Web Desc
Molecular Targets for Cancer
joint with Mouse Models at the Frontiers of Cancer Discovery
Organizer(s): William G. Kaelin Jr. and Sara A. Courtneidge
Date: March 18 - 23, 2007
Location: Whistler Conference Centre, Whistler, BC, Canada
Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development
Summary of Meeting:
The molecular circuits that are altered in cancers and responsible for malignant transformation are coming into better focus. In some cases cancer cells become ‘addicted’ to these abnormal circuits (networks). Discoveries related to cancer-relevant mutations, and the dependencies they create, will likely accelerate due to cancer resequencing efforts and phenotypic screens with genome-wide si/shRNA libraries. The success of imatinib for both chronic myelogenous leukemia and gastrointestinal stromal tumor and of gefitinib for lung cancers driven by mutant EGFR confirms that drugs targeting oncoproteins can induce tumor regressions with acceptable toxicity. Because of this, a number of agents that inhibit receptor tyrosine kinases, as well as downstream signaling molecules such as those in the Ras-Raf pathway and PI3K-AKT-mTOR pathway, are now being developed. The validity of preclinical models, and the need for robust pharmacodynamic assays, remains a challenge. This meeting will bring together experts and trainees to discuss these challenges in the context of present and future cancer drug targets.
Scholarship Deadline: November 20 2006
Discounted Abstract Deadline: November 20 2006
Abstract Deadline: December 19 2006
Discounted Registration Deadline: January 18 2007
We gratefully acknowledge additional support for this conference from:
Ariadne GenomicsCell Signaling Technology, Inc.Educational donation provided by AmgenEducational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology CompanyEntreMed, Inc.Integrated DNA TechnologiesInvitrogen CorporationPfizer Global Research & DevelopmentTeva Pharmaceutical Industries Ltd.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Global Research & Development

Proteolix, Inc.

Wyeth Pharmaceuticals
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA124284-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 18 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, March 18 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Sunday, March 18 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sky Ballroom B/C

Speaker 1 of 2
Hans C. Clevers, Hubrecht Institute, Netherlands
Wnt and Notch Cooperate to Maintain Proliferative Compartments in Crypts and Intestinal Neoplasma

Sunday, March 18 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Sky Ballroom B/C

Speaker 2 of 2
Gerard I. Evan, University of Cambridge, UK
Oncogenes and Tumor Suppressors: The Good, the Bad, and the Ugly

Monday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
Room: Ballroom A

Speaker 1 of 5
Jeffrey Settleman, Pfizer, USA
’Addiction’ to Oncogenic Kinases in Human Cancer

Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
Room: Ballroom A

Speaker 2 of 5
Samuel A. Wells, Duke University, USA
Small Molecule Targeted Therapy with Vandetanib in Patients with Metastatic Hereditary Medullary Thyroid Carcinoma

Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
Room: Ballroom A

Speaker 3 of 5
Paolo M. Comoglio, University of Torino Medical School, Italy
The MET Oncogene: Targeting Invasive Growth in Cancer and Stem Cells

Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
Room: Ballroom A

Speaker 4 of 5
Poul H. B. Sorensen, University of British Columbia, Canada
Short Talk: The ETV6-NTRK3 Oncogenic Tyrosine Kinase Directly Activates the Insulin-Like Growth Factor 1 Receptor (IGF-IR): Implications for Targeting IGF-IR in Human Tumors

Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
Room: Ballroom A

Speaker 5 of 5
John Hood, Wintherix, LLC, USA
Short Talk: TG101348, a Potent, Highly Selective JAK2 Inhibitor, Inhibits Colony Formation in Stem Cells from Polycythemia Vera Patients in Vitro & Prevents JAK2V617F-Mediated Splenomegaly and Death in an in Vivo Mouse Model

Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 5
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in vivo


Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 5
Andrew Koff, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: An Oncogenic Role for the Cdk Inhibitor p21Waf1/Cip1 in Gliomagenesis


Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 5
* Jacqueline A. Lees, Massachusetts Institute of Technology, USA
E2F Transcription Factors in Cancer Regulation


Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 5
Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
The p53 Pathways in Tumor Suppression


Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 5 of 5
Christopher J. Kemp, Fred Hutchinson Cancer Research Center, USA
Short Talk: Rescue of the Apoptosis Defect of p53 Null Cells by Mutation of Ku70, Ku80, or DNA-PKcs


Monday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, March 19 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom C/Foyer


Monday, March 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom C/Foyer


Monday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 19 | 5:00PM - 7:00PM
PI3K/AKT/mTOR Pathway
Room: Ballroom A

Speaker 1 of 3
Robert T. Abraham, Vividion Therapeutics, USA
The mTOR Signaling Pathway: Linking Basic Biology to Cancer Therapy

Monday, March 19 | 5:00PM - 7:00PM
PI3K/AKT/mTOR Pathway
Room: Ballroom A

Speaker 2 of 3
David J. Matthews, Exelixis Inc., USA
Targeting Aberrant PI-3 Kinase Signaling in Cancer

Monday, March 19 | 5:00PM - 7:00PM
PI3K/AKT/mTOR Pathway
Room: Ballroom A

Speaker 3 of 3
William A. Weiss, University of California, San Francisco, USA
Cooperative Inhibition of EGFR, PI3K alpha, and mTOR in PTEN-Mutant Glioma

Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 5
* Gerard I. Evan, University of Cambridge, UK


Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 5
Nancy A. Jenkins, Institute of Molecular and Cell Biology, Singapore
Insertional Mutagenesis Provides a Road Map for Characterizing the Cancer Genome


Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 5
Lynda Chin, University of Texas MD Anderson Cancer Center, USA
Oncogenomic analyses of mouse and human tumors


Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 5
Lara Shayne Collier, University of Minnesota, USA
Short Talk: Cancer Gene Discovery using the Sleeping Beauty Transposon System


Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 5 of 5
Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Cancer


Monday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Monday, March 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom C/Foyer


Tuesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Tuesday, March 20 | 8:00AM - 10:20AM
Ras/Raf/MAPK Pathway
Room: Ballroom A

Speaker 1 of 3
Julian H. Downward, Cancer Research UK, UK
Ras Oncogene Signaling Networks

Tuesday, March 20 | 8:00AM - 10:20AM
Ras/Raf/MAPK Pathway
Room: Ballroom A

Speaker 2 of 3
Patrick J. Casey, Duke University Medical Center, USA
Targeting Proliferation and Survival Pathways with Isoprenylcysteine Carboxymethyltransferase Inhibitors

Tuesday, March 20 | 8:00AM - 10:20AM
Ras/Raf/MAPK Pathway
Room: Ballroom A

Speaker 3 of 3
Judith Sebolt-Leopold, USA
Development of MEK Inhibitors – A Selective Approach to Targeting the Ras–MAP Kinase Pathway

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 7
* Joanna L. Groden, Ohio State University, USA
Chromosome Instability and Cancer


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 7
Catherine T. Yan, CBR Institute for Biomedical Research, USA
NHEJ and the Double-Strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 7
Erik S. Knudsen, UT Southwestern, USA
Short Talk: RB Loss Promotes Liver Tumorigenesis by Compromising Genome Integrity


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 7
Alan Ashworth, University of California, San Francisco, USA
Exploiting DNA Repair Defects in Tumors as a Therapeutic Strategy


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 5 of 7
Steven E. Artandi, Stanford University, USA
Short Talk: Regulation of Tissue Stem Cells by TERT


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 6 of 7
Sandy Chang, University of Texas MD Anderson Cancer Center, USA
Telomer End Protection in Senescence and Cancer


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 7 of 7
Philipp Kaldis, Institute of Molecular and Cell Biology, Singapore
Short Talk: Mouse Models to Investigate Cell Cycle and DNA Damage


Tuesday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 20 | 10:20AM - 11:00AM
BCR-ABL and Lympholeukemia
Room: Ballroom A

Speaker 1 of 1
Charles J. Sherr, St. Jude Children's Research Hospital, USA
Combating Non-Tumor-Cell-Autonomous Imatinib Resistance in Ph+ ALL

Tuesday, March 20 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom C/Foyer


Tuesday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom C/Foyer


Tuesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 20 | 5:00PM - 7:00PM
Protein Folding/Ubiquitination
Room: Ballroom A

Speaker 1 of 3
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Development of HSP90 Inhibitors for Cancer

Tuesday, March 20 | 5:00PM - 7:00PM
Protein Folding/Ubiquitination
Room: Ballroom A

Speaker 2 of 3
Michael Tyers, Canada
Pleonastic Phosphorylation, Substrate Recognition and Higher Order Structure of the SCF Ubiquitin Ligase

Tuesday, March 20 | 5:00PM - 7:00PM
Protein Folding/Ubiquitination
Room: Ballroom A

Speaker 3 of 3
Mark K. Bennett, Calithera Biosciences, USA
Development of Epoxyketone-based Proteasome Inhibitors

Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 5
Martin McMahon, University of Utah School of Medicine, USA
Tumorigenesis and Senescence Induction by Oncogenic BRafv600E in vivo


Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 5
Tavanna Buske, USA
Short Talk: A Hypomorphic Mutation in DNA Replication Gene Mcm4 Confers Mammary Specific Tumorigenesis in Mice


Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 5
Andrew Xiao, Yale University, USA
Short Talk: The WSTF-SNF2H Complex Regulates the H2A.X DNA Damage Response


Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 5
Al Charest, Tufts-NEMC, Massachusetts Institute of Technology, USA
Short Talk: Therapeutic Applicability of Nanoparticle-Mediated Delivery of siRNA in a Mouse Model of Glioblastoma Multiforme


Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 5 of 5
* Hong Wu, UCLA/IMED c/o Cyndi Haddad, USA
PTEN, Stem Cells and Tumorigenesis


Tuesday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Tuesday, March 20 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom C/Foyer


Wednesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
Room: Ballroom A

Speaker 1 of 4
Eli Keshet, Hebrew University, Israel
Lessons from Preclinical Models of VEGF-Dependent Angiogenesis

Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
Room: Ballroom A

Speaker 2 of 4
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Microenvironmental Signals and Angiogenesis

Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
Room: Ballroom A

Speaker 3 of 4
Jacques Pouysségur, University of Nice, France
Hypoxia Signaling and Cancer - Targeting Angiogenesis and Tumor Metabolism

Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
Room: Ballroom A

Speaker 4 of 4
Roy Bicknell, University of Birmingham, UK
Novel Anti-Cancer Targets in the Vasculature

Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 6
Kwok-Kin Wong, Dana-Farber Cancer Institute, USA
The Use of Mouse Lung Cancer Models for Preclinical Testing of Novel Targeted Therapeutics


Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 6
Ross A. Dickins, Monash University, Australia
Short Talk: Tissue-Specific and Reversible RNAi in Transgenic Mice


Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 6
Samir Hanash, Fred Hutchinson Cancer Research Center, USA
Cancer Biomarker Discovery Using Mouse Models


Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 6
* Douglas Hanahan, ISREC, Switzerland
Assessing Mechanism-based Cancer Therapeutics in Engineered Mouse Models of Cancer: Targeting EGFR and mTOR


Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 5 of 6
Trevor J. Hay, Cardiff University, UK
Short Talk: Regression of Brca2-/- p53-/- Mouse Mammary Tumours by PARP Inhibition


Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 6 of 6
Loren D. Walensky, Dana-Farber Cancer Institute, USA
Piloting “BH3 Replacement” Therapy in Murine Models of Deregulated Apoptosis


Wednesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom C/Foyer


Wednesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom C/Foyer


Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 21 | 5:00PM - 7:00PM
Stem Cell Pathways
Room: Ballroom A

Speaker 1 of 3
Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Modeling Human Cancer in the Mouse to Identify Relevant Pathways for Transformation or Progression

Wednesday, March 21 | 5:00PM - 7:00PM
Stem Cell Pathways
Room: Ballroom A

Speaker 2 of 3
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Gamma Secretase Inhibitors and Notch

Wednesday, March 21 | 5:00PM - 7:00PM
Stem Cell Pathways
Room: Ballroom A

Speaker 3 of 3
Frederic J. de Sauvage, Genentech, Inc., USA
Hedgehog Pathway and Cancer

Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 4
* Anton J. M. Berns, Netherlands Cancer Institute, Netherlands


Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 4
David W. Threadgill, University of North Carolina at Chapel Hill, USA
Complexities fo EGFR Signaling in Cancer


Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 4
Martine F. Roussel, St. Jude Children's Research Hospital, USA
Molecular Determinations of Medulloblastoma


Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 4
Elaine V. Fuchs, Rockefeller University, USA
Mouse Models of Cancer through Default of Focusing on Skin Morphogenesis


Wednesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Wednesday, March 21 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom C/Foyer


Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
Room: Ballroom A

Speaker 1 of 4
Michael Stratton, Wellcome Trust Sanger Institute, UK
Patterns of Somatic Mutation in Human Cancer Genomes

Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
Room: Ballroom A

Speaker 2 of 4
Matthias Mann, Max Planck Institute of Biochemistry, Germany
Global, Site Specific and Quantitative Phosphoproteomics for Drug Discovery

Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
Room: Ballroom A

Speaker 3 of 4
Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
Protein Microarrays

Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
Room: Ballroom A

Speaker 4 of 4
Roderick L. Beijersbergen, Netherlands Cancer Institute, Netherlands
Identification of Novel Drug Targets through Loss of Function Genetic Screens

Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 6
Robert Benezra, Memorial Sloan-Kettering Cancer Center, USA
The Role of Id Proteins in Tumor Angiogenesis


Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 6
Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Short Talk: Systemic Instigation of Indolent Tumor Growth by Distant Primary Tumors via Activation of Sca1+ Bone Marrow Cells


Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 6
* Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation, Humoral Immunity and Epithelial Cancer Development


Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 6
Harold L. Moses, Vanderbilt University, USA
Stromal and Epithelial TGF-beta Signaling in Carcinoma Initiation and Progression


Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 5 of 6
Victor D. Acevedo, Memorial Sloan Kettering, USA
Short Talk: Conditional Activation of FGF Receptor-1 Leads to an Irreversible Prostate Adenocarcinoma and Allows for an Epithelial to Mesenchymal Transition


Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 6 of 6
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
TGFbeta Signaling: From Cytostasis to Metastasis


Thursday, March 22 | 9:00AM - 12:00PM
Entertainment
Room: Ballroom C


Thursday, March 22 | 9:00AM - 12:00PM
Cash Bar
Room: Ballroom C


Thursday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 22 | 5:00PM - 7:00PM
Modulating Gene Expression
Room: Ballroom A

Speaker 1 of 3
Kapil N. Bhalla, MD Anderson Cancer Center, USA
HDACs as Therapeutic Targets

Thursday, March 22 | 5:00PM - 7:00PM
Modulating Gene Expression
Room: Ballroom A

Speaker 2 of 3
Todd R. Golub, Broad Institute, USA
Modulating Gene Expression Signatures with Small Molecules

Thursday, March 22 | 5:00PM - 7:00PM
Modulating Gene Expression
Room: Ballroom A

Speaker 3 of 3
Robert J. Klose, University of Oxford, UK
Histone Demethylases as Potential Therapeutic Targets in Cancer

Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 1 of 4
* Jeffrey M. Rosen, Baylor College of Medicine, USA
Stem/Progenitor Cells in the Etiology and Treatment of Breast Cancer


Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 2 of 4
Emmanuelle Passegué, Columbia University, USA
Cancer Stem Cells and Development of Blood Cancers


Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 3 of 4
Robert I. Glazer, Georgetown University, USA
Short Talk: Peroxisome Proliferator-Activated Receptor-gamma is a Regulator of Mammary Stem and Progenitor Cell Self-Renewal and Estrogen-Dependent Tumor Specification


Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
This session is from Mouse Models of Cancer Discove
Room: Ballroom B

Speaker 4 of 4
Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development


Thursday, March 22 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Friday, March 23 | 10:26AM - 10:26AM
Departure


*Session Chair.