Web Desc
Molecular Basis for Biological Membrane Organization
Organizer(s): Kai Simons, Ira Mellman and Petra Schwille
Date: January 12 - 17, 2008
Location: Big Sky Resort, Big Sky, MT, USA
Supported by the Director's Fund
Summary of Meeting:
The organization of cell membranes is a hot topic and the field is characterized by controversies regarding how proteins and lipids interact and how membranes become compartmentalized to form platforms that function in signaling, trafficking and cell polarization. Lipids and membranes are central to understanding the pathogenesis of important diseases such as atherosclerosis, Alzheimer’s Disease, AIDS, and influenza. Major questions revolve around how lipids interact with other lipids and, most importantly, how proteins and lipids interact. The goal of this meeting is to bring together scientists from biochemistry, structural biology, lipidomics, molecular cell biology and biomedicine to discuss major issues in the field. The multidisciplinary character of the meeting will promote discussion and the program is designed to stimulate exchange among investigators who would not otherwise interact.
Scholarship Deadline: September 12 2007
Discounted Abstract Deadline: September 12 2007
Abstract Deadline: October 15 2007
Discounted Registration Deadline: November 12 2007
We gratefully acknowledge additional support for this conference from:
Avanti Polar Lipids, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13GM081929-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 12 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Saturday, January 12 | 6:30PM - 7:30PM
Refreshments
Room: Lower Atrium


Saturday, January 12 | 7:30PM - 8:30PM
Keynote Address
Room: Gallatin

Speaker 1 of 2
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Saturday, January 12 | 7:30PM - 8:30PM
Keynote Address
Room: Gallatin

Speaker 2 of 2
Michael S. Brown, University of Texas Southwestern Medical Center, USA
The SREBP Pathway for Membrane Cholesterol Homeostasis

Sunday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Sunday, January 13 | 8:00AM - 11:00AM
Membrane Proteins
Room: Gallatin

Speaker 1 of 5
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Sunday, January 13 | 8:00AM - 11:00AM
Membrane Proteins
Room: Gallatin

Speaker 2 of 5
Harvey T. McMahon, MRC Laboratory of Molecular Biology, UK
Structural Biology of Cell Membrane Bending

Sunday, January 13 | 8:00AM - 11:00AM
Membrane Proteins
Room: Gallatin

Speaker 3 of 5
Margaret Kielian, Albert Einstein College of Medicine, USA
Virus-Membrane Fusion: Mechanisms and Lipid Interactions of Class II Fusion Proteins.

Sunday, January 13 | 8:00AM - 11:00AM
Membrane Proteins
Room: Gallatin

Speaker 4 of 5
Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structural Basis for Membrane Targeting by the HIV-1 Gag Protein

Sunday, January 13 | 8:00AM - 11:00AM
Membrane Proteins
Room: Gallatin

Speaker 5 of 5
Shinya Yoshikawa, University of Hyogo, Japan
Lipid-Protein Interactions in Cytochrome c Oxidase

Sunday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Sunday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson / Madison


Sunday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson / Madison


Sunday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Sunday, January 13 | 5:00PM - 7:00PM
Membrane Dynamics
Room: Gallatin

Speaker 1 of 5
* Petra Schwille, Max Planck Institute of Biochemistry, Germany

Sunday, January 13 | 5:00PM - 7:00PM
Membrane Dynamics
Room: Gallatin

Speaker 2 of 5
Pietro V. De Camilli, Yale University School of Medicine, USA
Role of Dynamin in Membrane Fission

Sunday, January 13 | 5:00PM - 7:00PM
Membrane Dynamics
Room: Gallatin

Speaker 3 of 5
Patricia Bassereau, Institut Curie, France
Membrane Nanotubes and Intracellular Traffic

Sunday, January 13 | 5:00PM - 7:00PM
Membrane Dynamics
Room: Gallatin

Speaker 4 of 5
Cameron Scott, University of Geneva, Switzerland
Short Talk: Lumenal Ion Composition and Endosomal Membrane Dynamics

Sunday, January 13 | 5:00PM - 7:00PM
Membrane Dynamics
Room: Gallatin

Speaker 5 of 5
Enrico Gratton, University of Illinois at Urbana Champaign, USA
Short Talk: Detecting Membrane Transient Zones Using Scanning Fluctuation Correlation Spectroscopy

Sunday, January 13 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Sunday, January 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson / Madison


Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Monday, January 14 | 8:00AM - 11:00AM
Membrane Phases
Room: Gallatin

Speaker 1 of 5
* Petra Schwille, Max Planck Institute of Biochemistry, Germany

Monday, January 14 | 8:00AM - 11:00AM
Membrane Phases
Room: Gallatin

Speaker 2 of 5
Gerald Feigenson, Cornell University, USA
Phase Diagrams as Models for Plasma Membranes

Monday, January 14 | 8:00AM - 11:00AM
Membrane Phases
Room: Gallatin

Speaker 3 of 5
Sarah Keller, University of Washington, USA
Domain Formation in Asymmetric Model Bilayers

Monday, January 14 | 8:00AM - 11:00AM
Membrane Phases
Room: Gallatin

Speaker 4 of 5
Tobias Baumgart, University of Pennsylvania, USA
Of Domains and Boundaries: Phase Behavior and Partitioning in Biomembrane Models

Monday, January 14 | 8:00AM - 11:00AM
Membrane Phases
Room: Gallatin

Speaker 5 of 5
Satyajit Mayor, National Centre for Biological Sciences, India
Active Membrane Organization in Living Cells

Monday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 14 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson / Madison


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson / Madison


Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Molecular Basis for Domains within Membranes
Room: Gallatin

Speaker 1 of 6
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Molecular Basis for Domains within Membranes
Room: Gallatin

Speaker 2 of 6
Peter Mayinger, Oregon Health and Science University, USA
Lipid Phosphatases Establish Spatially and Functionally Distinct Regions within the Golgi

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Molecular Basis for Domains within Membranes
Room: Gallatin

Speaker 3 of 6
Robin Klemm, University of Zurich, Switzerland
A Role for Lipid Rafts in Protein Sorting and Vesicle Formation at the trans Golgi Network

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Molecular Basis for Domains within Membranes
Room: Gallatin

Speaker 4 of 6
Jen Liou, University of Texas Southwestern Medical Center, USA
Dynamic Contact Formation of the Endoplasmic Reticulum and the Plasma Membrane during Store-Operated Ca2+ Entry

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Molecular Basis for Domains within Membranes
Room: Gallatin

Speaker 5 of 6
Ritva Tikkanen, University Clinic of Frankfurt, Germany
Lymphocyte Raft Protein Reggie-2/Flotillin-1 Directly Interacts with HIV-1 Gag Protein and Plays a Role in Virus Assembly and Release

Monday, January 14 | 2:30PM - 4:30PM
Workshop 1: Molecular Basis for Domains within Membranes
Room: Gallatin

Speaker 6 of 6
Angela Wandinger-Ness, University of New Mexico, USA
Sorting Out The Ciliary Transport Puzzle: Small GTPases and Renal Cystic
Disease


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, January 14 | 5:00PM - 7:00PM
Membrane Cytoskeleton
Room: Gallatin

Speaker 1 of 6
Ira Mellman, Genentech, Inc., USA

Monday, January 14 | 5:00PM - 7:00PM
Membrane Cytoskeleton
Room: Gallatin

Speaker 2 of 6
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Monday, January 14 | 5:00PM - 7:00PM
Membrane Cytoskeleton
Room: Gallatin

Speaker 3 of 6
Pekka Lappalainen, University of Helsinki, Finland
Regulation of the Actin Cytoskeleton and Plasma Membrane Dynamics by MIM/ABBA Family Proteins

Monday, January 14 | 5:00PM - 7:00PM
Membrane Cytoskeleton
Room: Gallatin

Speaker 4 of 6
Anthony P. Bretscher, Cornell University, USA
Regulation of the Cell Cortex by ERM and their Association Proteins

Monday, January 14 | 5:00PM - 7:00PM
Membrane Cytoskeleton
Room: Gallatin

Speaker 5 of 6
Tatyana Svitkina, University of Pennsylvania, USA
Membranes on the Move

Monday, January 14 | 5:00PM - 7:00PM
Membrane Cytoskeleton
Room: Gallatin

Speaker 6 of 6
Chiara Zurzolo, Institut Pasteur, France
Short Talk: Prions Hi-Jack TNTs for Intracellular Transfer

Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Monday, January 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson / Madison


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Tuesday, January 15 | 8:00AM - 11:00AM
Membrane Signaling
Room: Gallatin

Speaker 1 of 5
* Ira Mellman, Genentech, Inc., USA

Tuesday, January 15 | 8:00AM - 11:00AM
Membrane Signaling
Room: Gallatin

Speaker 2 of 5
Gillian Griffiths, Cambridge Institute for Medical Research, UK
Secretory Lysosome

Tuesday, January 15 | 8:00AM - 11:00AM
Membrane Signaling
Room: Gallatin

Speaker 3 of 5
Mark M. Davis, Stanford University School of Medicine, USA
T-Cell Receptor Signaling

Tuesday, January 15 | 8:00AM - 11:00AM
Membrane Signaling
Room: Gallatin

Speaker 4 of 5
Jay T. Groves, University of California, Berkeley, USA
Membrane Spatial Organization and the Mechanics of T Cell Receptor Signaling

Tuesday, January 15 | 8:00AM - 11:00AM
Membrane Signaling
Room: Gallatin

Speaker 5 of 5
Katharina Gaus, University of New South Wales, Australia
Functional Implications of Membrane Condensation for T Cell Activation

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 15 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson / Madison


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson / Madison


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 15 | 5:00PM - 7:00PM
Lipids and Fusion
Room: Gallatin

Speaker 1 of 5
* Petra Schwille, Max Planck Institute of Biochemistry, Germany

Tuesday, January 15 | 5:00PM - 7:00PM
Lipids and Fusion
Room: Gallatin

Speaker 2 of 5
Andrej Shevchenko, Max Planck Institute, Germany
Toward Comprehensive Profiling of Membrane Lipidomes

Tuesday, January 15 | 5:00PM - 7:00PM
Lipids and Fusion
Room: Gallatin

Speaker 3 of 5
Peter K. Kasson, University of Virginia, USA
Short Talk: Simulating Vesicle Fusion: Effects of Membrane Composition, Curvature, and Lipid Ordering

Tuesday, January 15 | 5:00PM - 7:00PM
Lipids and Fusion
Room: Gallatin

Speaker 4 of 5
Leonid V. Chernomordik, National Institute of Child Health and Human Development, USA
Protein-Lipid Interplay in Membrane Fusion

Tuesday, January 15 | 5:00PM - 7:00PM
Lipids and Fusion
Room: Gallatin

Speaker 5 of 5
Martin W. Hetzer, The Salk Institute for Biological Studies, USA
Short Talk: Nuclear Envelope Formation by Chromatin-Mediated Reorganization of the Endoplasmic Reticulum

Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Tuesday, January 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Jefferson / Madison


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson / Madison


Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Morphogenesis
Room: Gallatin

Speaker 1 of 6
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Morphogenesis
Room: Gallatin

Speaker 2 of 6
Tom A. Rapoport, Harvard University Medical School, USA
How the ER Gets into Shape

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Morphogenesis
Room: Gallatin

Speaker 3 of 6
Walther Mothes, Yale University School of Medicine, USA
Cell-to-Cell Transmission of Retroviruses via Filopodial Bridges

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Morphogenesis
Room: Gallatin

Speaker 4 of 6
Daniel M. Davis, Imperial College London, UK
Membrane Nanotubes in Human T Cell Biology

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Morphogenesis
Room: Gallatin

Speaker 5 of 6
Peter K. Jackson, Stanford University, USA
Biogenesis and Function of the Primary Cilium

Wednesday, January 16 | 8:00AM - 11:00AM
Membrane Morphogenesis
Room: Gallatin

Speaker 6 of 6
† Ruth Kroschewski, Swiss Federal Institute of Technology, Switzerland
Short Talk:

Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 1 of 7
* Ira Mellman, Genentech, Inc., USA

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 2 of 7
Tristan S. Ursell, California Institute of Technology, USA
Dynamic Morphologies and Coalescence of Lipid Domains

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 3 of 7
Inhee Chung, Genentech Incorporated, USA
Reversible Dimerization of Single Epidermal Growth Factor Receptor and its Spatial Heterogeneity in Live A431 Cell

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 4 of 7
Suliana Manley, National Institutes of Health, USA
Live Cell Photoactivated Localization Microscopy (PALM) for the Spatio-Temporal Mapping of Single Molecule Diffusion in the Plasma Membrane

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 5 of 7
Dimitrios Stamou, University of Copenhagen, Denmark
How BAR Domains and Amphipathic Helixes Recognize Membrane Curvature: A High-Throughput Single Vesicle Study

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 6 of 7
Xavier Michalet, University of California, Los Angeles, USA
Single-Molecule Tracking of GPI-Anchored Protein Using Quantum Dots Shows Dynamic Partitioning In and Out of GM1 and Cholesterol-Rich Domains in the Plasma Membrane of Live Cells

Wednesday, January 16 | 2:30PM - 4:30PM
Workshop 2: New Technologies for Addressing Challenges in St
udies of Biological Membranes
Room: Gallatin

Speaker 7 of 7
Salvatore Chiantia, MPI-CBG, Germany
Role of Ceramide Domains in Membrane Protein Organization Investigated by Simultaneous FCS and AFM

Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 16 | 5:00PM - 7:00PM
Membrane Sorting and Vesicle Formation
Room: Gallatin

Speaker 1 of 5
* Ira Mellman, Genentech, Inc., USA

Wednesday, January 16 | 5:00PM - 7:00PM
Membrane Sorting and Vesicle Formation
Room: Gallatin

Speaker 2 of 5
Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Genome-Wide Survey of Endocytosis by Quantitative Multi-Parametric Image Analysis

Wednesday, January 16 | 5:00PM - 7:00PM
Membrane Sorting and Vesicle Formation
Room: Gallatin

Speaker 3 of 5
Ari Helenius, ETH Zurich, Switzerland
Endocytic Pathways of Virus Entry

Wednesday, January 16 | 5:00PM - 7:00PM
Membrane Sorting and Vesicle Formation
Room: Gallatin

Speaker 4 of 5
Sandra L. Schmid, University of Texas Southwestern Medical Center, USA
Role of Dynamin in Clathrin-Mediated Endocytosis

Wednesday, January 16 | 5:00PM - 7:00PM
Membrane Sorting and Vesicle Formation
Room: Gallatin

Speaker 5 of 5
Jason A. Mears, Case Western Reserve University, USA
Short Talk: Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission

Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson / Madison


Wednesday, January 16 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson / Madison


Wednesday, January 16 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson / Madison


Thursday, January 17 | 10:25AM - 10:25AM
Departure


*Session Chair.