Web Desc
HIV Vaccines: From Basic Research to Clinical Trials
joint with Molecular and Cellular Determinants of HIV Pathogenesis
Organizer(s): Dennis R. Burton, Alexandra Trkola and David I. Watkins
Date: March 25 - 30, 2007
Location: Whistler Conference Centre, Whistler, BC, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation; Sponsored by Wyeth Vaccines Research
Summary of Meeting:
The development of a successful vaccine against HIV-1 faces enormous hurdles. The generation of immunogens able to elicit broadly-reactive neutralizing antibodies in humans remains elusive. The mechanisms responsible for the strong protection seen in macaques vaccinated with attenuated viruses are unknown. Furthermore, we do not fully understand why this virus persists or how some individuals control virus. The nature of transmitted viruses is still unclear. The meeting will focus on recent advances in the understanding of the interplay between the virus and the immune system that are of particular relevance for vaccine design. Leading experts in the field will provide us with insight into key findings in the area of cellular and humoral immunity to HIV, the design of novel immunogens and the mechanism of live attenuated vaccine protection. A strong emphasis of the meeting will also be on recent progress in human vaccine trials.
Global Health Travel Award Deadline: November 27 2006
Scholarship Deadline: November 27 2006
Discounted Abstract Deadline: November 27 2006
Abstract Deadline: December 27 2006
Discounted Registration Deadline: January 25 2007
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates Foundation
GenVec, Inc.
International AIDS Vaccine Initiative (IAVI)Office of AIDS Research, NIHWyeth Vaccines Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5 R13 AI068371-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 25 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, March 25 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Sunday, March 25 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B/C

Speaker 1 of 2
Richard A. Koup, NIAID, National Institutes of Health, USA
Immunopathogenesis of HIV Infection

Sunday, March 25 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B/C

Speaker 2 of 2
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Gained in Translation: Defective Ribosomal Products (DRiPs) as a Principal Source of MHC Class I Peptide Ligands

Monday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 1 of 7
* Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 2 of 7
Dorothy A. Mbori-Ngacha, University of Nairobi School of Medicine, Kenya
Mother-to-Child Transmission: From Research Policy to Implementation

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 3 of 7
Douglas D. Richman, University of California, San Diego, USA
HIV Transmission

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 4 of 7
Cynthia A. Derdeyn, Emory University, USA
Immune Escape in Early Subtype C Infection

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 5 of 7
Yang Liu, Monogram Biosciences, USA
Short Talk: Neutralization and Envelope Sequence Characteristics of a Subtype B HIV-1 Sexual Transmission Cluster: One Source and Four Recipients

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 6 of 7
Guido Silvestri, Emory University School of Medicine, USA
Understanding the Benign Nature of SIV Infection in Natural Hosts

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 7 of 7
Fran Van Heuverswyn, Institute of Research for Development (IRD), France
Short Talk: SIV Infection in Wild Gorillas and Chimpanzees in Cameroon

Monday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Monday, March 26 | 11:15AM - 1:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Monday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Foyer/Mountain View/Ballroom A


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 9
* Thomas J. Hope, Northwestern University, USA


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 9
Éric A. Cohen, Institut de Recherches Cliniques de Montréal, Canada
Productive HIV-1 Assembly Takes Place at the Plasma Membrane


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 9
Stuart G. Turville, WMI, University of Sydney, Australia
Dynamic Visualization of HIV-1 Intracellular Production, Assembly and Polarized Budding in Immature Dendritic Cells.


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 9
Olivier Schwartz, Institut Pasteur, France
Lymphocyte Activation, HIV Cell-to-Cell Spread and Virological Synapse Formation


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 9
Dmitri Ivanov, University of Texas Health Science Center, USA
Domain-Swapped Dimerization of the HIV Capsid C-Terminal Domain.


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 9
Sonia Jiménez-Baranda, National Center of Biotechnology, Spain
Filamin A (ABP280) Coordinates Actin Cytoskeleton Remodeling Required for HIV-1 Infection


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 7 of 9
Michael J. Root, Thomas Jefferson University, USA
Asymmetry in HIV-1 Inactivation Following Inhibitor Binding to gp41


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 8 of 9
Yuanfei Wu, Yale University School of Medicine, USA
Vpx Ubiquitination Modulates SIV Replication in Macrophages


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 9 of 9
Shari M. Kaiser, Institute for Systems Biology, USA
Human Trim5alpha Restriction of an Extinct Retrovirus


Monday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 4
Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Evolutionary Studies of Intrinsic Immunity against Retroviruses in Primate Genomes


Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 4
Mary Carrington, NCI, National Institutes of Health, USA
The Impact of Variation at the HLA and KIR Gene Clusters on HIV Disease


Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 4
* Steven Wolinsky, Northwestern University, USA
Viral Genetic Diversity and Adaptation


Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 4
John P. Moore, Weill Medical College of Cornell University, USA
Small Molecule CCR5 Inhibitor Resistant Viruses Use CCR5 Inhibitor Complex as an Entry Coreceptor


Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
Room: Ballroom B

Speaker 1 of 4
* Ronald C. Desrosiers, University of Miami Miller School of Medicine, USA
Use of gamma-2 Herpesviruses as Vaccine Viruses for AIDS

Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
Room: Ballroom B

Speaker 2 of 4
Louis J. Picker, Oregon Health & Science University, USA
The Cellular Immune Response in Macaques Infected with Attenuated SIV

Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
Room: Ballroom B

Speaker 3 of 4
Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Insights into Control of Pathogenic Viral Replication by Pharmacological Modulation of Virus/Host Balance in Primary SIV Infection?

Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
Room: Ballroom B

Speaker 4 of 4
Marjorie Robert-Guroff, NCI, National Institutes of Health, USA
Prime/Boost HIV Vaccine Strategies Based on Replication Competent Adenovirus Recombinants

Monday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Monday, March 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
Room: Ballroom B

Speaker 1 of 5
* David I. Watkins, University of Miami, USA
Vaccine-Induced Cellular Immune Responses in Monkeys


Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
Room: Ballroom B

Speaker 2 of 5
Philip J. Goulder, University of Oxford, UK
CD8 T-Cell-Mediated Control of the C Clade HIV Epidemic in Sub-Saharan Africa

Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
Room: Ballroom B

Speaker 3 of 5
Otto O. Yang, University of California, Los Angeles, USA
Interactions of Nef and CTL

Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
Room: Ballroom B

Speaker 4 of 5
John R. Mascola, NIAID, National Institutes of Health, USA
Epitope Specific Neutralizing Antibody Responses

Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
Room: Ballroom B

Speaker 5 of 5
Galit Alter, MIT and Harvard University, USA
Short Talk: Significant Inhibition of HIV-1 Replication by KIR3DS1+ NK Cells Derived From KIR3DS1+/HLA-Bw480I+ Individuals

Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 6
* Robert W. Doms, University of Pennsylvania School of Medicine, USA


Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 6
James J. Champoux, University of Washington, USA
Reverse Transcription: Displacement Synthesis, RNase H, and Recombination


Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 6
John V. Moran, University of Michigan Medical School, USA
Genetic and Biochemical Studies of LINE-1 Retrotransposition


Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 6
Eric Poeschla, University of Colorado School of Medicine, USA
Short Talk: LEDGF/p75: Testing the HIV Integration Cofactor Role in Multiple T Cell Lines and Primary Macrophages


Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 6
Katherine A. Jones, The Salk Institute, USA
HIV Tat and Transcription


Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 6
Paul D. Bieniasz, Rockefeller University, USA
Host Restriction of Retrovirus Replication


Tuesday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, March 27 | 11:00AM - 1:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 1 of 10
Gilad A. Ofek, National Institutes of Health, USA
Epitope-Scaffold Immunogens: Design, Characterization, and Molecular Mimicry of the 2F5 Epitope

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 2 of 10
Jean-Philippe Julien, Hospital for Sick Children Research Institute, Canada
Structural Insights into the Mechanism of Neutralization of the nmAb 2F5 Against HIV-1: Conformations of the 2F5 CDR3 Extended Loop and Residues Located at the C-Terminus of the DKW Core

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 3 of 10
Michael B. Zwick, The Scripps Research Institute, USA
Antibodies Against the N-heptad Repeat Hydrophobic Pocket Region of gp41 are Elicited During Natural Infection and by Immunization But Sterics Can Restrict Neutralization of Primary HIV-1

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 4 of 10
Marinieve Montero, CFRI/University of British Columbia, Canada
Immunogenicity of the Membrane Proximal External Region of HIV-1 gp41 in the Context of the Cell Surface

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 5 of 10
Sylvain Fleury, Mymetics Corporation, Switzerland
Without Mucosal Adjuvant, Virosomes-gp41 Peptides from the MPR can Elicit Protective Mucosal IgA in Vaccinated Macaques.

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 6 of 10
Carl R. Alving, Walter Reed Army Institute of Research, USA
Neutralizing Effects on HIV-1 of Murine and Human Monoclonal Antibodies That Bind to Phosphatidylinositol-4-phosphate

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 7 of 10
* Jamie K. Scott, Simon Fraser University, Canada
Reactivity Profiles of HIV-1-Neutralizing MAbs, 2F5 and 4E10, and the Anti-Cardiolipin MAb, CL15

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 8 of 10
Xiaoying Shen, Duke University Medical Center, USA
Analysis of a Rare HIV Envelope Sequence that is Highly Sensitive to Broadly Neutralizing Antibodies 2F5 and 4E10

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 9 of 10
Christopher J. Richards, National Cancer Institute, National Institutes of Health, USA
Activity of an Affordable Fusion Inhibiting Peptide

Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
Room: Ballroom B

Speaker 10 of 10
* Carol D. Weiss, US Food and Drug Administration, USA
Novel Mechanism of Resistance to HIV-1 Peptide Fusion Inhibitors

Tuesday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
Room: Ballroom B

Speaker 1 of 4
* Douglas D. Richman, University of California, San Diego, USA

Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
Room: Ballroom B

Speaker 2 of 4
Barton F. Haynes, Duke University Medical Center, USA
Update On CHAVI B Cell and Transmitted Virus Discovery Programs

Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
Room: Ballroom B

Speaker 3 of 4
Wayne C. Koff, Human Vaccines Project, USA
IAVI R&D Program Update: Fostering Innovation in AIDS Vaccine Discovery and Development

Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
Room: Ballroom B

Speaker 4 of 4
Gary J. Nabel, Sanofi, USA
Pushing the Envelope of HIV Vaccines: From Basic Research to Clinical Trials

Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 5
* Paul D. Bieniasz, Rockefeller University, USA


Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 5
Greg J. Towers, University College London, UK
TRIMs, Cyclophilins and Restriction of Retroviral Infection


Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 5
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
New Perspectives on APOBEC3G Biology


Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 5
Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Repression Insights into the Mechanisms of Action of Intrinsic Immune Antivirals


Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 5
Max W. Richardson, University of Pennsylvania, USA
Short Talk: Mode of Transmission Affects Sensitivity of HIV-1 to rTRIM5alpha Restriction


Tuesday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 1 of 6
* Dennis R. Burton, The Scripps Research Institute, USA

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 2 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
A Structural Approach to Vaccine Design

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 3 of 6
Stephen C. Harrison, Harvard Medical School, USA
HIV and SIV Env Glycoproteins

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 4 of 6
Ian A. Wilson, The Scripps Research Institute, USA
HIV Neutralizing Antibody Structures

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 5 of 6
Wesley I. Sundquist, University of Utah School of Medicine, USA
Mechansims of HIV Budding

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 6 of 6
Harold C. Smith, University of Rochester, USA
Short Talk: Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits

Wednesday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 10
* Richard A. Koup, NIAID, National Institutes of Health, USA


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 10
Anna Duda, University of Oxford, UK
A Cohort Study of HIV Adaptation and Reversion in the First Three Years After Transmission to New Hosts


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 10
Joe Casazza, NIAID, National Institutes of Health, USA
Evidence of a Protective Role for Cytokine/Chemokine Production in HIV Infection


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 10
Daniel E. Kaufmann, University of Montreal, Canada
CTLA-4 upregulation in HIV-specific CD4 T cells correlates with disease progression and defines a reversible immune dysfunction


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 10
Beda Brichacek, National Cancer Institute, USA
The Effect of TLR Ligands on HIV-1 Replication in Human Lymphoid Tissue ex vivo: A Potential Mechanism of Co-Pathogenesis


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 10
Richard T. Lester, University of Manitoba and University of British Columbia, Canada
Elevated Toll-like Receptor (TLR) Expression and Altered Cytokine Responses to TLR Ligands in Peripheral Blood Leukocytes of HIV-1 Positive Patients.


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 7 of 10
Judith N. Mandl, National Institutes of Health, USA
Investigating the Role of TLR7&9 Stimulation in Chronic Immune Activation during SIV Infection of Rhesus Macaques


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 8 of 10
Nichole R. Klatt, University of Miami, USA
The Main Determinant of Set-Point Viremia During Natural SIV Infection of Sooty Mangabeys is the Number of Activated CD4+ T Cells


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 9 of 10
Meritxell Genescà, Health Sciences Research Institute Germans Trias i Pujol Foundation, Spain
Live-Attenuated Lentivirus Immunization Mediated Protection of Rhesus Macaques From Intravaginal SIV Challenge is Associated With Survival and Polyfunctional Capacity of SIV-Specific CD8+ T Cell


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 10 of 10
Donald L. Sodora, Center for Infectious Disease Research, USA
Gamma/Delta T Cell Function is Impaired During HIV-Infection but Not During Nonpathogenic SIV-Infection of Sooty Mangabeys


Wednesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
Room: Ballroom B

Speaker 1 of 4
Kasper Hoebe, The Scripps Research Institute, USA
The Innate-Adaptive Connection: TLRs and Beyond

Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
Room: Ballroom B

Speaker 2 of 4
Annette Oxenius, Institute for Microbiology, ETH Zürich, Switzerland
CD8+ T Cell Dysfunction during Chronic Viral Infections

Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
Room: Ballroom B

Speaker 3 of 4
Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
HIV-1 gp120 Structure-based Immunogen Design

Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
Room: Ballroom B

Speaker 4 of 4
David Price, Cardiff University School of Medicine, UK
Short Talk: Evolution of Cytomegalovirus-Specific CD4+ T Cell Clonotypes in vivo: Vaccine Design Informed by Successful Immune Responses

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 5
* Charles R.M. Bangham, Imperial College Department of Medicine, UK


Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 5
Anthony L. Cunningham, Westmead Institute for Medical Research, Australia
Modulation of Dendritic Cell Function by HIV: Implications for Initial Infection and Pathogenesis


Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 5
Thomas J. Hope, Northwestern University, USA
Mechanism of Restriction Mediated by TRIM5 alpha


Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 5
Paul W. Spearman, Emory University, USA
Cellular Trafficking Pathways and the Role of Vpu in Retrovirus Assembly


Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 5
Juan Martin-Serrano, King's College London School of Medicine, UK
Short Talk: Interaction of Tsg101 With Components of the Cytokinesis Machinery and Role in Viral Budding


Wednesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 1 of 5
Alan N. Engelman, Dana-Farber Cancer Institute, USA
Host Factors and HIV-1 Integration

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 2 of 5
Charles R.M. Bangham, Imperial College Department of Medicine, UK
Efficiency of the Anti-Viral CTL Response: HTLV-1

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 3 of 5
Alexandra Trkola, University of Zürich, Switzerland
Prospects of Humoral Immunity to HIV-1

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 4 of 5
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Elite Control of HIV: Implications for Vaccine Design

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 5 of 5
Jason M. Brenchley, NIAID, National Institutes of Health, USA
Short Talk: Microbial Translocation is a Cause of Systemic Immune Activation in Chronic HIV Infection

Thursday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 29 | 11:00AM - 12:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 11:00AM - 12:00PM
Lunch
Room: Grand Foyer/Mountain View/Sky Ballroom A


Thursday, March 29 | 12:00PM - 4:30PM
Poster Session 4
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 1 of 12
* Marcus Altfeld, Heinrich-Pette-Institute, Germany

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 2 of 12
* Otto O. Yang, University of California, Los Angeles, USA

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 3 of 12
Tedi E. Asher, NIAID, National Institutes of Health, USA
Clonal Correlates of Vaccine-Induced Immune Protection Against SIV in Rhesus Macaques

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 4 of 12
Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
Intracellular Epitope Stability is Defined by Specific Residues and Correlates With HIV Epitope Hierarchy

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 5 of 12
Emma L. Turnbull, Jenner Institute, University of Oxford, UK
Mutational Escape, Rather than Reduced Avidity of Epitope-Specific T Cell Responses, may be More Relevant for Impairment of the HIV-Specific CD8+ T Cell Response During Early HIV-1 Infection

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 6 of 12
Jonah B. Sacha, Oregon Health & Science University, USA
Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 7 of 12
Hendrik Streeck, Military HIV Research Program, USA
Immunodomination by HLA-B27/-B57 Results in a Substantial Abrogation of Alternate HLA-Restricted HIV-Specific Responses in Primary HIV-1 Infection

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 8 of 12
Hayley Crawford, Oxford University, UK
Compensatory Mutation Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic HIV Infection

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 9 of 12
Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA
Preferential Targeting of HIV-Gag Epitopes in Elite Controllers

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 10 of 12
Hanneke Schuitemaker, Janssen Vaccines & Prevention B.V., Netherlands
Differential Clinical Course in HLA B57+ Long-Term Nonprogressors and Progressors Does not Relate to Frequencies of Gag Specific Cytotoxic T Lymphocytes or Sequence Dynamics in Gag CTL Epitopes but to HIV-1 Replicative Capacity

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 11 of 12
Stephen A. Migueles, NIAID, National Institutes of Health, USA
Diminished Proliferative Capacity of HIV-Specific CD8+ T Cells is not Restored by Antiretroviral Therapy or Exogenous IL-2

Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
Room: Ballroom B

Speaker 12 of 12
Teresa Lea Mattila, University of Minnesota, USA
In Situ Analysis of Virus-Specific CD8+ T Cells

Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
Room: Ballroom B

Speaker 1 of 6
* Ian A. Wilson, The Scripps Research Institute, USA

Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
Room: Ballroom B

Speaker 2 of 6
Hiroyuki Yamamoto, Institute of Medical Science, The University of Tokyo, Japan
SIV Control by Post-Infection Passive Immunization of Neutralizing Antibodies

Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
Room: Ballroom B

Speaker 3 of 6
Ping Zhu, Florida State University, USA
3D HIV-1 Envelope Spike Model as Revealed by Cryoelectron Tomography

Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
Room: Ballroom B

Speaker 4 of 6
Giulia Zanetti, Wellcome Trust Centre, University of Oxford, UK
Cryo-Electron Tomography of SIV Envelope Complex in situ

Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
Room: Ballroom B

Speaker 5 of 6
Sriram Subramaniam, University of British Columbia, Canada
Electron Tomography of Immunodeficiency Viruses and Structural Mechanisms of Cellular Entry

Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
Room: Ballroom B

Speaker 6 of 6
Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Increasing HIV-1 Env Immunogenicity by Modulation of Intrinsic and Extrinsic Factors

Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 1 of 6
* Michael H. Malim, King's College London, UK


Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 2 of 6
Daniel R. Kuritzkes, Brigham and Women's Hospital, Harvard Medical School, USA
Drug Resistance and Viral Fitness in HIV-1


Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 3 of 6
David Heckerman, Human Longevity, Inc., USA
Short Talk: Estimate of the Proportion of Within-Host Sequence Evolution in HIV-1 Mediated by Human Leukocyte Antigen (HLA) Class I Selective Pressures


Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 4 of 6
Celia C. LaBranche, Global Vaccines, Inc., USA
Development of CCR5 Antagonists as HIV Antiviral Drugs


Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 5 of 6
Laura A. Napolitano, Gladstone Institute of Virology and Immunology, USA
Short Talk: Growth Hormone Therapy Enhances Thymic Function in HIV-infected Adults: A Randomized Prospective Analysis


Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
This session is from HIV Pathogenesis
Room: Ballroom C

Speaker 6 of 6
Yonchu Jenkins, Rigel Pharmaceuticals, Inc., USA
Short Talk: Identification of Novel Antiretroviral Compounds by Targeting HIV Vif Function


Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 8:00PM - 11:00PM
Entertainment
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 8:00PM - 11:00PM
Cash Bar
Room: Grand Foyer/Mountain View/Ballroom A


Friday, March 30 | 10:26AM - 10:26AM
Departure


*Session Chair.