Web Desc
Apoptotic and Non-Apoptotic Cell Death Pathways
joint with Autophagy in Health and Disease
Organizer(s): Junying Yuan, Dale E. Bredesen and Zahra Zakeri
Date: April 15 - 20, 2007
Location: Portola Hotel & Spa, Monterey, CA, USA
Sponsored by Genentech, Inc.
Summary of Meeting:
There is an increasing awareness in the cell death field that apoptosis may not be the only cellular mechanism for programmed cell death. The demonstration that the classical death receptor mediated pro-apoptotic signaling led to necrotic cell death under apoptosis deficient conditions in selective cell types suggests the existence of a cellular mechanism for necrotic cell death. The ability of Bax/Bak double knockout cells to undergo autophagy cell death suggests that autophagy might provide an alternative mechanism of cell death. The ability of caspase inhibitors to induce autophagy cell death in specific cell types suggests that caspases may normally inhibit the activation of alternative cell death pathways. The cell death field is on the verge of major breakthroughs in the identification of alternative cellular mechanisms of cell death. Since this will be the first international meeting emphasizing the mechanisms of non-apoptotic cell death, we intend to provide a historical review as well as the current views of apoptotic vs. non-apoptotic cell death mechanisms by inviting two keynote speakers: Dr. Richard Lockshin, one of the first persons to notice alternative forms of cell death during normal animal development, and Dr. Craig Thompson, a leader in the cell death research. The meeting will have two major objectives. First, evidence will be provided to document the existence of alternative cellular mechanisms of cell death in normal development, cancer and neurodegenerative diseases. Second, invited speakers will provide new insights into the molecular mechanisms of non-apoptotic cell death. In addition to the poster sessions, we will also leave a significant number of speaker slots for new and hot results selected from abstracts submitted. We expect this meeting will have major impacts on the cell death research in general by highlighting the importance of nonapoptotic cell death mechanisms.
Scholarship Deadline: December 15 2006
Discounted Abstract Deadline: December 15 2006
Abstract Deadline: January 18 2007
Discounted Registration Deadline: February 15 2007
We gratefully acknowledge additional support for this conference from:
Ariadne GenomicsEducational donation provided by AmgenEntreMed, Inc.Genentech, Inc.UCB Celltech
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Abbott Laboratories

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM080958-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 15 | 3:00PM - 7:30PM
Registration
Room: De Anza Foyer


Sunday, April 15 | 6:30PM - 7:30PM
Refreshments
Room: De Anza Foyer


Sunday, April 15 | 7:30PM - 10:00PM
Keynote Session (Joint)
Room: Steinbeck Forum

Speaker 1 of 3
Richard A. Lockshin, St. John's University, USA
Apoptosis, Autophagy, and More

Sunday, April 15 | 7:30PM - 10:00PM
Keynote Session (Joint)
Room: Steinbeck Forum

Speaker 2 of 3
Yoshinori Ohsumi, Tokyo Institute of Technology, Japan
Molecular Mechanism of Membrane Dynamics during Autophagy

Sunday, April 15 | 7:30PM - 10:00PM
Keynote Session (Joint)
Room: Steinbeck Forum

Speaker 3 of 3
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Autophagy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress

Monday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: Lower Atrium and Portola Room


Monday, April 16 | 8:00AM - 11:15AM
Multiple Cell Death Mechanisms in Mammalian Cells
Room: Steinbeck Forum

Speaker 1 of 5
* Dale E. Bredesen, Buck Institute for Research on Aging, USA
Toward a Mechanistic Taxonomy of Cell Death

Monday, April 16 | 8:00AM - 11:15AM
Multiple Cell Death Mechanisms in Mammalian Cells
Room: Steinbeck Forum

Speaker 2 of 5
Yoshihide Tsujimoto, Osaka University Medical School, Japan
Multiple Mechanisms of Cell Death and their Regulation by Bcl-2

Monday, April 16 | 8:00AM - 11:15AM
Multiple Cell Death Mechanisms in Mammalian Cells
Room: Steinbeck Forum

Speaker 3 of 5
Judy Lieberman, Harvard University, USA
Many Ways to Die: The Caspase-Independent Granzyme A Pathway

Monday, April 16 | 8:00AM - 11:15AM
Multiple Cell Death Mechanisms in Mammalian Cells
Room: Steinbeck Forum

Speaker 4 of 5
Douglas R. Green, St. Jude Children's Research Hospital, USA
Life after Cytochrome c Release

Monday, April 16 | 8:00AM - 11:15AM
Multiple Cell Death Mechanisms in Mammalian Cells
Room: Steinbeck Forum

Speaker 5 of 5
Vishva M. Dixit, Genentech, Inc., USA
Regulation of NF-kappa B Activation

Monday, April 16 | 8:00AM - 11:00AM
Membrane Dynamics of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 6
* Suresh Subramani, University of California, San Diego, USA


Monday, April 16 | 8:00AM - 11:00AM
Membrane Dynamics of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 6
Daniel J. Klionsky, University of Michigan, USA
Cycling of Autophagy-Related Proteins


Monday, April 16 | 8:00AM - 11:00AM
Membrane Dynamics of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 6
Eeva-Liisa Eskelinen, University of Turku, Finland
Autophagic Degradation in the Lysosome


Monday, April 16 | 8:00AM - 11:00AM
Membrane Dynamics of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 6
Tamotsu Yoshimori, Osaka University, Japan
New Insights into Molecular Mechanisms of the Canonical and Specialized Autophagy


Monday, April 16 | 8:00AM - 11:00AM
Membrane Dynamics of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 5 of 6
Zvulun Elazar, Weizmann Institute of Science, Israel
Regulation of Autophagy in Yeast and Mammals


Monday, April 16 | 8:00AM - 11:00AM
Membrane Dynamics of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 6 of 6
Sheila M. Thomas, Harvard Medical School, USA
Short Talk: Teaching an Old Dog New Tricks: Role for Paxillin in Autophagy


Monday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Monday, April 16 | 11:15AM - 1:00PM
Poster Setup
Room: DeAnza 1-2


Monday, April 16 | 1:00PM - 10:00PM
Poster Viewing
Room: DeAnza 1-2


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 1 of 8
* Roya Khosravi-Far, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Evasion from Apoptosis: A Hallmark of Cancer

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 2 of 8
Jonathan L. Coloff, University of Illinois at Chicago, USA
Active Akt Requires Pentose Phosphate Pathway Activity to Maintain Mcl-1 Levels and Prevent Cell Death Upon Cytokine Withdrawal

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 3 of 8
Elizabeth Yang, Vanderbilt University School of Medicine, USA
PP2A Regulates the Pro-Apoptotic Activity of FOXO1

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 4 of 8
Jon D. Lane, University of Bristol, UK
GRASP65 and Apoptotic Signalling at the Golgi apparatus

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 5 of 8
Eli Arama, Weizmann Institute of Science, Israel
A Ubiquitin Ligase Complex Regulates Caspase Activation during Sperm Differentiation in Drosophila

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 6 of 8
Ameeta Kelekar, University of Minnesota, USA
Phosphorylation Regulates the Function and Intacellular Localization OF BH3 Only Protein NOXA in Human Leukemias

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 7 of 8
Ashish Banerjee, Monash University, Australia
Non-Transcriptional Role of NF-kappaB in Regulating
B Cell Survival


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Signal Transduction to Cell Death
Room: Steinbeck Forum

Speaker 8 of 8
Bingnan N. Kang, Johns Hopkins University, USA
Death-Associated Protein Kinase Regulated by DANGER, an IP3 Receptor Binding Protein

Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 9
* Daniel J. Klionsky, University of Michigan, USA


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 9
* Noboru Mizushima, University of Tokyo, Japan


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 9
Dale W. Hailey, National Institutes of Health, USA
Using Photoactivatable GFP Fusions to Monitor Autophagosome Lifetime


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 9
Claudine Kraft, University of Freiburg, Germany
Ribophagy: Regulated Ribosome Turnover by Autophagy


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 5 of 9
Amandine Bugnicourt, Institut Jacques Monod, France
Irs4p/Tax4p: Two Yeast EH Domain Proteins Involved in Autophagy


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 6 of 9
Yasuyoshi Sakai, Graduate School of Agriculture, Kyoto University, Japan
Roles of Atg26 in Methanol-Induced Autophagy and Plant Pathogenicity


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 7 of 9
Yu-Yun Chang, University of Minnesota, USA
The Regulation and Function of Drosophila Atg1 in Autophagy


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 8 of 9
Jessica P. Monserrate, University of California, Irvine, USA
Determining the Role of the Drosophila Bcl-2 Protein, Buffy, in Mediating Autophagy


Monday, April 16 | 2:00PM - 4:00PM
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 9 of 9
Julian J. Lum, British Columbia Cancer Agency, Canada
HIF-1alpha is a Hypoxia-Dependent Regulator of Autophagy


Monday, April 16 | 4:00PM - 4:30PM
Coffee Available
Room: De Anza Foyer


Monday, April 16 | 4:30PM - 6:30PM
Apoptotic and Non-Apoptotic Cell Death in Invertebrates
Room: Steinbeck Forum

Speaker 1 of 4
* Masayuki Miura, University of Tokyo, Japan
Non-Apoptotic Function of Caspase Signaling in Drosophila

Monday, April 16 | 4:30PM - 6:30PM
Apoptotic and Non-Apoptotic Cell Death in Invertebrates
Room: Steinbeck Forum

Speaker 2 of 4
Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
DRP-1-Mediated Mitochondrial Fragmentation during EGL-1-Induced Apoptosis in C. elegans

Monday, April 16 | 4:30PM - 6:30PM
Apoptotic and Non-Apoptotic Cell Death in Invertebrates
Room: Steinbeck Forum

Speaker 3 of 4
Monica Driscoll, Rutgers University, USA
Dying by Injury Rather Than by Design: Deciphering Necrotic-like Neuronal Death Mechanisms in C. elegans

Monday, April 16 | 4:30PM - 6:30PM
Apoptotic and Non-Apoptotic Cell Death in Invertebrates
Room: Steinbeck Forum

Speaker 4 of 4
A. Louise McCormick, Emory University, USA
Short Talk: Human Cytomegalovirus Subverts Caspase-Independent Death

Monday, April 16 | 4:30PM - 6:30PM
Regulation and Physiology of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 5
* Tamotsu Yoshimori, Osaka University, Japan


Monday, April 16 | 4:30PM - 6:30PM
Regulation and Physiology of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 5
Patrice Codogno, INSERM, France
Regulation of Macroautophagy by Sphingolipids


Monday, April 16 | 4:30PM - 6:30PM
Regulation and Physiology of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 5
Thomas P. Neufeld, University of Minnesota, USA
TOR Signaling Pathway and Control of Autophagy in Drosophila


Monday, April 16 | 4:30PM - 6:30PM
Regulation and Physiology of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 5
Noboru Mizushima, University of Tokyo, Japan
Physiological Role of Autophagy in Protein Metabolism in Mice


Monday, April 16 | 4:30PM - 6:30PM
Regulation and Physiology of Autophagy
This session is from Autophagy
Room: De Anza 3

Speaker 5 of 5
Jinghui Zhao, AbbVie, Inc., USA
Short Talk: FoxO3 Stimulates Macroautophagy in Muscle Cells


Monday, April 16 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: DeAnza 1-2


Monday, April 16 | 7:30PM - 10:00PM
Poster Session 1
Room: DeAnza 1-2


Tuesday, April 17 | 7:00AM - 8:00AM
Breakfast
Room: Lower Atrium and Portola Room


Tuesday, April 17 | 8:00AM - 11:00AM
Apoptosis and Nonapoptosis in Cancer Cells
Room: Steinbeck Forum

Speaker 1 of 6
* Marja Jäättelä, Danish Cancer Society Research Center, Denmark
Lysosomal Control of Tumor Cell Death

Tuesday, April 17 | 8:00AM - 11:00AM
Apoptosis and Nonapoptosis in Cancer Cells
Room: Steinbeck Forum

Speaker 2 of 6
Joan S. Brugge, Harvard Medical School, USA
Multiple Mechanisms Mediate Cell Death Associated with Loss of Extracellular Matrix Attachment

Tuesday, April 17 | 8:00AM - 11:00AM
Apoptosis and Nonapoptosis in Cancer Cells
Room: Steinbeck Forum

Speaker 3 of 6
Marco Emilio Bianchi, Università Vita-Salute San Raffaele, Italy
HMGB1 in Living and Dead Cells

Tuesday, April 17 | 8:00AM - 11:00AM
Apoptosis and Nonapoptosis in Cancer Cells
Room: Steinbeck Forum

Speaker 4 of 6
Jean H. Overmeyer, University of Toledo College of Medicine, USA
Short Talk: Activated Ras Induces a Unique Form of Type-II Death in Glioblastoma Cells by Mechanisms Distinct from Macroautophagy

Tuesday, April 17 | 8:00AM - 11:00AM
Apoptosis and Nonapoptosis in Cancer Cells
Room: Steinbeck Forum

Speaker 5 of 6
Kristin M. Tracy, University of Chicago, USA
Short Talk: The RB Tumor Suppressor Blocks Non-Apoptotic Cell Death and Represses Expression of the Autophagy Regulator BNip3

Tuesday, April 17 | 8:00AM - 11:00AM
Apoptosis and Nonapoptosis in Cancer Cells
Room: Steinbeck Forum

Speaker 6 of 6
Kay F. Macleod, University of Chicago, USA
Short Talk

Tuesday, April 17 | 8:00AM - 11:00AM
Specific Autophagy and Organelle Degradation
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 6
* Zvulun Elazar, Weizmann Institute of Science, Israel


Tuesday, April 17 | 8:00AM - 11:00AM
Specific Autophagy and Organelle Degradation
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 6
Suresh Subramani, University of California, San Diego, USA
Role of ATG30 in Selective Peroxisome Turnover in Pichia pastoris


Tuesday, April 17 | 8:00AM - 11:00AM
Specific Autophagy and Organelle Degradation
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 6
John J. Lemasters, Medical University of South Carolina, USA
Mitochondrial Autophagy (Mitophagy) in Living Hepatocytes


Tuesday, April 17 | 8:00AM - 11:00AM
Specific Autophagy and Organelle Degradation
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 6
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy


Tuesday, April 17 | 8:00AM - 11:00AM
Specific Autophagy and Organelle Degradation
This session is from Autophagy
Room: De Anza 3

Speaker 5 of 6
Ron R. Kopito, Stanford University, USA
Role of Autophagy in the Degradation of Polyglutamine Aggregates


Tuesday, April 17 | 8:00AM - 11:00AM
Specific Autophagy and Organelle Degradation
This session is from Autophagy
Room: De Anza 3

Speaker 6 of 6
Sebastian Schuck, HHMI/University of California, San Francisco, USA
Short Talk: Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response


Tuesday, April 17 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Tuesday, April 17 | 11:15AM - 1:00PM
Poster Setup
Room: DeAnza 1-2


Tuesday, April 17 | 1:00PM - 10:00PM
Poster Viewing
Room: DeAnza 1-2


Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 1 of 7
* Zahra F. Zakeri, Queens College of City University of New York, USA

Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 2 of 7
Noboru Mizushima, University of Tokyo, Japan
Biochemical and Light Microscopic Detection of Autophagosome Formation and Autophagic Degradation

Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 3 of 7
Eeva-Liisa Eskelinen, University of Turku, Finland
Electron Microscopic Detection of Autophagy

Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 4 of 7
Patrice Codogno, INSERM, France
Autophagic Cell Death: Does Autophagy have a License to Kill?

Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 5 of 7
Henrick N. Horita, University of Colorado at Denver & HSC, USA
So Many Ways to Die: Elucidating the Mechanism by Which DT-IL3 Kills Acute Myelogenous Leukemia Cells

Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 6 of 7
Bahrad A. Sokhansanj, Drexel University, USA
Systems Approach to Quantifying Cell Death Mechanism in Stress Response

Tuesday, April 17 | 2:00PM - 4:00PM
Workshop 2 (Joint): Technique Discussion: How to Differentia
te Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
Room: Steinbeck Forum

Speaker 7 of 7
Einat Zalckvar, Weizmann Institute of Science, Israel
System Level Analysis of the Cell Death Network by Single and Double RNAi–Mediated Perturbations

Tuesday, April 17 | 4:00PM - 4:30PM
Coffee Available
Room: De Anza Foyer


Tuesday, April 17 | 4:30PM - 6:30PM
Interaction of Apoptosis and Autophagy Pathways (Joint)
Room: Steinbeck Forum

Speaker 1 of 4
* Michael J. Lenardo, NIAID, National Institutes of Health, USA
Role of Autophagy in Caspase-Independent Cell Death

Tuesday, April 17 | 4:30PM - 6:30PM
Interaction of Apoptosis and Autophagy Pathways (Joint)
Room: Steinbeck Forum

Speaker 2 of 4
Adi Kimchi, Weizmann Institute of Science, Israel
System Level Analysis of Programmed Cell Death: Switching between Apoptosis, Autophagy and Necrosis

Tuesday, April 17 | 4:30PM - 6:30PM
Interaction of Apoptosis and Autophagy Pathways (Joint)
Room: Steinbeck Forum

Speaker 3 of 4
Guido Kroemer, Cordeliers Research Center, France
The Intricate Interplay between Apoptosis and Autophagy

Tuesday, April 17 | 4:30PM - 6:30PM
Interaction of Apoptosis and Autophagy Pathways (Joint)
Room: Steinbeck Forum

Speaker 4 of 4
Adam Oberstein, Princeton University, USA
Short Talk: Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex: Beclin 1 is a Novel BH3-Only Protein

Tuesday, April 17 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: DeAnza 1-2


Tuesday, April 17 | 7:30PM - 10:00PM
Poster Session 2
Room: DeAnza 1-2


Wednesday, April 18 | 7:00AM - 8:00AM
Breakfast
Room: Lower Atrium and Portola Room


Wednesday, April 18 | 8:00AM - 11:00AM
Apoptotic and Nonapoptotic Neuronal Cell Death
Room: Steinbeck Forum

Speaker 1 of 6
* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Regulation of Mitochondrial Function by Bcl-2 family Proteins

Wednesday, April 18 | 8:00AM - 11:00AM
Apoptotic and Nonapoptotic Neuronal Cell Death
Room: Steinbeck Forum

Speaker 2 of 6
Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Parthanatos is a Key Regulator of Cell Death: PARP-1 and AIF Signaling

Wednesday, April 18 | 8:00AM - 11:00AM
Apoptotic and Nonapoptotic Neuronal Cell Death
Room: Steinbeck Forum

Speaker 3 of 6
Claudio Soto, University of Texas Medical School at Houston, USA
Mechanisms of Prion Neurotoxicity

Wednesday, April 18 | 8:00AM - 11:00AM
Apoptotic and Nonapoptotic Neuronal Cell Death
Room: Steinbeck Forum

Speaker 4 of 6
Axel Niemann, ETH Zürich, Switzerland
Short Talk: Charcot-Marie-Tooth Disease Type 4A: A Human Disorder Caused by Mutations in the Gene Encoding GDAP1, a Mitochondrial Fission Factor

Wednesday, April 18 | 8:00AM - 11:00AM
Apoptotic and Nonapoptotic Neuronal Cell Death
Room: Steinbeck Forum

Speaker 5 of 6
Daniel Tondera, Dana-Faber Cancer Institute, USA
Short Talk: Acute Mitochondrial Hyperfusion is a Stress-Induced Survival Mechanism

Wednesday, April 18 | 8:00AM - 11:00AM
Apoptotic and Nonapoptotic Neuronal Cell Death
Room: Steinbeck Forum

Speaker 6 of 6
Claudio A. Hetz, University of Chile, Chile
Short Talk: The Pro-Apoptotic BCL-2 Family Member BIM Mediates Motoneuron Loss in a Model of Amyotrophic Lateral Sclerosis

Wednesday, April 18 | 8:00AM - 11:00AM
Autophagy in Immunity and Infection
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 6
* Beth Levine, University of Texas Southwestern Medical Center, USA
Bcl-2 Anti-Apoptotic Proteins Function as Anti-Autophagy Proteins


Wednesday, April 18 | 8:00AM - 11:00AM
Autophagy in Immunity and Infection
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 6
Christian Münz, University of Zurich, Switzerland
Role of Autophagy in Viral Antigen Presentation by Class II MHC Molecules


Wednesday, April 18 | 8:00AM - 11:00AM
Autophagy in Immunity and Infection
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 6
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy as an Immune Effector in Tuberculosis and HIV


Wednesday, April 18 | 8:00AM - 11:00AM
Autophagy in Immunity and Infection
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 6
Karla A. Kirkegaard, Stanford University School of Medicine, USA
Subversion of Cellular Autophagosomal Machinery by RNA Viruses


Wednesday, April 18 | 8:00AM - 11:00AM
Autophagy in Immunity and Infection
This session is from Autophagy
Room: De Anza 3

Speaker 5 of 6
Martine Biard-Piechaczyk, Le Centre de Pharmacologie et Biotechnologie pour la Santé, France
Short Talk: Autophagy is Involved in CD4 T Cell Apoptosis Triggered by HIV-1 Envelope Proteins


Wednesday, April 18 | 8:00AM - 11:00AM
Autophagy in Immunity and Infection
This session is from Autophagy
Room: De Anza 3

Speaker 6 of 6
Luc English, University of Montreal, Canada
Short Talk: Contribution of the Auto/Phagolysosomal Compartment in the Presentation of Endogenous HSV-1 Viral Antigens on MHC Class I Molecules


Wednesday, April 18 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Wednesday, April 18 | 11:00AM - 1:00PM
Poster Setup
Room: DeAnza 1-2


Wednesday, April 18 | 1:00PM - 10:00PM
Poster Viewing
Room: DeAnza 1-2


Wednesday, April 18 | 4:00PM - 4:30PM
Coffee Available
Room: De Anza Foyer


Wednesday, April 18 | 4:30PM - 6:30PM
Models of Apoptotic and Nonapoptotic Cell Death
Room: Steinbeck Forum

Speaker 1 of 4
* Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Regulation of Caspase 2

Wednesday, April 18 | 4:30PM - 6:30PM
Models of Apoptotic and Nonapoptotic Cell Death
Room: Steinbeck Forum

Speaker 2 of 4
Zahra F. Zakeri, Queens College of City University of New York, USA
Viral Infection Induces Multiple Cell Death Pathways

Wednesday, April 18 | 4:30PM - 6:30PM
Models of Apoptotic and Nonapoptotic Cell Death
Room: Steinbeck Forum

Speaker 3 of 4
Pierre Golstein, Centre d'Immunologie de Marseille-Luminy, France
A Necrotic Cell Death Model

Wednesday, April 18 | 4:30PM - 6:30PM
Models of Apoptotic and Nonapoptotic Cell Death
Room: Steinbeck Forum

Speaker 4 of 4
Thomas Rudel, University of Würzburg, Germany
Short Talk: Control of cFLIP Expression by microRNAs to Confer Apoptosis Resistance of Infected Cells

Wednesday, April 18 | 4:30PM - 6:30PM
Autophagy as a Target in Cancer Therapy
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 4
* Adi Kimchi, Weizmann Institute of Science, Israel


Wednesday, April 18 | 4:30PM - 6:30PM
Autophagy as a Target in Cancer Therapy
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 4
Seiji Kondo, Sakura Home Clinic, Japan
Treatment of Malignant Gliomas with Manipulation of Autophagy


Wednesday, April 18 | 4:30PM - 6:30PM
Autophagy as a Target in Cancer Therapy
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 4
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
UVRAG, Autophagy and Cancer


Wednesday, April 18 | 4:30PM - 6:30PM
Autophagy as a Target in Cancer Therapy
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 4
Yoshinori Takahashi, Pennsylvania State College of Medicine, USA
Short Talk: Regulation of Autophagy-Dependent Cell Death and Tumorigenesis by Endophilin B1/Bif-1


Wednesday, April 18 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: DeAnza 1-2


Wednesday, April 18 | 7:30PM - 10:00PM
Poster Session 3
Room: DeAnza 1-2


Thursday, April 19 | 7:00AM - 8:00AM
Breakfast
Room: Lower Atrium and Portola Room


Thursday, April 19 | 8:00AM - 11:00AM
Autophagy in Cell Survival and Cell Death (Joint)
Room: Steinbeck Forum

Speaker 1 of 6
* Eileen P. White, Rutgers Cancer Institute of New Jersey, USA
Role of Autophagy in Cancer

Thursday, April 19 | 8:00AM - 11:00AM
Autophagy in Cell Survival and Cell Death (Joint)
Room: Steinbeck Forum

Speaker 2 of 6
Beth Levine, University of Texas Southwestern Medical Center, USA
Novel Connections between Autophagy and Apoptosis

Thursday, April 19 | 8:00AM - 11:00AM
Autophagy in Cell Survival and Cell Death (Joint)
Room: Steinbeck Forum

Speaker 3 of 6
Eric H. Baehrecke, University of Massachusetts Medical School, USA
Autophagic Cell Death in Drosophila

Thursday, April 19 | 8:00AM - 11:00AM
Autophagy in Cell Survival and Cell Death (Joint)
Room: Steinbeck Forum

Speaker 4 of 6
Virginie M. Betin, University of Bristol, UK
Short Talk: Functional Characterization of Human Atg4D: Processing of Atg8 Homologues and Regulation by Caspases

Thursday, April 19 | 8:00AM - 11:00AM
Autophagy in Cell Survival and Cell Death (Joint)
Room: Steinbeck Forum

Speaker 5 of 6
Cindy K. Miranti, Van Andel Research Institute, USA
Short Talk: Inhibition of Integrin-Mediated Crosstalk with EGFR/Erk or Src Signaling Pathways in Autophagic Prostate Epithelial Cells Induces Caspase-Independent Death

Thursday, April 19 | 8:00AM - 11:00AM
Autophagy in Cell Survival and Cell Death (Joint)
Room: Steinbeck Forum

Speaker 6 of 6
Francesco Cecconi, University of Rome Tor Vergata, Italy
Short Talk: Ambra-1 Regulates Autophagy and Nervous System Development

Thursday, April 19 | 9:20AM - 9:40AM
Coffee Break
Room: De Anza Foyer


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 1 of 8
* Dale E. Bredesen, Buck Institute for Research on Aging, USA

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 2 of 8
Ernst-Jan A.J. Geutjes, Netherlands Cancer Institute, Netherlands
A High Throughput DUB siRNA Screen for Novel Regulators of the Pro-Apoptotic TNFR Pathway

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 3 of 8
Lydia Lartigue, La Jolla Institute for Allergy and Immunology, USA
Consequences of Mitochondrial Outer Membrane Permeabilization in the Absence of Caspase Activation

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 4 of 8
Yongqiang Chen, Manitoba Institute of Cell Biology, Canada
Reactive Oxygen Species Induce Autophagic Cell Death in Transformed and Cancer Cells

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 5 of 8
Anath Shalev, University of Alabama at Birmingham, USA
Glucose-Induced Apoptosis of Pancreatic Beta Cells is Mediated by Thioredoxin-Interacting Protein

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 6 of 8
Yolanda Huang, University of North Carolina, Chapel Hill, USA
Therapeutic Strategy for Inducing Apoptosis in Brain Tumors without Affecting Primary Neurons

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 7 of 8
Karin Nowikovsky, Max F. Perutz Laboratories, Vienna University, Austria
Loss of Mitochondrial K+/H+ Exchange Activity Causes Osmotic Swelling and Microautophagy

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Execution Mechanisms of Cell Death
Room: Steinbeck Forum

Speaker 8 of 8
Jerry E. Chipuk, St. Jude Children's Research Hospital, USA
Mitochondrial Outer Membrane Permeabilization Requires Endoplasmic Reticulum-Derived Sphingolipid Metabolism

Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 1 of 10
* Guido Kroemer, Cordeliers Research Center, France


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 2 of 10
* Vojo Deretic, University of New Mexico Health Sciences Center, USA


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 3 of 10
Claire Ying Chen Hou, Genome Sciences Centre, Canada
Common Regulators of Apoptosis and Autophagy – An analysis of Known Cell Death Genes in Starvation-Induced Autophagy


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 4 of 10
Tri M. Bui Nguyen, University of Minnesota, USA
Kringle 5 of Human Plasminogen, an Angiogenesis Inhibitor, Induces Both Autophagy and Apoptotic Death in Endothelial Cells


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 5 of 10
John Hunter Brumell, Hospital for Sick Children, Canada
Ubiquitinated-Protein Aggregates Form in Pancreatic beta-Cells During Diabetes-Induced Oxidative Stress and are Regulated by Autophagy


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 6 of 10
Masaaki Komatsu, Juntendo University School of Medicine, Japan
Selective Autophagy Regulates Formation of Intracytoplamic Inclusions


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 7 of 10
Paul Tannous, University of Texas Southwestern Medical Center, USA
Cardiomyocyte Autophagy Attenuates Desmin-Related Cardiomyopathy


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 8 of 10
Gutian Xiao, University of Pittsburgh Medical Center, USA
Autophagy Kisses NF-kappaB to Death without Hsp90 Chaperoning


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 9 of 10
Heather Hartig Pua, Duke University Medical Center, USA
A Critical Role for the Autophagy Gene Atg5 in T Cell Survival and Proliferation


Thursday, April 19 | 2:00PM - 4:00PM
Workshop 3: Autophagy in Cell Death and Disease
This session is from Autophagy
Room: De Anza 3

Speaker 10 of 10
Monica Andrea Delgado Vargas, Lovelace Respiratory Research Institute, USA
TLR Ligands Control Induction of Autophagy in Macrophages


Thursday, April 19 | 4:00PM - 4:30PM
Coffee Available
Room: De Anza Foyer


Thursday, April 19 | 4:30PM - 6:30PM
Small Molecule Regulators of Apoptosis and Necrosis
Room: Steinbeck Forum

Speaker 1 of 3
Shaomeng Wang, University of Michigan, USA
Insights into the Mechanism of Action of Apoptosis Induction by Ultra-Potent Small-Molecule Smac Mimetics

Thursday, April 19 | 4:30PM - 6:30PM
Small Molecule Regulators of Apoptosis and Necrosis
Room: Steinbeck Forum

Speaker 2 of 3
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer

Thursday, April 19 | 4:30PM - 6:30PM
Small Molecule Regulators of Apoptosis and Necrosis
Room: Steinbeck Forum

Speaker 3 of 3
* Junying Yuan, Harvard Medical School, USA
Studying Mechanisms of Cell Death: From Apoptosis to Necrosis

Thursday, April 19 | 4:30PM - 6:30PM
Autophagy as a Therapeutic Target in Neurodegenerative Disea
ses
This session is from Autophagy

Room: De Anza 3

Speaker 1 of 5
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA


Thursday, April 19 | 4:30PM - 6:30PM
Autophagy as a Therapeutic Target in Neurodegenerative Disea
ses
This session is from Autophagy

Room: De Anza 3

Speaker 2 of 5
David C. Rubinsztein, Cambridge Institute for Medical Research, UK
Autophagic Clearance of Aggregate-Prone Proteins: Therapeutic Implications


Thursday, April 19 | 4:30PM - 6:30PM
Autophagy as a Therapeutic Target in Neurodegenerative Disea
ses
This session is from Autophagy

Room: De Anza 3

Speaker 3 of 5
Tony Wyss-Coray, Stanford University School of Medicine, USA
Autophagy Deficiency in Alzheimer’s Disease and Neurodegeneration


Thursday, April 19 | 4:30PM - 6:30PM
Autophagy as a Therapeutic Target in Neurodegenerative Disea
ses
This session is from Autophagy

Room: De Anza 3

Speaker 4 of 5
Ralph A. Nixon, New York University, Langone Medical Center, USA
Macroautophagy Failure in Alzheimer's Disease: Genetic Factors and Pathological Consequences


Thursday, April 19 | 4:30PM - 6:30PM
Autophagy as a Therapeutic Target in Neurodegenerative Disea
ses
This session is from Autophagy

Room: De Anza 3

Speaker 5 of 5
Maria L. Florez-McClure, Martek Biosciences Corp., USA
Short Talk: Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of beta-Amyloid Peptide in C. elegans


Thursday, April 19 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: DeAnza 1-2


Thursday, April 19 | 7:30PM - 10:30PM
Entertainment
Room: De Anza 1-2


Thursday, April 19 | 7:30PM - 10:30PM
Cash Bar
Room: De Anza 1-2


Friday, April 20 | 10:26AM - 10:26AM
Departure


*Session Chair.