Web Desc
Metabolic Syndrome and Cardiovascular Risk
joint with Nuclear Receptor Pathways to Metabolic Regulation
Organizer(s): Bart Staels, Jean E. Schaffer and Juleen R. Zierath
Date: March 27 - April 01, 2007
Location: Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA
Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development
For important information on the coronavirus, please click here
Summary of Meeting:
The metabolic syndrome is a complex entity of metabolic disorders clustering around acquired visceral obesity. These metabolic abnormalities include alterations in glucose homeostasis associated with insulin resistance, atherogenic dyslipidemia, coagulation disturbances and, in many cases, hypertension. Metabolic syndrome patients are at high risk to develop type 2 diabetes and most often die from cardiovascular diseases. Already identified in the early 1950’s and formally presented as syndrome X in the 1980’s, the metabolic syndrome is achieving epidemic proportions in the 21st century, due to global changes in life-style. In this meeting, the most recent conceptual advances in our understanding of the pathogenesis of the metabolic syndrome, its different metabolic components as well as its cardiovascular complications, will be discussed. This meeting aims to integrate approaches from basic and translational science, with an overall goal of understanding 1) how to translate this science into a more optimal lifestyle management and 2) the prospects for therapeutic intervention.
Scholarship Deadline: November 27 2006
Discounted Abstract Deadline: November 27 2006
Abstract Deadline: December 28 2006
Discounted Registration Deadline: January 29 2007
Meeting is full. Please contact info@keystonesymposia.org for questions or to be placed on a waitlist.


We gratefully acknowledge additional support for this conference from:
EMD MilliporePfizer Global Research & Development
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories

Sanofi US
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1 R13 DK076500-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 27 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, March 27 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 1 of 4
* Bart Staels, Institut Pasteur de Lille, Université Lille, France

Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 2 of 4
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 3 of 4
Gerald M. Reaven, Stanford University, USA
Insulin Resistance and the Many Faces of the Metabolic Syndrome

Tuesday, March 27 | 7:30PM - 9:30PM
Keynote Session: Clinical and Epidemiological Definition of
the Metabolic Syndrome (Joint)
Room: Ballroom

Speaker 4 of 4
Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Obesity, Risk Factors and CV Disease: NHLBI Perspectives

Wednesday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 1 of 6
* Sheila Collins, Vanderbilt University Medical Center, USA

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 2 of 6
Christopher K. Glass, University of California, San Diego, USA
Nuclear Receptors, Inflammation, and metabolic syndrome

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 3 of 6
Ronald M. Evans, HHMI/The Salk Institute, USA
ERR alpha & PGC-1 beta: a Gateway to INFgamma Signaling in Innate Immunity: Balancing the Fat Equation

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 4 of 6
Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Energy Homeostasis and Metabolic Disease

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 5 of 6
Peter Tontonoz, University of California, Los Angeles, USA
PPAR gamma as a Central Regulator of Adipocyte Differentiation and Lipid/Glucose Metabolism

Wednesday, March 28 | 8:00AM - 11:00AM
NR and the MS I (Joint)
Room: Ballroom

Speaker 6 of 6
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Short Talk: Novel Role of Adiponectin in PPAR gamma-Mediated Gene Regulation

Wednesday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 28 | 11:00AM - 1:00PM
Poster Setup
Room: Rainbow/Twilight/Sunrise/Sunshine


Wednesday, March 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Rainbow/Twilight/Sunrise/Sunshine


Wednesday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
Room: Sunshine

Speaker 1 of 5
* Dawn M. Waterworth, GlaxoSmithKline, USA

Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
Room: Sunshine

Speaker 2 of 5
Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK
11beta-Hydroxysteroid Dehydrogenase Type 1 and teh Metabolic Syndrome

Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
Room: Sunshine

Speaker 3 of 5
Anne-Marie Galzin, Sanofi-Aventis Research & Development, France
The Endocannabinoid System as a Target for Managing Obesity / Cardio-Metabolic Risk Factors

Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
Room: Sunshine

Speaker 4 of 5
Bei B. Zhang, Pfizer Inc., USA
Targeting the Glucagon Receptor for Glycemia Control and Beyond

Wednesday, March 28 | 5:00PM - 7:00PM
Novel Therapeutics for the MS
Room: Sunshine

Speaker 5 of 5
Shin-ichiro Imai, Washington University School of Medicine, USA
Short Talk: Nampt/PBEF/Visfatin Regulates Insulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme

Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 1 of 5
* Ronald M. Evans, HHMI/The Salk Institute, USA


Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 2 of 5
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
NR Corepressors and Metabolism


Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 3 of 5
Malcolm G. Parker, Imperial College London, UK
Regulation of Metabolic Gene Networks by the RIP140 Transcriptional Cofactor


Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 4 of 5
Ajay Chawla, Merck and University of California, San Francisco, USA
PPARs, Macrophage Activation and Insulin Resistance


Wednesday, March 28 | 5:00PM - 7:00PM
NR Coregulators and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 5 of 5
Reuben J. Shaw, The Salk Institute for Biological Studies, USA
Short Talk: The LKB1/AMPK Pathway Controls Key Transcriptional Programs


Wednesday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Wednesday, March 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 1 of 7
* Anna Krook, Karolinska Institutet, Sweden

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 2 of 7
Hannele Yki-Järvinen, University of Helsinki, Finland
Clinical Relevance and Pathogenesis of Hepatic Steatosis

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 3 of 7
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Independent Pathways of Insulin Action In Regulation Of Glucose and Lipid Metabolism

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 4 of 7
Jay D. Horton, University of Texas Southwestern Medical Center, USA
SREBPs and Components of the Metabolic Syndrome

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 5 of 7
Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Impact of Inflammation as a Pathogenic Mediator in the Metabolic Syndrome

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 6 of 7
Carl de Luca, USA
Short Talk: Myeloid-Derived Toll-Like Receptor 4 (TLR4) is Required for High Fat Diet Induced Hepatic Insulin Resistance

Thursday, March 29 | 8:00AM - 11:15AM
Hepatic Steatosis: Cause or Consequence of the MS?
Room: Sunshine

Speaker 7 of 7
Kristiaan Wouters, Maastricht University, Netherlands
Short Talk: Hyperactivation of Macrophage TNF Signaling Inhibits Steatosis

Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 1 of 6
* Thomas P. Burris, Washington University School of Medicine, USA


Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 2 of 6
Vincent Giguère, McGill University, Canada
Genome-wide orchestration of cardiac energetics and functions by orphan nuclear receptors ERRalpha and gamma


Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 3 of 6
Richard A. Heyman, ORIC Pharmaceuticals, USA
Targeting Metabolic Syndrome with Selective PPARgamma Agonist: Discovery and Clinical Development


Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 4 of 6
Jorge Plutzky, Brigham and Women's Hospital, USA
PPARs and Lipases


Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 5 of 6
Peter A. Edwards, UCLA, USA
FXR Modulates Lipid and Glucose Metabolism


Thursday, March 29 | 8:00AM - 11:00AM
Nuclear Receptors and Lipid Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 6 of 6
Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: PPARg Regulates Immune Cell Function by Turning on Retinoic Acid Synthesis and RAR-Dependent Gene Expression in Developing Human Dendritic Cells


Thursday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 29 | 11:15AM - 1:00PM
Poster Setup
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
Room: Sunshine

Speaker 1 of 5
* Nikolaus Marx, University Hospital Aachen, Germany

Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
Room: Sunshine

Speaker 2 of 5
Daniel S. Ory, Washington University, USA
Deficiency of an Endogenous LXR Ligand Promotes Atherosclerosis

Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
Room: Sunshine

Speaker 3 of 5
Gwendalyn J. Randolph, Washington University, USA
Monocyte Subpopulations: Evaluating their Roles

Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
Room: Sunshine

Speaker 4 of 5
E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Mitochondrial Dysfunction in the Metabolic Syndrome-Molecular Mechanisms

Thursday, March 29 | 5:00PM - 7:00PM
Cardiovascular Disease in the MS
Room: Sunshine

Speaker 5 of 5
Martin E. Young, University of Alabama at Birmingham, USA
Short Talk: The Intrinsic Circadian Clock within the Cardiomyocyte Directly Regulates Myocardial Gene Expression, Metabolism, and Function

Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 1 of 5
* Susanne Mandrup, University of Southern Denmark, Denmark


Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 2 of 5
Anastasia Kralli, Johns Hopkins Medical School, USA
ERRalpha, a Regulator of Mitochondrial Biogenesis and Adaptive Metabolism


Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 3 of 5
Keith L. Parker, University of Texas Southwestern Medical Center, USA
Brain-Specific Inactivation of Steroidogenic Factor 1 Causes a Metabolic Syndrome and Anxiety-like Behavior


Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 4 of 5
David D. Moore, Baylor College of Medicine, USA
SHP and Energy Metabolism, Bile Acids and Circadian Rhythm


Thursday, March 29 | 5:00PM - 7:00PM
NRs and Energy Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 5 of 5
Shamina M. Rangwala, Pfizer, USA
Short Talk: Mice Overexpressing PGC-1alpha in Muscle Display Alterations in Fuel Selection and Oxidative Capacity


Thursday, March 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Thursday, March 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 1 of 7
* Dennis Bruemmer, University of Kentucky, USA

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 2 of 7
Jean E. Schaffer, Harvard University, USA
Lipotoxicity: A Cardiovascular Risk in the Metabolic Syndrome

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 3 of 7
Robert V. Farese Jr., Harvard School of Public Health, USA
Metabolic Syndrome and Triglyceride Synthesis

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 4 of 7
Mary-Elizabeth Patti, Joslin Diabetes Center, USA
PGC-1 Dependent and Independent Pathways to MS and Diabetes Risk

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 5 of 7
Karen Reue, University of California, Los Angeles, USA
The Role of Lipin Proteins in Metabolism

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 6 of 7
Peter A. Crawford, University of Minnesota, USA
Short Talk: Myocardial Physiology is Influenced by the Gut Microbiota

Friday, March 30 | 8:00AM - 11:15AM
Energy Metabolism, Mitochondrial Function and Lipotoxicity i
n the MS

Room: Sunshine

Speaker 7 of 7
Martin S. Obin, JMUSDA-HNRCA, Tufts University, USA
Short Talk: Obesity-Associated Adipocyte Death: Role in Inflammation, Peripheral Insulin Resistance and Hepatic Steatosis

Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 1 of 6
* Andrea L. Hevener, University of California, Los Angeles, USA


Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 2 of 6
Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Hormone Receptors and the Endocrine Pancrease: LXRs and Glucose Metabolism


Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 3 of 6
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
HNF-4alpha in beta-cell proliferation and glucose homeostasis.


Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 4 of 6
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
Co-Factors to Coordinate Energy Expenditure


Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 5 of 6
Frank J. Gonzalez, National Institutes of Health, USA
PPARalpha Control of Hepatic Gene Expression and Carcinogenesis


Friday, March 30 | 8:00AM - 11:00AM
NRs and Glucose Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 6 of 6
Enrique Saez, The Scripps Research Institute, USA
Short Talk: The Oxysterol Receptor LXR is a Glucose Sensor


Friday, March 30 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, March 30 | 11:15AM - 1:00PM
Poster Setup
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Ballroom

Speaker 1 of 4
* Sander Kersten, Wageningen University, Netherlands

Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Ballroom

Speaker 2 of 4
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nuclear Receptors and FGFs: The New Endocrinology of Metabolism

Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Ballroom

Speaker 3 of 4
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin, PPARs, IRSs, and Metabolic Syndrome

Friday, March 30 | 5:00PM - 7:00PM
NR and the MS II (Joint)
Room: Ballroom

Speaker 4 of 4
Daniel P. Kelly, University of Pennsylvania, USA
PPARs and Striated Muscle Lipid Metabolism

Friday, March 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Rainbow/Twilight/Sunrise/Sunshine


Friday, March 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Rainbow/Twilight/Sunrise/Sunshine


Saturday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Bear River


Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 1 of 7
* Matthew Watt, University of Melbourne, Australia

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 2 of 7
Juleen R. Zierath, Karolinska Institutet, Sweden
Targeting Signaling Cascades in Insulin Resistance

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 3 of 7
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 4 of 7
D. Grahame Hardie, University of Dundee, UK
Role of the AMPK System in the Metabolic Syndrome

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 5 of 7
Yannick Le Marchand-Brustel, INSERM, France
Defects in Insulin Signaling in Metabolic Syndrome

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 6 of 7
Daniel Lindén, AstraZeneca, Sweden
Short Talk: Opposing Effects of Adiponectin Receptor 1 and 2 on Energy Metabolism

Saturday, March 31 | 8:00AM - 11:15AM
Signaling Cascades in the MS
Room: Sunshine

Speaker 7 of 7
Giovanni Solinas, University of California, San Diego, USA
Short Talk: JNK in Macrophages Plays a Key Role in the Development of
Obesity-Induced Insulin Resistance


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 1 of 6
* Edwin R. Sanchez, University of Toledo College of Medicine, USA


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 2 of 6
Beatrice Desvergne, University of Lausanne, Switzerland
PPARbeta/delta in Gut Homeostasis


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 3 of 6
Timothy M. Willson, GlaxoSmithKline, USA
Orphan Nuclear Receptors: Drug Targets for Metabolic Diseases


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 4 of 6
Holly A. Ingraham, University of California, San Francisco, USA
Nuclear Receptors in Metabolism (in the CNS)


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 5 of 6
Jan-Åke Gustafsson, University of Houston, USA
Estrogen Signaling in Glucose Homeostasis


Saturday, March 31 | 8:00AM - 11:00AM
New Insights into NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 6 of 6
Sheila Collins, Vanderbilt University Medical Center, USA
Short Talk: LXRalpha Represses Uncoupling Protein-1 Gene Transcription and Mitochondriogenesis in Adipocytes.


Saturday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
Room: Sunshine

Speaker 1 of 5
* Ira J. Goldberg, New York University, USA

Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
Room: Sunshine

Speaker 2 of 5
Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA
Regulation of VLDL Metabolism: Substrates, Hormones, and PPARgamma

Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
Room: Sunshine

Speaker 3 of 5
Fred W. Turek, Northwestern University, USA
Circadian Control of Sleep and Energy Balance

Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
Room: Sunshine

Speaker 4 of 5
Bart Staels, Institut Pasteur de Lille, Université Lille, France
FXR: A Target For The Metabolic Syndrome?

Saturday, March 31 | 5:00PM - 7:00PM
Dyslipidemia of the MS: The Atherogenic Triad
Room: Sunshine

Speaker 5 of 5
Brian N. Finck, Washington University School of Medicine, USA
Short Talk: Involvement of Lipin 1 in the Regulation of Hepatic Triglyceride Secretion

Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 1 of 4
* John D. Baxter, University of California, San Francisco, USA
Using the Thyroid Hormone Receptor to Attack the Metabolic Syndrome


Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 2 of 4
Jacques Samarut, Centre National de la Recherche Scientifique, France
Thyroid Hormone Receptors in the Control of Fat Metabolism


Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 3 of 4
Antonio C. Bianco, University of Miami Miller School of Medicine, USA
Regulation of TR Ligand Production


Saturday, March 31 | 5:00PM - 7:00PM
Classical NRs and Metabolism
This session is from Nuclear Receptors and Metaboli
Room: Mt Werner/Storm Peak

Speaker 4 of 4
Françoise Gofflot, France
Short Talk: MousePat or Systematic Expression Mapping of Nuclear Receptors in the Mouse Brain


Saturday, March 31 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Storm Peak/Sunshine/Mt. Werner


Saturday, March 31 | 8:00PM - 11:00PM
Entertainment
Room: Storm Peak/Sunshine/Mt. Werner


Saturday, March 31 | 8:00PM - 11:00PM
Cash Bar
Room: Storm Peak/Sunshine/Mt. Werner


Sunday, April 01 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.