte Behavior Outside the Lymph Node
Room: Grays Peak 2-3

Speaker 4 of 4
Mark C. Coles, University of Oxford, UK
Imaging Lymphoid Tissue Development and Maturation

Tuesday, February 27 | 5:00PM - 7:00PM
DC Migration and Antigen Uptake
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 4
* Colin Watts, University of Dundee, UK
Regulation of Cytoskeleton during DC Migration and Antigen Uptake


Tuesday, February 27 | 5:00PM - 7:00PM
DC Migration and Antigen Uptake
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 4
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
TLR-Induced Gene Expression


Tuesday, February 27 | 5:00PM - 7:00PM
DC Migration and Antigen Uptake
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 4
Pierre Guermonprez, Kings College London, UK
Short Talk: the IFN Inducible p47 Small GTPase IGTP is Involved in
Cross-presentation by MHC Class I in Dendritic Cells


Tuesday, February 27 | 5:00PM - 7:00PM
DC Migration and Antigen Uptake
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 4
Gwendalyn J. Randolph, Washington University, USA
Origins and Migratory Fate of Pulmonary Dendritic Cells


Tuesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Tuesday, February 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone/Red Cloud


Wednesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Wednesday, February 28 | 8:00AM - 11:00AM
Longitudinal Imaging of Immune Responses
Room: Grays Peak 2-3

Speaker 1 of 5
Robert M. Hoffman, AntiCancer, Inc., USA
Tri-Color Imaging of the Interaction of the Host Immune System and Tumor Cells in the Living Mouse

Wednesday, February 28 | 8:00AM - 11:00AM
Longitudinal Imaging of Immune Responses
Room: Grays Peak 2-3

Speaker 2 of 5
John C. Boothroyd, Stanford University School of Medicine, USA
Dissecting Virulence and Reactivation in Toxoplasmosis Using In Vivo Imaging

Wednesday, February 28 | 8:00AM - 11:00AM
Longitudinal Imaging of Immune Responses
Room: Grays Peak 2-3

Speaker 3 of 5
* Chien Ho, Carnegie Mellon University, USA
Recent Cellular Imaging Studies Using Nano-sized Iron Oxide Particles: A New Non-invasive Approach to Detect Cardiac Transplant Rejection by MRI

Wednesday, February 28 | 8:00AM - 11:00AM
Longitudinal Imaging of Immune Responses
Room: Grays Peak 2-3

Speaker 4 of 5
Kamal M. Khanna, University of Connecticut Health Center, USA
Short Talk: Imaging the Endogenous CD8 T Cell Response to Infection: From Naïve to Memory

Wednesday, February 28 | 8:00AM - 11:00AM
Longitudinal Imaging of Immune Responses
Room: Grays Peak 2-3

Speaker 5 of 5
Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Short Talk: Real-Time Imaging of the Pancreas During Development of Diabetes

Wednesday, February 28 | 8:00AM - 11:30AM
DC in Tolerance/Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 6
Maries F. van den Broek, University Hospital Zurich, Switzerland
In Vivo Models for Studying Peripheral Tolerance


Wednesday, February 28 | 8:00AM - 11:30AM
DC in Tolerance/Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 6
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Signaling Molecules Modulating Tolerance and Autoimmunity


Wednesday, February 28 | 8:00AM - 11:30AM
DC in Tolerance/Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 6
Tim D. Sparwasser, Institute of Infection and Immunology, Germany
Short Talk: Ovalbumin-Specific Immunity in the Absence of Dendritic Cell Activation after Depletion of Regulatory T Cells in DEREG Mice


Wednesday, February 28 | 8:00AM - 11:30AM
DC in Tolerance/Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 6
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Foxp3 as the Regulatory T Cell Lineage Specification Factor


Wednesday, February 28 | 8:00AM - 11:30AM
DC in Tolerance/Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 6
* Ira Mellman, Genentech, Inc., USA
DC Maturation: Transformation and Function


Wednesday, February 28 | 8:00AM - 11:30AM
DC in Tolerance/Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 6
Sebastian Amigorena, Institut Curie, France
Antigen Cross Presentation in Dendritic Cells


Wednesday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 1 of 8
* Darrell J. Irvine, Massachusetts Institute of Technology, USA
Imaging Dendritic Cell Chemotaxis: Chemokine-Releasing Microspheres as Vaccine Adjuvants and Tools to Analyze Directed DC Migration

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 2 of 8
Katalin Mikecz, Rush University Medical Center, USA
Anti-CD44 Antibody Treatment, but not CD44 Deficiency, Dramatically Alters Leukocyte Recruitment in Inflamed Mouse Joints

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 3 of 8
Melanie P. Matheu, University of California, Irvine, USA
Imaging Effector Memory T Cell Response and Suppression by Potassium Channel Blockade

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 4 of 8
Tatyana Chtanova, University of California, Berkeley, USA
Visualizing the Immune Response Against T. Gondii

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 5 of 8
Heather D. Hickman, NIAID, National Institutes of Health, USA
Visualization of Early Immune Interactions After Vaccinia Virus Infection In Vivo

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 6 of 8
Tomasz Zal, University of Texas MD Anderson Cancer Center, USA
Dynamics of Endogenous Foxp3+ Regulatory T Cells in Subcutaneous and Metastatic Tumors

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 7 of 8
David A. Schaer, Memorial Sloan-Kettering Cancer Center, USA
Imaging T Cell Responses Against Melanoma

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Immune Imaging in Translational and Clinical Set
tings
Room: Grays Peak 2-3

Speaker 8 of 8
Dorian B. McGavern, NINDS, National Institutes of Health, USA
Visualizing the Immunotherapeutic Clearance of a Persistent Viral Infection

Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 7
* William R. Heath, University of Melbourne, Australia
The Role of Dendritic Cell Subsets in Naive and Memory Responses to Infection


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 7
Alice O. Kamphorst, Emory University, USA
Antigen Targeting to CD8- DCs In Vivo


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 7
Burkhard Ludewig, Kantonsspital St. Gallen, Switzerland
Activation of Macrophages through Plasmacytoid Dendritic Cell-Derived Type I Interferon Secures Control of Murine Coronavirus Infection


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 7
Peter Siegfried Jähn, Milteniy Biotec GmbH, Germany
Functional Dichotomy of Plasmacytoid Dendritic Cells: Specific Activation of T-Cells Versus Production of Type I Interferon


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 7
Heli Uronen-Hansson, BioInvent, Sweden
Role of CD103+ DCs in the Generation of Intestinal Immune Responses


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 7
Juergen M. Ruland, Technical University of Munich, Germany
CARD9 Couples Dectin-1/Syk Signaling to NF-kappaB Activation for Antifungal Immunity


Wednesday, February 28 | 2:30PM - 4:30PM
Workshop 3: Interplay between DC Subsets in Induction of Imm
unity and Tolerance
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 7 of 7
Florent Ginhoux, Singapore Immunology Network, Singapore
Developmental Regulation of Chemokines Expression Controls the Recruitment of Langerhans Cells Precursors to the Skin


Wednesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Wednesday, February 28 | 5:00PM - 7:00PM
Application of Clinical Imaging Methods to Animal Models
Room: Grays Peak 2-3

Speaker 1 of 3
Anna Moore, Michigan State University, USA
In Vivo Imaging of Inflammation in Type 1 Diabetes

Wednesday, February 28 | 5:00PM - 7:00PM
Application of Clinical Imaging Methods to Animal Models
Room: Grays Peak 2-3

Speaker 2 of 3
* Diane Mathis, Harvard Medical School, USA
Imaging beta-Cell Destruction in situ

Wednesday, February 28 | 5:00PM - 7:00PM
Application of Clinical Imaging Methods to Animal Models
Room: Grays Peak 2-3

Speaker 3 of 3
David Piwnica-Worms, Washington University at St. Louis, USA
Molecular Imaging: Strategies to Probe Signal Transduction in Immune Responses In Vivo

Wednesday, February 28 | 5:00PM - 7:00PM
DC Instruction of Adaptive Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 4
Muriel Moser, Université Libre de Bruxelles, Belgium
Injection of anti-CTLA4 mAb in primed mice induces adaptive regulatory T cells with anti-inflammatory properties


Wednesday, February 28 | 5:00PM - 7:00PM
DC Instruction of Adaptive Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 4
* Yong-Jun Liu, Sanofi, USA
Th Instruction by DCs


Wednesday, February 28 | 5:00PM - 7:00PM
DC Instruction of Adaptive Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 4
Philipp Alberts, Northern Biologics, Canada
Short Talk: Dendritic Cells Control the Expression of a VAMP8 Positive Membrane Compartment to Allow for Regulated IL12 Release


Wednesday, February 28 | 5:00PM - 7:00PM
DC Instruction of Adaptive Immunity
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 4
Edith Margarethe Janssen, La Jolla Institute for Allergy and Immunology, USA
Viral Modification of DC Function


Wednesday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Thursday, March 01 | 8:00AM - 11:00AM
DC in Autoimmunity and Allergy
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 6
Diane Mathis, Harvard Medical School, USA
DC in Diabetes


Thursday, March 01 | 8:00AM - 11:00AM
DC in Autoimmunity and Allergy
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 6
Irah King, McGill University, Canada
Short Talk: GM-CSF Triggers Accelerated Myelopoiesis During EAE


Thursday, March 01 | 8:00AM - 11:00AM
DC in Autoimmunity and Allergy
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 6
* Fiona M. Powrie, University of Oxford, UK
Immune Regulation in the Intestine: A Balancing Act between Effector and Regulatory T Cells


Thursday, March 01 | 8:00AM - 11:00AM
DC in Autoimmunity and Allergy
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 6
Dale T. Umetsu, Genentech, Inc., USA
TIM-1 and the Development of Atopy


Thursday, March 01 | 8:00AM - 11:00AM
DC in Autoimmunity and Allergy
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 6
Bart N. Lambrecht, VIB, Ghent University, Belgium
DC in Asthma


Thursday, March 01 | 8:00AM - 11:00AM
DC in Autoimmunity and Allergy
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 6
Kristin V. Tarbell, Amgen, USA
Short Talk: DC-Expanded, Islet-Specific, Regulatory T Cells Increase Endogenous Foxp3+ Cells and Restore Normoglycemia in Diabetic NOD Mice


Thursday, March 01 | 10:26AM - 10:26AM
Departure


*Session Chair.

Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 7
* Matthew L. Albert, Genentech, Inc., USA
Antigen Persistence is Required for Efficient Cross-Priming of Minor Histocompatibility Antigen Specific CD8+ T Cells


Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 7
Michael Y. Gerner, NIAID, National Institutes of Health, USA
Defective Direct Presentation by DC Limits CD4 T Cell Help and Causes Tolerogenic Anti-Tumor CD8 T Cell Responses


Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 7
Anne Hosmalin, INSERM U1016 Institut Cochin, Université Paris Descartes, France
Human Plasmacytoid Dendritic Cells Perform Cross-Presentation


Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 7
Cornelius Maihoefer, Ludwig Maximilians University Munich, Germany
RIG-I-Ligands in Tumor Therapy


Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 5 of 7
Phillip J. Sanchez, National Jewish Medical and Research Center, USA
The Expression of CD70 on Dendritic Cells in vivo and its Role in Primary and Memory CD8+ T Cell Responses


Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 6 of 7
Connie M. Krawczyk, Van Andel Research Institute, USA
The Effect of Jagged Expression on Dendritic Cell-Mediated Th Differentiation


Thursday, March 01 | 1:30PM - 3:30PM
Workshop 4: DC in Tolerance Induction
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 7 of 7
Jan C. Dudda, Twincore, Germany
The Way of Regulatory T Cells from Thymus to Periphery is Imprinted by Tissue-Specific Dendritic Cells and Crucial for the Suppression of Autoimmunity


Thursday, March 01 | 4:00PM - 6:15PM
DC in Cancer
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 4
A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
DCs as Vectors and Targets in Cancer Immunotherapy


Thursday, March 01 | 4:00PM - 6:15PM
DC in Cancer
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 2 of 4
Pierre G. Coulie, University of Louvain, Brussels, Belgium
Possible Mechanism of Tumor Regression Following MAGE Vaccination of Melanoma Patients.


Thursday, March 01 | 4:00PM - 6:15PM
DC in Cancer
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 3 of 4
* Carl G. Figdor, Radboud University Medical Center, Netherlands
DC Cell Immunotherapy: Monitoring, Migration and Targeting


Thursday, March 01 | 4:00PM - 6:15PM
DC in Cancer
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 4 of 4
Lieping Chen, Yale University, USA
B7-H1/PD-1 Pathway in Immune Tolerance


Thursday, March 01 | 6:15PM - 7:15PM
Concluding Keynote Address
This session is from Dendritic Cell Function
Room: Shavano/Torreys

Speaker 1 of 1
Ralph M. Steinman, Rockefeller University, USA
Dendritic Cells and Vacine Biology