Web Desc
Stem Cell Interactions with their Microenvironmental Niche
joint with Stem Cells and Cancer
Organizer(s): David T. Scadden and Allan C. Spradling
Date: March 02 - 07, 2007
Location: Keystone Resort, Keystone, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Stem cells are defined by their function in complex microenvironments that are just beginning to be defined. The architecture of these anatomic sites in molecular, cellular and developmental terms has provided insight into how tissues are formed and maintained throughout life. They now provide an opportunity for examining settings of disease and offering a distinct group of possible therapeutic interventions. This meeting will examine select stem cell niches to explore unifying principles and identify opportunities for application in tissue regeneration and cancer therapy.
Scholarship Deadline: November 2 2006
Discounted Abstract Deadline: November 2 2006
Abstract Deadline: December 1 2006
Discounted Registration Deadline: January 2 2007
We gratefully acknowledge additional support for this conference from:
JDRF
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL088881-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 02 | 3:00PM - 7:30PM
Registration
Room: Shavano Foyer


Friday, March 02 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Friday, March 02 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: Colorado Rockies Ballroom

Speaker 1 of 1
Allan C. Spradling, HHMI/Carnegie Institute, USA
Analyzing Stem Cells Within Intact Drosophila Tissues

Saturday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs Peak


Saturday, March 03 | 8:00AM - 11:00AM
Mechanisms Governing Normal and Malignant Stem Cells (Joint)
Room: Colorado Rockies Ballroom

Speaker 5 of 5
Andreas Androutsellis-Theotokis, NINDS, National Institutes of Health, USA
Short Talk: STAT3-Ser727: Integrator of Stem Cell Niche Survival Signals

Saturday, March 03 | 8:00AM - 11:00AM
Mechanisms Governing Normal and Malignant Stem Cells (Joint)
Room: Colorado Rockies Ballroom

Speaker 4 of 5
Mary Armanios, Johns Hopkins University School of Medicine, USA
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

Saturday, March 03 | 8:00AM - 11:00AM
Mechanisms Governing Normal and Malignant Stem Cells (Joint)
Room: Colorado Rockies Ballroom

Speaker 3 of 5
Haifan Lin, Yale University, USA
Stem Cells, Small RNAs, and Self-Renewal

Saturday, March 03 | 8:00AM - 11:00AM
Mechanisms Governing Normal and Malignant Stem Cells (Joint)
Room: Colorado Rockies Ballroom

Speaker 2 of 5
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Prostaglandin E2 is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis

Saturday, March 03 | 8:00AM - 11:00AM
Mechanisms Governing Normal and Malignant Stem Cells (Joint)
Room: Colorado Rockies Ballroom

Speaker 1 of 5
* Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Self-Renewal

Saturday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, March 03 | 11:15AM - 1:00PM
Poster Setup
Room: Grays/Longs Peak


Saturday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays/Longs Peak


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 7 of 7
Silvia Buonamici, H3 Biomedicine, Inc., USA
Targeting the NF-kappaB Signaling Pathway in Notch1-Induced T Cell Leukemia


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 6 of 7
Aniruddha Deshpande, Memorial Sloan-Kettering Cancer Center, USA
Acute Myeloid Leukemia is Propagated by a Leukemic Stem Cell with Lymphoid Characteristics in a Mouse Model of CALM/AF10 Positive Leukemia


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 5 of 7
Yosuke Minami, Kobe University Hospital, Japan
Leukemia Stem Cells Induced by BCR-ABL Display Innate Resistance to Imatinib


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 4 of 7
Naoki Hosen, Osaka University Graduate School of Medicine, Japan
CD96 is a Candidate for Leukemic Stem Cell-Specific Therapeutic Target


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 7
Eric R. Lechman, University Health Network, Canada
Identification of a Leukemia Stem Cell Specific miRNA Profile and the Requirement of miR-155 for the Maintenance of the Leukemogenic State


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 7
* Michael W. Becker, University of Rochester School of Medicine, USA


Saturday, March 03 | 2:30PM - 4:30PM
Workshop 1: Stem Cells on Hematopoietic Malignancies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 7
* Catriona H.M. Jamieson, University of California, San Diego, USA


Saturday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Saturday, March 03 | 5:00PM - 7:00PM
Remaking Cell Fate through Cell Interaction
Room: Shavano/Torreys

Speaker 1 of 4
Gerd Hasenfuss, Georg-August-University of Göttingen, Germany
Pluripotency of Spermatogonial Stem Cells From Adult Mouse Testis

Saturday, March 03 | 5:00PM - 7:00PM
Hematopoietic and Model Microenvironments
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 3
* John E. Dick, Princess Margaret Cancer Centre, Canada
AML Stem cells


Saturday, March 03 | 5:00PM - 7:00PM
Hematopoietic and Model Microenvironments
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 3
Linheng Li, Stowers Institute for Medical Research, USA
Regulation of Stem Cells in Hematopoietic and Intestinal Niches by BMP and PTEN Pathways


Saturday, March 03 | 5:00PM - 7:00PM
Hematopoietic and Model Microenvironments
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 3
Tannishtha Reya, University of California, San Diego, USA
Wnt Signaling in Stem Cells and Cancer


Saturday, March 03 | 5:00PM - 7:00PM
Remaking Cell Fate through Cell Interaction
Room: Shavano/Torreys

Speaker 2 of 4
Erika Matunis, Johns Hopkins University School of Medicine, USA
Converting Differentiating Cells to Stem Cells in the Drosophila Testis

Saturday, March 03 | 5:00PM - 7:00PM
Remaking Cell Fate through Cell Interaction
Room: Shavano/Torreys

Speaker 3 of 4
* Helen M. Blau, Stanford University, USA
Directing Behavior of Single Stem Cells in Bioengineered Arrayed Niches

Saturday, March 03 | 5:00PM - 7:00PM
Remaking Cell Fate through Cell Interaction
Room: Shavano/Torreys

Speaker 4 of 4
Ian Chambers, University of Edinburgh, UK
Short Talk: Nanog Function in Pluripotency and Germ Cell Development

Saturday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays/Longs Peak


Saturday, March 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays/Longs Peak


Sunday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs Peak


Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 1 of 7
* Patrick O. Brown, Impossible Foods, USA
Cancer Stroma

Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 2 of 7
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis Initiating Functions

Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 3 of 7
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling in Stem Cells and Cancer

Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 4 of 7
Napoleone Ferrara, University of California, San Diego, USA
VEGF and Angiogenesis

Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 5 of 7
Louise E. Purton, St. Vincent's Institute of Medical Research, Australia
Short Talk: A Microenvironment-Induced Myeloproliferative Disease Caused by RARgamma Deficiency

Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 6 of 7
Renee D. Read, Emory University School of Medicine, USA
Short Talk: Modeling Human Brain Cancer in Fruit Flies

Sunday, March 04 | 8:00AM - 11:15AM
Cancer Microenvironment or Tumor Microenvironment and Blood
Vessels (Joint)

Room: Colorado Rockies Ballroom

Speaker 7 of 7
Sophia W.M. Bruggeman, University Medical Center Groningen, Netherlands
Short Talk: Polycomb Group Proteins Control Neutral Stem Cells and Brain Development, and Contribute to Gliomagenesis in an Ink4a/Afr Independent Manner

Sunday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, March 04 | 11:30AM - 1:00PM
Poster Setup
Room: Grays/Longs Peak


Sunday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays/Longs Peak


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 1 of 7
* Haifan Lin, Yale University, USA

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 2 of 7
Maria Victoria Gómez-Gaviro, National Institute for Medical Research, UK
Role of the Vasculature in the Cytoarchitecture of the Neural Stem Niche

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 3 of 7
Laura A. Banaszynski, University of Texas Southwestern Medical Center, USA
Regulated Expression of Transcription Factors Involved in the Establishment and Maintenance of Pluripotency

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 4 of 7
Michaela Gruber, University of Pennsylvania, USA
HIF-2alpha‘s Role in Erythropoiesis and Adult Stem Cells

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 5 of 7
Matthias Kieslinger, Helmholtz Center - National Research Center for Environment and Health, Germany
Expression of EBF2 in Osteoblastic Cells is Required for Sustained Haematopoiesis

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 6 of 7
Drew L. Sellers, University of Washington, USA
Thrombin Acts as an Early Response Cue Within the Adult Neural Stem Niche to Direct Proliferation and Differentiation in Response to Traumatic Injury

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 7 of 7
Sharon Gerecht-Nir, USA
Nanotopography Regulates Cytoskeletal Organization of Human Stem Cells

Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 8
* Edison T. Liu, The Jackson Laboratory, USA


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 8
* Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 8
Mark LaBarge, City of Hope, USA
Cell-Microenvironment Interactions Guide Human Mammary Progenitor Cell Fate


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 4 of 8
Xin-Hai Pei, University of North Carolina, USA
Functional Collaboration of p18Ink4c and Brca1 in Mammary Stem Cell Regulation and Tumor Suppression


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 5 of 8
Susanne Schlisio, Karolinska Institute, Ludwig Institute for Cancer Research, Sweden
Neuronal Apoptosis by Prolyl hydroxylase EglN3: O2- Sensing and Cancer


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 6 of 8
Danielle Christina Shing, European Institute of Oncology, Italy
The PR Domain-negative Isoform of PRDM16 Induces a Stem Cell Phenotype and is Leukaemogenic


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 7 of 8
David M. Langenau, Massachusetts General Hospital, USA
Identifying the Cancer Stem Cell in Transgenic Zebrafish Models of Embryonal Rhabdomyosarcoma


Sunday, March 04 | 2:30PM - 4:30PM
Workshop 2: Cancer Genes and Cancer Progressions
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 8 of 8
Robert B. Clarke, University of Manchester, UK
Primary Human Breast Ductal Carcinoma in situ (DCIS) Mammosphere Formation: Importance of the EGF and Notch Receptor Signalling Pathways


Sunday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Sunday, March 04 | 5:00PM - 7:00PM
Organization of Skin
Room: Shavano/Torreys

Speaker 1 of 4
* Elaine V. Fuchs, Rockefeller University, USA
From Stem Cells to Tissue: Signaling, Transcription and Cytoskeletal Dynamics in Skin Morphogenesis

Sunday, March 04 | 5:00PM - 7:00PM
Organization of Skin
Room: Shavano/Torreys

Speaker 2 of 4
Fiona M. Watt, King's College London School of Medicine, UK
Stem Cells and Lineage Selection in Mammalian Epidermis

Sunday, March 04 | 5:00PM - 7:00PM
Organization of Skin
Room: Shavano/Torreys

Speaker 3 of 4
Yann Barrandon, École Polytechnique Fédérale de Lausanne, Switzerland
Microenvironmental Changes and Stem Cell Behavior

Sunday, March 04 | 5:00PM - 7:00PM
Organization of Skin
Room: Shavano/Torreys

Speaker 4 of 4
Sergei Y. Sokol, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Regulation of Epidermal and Neuronal Progenitor Differentiation by aPKC and PAR-1

Sunday, March 04 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells of Epithelial Tissues
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 3
* Owen N. Witte, HHMI/University of California, Los Angeles, USA
Prostate Stem Cells


Sunday, March 04 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells of Epithelial Tissues
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 3
Michael F. Clarke, Stanford University, USA
Epithelial Cancer Stem Cells


Sunday, March 04 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells of Epithelial Tissues
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 3
Peter Dirks, Hospital for Sick Children, Canada
Brain Tumor Stem Cells


Sunday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays/Longs Peak


Sunday, March 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays/Longs Peak


Monday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs Peak


Monday, March 05 | 8:00AM - 11:15AM
Microenvironments of the Bone Marrow
Room: Shavano/Torreys

Speaker 1 of 6
* David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cells and their Niche(s)

Monday, March 05 | 8:00AM - 11:15AM
Microenvironments of the Bone Marrow
Room: Shavano/Torreys

Speaker 2 of 6
Paul J. Simmons, University of Texas Health Science Center at Houston, USA
Phenotypic Dissection of Stem Cell Niches and Mesenchymal Stem Cell Interactions in Bone Marrow

Monday, March 05 | 8:00AM - 11:15AM
Microenvironments of the Bone Marrow
Room: Shavano/Torreys

Speaker 3 of 6
Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Identification of Hematopoietic Stem Cells and Their Niches

Monday, March 05 | 8:00AM - 11:15AM
Microenvironments of the Bone Marrow
Room: Shavano/Torreys

Speaker 4 of 6
Toshio Suda, Keio University, Japan
Molecular Interactions at the Bone: Stem Cell Interface

Monday, March 05 | 8:00AM - 11:15AM
Microenvironments of the Bone Marrow
Room: Shavano/Torreys

Speaker 5 of 6
Ivan Maillard, University of Michigan, USA
Short Talk: Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver Through Effects on the Stem Cell Microenvironment

Monday, March 05 | 8:00AM - 11:15AM
Microenvironments of the Bone Marrow
Room: Shavano/Torreys

Speaker 6 of 6
Masataka Kasai, National Institutes of Health, Japan
Short Talk: Negative Regulation of Stem Cell Self-Renewal and Osteoblast Formation

Monday, March 05 | 8:00AM - 11:00AM
Cancer Genome Immunological Approaches Applicable to Cancer
Stem Cell Therapies
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 1 of 4
Mark M. Davis, Stanford University School of Medicine, USA
Title to be Determined


Monday, March 05 | 8:00AM - 11:00AM
Cancer Genome Immunological Approaches Applicable to Cancer
Stem Cell Therapies
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 2 of 4
Philip D. Greenberg, University of Washington, USA
Isolating/Creating T Cells That Can Target and Eliminate Cancer Stem Cells


Monday, March 05 | 8:00AM - 11:00AM
Cancer Genome Immunological Approaches Applicable to Cancer
Stem Cell Therapies
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 3 of 4
Jeffrey J. Molldrem, University of Texas MD Anderson Cancer Center, USA
Peptide Vaccination Against Proteases Reverses T Cell Tolerance and Eliminates
Leukemia Stem Cells


Monday, March 05 | 8:00AM - 11:00AM
Cancer Genome Immunological Approaches Applicable to Cancer
Stem Cell Therapies
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 4 of 4
James P. Allison, University of Texas MD Anderson Cancer Center, USA


Monday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 05 | 11:15AM - 1:00PM
Poster Setup
Room: Grays/Longs Peak


Monday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays/Longs Peak


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 8
* Laurie Elizabeth Ailles, Stanford University, USA


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 8
* Mark E.P. Prince, University of Michigan, USA


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 8
Shideng Bao Bao, Duke University Medical Center, USA
Cancer Stem Cells Contribute to Glioblastoma Radioresistance through Preferential Activation of DNA Damage Checkpoint and Repair


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 4 of 8
Catherine A. O'Brien, University Health Network, Canada
Identification of a Human Colon Cancer Cell Capable of Initiating Tumor Growth


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 5 of 8
Scott J. Dylla, Stemcentrx, Inc., USA
Colorectal Cancer Stem Cells (CoCSC) are Enriched in Residual Tumors following Cyclophosphamide Administration


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 6 of 8
Kent L. Erickson, University of California, Davis, USA
Small Molecule Combinatorial Libraries to Identify New Mammary Stem Cell Markers


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 7 of 8
Sheila R. Alcantara, University of Texas Southwestern Medical Center at Dallas, USA
Isolation and Characterization of Cancer Stem Cells in a Glioma Mouse Model


Monday, March 05 | 2:30PM - 4:30PM
Workshop 3: Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 8 of 8
Carol Ann Sartorius, University of Colorado Anschutz Medical Campus, USA
Rare CK5+ Cells in Experimental Human Breast Tumors Express a Panel of “Stem-like” Genes


Monday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, March 05 | 5:00PM - 7:00PM
Neural Stem Cell Microenvironments
Room: Shavano/Torreys

Speaker 1 of 3
Jeffrey D. Macklis, Harvard University-MGH-HMS, USA
Molecular Development and Repair of Corticospinal Motor Neuron and Other Forebrain Projection Neuron Circuitry


Monday, March 05 | 5:00PM - 7:00PM
Neural Stem Cell Microenvironments
Room: Shavano/Torreys

Speaker 2 of 3
* Charles Ffrench-Constant, University of Edinburgh, UK
Regulation of Neural Stem Cells by Extracellular Matrix Molecules of the Ventricular Zone Niche

Monday, March 05 | 5:00PM - 7:00PM
Neural Stem Cell Microenvironments
Room: Shavano/Torreys

Speaker 3 of 3
Chay T. Kuo, Duke University School of Medicine, USA
Short Talk: Postnatal Deletion of Numb/Numblike Reveals Remodeling Capacity in Neurogenic Niche

Monday, March 05 | 5:00PM - 5:40PM
High Throughput Analysis of Cancer Genes Applicable to Cance
r Stem Cells
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 1 of 1
* Frederick W. Alt, Boston Children's Hospital, USA
NHEJ and the Double-Strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma


Monday, March 05 | 5:40PM - 7:00PM
Genetic and Epigenetic Alterations in Cancers & Epigenetic R
egulation of Cancer Stem Cells
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 1 of 2
Tim C.P. Somervaille, Stanford University School of Medicine, USA
Transformation of Myeloid Progenitors to Leukemia Stem Cells by MLL Oncogenes


Monday, March 05 | 5:40PM - 7:00PM
Genetic and Epigenetic Alterations in Cancers & Epigenetic R
egulation of Cancer Stem Cells
This session is from Stem Cells and Cancer

Room: Crestone/Red Cloud

Speaker 2 of 2
Tian Xu, Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Progression and Metastasis


Monday, March 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Longs Peak Foyer


Monday, March 05 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays/Longs Peak


Tuesday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Grays/Longs Peak


Tuesday, March 06 | 8:00AM - 11:15AM
Germ Cell Niche
Room: Shavano/Torreys

Speaker 1 of 6
Margaret T. Fuller, Stanford University, USA
Stromal-Stem Cell Interactions in the Fruit Fly Set Up an Oriented Mitotic Spindle for Asymmetric Stem Cell Division

Tuesday, March 06 | 8:00AM - 11:15AM
Germ Cell Niche
Room: Shavano/Torreys

Speaker 2 of 6
Judith E. Kimble, University of Wisconsin, Madison, USA
Controls of Germline Stem Cells in C. elegans

Tuesday, March 06 | 8:00AM - 11:15AM
Germ Cell Niche
Room: Shavano/Torreys

Speaker 3 of 6
Ting Xie, Stowers Institute for Medical Research, USA
Interactions Between Germline Stem Cells and Their Niche in the Drosophila Ovary

Tuesday, March 06 | 8:00AM - 11:15AM
Germ Cell Niche
Room: Shavano/Torreys

Speaker 4 of 6
* Takashi Shinohara, Kyoto University, Japan
Culture and Genetic Modification of Mouse Germline Stem (GS) Cells

Tuesday, March 06 | 8:00AM - 11:15AM
Germ Cell Niche
Room: Shavano/Torreys

Speaker 5 of 6
Niels Geijsen, Massachusetts General Hospital, USA
Short Talk: “Humanized” Murine Embryonic Stem Cells

Tuesday, March 06 | 8:00AM - 11:15AM
Germ Cell Niche
Room: Shavano/Torreys

Speaker 6 of 6
Paul S. Cooke, University of Illinois at Urbana-Champaign, USA
Short Talk: Ets-Related Molecule (ERM) and Spermatogonial Stem Cell Self-Renewal

Tuesday, March 06 | 8:00AM - 11:00AM
Finding Therapeutic Targets in Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 4
* Tessa L. Holyoake, University of Glasgow, UK
Characterisation of Cancer Stem Cells in CML


Tuesday, March 06 | 8:00AM - 11:00AM
Finding Therapeutic Targets in Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 4
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Gamma Secretase Inhibitors for the Treatment of ALL


Tuesday, March 06 | 8:00AM - 11:00AM
Finding Therapeutic Targets in Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 4
D. Gary Gilliland, Merck & Co., Inc., USA
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress


Tuesday, March 06 | 8:00AM - 11:00AM
Finding Therapeutic Targets in Cancer Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 4 of 4
Gregory L. Verdine, Harvard University, USA
Drugging the Undruggable


Tuesday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 2
Room: Shavano/Torreys

Speaker 1 of 6
* Allan C. Spradling, HHMI/Carnegie Institute, USA

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 2
Room: Shavano/Torreys

Speaker 2 of 6
Arianna DellaValle, San Raffaele Scientific Institute, Italy
Pericytes of Human Post-Natal Skeletal Muscle are Myogenic Precursors, Distinct From Satellite Cells, and Efficiently Repair Dystrophic Muscle

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 2
Room: Shavano/Torreys

Speaker 3 of 6
Xudong Shi, University of Wisconsin, Madison, USA
Anchorage Independent Culture Maintains a Population of Prostate Progenitor Cells In Vitro

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 2
Room: Shavano/Torreys

Speaker 4 of 6
David R. Whikehart, University of Alabama at Birmingham, USA
Stem Cells in the Human Ocular Limbus Are Contained in a Niche Defined by Schwalbe’s Line

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 2
Room: Shavano/Torreys

Speaker 5 of 6
Indira U. Mysorekar, Washington University School of Medicine, USA
Molecular Regulation of the Bladder Epithelial Stem Cell Niche

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 2
Room: Shavano/Torreys

Speaker 6 of 6
John Yu, Institute of Stem Cell and Translational Cancer Research, Taiwan
Characterization of Pulmonary Stem Cells as Model for SARS and H5N1 Virus Infections

Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 4: Novel Cancer Therapies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 6
* Austin Gurney, Napa Biotechnology Consulting, USA
Prognostic Role of Cancer Stem Cell Gene Signatures and Strategies to Target Tumorigenic Cell Populations


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 4: Novel Cancer Therapies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 6
Chris Alan Joseph Folkins, Sunnybrook Health Sciences Centre, Canada
Therapies Combining Cytotoxic and Anti-angiogenic Effects Reduce the Fraction of Tumor Sphere Forming Cells in Glioma Xenograft Tumors


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 4: Novel Cancer Therapies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 6
Christine E. Brown, Beckman Research Institute, City of Hope, USA
Targeted Elimination of Brain Tumor Initiating Cells with Adoptively Transferred T Cells


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 4: Novel Cancer Therapies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 4 of 6
Xing Fan, Johns Hopkins University School of Medicine, USA
Depleting Cancer Stem Cells in Glioblastoma by Notch Pathway Blockade


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 4: Novel Cancer Therapies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 5 of 6
Jie Zheng, St. Jude Children's Research Hospital, USA
Structure-based Investigation of Wnt Signaling Inhibitors


Tuesday, March 06 | 2:30PM - 4:30PM
Workshop 4: Novel Cancer Therapies
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 6 of 6
Craig Gedye, Melbourne Center for Clinical Science, Australia
Melanoma Stem-like Cells can be Eliminated by Targeting Cancer/Testis Antigens


Tuesday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, March 06 | 5:00PM - 7:00PM
Designer Niches: Modeling and Making Microenvironments
Room: Shavano/Torreys

Speaker 1 of 4
* Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Mechanical Control of Cell Fate Switching

Tuesday, March 06 | 5:00PM - 7:00PM
Designer Niches: Modeling and Making Microenvironments
Room: Shavano/Torreys

Speaker 2 of 4
David J. Mooney, Harvard University, USA
Constructing Tissue Microenvironments

Tuesday, March 06 | 5:00PM - 7:00PM
Designer Niches: Modeling and Making Microenvironments
Room: Shavano/Torreys

Speaker 3 of 4
Geeta Mehta, University of Michigan, USA
Short Talk: Creating Ex Vivo Niches for Hematopoeitic Stem Cells

Tuesday, March 06 | 5:00PM - 7:00PM
Designer Niches: Modeling and Making Microenvironments
Room: Shavano/Torreys

Speaker 4 of 4
Seth A. Townsend, Massachusetts Institute of Technology, USA
Short Talk: Novel Three-Dimensional Environments for in Vitro Growth of Stem Cells

Tuesday, March 06 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 1 of 4
Nobuko Uchida, StemCells, Inc., USA
Biology of Human Neural Stem Cells


Tuesday, March 06 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 2 of 4
* Irving L. Weissman, Stanford University, USA
Normal and Leukemic Stem Cells


Tuesday, March 06 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 3 of 4
Jeremy Naftali Rich, Cleveland Clinic, USA
Glioma Cancer Stem Cells Promote Tumor Radioresistance and Angiogenesis


Tuesday, March 06 | 5:00PM - 7:00PM
Normal and Neoplastic Stem Cells
This session is from Stem Cells and Cancer
Room: Crestone/Red Cloud

Speaker 4 of 4
Diane M. Simeone, University of Michigan, USA
Short Talk: Identification of Pancreatic Cancer Stem Cells


Tuesday, March 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays/Longs Peak


Tuesday, March 06 | 8:00PM - 11:00PM
Entertainment
Room: Grays/Longs Peak


Tuesday, March 06 | 8:00PM - 11:00PM
Cash Bar
Room: Grays/Longs Peak


Wednesday, March 07 | 10:26AM - 10:26AM
Departure


*Session Chair.