Web Desc
Nuclear Receptor Pathways to Metabolic Regulation
joint with Metabolic Syndrome and Cardiovascular Risk
Organizer(s): Mitchell A. Lazar and Richard A. Heyman
Date: March 27 - April 01, 2007
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Supported by the Director's Fund
Summary of Meeting:
The most exciting current research on nuclear receptors and metabolism takes a systems approach, utilizing functional genomics, molecular biology, and bioinformatics to understand the role of nuclear receptors in physiology and in the pathophysiology of metabolic diseases such as obesity, diabetes ,and metabolic syndrome. The major roadblocks to this research include the biological variation and technical precision of the state-of-art-measures of RNA, protein, and gene occupation by transcription factors, and the ability to accurately relate changes in nuclear receptor ligands and abundance to phenotypic changes. The goal of this meeting is to bring together investigators working on different nuclear receptors, and the regulation of different metabolic pathways, to present the latest and most exciting paradigmatic and technical breakthroughs.
We gratefully acknowledge additional support for this conference from:
Ariadne GenomicsInvitrogen CorporationNovus Biologicals, Inc.Seahorse Bioscience, Inc.Takeda Pharmaceuticals America, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

Kalypsys, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK076500-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 27 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, March 27 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 1 of 4
* Bart Staels, Institut Pasteur de Lille, Université Lille, France

Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 2 of 4
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 3 of 4
Gerald M. Reaven, Stanford University, USA
Insulin Resistance and the Many Faces of the Metabolic Syndrome

Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 4 of 4
Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Obesity, Risk Factors and CV Disease: NHLBI Perspectives

Wednesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 1 of 6
* Sheila Collins, Vanderbilt University Medical Center, USA

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 2 of 6
Christopher K. Glass, University of California, San Diego, USA
Nuclear Receptors, Inflammation, and metabolic syndrome

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 3 of 6
Ronald M. Evans, HHMI/The Salk Institute, USA
ERR alpha & PGC-1 beta: a Gateway to INFgamma Signaling in Innate Immunity: Balancing the Fat Equation

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 4 of 6
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Energy Homeostasis and Metabolic Disease

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 5 of 6
Peter Tontonoz, University of California, Los Angeles, USA
PPAR gamma as a Central Regulator of Adipocyte Differentiation and Lipid/Glucose Metabolism

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 6 of 6
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Short Talk: Novel Role of Adiponectin in PPAR gamma-Mediated Gene Regulation

Wednesday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Rainbow/Twilight/Sunrise/Sunshine


Wednesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Rainbow/Twilight/Sunrise/Sunshine


Wednesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
Room: Mt Werner/Storm Peak

Speaker 1 of 5
* Ronald M. Evans, HHMI/The Salk Institute, USA

Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
Room: Mt Werner/Storm Peak

Speaker 2 of 5
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
NR Corepressors and Metabolism

Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
Room: Mt Werner/Storm Peak

Speaker 3 of 5
Malcolm G. Parker, Imperial College London, UK
Regulation of Metabolic Gene Networks by the RIP140 Transcriptional Cofactor

Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
Room: Mt Werner/Storm Peak

Speaker 4 of 5
Ajay Chawla, Merck Research Labs, USA
PPARs, Macrophage Activation and Insulin Resistance

Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
Room: Mt Werner/Storm Peak

Speaker 5 of 5
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
Short Talk: The LKB1/AMPK Pathway Controls Key Transcriptional Programs

Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 1 of 5
* Dawn M. Waterworth, GlaxoSmithKline, USA


Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 2 of 5
Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK
11beta-Hydroxysteroid Dehydrogenase Type 1 and teh Metabolic Syndrome


Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 3 of 5
Anne-Marie Galzin, Sanofi-Aventis Research & Development, France
The Endocannabinoid System as a Target for Managing Obesity / Cardio-Metabolic Risk Factors


Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 4 of 5
Bei B. Zhang, Pfizer Inc., USA
Targeting the Glucagon Receptor for Glycemia Control and Beyond


Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 5 of 5
Shin-ichiro Imai, Washington University School of Medicine, USA
Short Talk: Nampt/PBEF/Visfatin Regulates Insulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme


Wednesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Wednesday, March 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
Room: Mt Werner/Storm Peak

Speaker 1 of 6
* Thomas P. Burris, Washington University School of Medicine, USA

Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
Room: Mt Werner/Storm Peak

Speaker 2 of 6
Vincent Giguère, McGill University, Canada
Genome-wide orchestration of cardiac energetics and functions by orphan nuclear receptors ERRalpha and gamma

Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
Room: Mt Werner/Storm Peak

Speaker 3 of 6
Richard A. Heyman, ORIC Pharmaceuticals, USA
Targeting Metabolic Syndrome with Selective PPARgamma Agonist: Discovery and Clinical Development

Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
Room: Mt Werner/Storm Peak

Speaker 4 of 6
Jorge Plutzky, Brigham and Women's Hospital, USA
PPARs and Lipases

Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
Room: Mt Werner/Storm Peak

Speaker 5 of 6
Peter A. Edwards, UCLA, USA
FXR Modulates Lipid and Glucose Metabolism

Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
Room: Mt Werner/Storm Peak

Speaker 6 of 6
Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: PPARg Regulates Immune Cell Function by Turning on Retinoic Acid Synthesis and RAR-Dependent Gene Expression in Developing Human Dendritic Cells

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 1 of 7
* Anna Krook, Karolinska Institutet, Sweden


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 2 of 7
Hannele Yki-Järvinen, University of Helsinki, Finland
Clinical Relevance and Pathogenesis of Hepatic Steatosis


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 3 of 7
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Independent Pathways of Insulin Action In Regulation Of Glucose and Lipid Metabolism


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 4 of 7
Jay D. Horton, University of Texas Southwestern Medical Center, USA
SREBPs and Components of the Metabolic Syndrome


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 5 of 7
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Impact of Inflammation as a Pathogenic Mediator in the Metabolic Syndrome


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 6 of 7
Carl de Luca, USA
Short Talk: Myeloid-Derived Toll-Like Receptor 4 (TLR4) is Required for High Fat Diet Induced Hepatic Insulin Resistance


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 7 of 7
Kristiaan Wouters, Maastricht University, Netherlands
Short Talk: Hyperactivation of Macrophage TNF Signaling Inhibits Steatosis


Thursday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
Room: Mt Werner/Storm Peak

Speaker 1 of 5
* Susanne Mandrup, University of Southern Denmark, Denmark

Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
Room: Mt Werner/Storm Peak

Speaker 2 of 5
Anastasia Kralli, Johns Hopkins Medical School, USA
ERRalpha, a Regulator of Mitochondrial Biogenesis and Adaptive Metabolism

Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
Room: Mt Werner/Storm Peak

Speaker 3 of 5
Keith L. Parker, University of Texas Southwestern Medical Center, USA
Brain-Specific Inactivation of Steroidogenic Factor 1 Causes a Metabolic Syndrome and Anxiety-like Behavior

Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
Room: Mt Werner/Storm Peak

Speaker 4 of 5
David D. Moore, Baylor College of Medicine, USA
SHP and Energy Metabolism, Bile Acids and Circadian Rhythm

Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
Room: Mt Werner/Storm Peak

Speaker 5 of 5
Shamina M. Rangwala, Pfizer, USA
Short Talk: Mice Overexpressing PGC-1alpha in Muscle Display Alterations in Fuel Selection and Oxidative Capacity

Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 1 of 5
* Nikolaus Marx, RWTH Aachen University Hospital, Germany


Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 2 of 5
Daniel S. Ory, Washington University, USA
Deficiency of an Endogenous LXR Ligand Promotes Atherosclerosis


Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 3 of 5
Gwendalyn J. Randolph, Washington University, USA
Monocyte Subpopulations: Evaluating their Roles


Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 4 of 5
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Mitochondrial Dysfunction in the Metabolic Syndrome-Molecular Mechanisms


Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 5 of 5
Martin E. Young, University of Alabama at Birmingham, USA
Short Talk: The Intrinsic Circadian Clock within the Cardiomyocyte Directly Regulates Myocardial Gene Expression, Metabolism, and Function


Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
Room: Mt Werner/Storm Peak

Speaker 1 of 6
* Andrea L. Hevener, University of California, Los Angeles, USA

Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
Room: Mt Werner/Storm Peak

Speaker 2 of 6
Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Hormone Receptors and the Endocrine Pancrease: LXRs and Glucose Metabolism

Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
Room: Mt Werner/Storm Peak

Speaker 3 of 6
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
HNF-4alpha in beta-cell proliferation and glucose homeostasis.

Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
Room: Mt Werner/Storm Peak

Speaker 4 of 6
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Co-Factors to Coordinate Energy Expenditure

Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
Room: Mt Werner/Storm Peak

Speaker 5 of 6
Frank J. Gonzalez, National Institutes of Health, USA
PPARalpha Control of Hepatic Gene Expression and Carcinogenesis

Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
Room: Mt Werner/Storm Peak

Speaker 6 of 6
Enrique Saez, The Scripps Research Institute, USA
Short Talk: The Oxysterol Receptor LXR is a Glucose Sensor

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 1 of 7
* Dennis Bruemmer, University of Kentucky, USA


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 2 of 7
Jean E. Schaffer, Joslin Diabetes Center, Harvard Medical School, USA
Lipotoxicity: A Cardiovascular Risk in the Metabolic Syndrome


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 3 of 7
Robert V. Farese Jr., Harvard School of Public Health, USA
Metabolic Syndrome and Triglyceride Synthesis


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 4 of 7
Mary-Elizabeth Patti, Joslin Diabetes Center, USA
PGC-1 Dependent and Independent Pathways to MS and Diabetes Risk


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 5 of 7
Karen Reue, University of California, Los Angeles, USA
The Role of Lipin Proteins in Metabolism


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 6 of 7
Peter A. Crawford, University of Minnesota, USA
Short Talk: Myocardial Physiology is Influenced by the Gut Microbiota


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS
This session is from Metabolic Syndrome and Cardiov

Room: Sunshine

Speaker 7 of 7
Martin S. Obin, JMUSDA-HNRCA, Tufts University, USA
Short Talk: Obesity-Associated Adipocyte Death: Role in Inflammation, Peripheral Insulin Resistance and Hepatic Steatosis


Friday, March 30 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, March 30 | 11:00AM - 1:00PM
Poster Setup
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Sunshine/Mt. Werner

Speaker 1 of 4
* Sander Kersten, Wageningen University, Netherlands

Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Sunshine/Mt. Werner

Speaker 2 of 4
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nuclear Receptors and FGFs: The New Endocrinology of Metabolism

Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Sunshine/Mt. Werner

Speaker 3 of 4
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin, PPARs, IRSs, and Metabolic Syndrome

Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Sunshine/Mt. Werner

Speaker 4 of 4
Daniel P. Kelly, University of Pennsylvania, USA
PPARs and Striated Muscle Lipid Metabolism

Friday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Rainbow/Twilight/Sunrise/Sunshine


Saturday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 1 of 6
* Edwin R. Sanchez, University of Toledo College of Medicine, USA

Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 2 of 6
Beatrice Desvergne, University of Lausanne, Switzerland
PPARbeta/delta in Gut Homeostasis

Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 3 of 6
Timothy M. Willson, GlaxoSmithKline, USA
Orphan Nuclear Receptors: Drug Targets for Metabolic Diseases

Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 4 of 6
Holly A. Ingraham, University of California, San Francisco, USA
Nuclear Receptors in Metabolism (in the CNS)

Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 5 of 6
Jan-Åke Gustafsson, University of Houston, USA
Estrogen Signaling in Glucose Homeostasis

Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 6 of 6
Sheila Collins, Vanderbilt University Medical Center, USA
Short Talk: LXRalpha Represses Uncoupling Protein-1 Gene Transcription and Mitochondriogenesis in Adipocytes.

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 1 of 7
* Matthew Watt, University of Melbourne, Australia


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 2 of 7
Juleen R. Zierath, Karolinska Institutet, Sweden
Targeting Signaling Cascades in Insulin Resistance


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 3 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 4 of 7
D. Grahame Hardie, University of Dundee, UK
Role of the AMPK System in the Metabolic Syndrome


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 5 of 7
Yannick Le Marchand-Brustel, INSERM, France
Defects in Insulin Signaling in Metabolic Syndrome


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 6 of 7
Daniel Lindén, AstraZeneca, Sweden
Short Talk: Opposing Effects of Adiponectin Receptor 1 and 2 on Energy Metabolism


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 7 of 7
Giovanni Solinas, University of California, San Diego, USA
Short Talk: JNK in Macrophages Plays a Key Role in the Development of
Obesity-Induced Insulin Resistance


Saturday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 1 of 4
* John D. Baxter, University of California, San Francisco, USA
Using the Thyroid Hormone Receptor to Attack the Metabolic Syndrome

Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 2 of 4
Jacques Samarut, Centre National de la Recherche Scientifique, France
Thyroid Hormone Receptors in the Control of Fat Metabolism

Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 3 of 4
Antonio C. Bianco, University of Miami Miller School of Medicine, USA
Regulation of TR Ligand Production

Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
Room: Mt Werner/Storm Peak

Speaker 4 of 4
Françoise Gofflot, France
Short Talk: MousePat or Systematic Expression Mapping of Nuclear Receptors in the Mouse Brain

Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 1 of 5
* Ira J. Goldberg, New York University, USA


Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 2 of 5
Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA
Regulation of VLDL Metabolism: Substrates, Hormones, and PPARgamma


Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 3 of 5
Fred W. Turek, Northwestern University, USA
Circadian Control of Sleep and Energy Balance


Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 4 of 5
Bart Staels, Institut Pasteur de Lille, Université Lille, France
FXR: A Target For The Metabolic Syndrome?


Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
This session is from Metabolic Syndrome and Cardiov
Room: Sunshine

Speaker 5 of 5
Brian N. Finck, Washington University School of Medicine, USA
Short Talk: Involvement of Lipin 1 in the Regulation of Hepatic Triglyceride Secretion


Saturday, March 31 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Saturday, March 31 | 8:00PM - 11:00PM
Entertainment
Room: Storm Peak/Sunshine/Mt. Werner


Saturday, March 31 | 8:00PM - 11:00PM
Cash Bar
Room: Storm Peak/Sunshine/Mt. Werner


Sunday, April 01 | 10:26AM - 10:26AM
Departure


*Session Chair.