Web Desc
Molecular and Cellular Determinants of HIV Pathogenesis
joint with HIV Vaccines: From Basic Research to Clinical Trials
Organizer(s): Michael H. Malim, Julie M. Overbaugh and Robert W. Doms
Date: March 25 - 30, 2007
Location: Whistler Conference Centre, Whistler, BC, Canada
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
Recent research has highlighted the dynamic nature of the ongoing conflict between HIV and its infected host; if left untreated, this is a battle that is almost always won by the virus. Much progress has been made in understanding critical host-pathogen interactions at the molecular and cellular levels. For instance, viral and cellular determinants of transmission have been defined, new mechanisms of innate anti-HIV resistance discovered, key differences between pathogenic and non-pathogenic HIV/SIV infections identified, immunopathogenic consequences of HIV infection elucidated and three-dimensional structures of critical cellular and viral proteins (and RNAs) deduced. Major future challenges for HIV/AIDS researchers include not only incorporating this information into models of HIV pathogenesis, but also defining logical new therapeutic targets and providing rational perspectives to vaccine design. By bringing together international leaders in research, new and exciting findings in these areas will be discussed, emerging concepts debated and new paradigms established. Finally, by including “abstract-driven workshops” in our program, less-senior investigators and trainees will get the opportunity to showcase their talents and contribute to the appeal and success of the meeting.
Global Health Travel Award Deadline: November 27 2006
Scholarship Deadline: November 27 2006
Discounted Abstract Deadline: November 27 2006
Abstract Deadline: December 27 2006
Discounted Registration Deadline: January 25 2007
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBoehringer Ingelheim (Canada) Ltd.Gilead Sciences, Inc.Office of AIDS Research, NIH
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5 R13 AI068352-02
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 25 | 3:00PM - 7:30PM
Registration
Room: Grand Foyer


Sunday, March 25 | 6:30PM - 7:30PM
Refreshments
Room: Grand Foyer


Sunday, March 25 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B/C

Speaker 1 of 2
Richard A. Koup, NIAID, National Institutes of Health, USA
Immunopathogenesis of HIV Infection

Sunday, March 25 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Ballroom B/C

Speaker 2 of 2
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Gained in Translation: Defective Ribosomal Products (DRiPs) as a Principal Source of MHC Class I Peptide Ligands

Monday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 1 of 7
* Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 2 of 7
Dorothy A. Mbori-Ngacha, University of Nairobi School of Medicine, Kenya
Mother-to-Child Transmission: From Research Policy to Implementation

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 3 of 7
Douglas D. Richman, University of California, San Diego, USA
HIV Transmission

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 4 of 7
Cynthia A. Derdeyn, Emory University, USA
Immune Escape in Early Subtype C Infection

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 5 of 7
Yang Liu, Monogram Biosciences, USA
Short Talk: Neutralization and Envelope Sequence Characteristics of a Subtype B HIV-1 Sexual Transmission Cluster: One Source and Four Recipients

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 6 of 7
Guido Silvestri, Emory University School of Medicine, USA
Understanding the Benign Nature of SIV Infection in Natural Hosts

Monday, March 26 | 8:00AM - 11:15AM
Transmission and New Infection (Joint)
Room: Ballroom B/C

Speaker 7 of 7
Fran Van Heuverswyn, Institute of Research for Development (IRD), France
Short Talk: SIV Infection in Wild Gorillas and Chimpanzees in Cameroon

Monday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Monday, March 26 | 11:15AM - 1:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Monday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Foyer/Mountain View/Ballroom A


Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 1 of 9
* Thomas J. Hope, Northwestern University, USA

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 2 of 9
Éric A. Cohen, Institut de Recherches Cliniques de Montréal, Canada
Productive HIV-1 Assembly Takes Place at the Plasma Membrane

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 3 of 9
Stuart G. Turville, WMI, University of Sydney, Australia
Dynamic Visualization of HIV-1 Intracellular Production, Assembly and Polarized Budding in Immature Dendritic Cells.

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 4 of 9
Olivier Schwartz, Institut Pasteur, France
Lymphocyte Activation, HIV Cell-to-Cell Spread and Virological Synapse Formation

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 5 of 9
Dmitri Ivanov, University of Texas Health Science Center, USA
Domain-Swapped Dimerization of the HIV Capsid C-Terminal Domain.

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 6 of 9
Sonia Jiménez-Baranda, National Center of Biotechnology, Spain
Filamin A (ABP280) Coordinates Actin Cytoskeleton Remodeling Required for HIV-1 Infection

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 7 of 9
Michael J. Root, Thomas Jefferson University, USA
Asymmetry in HIV-1 Inactivation Following Inhibitor Binding to gp41

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 8 of 9
Yuanfei Wu, Yale University School of Medicine, USA
Vpx Ubiquitination Modulates SIV Replication in Macrophages

Monday, March 26 | 2:00PM - 4:30PM
Workshop 1: Molecular Interactions and Virus Replication
Room: Ballroom C

Speaker 9 of 9
Shari M. Kaiser, Institute for Systems Biology, USA
Human Trim5alpha Restriction of an Extinct Retrovirus

Monday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
Room: Ballroom C

Speaker 1 of 4
Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Evolutionary Studies of Intrinsic Immunity against Retroviruses in Primate Genomes

Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
Room: Ballroom C

Speaker 2 of 4
Mary Carrington, NCI, National Institutes of Health, USA
The Impact of Variation at the HLA and KIR Gene Clusters on HIV Disease

Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
Room: Ballroom C

Speaker 3 of 4
* Steven Wolinsky, Northwestern University, USA
Viral Genetic Diversity and Adaptation

Monday, March 26 | 5:00PM - 7:15PM
Host and Viral Genetics
Room: Ballroom C

Speaker 4 of 4
John P. Moore, Weill Medical College of Cornell University, USA
Small Molecule CCR5 Inhibitor Resistant Viruses Use CCR5 Inhibitor Complex as an Entry Coreceptor

Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 4
* Ronald C. Desrosiers, University of Miami Miller School of Medicine, USA
Use of gamma-2 Herpesviruses as Vaccine Viruses for AIDS


Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 4
Louis J. Picker, Oregon Health & Science University, USA
The Cellular Immune Response in Macaques Infected with Attenuated SIV


Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 4
Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Insights into Control of Pathogenic Viral Replication by Pharmacological Modulation of Virus/Host Balance in Primary SIV Infection?


Monday, March 26 | 5:00PM - 7:15PM
Live Attenuated Vaccines
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 4
Marjorie Robert-Guroff, NCI, National Institutes of Health, USA
Prime/Boost HIV Vaccine Strategies Based on Replication Competent Adenovirus Recombinants


Monday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Monday, March 26 | 7:30PM - 10:00PM
Poster Session 1
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
Room: Ballroom C

Speaker 1 of 6
* Robert W. Doms, University of Pennsylvania School of Medicine, USA

Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
Room: Ballroom C

Speaker 2 of 6
James J. Champoux, University of Washington, USA
Reverse Transcription: Displacement Synthesis, RNase H, and Recombination

Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
Room: Ballroom C

Speaker 3 of 6
John V. Moran, University of Michigan Medical School, USA
Genetic and Biochemical Studies of LINE-1 Retrotransposition

Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
Room: Ballroom C

Speaker 4 of 6
Eric Poeschla, University of Colorado School of Medicine, USA
Short Talk: LEDGF/p75: Testing the HIV Integration Cofactor Role in Multiple T Cell Lines and Primary Macrophages

Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
Room: Ballroom C

Speaker 5 of 6
Katherine A. Jones, The Salk Institute, USA
HIV Tat and Transcription

Tuesday, March 27 | 8:00AM - 11:00AM
Intracellular Events (Early and Late)
Room: Ballroom C

Speaker 6 of 6
Paul D. Bieniasz, Rockefeller University, USA
Host Restriction of Retrovirus Replication

Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 5
* David I. Watkins, University of Miami, USA
Vaccine-Induced Cellular Immune Responses in Monkeys


Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 5
Philip J. Goulder, University of Oxford, UK
CD8 T-Cell-Mediated Control of the C Clade HIV Epidemic in Sub-Saharan Africa


Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 5
Otto O. Yang, University of California, Los Angeles, USA
Interactions of Nef and CTL


Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 5
John R. Mascola, NIAID, National Institutes of Health, USA
Epitope Specific Neutralizing Antibody Responses


Tuesday, March 27 | 8:00AM - 11:00AM
Immune Responses and HIV Vaccine Development
This session is from HIV Vaccines
Room: Ballroom B

Speaker 5 of 5
Galit Alter, MIT and Harvard University, USA
Short Talk: Significant Inhibition of HIV-1 Replication by KIR3DS1+ NK Cells Derived From KIR3DS1+/HLA-Bw480I+ Individuals


Tuesday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, March 27 | 11:00AM - 1:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 10
Gilad A. Ofek, National Institutes of Health, USA
Epitope-Scaffold Immunogens: Design, Characterization, and Molecular Mimicry of the 2F5 Epitope


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 10
Jean-Philippe Julien, Hospital for Sick Children Research Institute, Canada
Structural Insights into the Mechanism of Neutralization of the nmAb 2F5 Against HIV-1: Conformations of the 2F5 CDR3 Extended Loop and Residues Located at the C-Terminus of the DKW Core


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 10
Michael B. Zwick, The Scripps Research Institute, USA
Antibodies Against the N-heptad Repeat Hydrophobic Pocket Region of gp41 are Elicited During Natural Infection and by Immunization But Sterics Can Restrict Neutralization of Primary HIV-1


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 10
Marinieve Montero, CFRI/University of British Columbia, Canada
Immunogenicity of the Membrane Proximal External Region of HIV-1 gp41 in the Context of the Cell Surface


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 5 of 10
Sylvain Fleury, Mymetics Corporation, Switzerland
Without Mucosal Adjuvant, Virosomes-gp41 Peptides from the MPR can Elicit Protective Mucosal IgA in Vaccinated Macaques.


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 6 of 10
Carl R. Alving, Walter Reed Army Institute of Research, USA
Neutralizing Effects on HIV-1 of Murine and Human Monoclonal Antibodies That Bind to Phosphatidylinositol-4-phosphate


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 7 of 10
* Jamie K. Scott, Simon Fraser University, Canada
Reactivity Profiles of HIV-1-Neutralizing MAbs, 2F5 and 4E10, and the Anti-Cardiolipin MAb, CL15


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 8 of 10
Xiaoying Shen, Duke University Medical Center, USA
Analysis of a Rare HIV Envelope Sequence that is Highly Sensitive to Broadly Neutralizing Antibodies 2F5 and 4E10


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 9 of 10
Christopher J. Richards, National Cancer Institute, National Institutes of Health, USA
Activity of an Affordable Fusion Inhibiting Peptide


Tuesday, March 27 | 2:00PM - 4:30PM
Workshop 2: gp41 as an HIV Vaccine Target
This session is from HIV Vaccines
Room: Ballroom B

Speaker 10 of 10
* Carol D. Weiss, US Food and Drug Administration, USA
Novel Mechanism of Resistance to HIV-1 Peptide Fusion Inhibitors


Tuesday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
Room: Ballroom C

Speaker 1 of 5
* Paul D. Bieniasz, Rockefeller University, USA

Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
Room: Ballroom C

Speaker 2 of 5
Greg J. Towers, University College London, UK
TRIMs, Cyclophilins and Restriction of Retroviral Infection

Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
Room: Ballroom C

Speaker 3 of 5
Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
New Perspectives on APOBEC3G Biology

Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
Room: Ballroom C

Speaker 4 of 5
Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Repression Insights into the Mechanisms of Action of Intrinsic Immune Antivirals

Tuesday, March 27 | 5:00PM - 7:00PM
Restriction Factors
Room: Ballroom C

Speaker 5 of 5
Max W. Richardson, University of Pennsylvania, USA
Short Talk: Mode of Transmission Affects Sensitivity of HIV-1 to rTRIM5alpha Restriction

Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 4
* Douglas D. Richman, University of California, San Diego, USA


Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 4
Barton F. Haynes, Duke University Medical Center, USA
Update On CHAVI B Cell and Transmitted Virus Discovery Programs


Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 4
Wayne C. Koff, Human Vaccines Project, USA
IAVI R&D Program Update: Fostering Innovation in AIDS Vaccine Discovery and Development


Tuesday, March 27 | 5:00PM - 7:00PM
HIV Vaccine Program Updates
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 4
Gary J. Nabel, Sanofi, USA
Pushing the Envelope of HIV Vaccines: From Basic Research to Clinical Trials


Tuesday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Tuesday, March 27 | 7:30PM - 10:00PM
Poster Session 2
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 1 of 6
* Dennis R. Burton, The Scripps Research Institute, USA

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 2 of 6
Peter D. Kwong, NIAID, National Institutes of Health, USA
A Structural Approach to Vaccine Design

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 3 of 6
Stephen C. Harrison, Harvard Medical School, USA
HIV and SIV Env Glycoproteins

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 4 of 6
Ian A. Wilson, The Scripps Research Institute, USA
HIV Neutralizing Antibody Structures

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 5 of 6
Wesley I. Sundquist, University of Utah School of Medicine, USA
Mechansims of HIV Budding

Wednesday, March 28 | 8:00AM - 11:00AM
Structures (Joint)
Room: Ballroom B/C

Speaker 6 of 6
Harold C. Smith, University of Rochester, USA
Short Talk: Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits

Wednesday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 1 of 10
* Richard A. Koup, NIAID, National Institutes of Health, USA

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 2 of 10
Anna Duda, University of Oxford, UK
A Cohort Study of HIV Adaptation and Reversion in the First Three Years After Transmission to New Hosts

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 3 of 10
Joe Casazza, NIAID, National Institutes of Health, USA
Evidence of a Protective Role for Cytokine/Chemokine Production in HIV Infection

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 4 of 10
Daniel E. Kaufmann, University of Montreal, Canada
CTLA-4 upregulation in HIV-specific CD4 T cells correlates with disease progression and defines a reversible immune dysfunction

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 5 of 10
Beda Brichacek, National Cancer Institute, USA
The Effect of TLR Ligands on HIV-1 Replication in Human Lymphoid Tissue ex vivo: A Potential Mechanism of Co-Pathogenesis

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 6 of 10
Richard T. Lester, University of Manitoba and University of British Columbia, Canada
Elevated Toll-like Receptor (TLR) Expression and Altered Cytokine Responses to TLR Ligands in Peripheral Blood Leukocytes of HIV-1 Positive Patients.

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 7 of 10
Judith N. Mandl, National Institutes of Health, USA
Investigating the Role of TLR7&9 Stimulation in Chronic Immune Activation during SIV Infection of Rhesus Macaques

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 8 of 10
Nichole R. Klatt, University of Miami, USA
The Main Determinant of Set-Point Viremia During Natural SIV Infection of Sooty Mangabeys is the Number of Activated CD4+ T Cells

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 9 of 10
Meritxell Genescà, Health Sciences Research Institute Germans Trias i Pujol Foundation, Spain
Live-Attenuated Lentivirus Immunization Mediated Protection of Rhesus Macaques From Intravaginal SIV Challenge is Associated With Survival and Polyfunctional Capacity of SIV-Specific CD8+ T Cell

Wednesday, March 28 | 2:00PM - 4:30PM
Workshop 3: Pathogenesis and Immune Responses
Room: Ballroom C

Speaker 10 of 10
Donald L. Sodora, Center for Infectious Disease Research, USA
Gamma/Delta T Cell Function is Impaired During HIV-Infection but Not During Nonpathogenic SIV-Infection of Sooty Mangabeys

Wednesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
Room: Ballroom C

Speaker 1 of 5
* Charles R.M. Bangham, Imperial College Department of Medicine, UK

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
Room: Ballroom C

Speaker 2 of 5
Anthony L. Cunningham, Westmead Institute for Medical Research, Australia
Modulation of Dendritic Cell Function by HIV: Implications for Initial Infection and Pathogenesis

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
Room: Ballroom C

Speaker 3 of 5
Thomas J. Hope, Northwestern University, USA
Mechanism of Restriction Mediated by TRIM5 alpha

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
Room: Ballroom C

Speaker 4 of 5
Paul W. Spearman, Emory University, USA
Cellular Trafficking Pathways and the Role of Vpu in Retrovirus Assembly

Wednesday, March 28 | 5:00PM - 7:00PM
Viral Assembly, Viral Synapse & Cell Biology
Room: Ballroom C

Speaker 5 of 5
Juan Martin-Serrano, King's College London School of Medicine, UK
Short Talk: Interaction of Tsg101 With Components of the Cytokinesis Machinery and Role in Viral Budding

Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 4
Kasper Hoebe, The Scripps Research Institute, USA
The Innate-Adaptive Connection: TLRs and Beyond


Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 4
Annette Oxenius, Institute for Microbiology, ETH Zürich, Switzerland
CD8+ T Cell Dysfunction during Chronic Viral Infections


Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 4
Richard T. Wyatt, IAVI Neutralizing Antibody Center, The Scripps Research Institute, USA
HIV-1 gp120 Structure-based Immunogen Design


Wednesday, March 28 | 5:00PM - 7:00PM
Relevant Lessons from Other Systems
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 4
David Price, Cardiff University School of Medicine, UK
Short Talk: Evolution of Cytomegalovirus-Specific CD4+ T Cell Clonotypes in vivo: Vaccine Design Informed by Successful Immune Responses


Wednesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Wednesday, March 28 | 7:30PM - 10:00PM
Poster Session 3
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Foyer, Ballroom A, Lower Level


Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 1 of 5
Alan N. Engelman, Dana-Farber Cancer Institute, USA
Host Factors and HIV-1 Integration

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 2 of 5
Charles R.M. Bangham, Imperial College Department of Medicine, UK
Efficiency of the Anti-Viral CTL Response: HTLV-1

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 3 of 5
Alexandra Trkola, University of Zürich, Switzerland
Prospects of Humoral Immunity to HIV-1

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 4 of 5
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Elite Control of HIV: Implications for Vaccine Design

Thursday, March 29 | 8:00AM - 11:00AM
Mechanisms of Viral Persistence and Immune Avoidance (Joint)
Room: Ballroom B/C

Speaker 5 of 5
Jason M. Brenchley, NIAID, National Institutes of Health, USA
Short Talk: Microbial Translocation is a Cause of Systemic Immune Activation in Chronic HIV Infection

Thursday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Thursday, March 29 | 11:00AM - 12:00PM
Poster Setup
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 11:00AM - 12:00PM
Lunch
Room: Grand Foyer/Mountain View/Sky Ballroom A


Thursday, March 29 | 12:00PM - 4:30PM
Poster Session 4
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 12
* Marcus Altfeld, Heinrich-Pette-Institute, Germany


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 12
* Otto O. Yang, University of California, Los Angeles, USA


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 12
Tedi E. Asher, NIAID, National Institutes of Health, USA
Clonal Correlates of Vaccine-Induced Immune Protection Against SIV in Rhesus Macaques


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 12
Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School, USA
Intracellular Epitope Stability is Defined by Specific Residues and Correlates With HIV Epitope Hierarchy


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 5 of 12
Emma L. Turnbull, Jenner Institute, University of Oxford, UK
Mutational Escape, Rather than Reduced Avidity of Epitope-Specific T Cell Responses, may be More Relevant for Impairment of the HIV-Specific CD8+ T Cell Response During Early HIV-1 Infection


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 6 of 12
Jonah B. Sacha, Oregon Health & Science University, USA
Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 7 of 12
Hendrik Streeck, Military HIV Research Program, USA
Immunodomination by HLA-B27/-B57 Results in a Substantial Abrogation of Alternate HLA-Restricted HIV-Specific Responses in Primary HIV-1 Infection


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 8 of 12
Hayley Crawford, Oxford University, UK
Compensatory Mutation Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic HIV Infection


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 9 of 12
Nicole Frahm, Bill & Melinda Gates Medical Research Institute, USA
Preferential Targeting of HIV-Gag Epitopes in Elite Controllers


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 10 of 12
Hanneke Schuitemaker, Janssen Vaccines & Prevention B.V., Netherlands
Differential Clinical Course in HLA B57+ Long-Term Nonprogressors and Progressors Does not Relate to Frequencies of Gag Specific Cytotoxic T Lymphocytes or Sequence Dynamics in Gag CTL Epitopes but to HIV-1 Replicative Capacity


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 11 of 12
Stephen A. Migueles, NIAID, National Institutes of Health, USA
Diminished Proliferative Capacity of HIV-Specific CD8+ T Cells is not Restored by Antiretroviral Therapy or Exogenous IL-2


Thursday, March 29 | 2:00PM - 4:30PM
Workshop 4: CTL Function, Dysfunction and Escape
This session is from HIV Vaccines
Room: Ballroom B

Speaker 12 of 12
Teresa Lea Mattila, University of Minnesota, USA
In Situ Analysis of Virus-Specific CD8+ T Cells


Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Grand Foyer


Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
Room: Ballroom C

Speaker 1 of 6
* Michael H. Malim, King's College London, UK

Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
Room: Ballroom C

Speaker 2 of 6
Daniel R. Kuritzkes, Brigham and Women's Hospital, Harvard Medical School, USA
Drug Resistance and Viral Fitness in HIV-1

Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
Room: Ballroom C

Speaker 3 of 6
David Heckerman, Human Longevity, Inc., USA
Short Talk: Estimate of the Proportion of Within-Host Sequence Evolution in HIV-1 Mediated by Human Leukocyte Antigen (HLA) Class I Selective Pressures

Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
Room: Ballroom C

Speaker 4 of 6
Celia C. LaBranche, Global Vaccines, Inc., USA
Development of CCR5 Antagonists as HIV Antiviral Drugs

Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
Room: Ballroom C

Speaker 5 of 6
Laura A. Napolitano, Gladstone Institute of Virology and Immunology, USA
Short Talk: Growth Hormone Therapy Enhances Thymic Function in HIV-infected Adults: A Randomized Prospective Analysis

Thursday, March 29 | 5:00PM - 7:15PM
Drugs and Viral Fitness
Room: Ballroom C

Speaker 6 of 6
Yonchu Jenkins, Rigel Pharmaceuticals, Inc., USA
Short Talk: Identification of Novel Antiretroviral Compounds by Targeting HIV Vif Function

Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
This session is from HIV Vaccines
Room: Ballroom B

Speaker 1 of 6
* Ian A. Wilson, The Scripps Research Institute, USA


Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
This session is from HIV Vaccines
Room: Ballroom B

Speaker 2 of 6
Hiroyuki Yamamoto, Institute of Medical Science, The University of Tokyo, Japan
SIV Control by Post-Infection Passive Immunization of Neutralizing Antibodies


Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
This session is from HIV Vaccines
Room: Ballroom B

Speaker 3 of 6
Ping Zhu, Florida State University, USA
3D HIV-1 Envelope Spike Model as Revealed by Cryoelectron Tomography


Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
This session is from HIV Vaccines
Room: Ballroom B

Speaker 4 of 6
Giulia Zanetti, Wellcome Trust Centre, University of Oxford, UK
Cryo-Electron Tomography of SIV Envelope Complex in situ


Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
This session is from HIV Vaccines
Room: Ballroom B

Speaker 5 of 6
Sriram Subramaniam, University of British Columbia, Canada
Electron Tomography of Immunodeficiency Viruses and Structural Mechanisms of Cellular Entry


Thursday, March 29 | 5:00PM - 7:00PM
Novel Immunogens
This session is from HIV Vaccines
Room: Ballroom B

Speaker 6 of 6
Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Increasing HIV-1 Env Immunogenicity by Modulation of Intrinsic and Extrinsic Factors


Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 8:00PM - 11:00PM
Entertainment
Room: Grand Foyer/Mountain View/Ballroom A


Thursday, March 29 | 8:00PM - 11:00PM
Cash Bar
Room: Grand Foyer/Mountain View/Ballroom A


Friday, March 30 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.