Web Desc
Eicosanoids and Other Mediators of Chronic Inflammation
Organizer(s): Roy J. Soberman, Garret A. FitzGerald and Bart N. Lambrecht
Date: January 07 - 12, 2008
Location: Big Sky Resort, Big Sky, MT, USA
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Eicosanoids and interacting molecules regulate chronic inflammatory diseases by recruitment and activation of cells. To achieve the design of optimal therapeutic strategies for chronic inflammatory diseases, it is critical to understand how different pathways integrate with eicosanoids. To achieve this goal the meeting will focus on clinical areas where chronic inflammation is superimposed on pathobiology modulated by genetic and environmental susceptibilities: atherosclerosis, rheumatoid arthritis, pulmonary fibrosis, and allergic pulmonary inflammation. It will address unanswered questions as to specific signal transduction pathways and related biology of eicosanoid receptors and the structure of key biosynthetic enzymes. The meeting will examine how eicosanoids integrate with other mediators of chronic inflammation at the molecular, cellular, and organism level to regulate disease processes that include fibrosis, atherosclerosis, and allergic inflammation. The meeting will also focus on how eicosanoids regulate the function of macrophages and dendritic cells to control chronic inflammation. Basic, translational, clinical, and therapeutic findings will be highlighted. Upon completion of this meeting, participants should be able: • To explain current knowledge of the molecular mechanisms regulating the synthesis and response to eicosanoids. • To identify the roles of eicosanoids in chronic inflammatory diseases. • To identify mechanisms and gene networks which initiate and perpetuate chronic inflammation and their role relative to that of eicosanoids. • To understand molecular mechanisms of signaling pathways that integrate with eicosanoid receptors.
Scholarship Deadline: September 12 2007
Discounted Abstract Deadline: September 12 2007
Abstract Deadline: October 15 2007
Discounted Registration Deadline: November 7 2007
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI075835-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 07 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Monday, January 07 | 6:30PM - 7:30PM
Refreshments
Room: Lower Atrium


Monday, January 07 | 7:30PM - 8:30PM
Keynote Address
Room: Gallatin

Speaker 1 of 1
Raymond N. DuBois, Arizona State University, USA
PGE2 Signaling in Growth, Inflammation, and Cancer

Tuesday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Tuesday, January 08 | 8:00AM - 11:00AM
Cardiovascular Disease
Room: Gallatin

Speaker 1 of 5
* Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandin Inhibition and Cardiovascular Biology

Tuesday, January 08 | 8:00AM - 11:00AM
Cardiovascular Disease
Room: Gallatin

Speaker 2 of 5
Emer Smyth, University of Pennsylvania School of Medicine, USA
Dimerization of Prostanoid Receptors

Tuesday, January 08 | 8:00AM - 11:00AM
Cardiovascular Disease
Room: Gallatin

Speaker 3 of 5
Colin D. Funk, Queen's University, Canada
Eicosanoid Function and Signaling in the Cardiovascular System of Genetically Modified Mice

Tuesday, January 08 | 8:00AM - 11:00AM
Cardiovascular Disease
Room: Gallatin

Speaker 4 of 5
William L. Smith, University of Michigan, USA
Function of the Homodimeric Structure of Cyclooxygenases

Tuesday, January 08 | 8:00AM - 11:00AM
Cardiovascular Disease
Room: Gallatin

Speaker 5 of 5
Douglas Kenneth Miller, Miller Associates, LLC, USA
Short Talk: Genetic Variations in 5-LO, FLAP and Leukotriene Pathway Genes are Associated with Coronary Artery Disease Risk

Tuesday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson / Madison


Tuesday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson / Madison


Tuesday, January 08 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 08 | 5:00PM - 7:00PM
Genetics and Genomics of Eicosanoids
Room: Gallatin

Speaker 1 of 4
Eric Schadt, Mount Sinai School of Medicine, USA
An Integrative Genomics Approach to Identify a Key Inflammation Sub-Network as a Key Driver of Metabolic Syndrome Traits

Tuesday, January 08 | 5:00PM - 7:00PM
Genetics and Genomics of Eicosanoids
Room: Gallatin

Speaker 2 of 4
Desmond Joseph Fitzgerald, University College Dublin - UCD Research Building, Ireland
Genomics and Proteomics of Platelets in Vascular Inflammation

Tuesday, January 08 | 5:00PM - 7:00PM
Genetics and Genomics of Eicosanoids
Room: Gallatin

Speaker 3 of 4
John A. Oates, Vanderbilt University School of Medicine, USA
Genetic Defect of cPLA2 and NSAID Toxicity

Tuesday, January 08 | 5:00PM - 7:00PM
Genetics and Genomics of Eicosanoids
Room: Gallatin

Speaker 4 of 4
* Edward A. Dennis, University of California, San Diego, USA
Short Talk: Metabolomics of Eicosanoids from Macrophages to Tissues

Tuesday, January 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Tuesday, January 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson / Madison


Wednesday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 1 of 7
* Roy J. Soberman, Harvard Medical School, USA

Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 2 of 7
Takao Shimizu, University of Tokyo, Japan
Biochemical and Pathophysiological roles of Two Types of Leukotriene B4 Receptors (BLT1 and BLT2)

Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 3 of 7
Christopher K. Glass, University of California, San Diego, USA
Transcripton Factors that Control Macrophage Function in Inflammation

Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 4 of 7
Shuh Narumiya, Kyoto University, Japan
Prostanoid Receptors in Signaling Network of Chronic Inflammation

Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 5 of 7
Christina C. Leslie, National Jewish Health, USA
Activation of Group IVA cPLA2 and Eicosanoid Production by Fungal and Bacterial Pathogens in Mcrophages

Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 6 of 7
Astrid M.L. Bengtsson, Lund University, Sweden
Short Talk: Pro-Inflammatory Mediator Leukotriene D4 Induces AP-1 but not NF-kappaB Signaling in Intestinal Epithelial Cells

Wednesday, January 09 | 8:00AM - 11:00AM
Signaling Networks that Intersect with Eicosanoids
Room: Gallatin

Speaker 7 of 7
Grzegorz Woszczek, King's College London, UK
Short Talk: IL-10 Inhibits Cysteinyl Leukotrienes Induced Activation of Human Monocytes and Monocyte-Derived Dendritic Cells

Wednesday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson / Madison


Wednesday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson / Madison


Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 1 of 8
* Jilly F. Evans, PharmAkea Therapeutics, USA

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 2 of 8
Vineet Gupta, University of Miami, Miller School of Medicine, USA
Insights into Platelet Biology using Platelet Protein-Protein Interaction Networks

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 3 of 8
William L. Smith, University of Michigan, USA
Two Pathways for COX-2 Protein Degradation

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 4 of 8
Kelly Doyle, University of Utah, USA
Oxidation of 2-cys-Perxoiredoxins by Lipid Peroxide Metabolites of Lipoxygenases and Cyclooxygenase-2

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 5 of 8
Dan A. Dixon, University of South Carolina, USA
MicroRNA-Mediated Regulation of COX-2 Expression

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 6 of 8
Anita Sjölander, Lund University, Sweden
Beta-Catenin Increases Mitochondria Activity in Response to LTD4 Stimulation

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 7 of 8
Weisong Zhou, Vanderbilt University Medical Center, USA
The Protective Effect of PGI2 Overexpression in the Lung on Bleomycin-Induced Mortality and Pulmonary Cell Apoptosis

Wednesday, January 09 | 2:30PM - 4:30PM
Workshop 1 : Mechanisms of Chronic Inflammation
Room: Gallatin

Speaker 8 of 8
Akiko Maekawa, Brigham and Women's Hospital, USA
GPR17 Counterregulates the CysLT1 Receptor Response

Wednesday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 09 | 5:00PM - 7:00PM
Eicosanoids, Chronic Inflammation and Malignant Transformati
on

Room: Gallatin

Speaker 1 of 5
* Christina C. Leslie, National Jewish Health, USA

Wednesday, January 09 | 5:00PM - 7:00PM
Eicosanoids, Chronic Inflammation and Malignant Transformati
on

Room: Gallatin

Speaker 2 of 5
Monica M. Bertagnolli, Brigham and Women's Hospital, USA
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Colon Cancer

Wednesday, January 09 | 5:00PM - 7:00PM
Eicosanoids, Chronic Inflammation and Malignant Transformati
on

Room: Gallatin

Speaker 3 of 5
Cornelia M. Ulrich, Fred Hutchinson Cancer Research Center, USA
Pharmacogenetics and COX-Inhibitors -- Can we Tailor Cancer Prevention?

Wednesday, January 09 | 5:00PM - 7:00PM
Eicosanoids, Chronic Inflammation and Malignant Transformati
on

Room: Gallatin

Speaker 4 of 5
Masataka Majima, Kitasato University School of Medicine, Japan
Roles of TP Signaling in Enhancement of Angiogenesis during Acute Ischemia and Proliferative Inflammation

Wednesday, January 09 | 5:00PM - 7:00PM
Eicosanoids, Chronic Inflammation and Malignant Transformati
on

Room: Gallatin

Speaker 5 of 5
Michael Backlund, Vanderbilt University, USA
Short Talk: Tumor Necrosis Factor-alpha Induction of NF-kB and E-Box Transcriptional Repressors Results in Diminution of 15-Hydroxyprostaglandin Dehydrogenase Expression in Colorectal Cancer Cells

Wednesday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Wednesday, January 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson / Madison


Thursday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 1 of 7
* K. Frank Austen, Harvard Medical School, USA

Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 2 of 7
Yoshihide Kanaoka, Harvard Medical School, USA
Structural Basis for Cysteinyl Leukotriene Biosynthesis: X Ray Crystal Structure of the Human LTC4 Synthase

Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 3 of 7
Ingeborg Schmidt-Krey, Georgia Institute of Technology, USA
Structural Biology of LTC4 Synthase

Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 4 of 7
Jilly F. Evans, PharmAkea Therapeutics, USA
The Crystal Structure of 5-Lipoxygenase-Activating Protein (FLAP)

Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 5 of 7
Roy J. Soberman, Harvard Medical School, USA
Identification and Assembly of Distinct Leukotriene Biosynthetic Membrane Complexes


Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 6 of 7
Christopher L. Rector, University of Colorado Health Sciences Center, USA
Short Talk: Determining LTA4 Stabilization in Human Neutrophils by the S100A8/A9 Complex

Thursday, January 10 | 8:00AM - 11:00AM
Cellular and Molecular Organization of the 5-Lipoxygenase Pa
thway

Room: Gallatin

Speaker 7 of 7
Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Leukotriene E4 Activates Peroxisome Proliferator Activated Receptor gamma and Potently Induces Prostaglandin D2 Generation by Human Mast Cells

Thursday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 1 of 9
* Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 2 of 9
* Roy J. Soberman, Harvard Medical School, USA

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 3 of 9
Yasuyuki Kihara, University of Tokyo, Japan
Metabolism of Lipid Mediators in Experimental Allergic Encephalomyelitis

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 4 of 9
Chiara Carnini, Brigham and Women's Hospital, USA
Cysteinyl Leukotrienes in Pulmonary Fibrosis: Modulation of the Functions of Fibrocytes and Fibroblasts

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 5 of 9
Jui-Hung (Jimmy) Yen, Indiana University School of Medicine, USA
PGE2-Induced Metalloproteinase-9 Promotes Dendritic Cell Migration in vitro and in vivo

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 6 of 9
Kip M. Connor, Children's Hospital Boston/Harvard Medical School, USA
Dietary omega-3 Polyunsaturated Fatty Acids and their Bioactive Metabolites Protect against Pathologic Retinal Neovascularization through Modulation of Microglial Derived Cytokines

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 7 of 9
William R. Ferrell, University of Glasgow, UK
PAR2 in the Pathogenesis of Rheumatoid Arthritis

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 8 of 9
Victoria A. Blaho, Weill Cornell Medical College, USA
Blockade of the Leukotriene B4 Receptor BLT1 Increases the Severity and Duration of Arthritis in a Murine Model of Lyme Disease

Thursday, January 10 | 2:30PM - 4:30PM
Workshop 2 : Eicosanoids in Immune Regulation
Room: Gallatin

Speaker 9 of 9
Jana Stankova, Université de Sherbrooke, Canada
Human Natural Killer Cells Express the Leukotriene B4 Receptor, BLT1

Thursday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, January 10 | 5:00PM - 7:00PM
Chemical Biological Dissection of the Function of Eicosanoid
s and Related Molecules

Room: Gallatin

Speaker 1 of 3
Benjamin F. Cravatt III, The Scripps Research Institute, USA
Probing the Action of Fatty Acid Amides via Fatty Acid Amide Hydrolase

Thursday, January 10 | 5:00PM - 7:00PM
Chemical Biological Dissection of the Function of Eicosanoid
s and Related Molecules

Room: Gallatin

Speaker 2 of 3
Michael H. Gelb, University of Washington, USA
Role of Phospholipases A2 in Eicosanoid Generation and Inflammation

Thursday, January 10 | 5:00PM - 7:00PM
Chemical Biological Dissection of the Function of Eicosanoid
s and Related Molecules

Room: Gallatin

Speaker 3 of 3
* Robert C. Murphy, University of Colorado Denver, USA
Eicosanoids and the Response to Oxidative Stress

Thursday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Thursday, January 10 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson / Madison


Thursday, January 10 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson / Madison


Friday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Friday, January 11 | 8:00AM - 11:15AM
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Room: Gallatin

Speaker 1 of 6
* Bart N. Lambrecht, VIB, Ghent University, Belgium
Dendritic Cells in the Initiation and Maintenance of Chronic Inflammation

Friday, January 11 | 8:00AM - 11:15AM
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Room: Gallatin

Speaker 2 of 6
Chun Geun Lee, Yale University School of Medicine, USA
A Critical Role for YKL-40 in the Regulation of Th2 Immunity

Friday, January 11 | 8:00AM - 11:15AM
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Room: Gallatin

Speaker 3 of 6
Francois Trottein, Institut Pasteur de Lille, France
Prostaglandin D2 in Dendritic Cell/Innate Immune Cell Interplay

Friday, January 11 | 8:00AM - 11:15AM
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Room: Gallatin

Speaker 4 of 6
Charlie Weller, Wellcome Trust, UK
Mast Cell Trafficking: Identification of Chemotactic Factors

Friday, January 11 | 8:00AM - 11:15AM
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Room: Gallatin

Speaker 5 of 6
Sybille van den Brule, Université catholique de Louvain, Belgium
Short Talk: Implication of PGD2/DP in the Protective Effect of IL-9 against Lung Fibrosis

Friday, January 11 | 8:00AM - 11:15AM
Dendritic Cells, Macrophages, and Pulmonary Inflammation
Room: Gallatin

Speaker 6 of 6
Hans-Erik Claesson, Biolipox AB, Sweden
Short Talk: Eoxins - Novel Proinflammatory Arachidonic Acid Metabolites Produced via the 15-Lipoxygenase-1 Pathway in Human Eosinophils and Mast Cells

Friday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Friday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Friday, January 11 | 5:00PM - 7:00PM
Eicosanoid-Based Therapies for Chronic Inflammatory Disease
Room: Gallatin

Speaker 1 of 4
* Paola Patrignani, G. D'Annunzio University, Italy
Biochemistry of Long-term NSAID Therapy

Friday, January 11 | 5:00PM - 7:00PM
Eicosanoid-Based Therapies for Chronic Inflammatory Disease
Room: Gallatin

Speaker 2 of 4
Emanuela Ricciotti, University of Pennsylvania, USA
Short Talk: An Unbiased Approach to Identifying Off-Target Effects of Selective Cyclooxygenase-2 Inhibitors

Friday, January 11 | 5:00PM - 7:00PM
Eicosanoid-Based Therapies for Chronic Inflammatory Disease
Room: Gallatin

Speaker 3 of 4
Jonathan H. Gillard, University of Cambridge, UK
Imaging Macrophages in Carotid Atheroma

Friday, January 11 | 5:00PM - 7:00PM
Eicosanoid-Based Therapies for Chronic Inflammatory Disease
Room: Gallatin

Speaker 4 of 4
William Kerwin, University of Washington School of Medicine, USA
Quantifying the Effects of Inflammation in Carotid Atherosclerotic Plaque by MRI

Friday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Saturday, January 12 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.