Web Desc
Mouse Models at the Frontiers of Cancer Discovery
joint with Molecular Targets for Cancer
Organizer(s): Terry A. Van Dyke, Guillermina Lozano and Scott W. Lowe
Date: March 18 - 23, 2007
Location: Whistler Conference Centre, Whistler, BC, Canada
Supported by the Director's Fund
Summary of Meeting:
Manipulation of the mouse provides an avenue for dissecting the complexities of cancer development. Ongoing research explores causal pathways and mechanisms, including their cell specificity. Significant advances are emerging in the study of microenvironment interactions among tumor cells, the immune system, vasculature, mesenchyme and circulating factors. Models that recapitulate properties of the human diseases are being established, providing the potential for discovery and preclinical testing. The application of genomics technologies has begun to show promise in informing the human disease. Nevertheless, the use of such models in translational research is in its infancy. This meeting will highlight advances in the understanding of complex cancer mechanisms and will address the successes, challenges, and needs in translating this research to the clinic. The meeting agenda includes world-class investigators presenting cutting edge science, but also addressing issues relevant to advancing the appropriate use of spontaneous cancer models in translational endeavors.
Scholarship Deadline: November 20 2006
Discounted Abstract Deadline: November 20 2006
Abstract Deadline: December 19 2006
Discounted Registration Deadline: January 18 2007
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenMerck Research LaboratoriesNovartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA124284-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 18 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, March 18 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Sunday, March 18 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B/C

Speaker 1 of 2
Hans C. Clevers, Hubrecht Institute, Netherlands
Wnt and Notch Cooperate to Maintain Proliferative Compartments in Crypts and Intestinal Neoplasma

Sunday, March 18 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B/C

Speaker 2 of 2
Gerard I. Evan, University of Cambridge, UK
Oncogenes and Tumor Suppressors: The Good, the Bad, and the Ugly

Monday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
Room: Ballroom B

Speaker 1 of 5
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in vivo

Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
Room: Ballroom B

Speaker 2 of 5
Andrew Koff, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: An Oncogenic Role for the Cdk Inhibitor p21Waf1/Cip1 in Gliomagenesis

Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
Room: Ballroom B

Speaker 3 of 5
* Jacqueline A. Lees, Massachusetts Institute of Technology, USA
E2F Transcription Factors in Cancer Regulation

Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
Room: Ballroom B

Speaker 4 of 5
Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
The p53 Pathways in Tumor Suppression

Monday, March 19 | 8:00AM - 11:00AM
Cancer Pathways: Function and Mechanism
Room: Ballroom B

Speaker 5 of 5
Christopher J. Kemp, Fred Hutchinson Cancer Research Center, USA
Short Talk: Rescue of the Apoptosis Defect of p53 Null Cells by Mutation of Ku70, Ku80, or DNA-PKcs

Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 5
Jeffrey Settleman, Pfizer, USA
’Addiction’ to Oncogenic Kinases in Human Cancer


Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 5
Samuel A. Wells, Duke University, USA
Small Molecule Targeted Therapy with Vandetanib in Patients with Metastatic Hereditary Medullary Thyroid Carcinoma


Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 5
Paolo M. Comoglio, University of Torino Medical School, Italy
The MET Oncogene: Targeting Invasive Growth in Cancer and Stem Cells


Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 4 of 5
Poul H. B. Sorensen, University of British Columbia, Canada
Short Talk: The ETV6-NTRK3 Oncogenic Tyrosine Kinase Directly Activates the Insulin-Like Growth Factor 1 Receptor (IGF-IR): Implications for Targeting IGF-IR in Human Tumors


Monday, March 19 | 8:00AM - 11:00AM
Receptor Tyrosine Kinases
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 5 of 5
John Hood, Wintherix, LLC, USA
Short Talk: TG101348, a Potent, Highly Selective JAK2 Inhibitor, Inhibits Colony Formation in Stem Cells from Polycythemia Vera Patients in Vitro & Prevents JAK2V617F-Mediated Splenomegaly and Death in an in Vivo Mouse Model


Monday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, March 19 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom C/Foyer


Monday, March 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom C/Foyer


Monday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
Room: Ballroom B

Speaker 1 of 5
* Gerard I. Evan, University of Cambridge, UK

Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
Room: Ballroom B

Speaker 2 of 5
Nancy A. Jenkins, Institute of Molecular and Cell Biology, Singapore
Insertional Mutagenesis Provides a Road Map for Characterizing the Cancer Genome

Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
Room: Ballroom B

Speaker 3 of 5
Lynda Chin, University of Texas MD Anderson Cancer Center, USA
Oncogenomic analyses of mouse and human tumors

Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
Room: Ballroom B

Speaker 4 of 5
Lara Shayne Collier, University of Minnesota, USA
Short Talk: Cancer Gene Discovery using the Sleeping Beauty Transposon System

Monday, March 19 | 5:00PM - 7:00PM
Cancer Pathways: Discovery Strategies
Room: Ballroom B

Speaker 5 of 5
Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Cancer

Monday, March 19 | 5:00PM - 7:00PM
PI3K/AKT/mTOR Pathway
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 3
Robert T. Abraham, Vividion Therapeutics, USA
The mTOR Signaling Pathway: Linking Basic Biology to Cancer Therapy


Monday, March 19 | 5:00PM - 7:00PM
PI3K/AKT/mTOR Pathway
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 3
David J. Matthews, Exelixis Inc., USA
Targeting Aberrant PI-3 Kinase Signaling in Cancer


Monday, March 19 | 5:00PM - 7:00PM
PI3K/AKT/mTOR Pathway
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 3
William A. Weiss, University of California, San Francisco, USA
Cooperative Inhibition of EGFR, PI3K alpha, and mTOR in PTEN-Mutant Glioma


Monday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Monday, March 19 | 7:30PM - 10:00PM
Poster Session 1
Room: Ballroom C/Foyer


Tuesday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 1 of 7
* Joanna L. Groden, Ohio State University, USA
Chromosome Instability and Cancer

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 2 of 7
Catherine T. Yan, CBR Institute for Biomedical Research, USA
NHEJ and the Double-Strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 3 of 7
Erik S. Knudsen, UT Southwestern, USA
Short Talk: RB Loss Promotes Liver Tumorigenesis by Compromising Genome Integrity

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 4 of 7
Alan Ashworth, University of California, San Francisco, USA
Exploiting DNA Repair Defects in Tumors as a Therapeutic Strategy

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 5 of 7
Steven E. Artandi, Stanford University, USA
Short Talk: Regulation of Tissue Stem Cells by TERT

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 6 of 7
Sandy Chang, University of Texas MD Anderson Cancer Center, USA
Telomer End Protection in Senescence and Cancer

Tuesday, March 20 | 8:00AM - 11:00AM
Genetic Instability and Cancer Evolution
Room: Ballroom B

Speaker 7 of 7
Philipp Kaldis, Institute of Molecular and Cell Biology, Singapore
Short Talk: Mouse Models to Investigate Cell Cycle and DNA Damage

Tuesday, March 20 | 8:00AM - 10:20AM
Ras/Raf/MAPK Pathway
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 3
Julian H. Downward, Cancer Research UK, UK
Ras Oncogene Signaling Networks


Tuesday, March 20 | 8:00AM - 10:20AM
Ras/Raf/MAPK Pathway
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 3
Patrick J. Casey, Duke University Medical Center, USA
Targeting Proliferation and Survival Pathways with Isoprenylcysteine Carboxymethyltransferase Inhibitors


Tuesday, March 20 | 8:00AM - 10:20AM
Ras/Raf/MAPK Pathway
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 3
Judith Sebolt-Leopold, USA
Development of MEK Inhibitors – A Selective Approach to Targeting the Ras–MAP Kinase Pathway


Tuesday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 20 | 10:20AM - 11:00AM
BCR-ABL and Lympholeukemia
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 1
Charles J. Sherr, St. Jude Children's Research Hospital, USA
Combating Non-Tumor-Cell-Autonomous Imatinib Resistance in Ph+ ALL


Tuesday, March 20 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom C/Foyer


Tuesday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom C/Foyer


Tuesday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
Room: Ballroom B

Speaker 1 of 5
Martin McMahon, University of Utah School of Medicine, USA
Tumorigenesis and Senescence Induction by Oncogenic BRafv600E in vivo

Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
Room: Ballroom B

Speaker 2 of 5
Tavanna Buske, USA
Short Talk: A Hypomorphic Mutation in DNA Replication Gene Mcm4 Confers Mammary Specific Tumorigenesis in Mice

Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
Room: Ballroom B

Speaker 3 of 5
Andrew Xiao, Yale University, USA
Short Talk: The WSTF-SNF2H Complex Regulates the H2A.X DNA Damage Response

Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
Room: Ballroom B

Speaker 4 of 5
Al Charest, Tufts-NEMC, Massachusetts Institute of Technology, USA
Short Talk: Therapeutic Applicability of Nanoparticle-Mediated Delivery of siRNA in a Mouse Model of Glioblastoma Multiforme

Tuesday, March 20 | 5:00PM - 7:00PM
Regulation and Cancer Evolution
Room: Ballroom B

Speaker 5 of 5
* Hong Wu, UCLA/IMED c/o Cyndi Haddad, USA
PTEN, Stem Cells and Tumorigenesis

Tuesday, March 20 | 5:00PM - 7:00PM
Protein Folding/Ubiquitination
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 3
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Development of HSP90 Inhibitors for Cancer


Tuesday, March 20 | 5:00PM - 7:00PM
Protein Folding/Ubiquitination
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 3
Michael Tyers, Canada
Pleonastic Phosphorylation, Substrate Recognition and Higher Order Structure of the SCF Ubiquitin Ligase


Tuesday, March 20 | 5:00PM - 7:00PM
Protein Folding/Ubiquitination
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 3
Mark K. Bennett, Calithera Biosciences, USA
Development of Epoxyketone-based Proteasome Inhibitors


Tuesday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Tuesday, March 20 | 7:30PM - 10:00PM
Poster Session 2
Room: Ballroom C/Foyer


Wednesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
Room: Ballroom B

Speaker 1 of 6
Kwok-Kin Wong, Dana-Farber Cancer Institute, USA
The Use of Mouse Lung Cancer Models for Preclinical Testing of Novel Targeted Therapeutics

Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
Room: Ballroom B

Speaker 2 of 6
Ross A. Dickins, Monash University, Australia
Short Talk: Tissue-Specific and Reversible RNAi in Transgenic Mice

Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
Room: Ballroom B

Speaker 3 of 6
Samir Hanash, Fred Hutchinson Cancer Research Center, USA
Cancer Biomarker Discovery Using Mouse Models

Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
Room: Ballroom B

Speaker 4 of 6
* Douglas Hanahan, ISREC, Switzerland
Assessing Mechanism-based Cancer Therapeutics in Engineered Mouse Models of Cancer: Targeting EGFR and mTOR

Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
Room: Ballroom B

Speaker 5 of 6
Trevor J. Hay, Cardiff University, UK
Short Talk: Regression of Brca2-/- p53-/- Mouse Mammary Tumours by PARP Inhibition

Wednesday, March 21 | 8:00AM - 11:00AM
The Experimental Mouse in Preclinical Discovery
Room: Ballroom B

Speaker 6 of 6
Loren D. Walensky, Dana-Farber Cancer Institute, USA
Piloting “BH3 Replacement” Therapy in Murine Models of Deregulated Apoptosis

Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 4
Eli Keshet, Hebrew University, Israel
Lessons from Preclinical Models of VEGF-Dependent Angiogenesis


Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 4
Luisa Iruela-Arispe, University of California, Los Angeles, USA
Microenvironmental Signals and Angiogenesis


Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 4
Jacques Pouysségur, University of Nice, France
Hypoxia Signaling and Cancer - Targeting Angiogenesis and Tumor Metabolism


Wednesday, March 21 | 8:00AM - 11:00AM
Angiogenesis
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 4 of 4
Roy Bicknell, University of Birmingham, UK
Novel Anti-Cancer Targets in the Vasculature


Wednesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: Ballroom C/Foyer


Wednesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Ballroom C/Foyer


Wednesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
Room: Ballroom B

Speaker 1 of 4
* Anton J. M. Berns, Netherlands Cancer Institute, Netherlands

Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
Room: Ballroom B

Speaker 2 of 4
David W. Threadgill, University of North Carolina at Chapel Hill, USA
Complexities fo EGFR Signaling in Cancer

Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
Room: Ballroom B

Speaker 3 of 4
Martine F. Roussel, St. Jude Children's Research Hospital, USA
Molecular Determinations of Medulloblastoma

Wednesday, March 21 | 5:00PM - 7:00PM
The Mouse in Translation: Highlight on Challenges
Room: Ballroom B

Speaker 4 of 4
Elaine V. Fuchs, Rockefeller University, USA
Mouse Models of Cancer through Default of Focusing on Skin Morphogenesis

Wednesday, March 21 | 5:00PM - 7:00PM
Stem Cell Pathways
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 3
Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Modeling Human Cancer in the Mouse to Identify Relevant Pathways for Transformation or Progression


Wednesday, March 21 | 5:00PM - 7:00PM
Stem Cell Pathways
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 3
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Gamma Secretase Inhibitors and Notch


Wednesday, March 21 | 5:00PM - 7:00PM
Stem Cell Pathways
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 3
Frederic J. de Sauvage, Genentech, Inc., USA
Hedgehog Pathway and Cancer


Wednesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Wednesday, March 21 | 7:30PM - 10:00PM
Poster Session 3
Room: Ballroom C/Foyer


Thursday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Ballroom C/Foyer


Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
Room: Ballroom B

Speaker 1 of 6
Robert Benezra, Memorial Sloan-Kettering Cancer Center, USA
The Role of Id Proteins in Tumor Angiogenesis

Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
Room: Ballroom B

Speaker 2 of 6
Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Short Talk: Systemic Instigation of Indolent Tumor Growth by Distant Primary Tumors via Activation of Sca1+ Bone Marrow Cells

Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
Room: Ballroom B

Speaker 3 of 6
* Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation, Humoral Immunity and Epithelial Cancer Development

Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
Room: Ballroom B

Speaker 4 of 6
Harold L. Moses, Vanderbilt University, USA
Stromal and Epithelial TGF-beta Signaling in Carcinoma Initiation and Progression

Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
Room: Ballroom B

Speaker 5 of 6
Victor D. Acevedo, Memorial Sloan Kettering, USA
Short Talk: Conditional Activation of FGF Receptor-1 Leads to an Irreversible Prostate Adenocarcinoma and Allows for an Epithelial to Mesenchymal Transition

Thursday, March 22 | 8:00AM - 11:00AM
Cancer Microenvironment
Room: Ballroom B

Speaker 6 of 6
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
TGFbeta Signaling: From Cytostasis to Metastasis

Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 4
Michael Stratton, Wellcome Trust Sanger Institute, UK
Patterns of Somatic Mutation in Human Cancer Genomes


Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 4
Matthias Mann, Max Planck Institute of Biochemistry, Germany
Global, Site Specific and Quantitative Phosphoproteomics for Drug Discovery


Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 4
Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
Protein Microarrays


Thursday, March 22 | 8:00AM - 11:00AM
New Technologies for Target Discovery
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 4 of 4
Roderick L. Beijersbergen, Netherlands Cancer Institute, Netherlands
Identification of Novel Drug Targets through Loss of Function Genetic Screens


Thursday, March 22 | 9:00AM - 12:00PM
Entertainment
Room: Ballroom C


Thursday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
Room: Ballroom B

Speaker 1 of 4
* Jeffrey M. Rosen, Baylor College of Medicine, USA
Stem/Progenitor Cells in the Etiology and Treatment of Breast Cancer

Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
Room: Ballroom B

Speaker 2 of 4
Emmanuelle Passegué, Columbia University, USA
Cancer Stem Cells and Development of Blood Cancers

Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
Room: Ballroom B

Speaker 3 of 4
Robert I. Glazer, Georgetown University, USA
Short Talk: Peroxisome Proliferator-Activated Receptor-gamma is a Regulator of Mammary Stem and Progenitor Cell Self-Renewal and Estrogen-Dependent Tumor Specification

Thursday, March 22 | 5:00PM - 7:00PM
Stem Cells and Cancer Stem Cells: The Beginning at the End
Room: Ballroom B

Speaker 4 of 4
Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development

Thursday, March 22 | 5:00PM - 7:00PM
Modulating Gene Expression
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 1 of 3
Kapil N. Bhalla, MD Anderson Cancer Center, USA
HDACs as Therapeutic Targets


Thursday, March 22 | 5:00PM - 7:00PM
Modulating Gene Expression
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 2 of 3
Todd R. Golub, Broad Institute, USA
Modulating Gene Expression Signatures with Small Molecules


Thursday, March 22 | 5:00PM - 7:00PM
Modulating Gene Expression
This session is from Molecular Targets for Cancer
Room: Ballroom A

Speaker 3 of 3
Robert J. Klose, University of Oxford, UK
Histone Demethylases as Potential Therapeutic Targets in Cancer


Thursday, March 22 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Ballroom C/Foyer


Thursday, March 22 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom C


Friday, March 23 | 10:26AM - 10:26AM
Departure


*Session Chair.