Web Desc
Forkhead Transcription Factor Networks in Development, Signaling, and Disease
Organizer(s): Kenneth S. Zaret, Klaus H. Kaestner and Susan E. Mango
Date: January 13 - 17, 2008
Location: Zermatt Resort & Spa - Utah, Midway, UT, USA
Supported by the Director's Fund
Summary of Meeting:
Forkhead box (FOX) transcription factors were discovered to bind target DNA sites in compacted chromatin, where many other transcription factors cannot bind, and subsequently found to play central roles in regulatory networks that control development, signaling, metabolism, and human disease. The proposed meeting will provide a rare opportunity for cross-fertilization of ideas from very different areas of biological sciences, spanning diverse model organisms and humans, all surrounding this special class of transcription factor. It is expected that the convergence of different models systems, approaches, and thinking will allow unique new insights and advances in each of the scientific domains in which FOXA factors are studied.
Scholarship Deadline: September 12 2007
Discounted Abstract Deadline: September 12 2007
Abstract Deadline: October 15 2007
Discounted Registration Deadline: November 13 2007
We gratefully acknowledge additional support for this conference from:
Developmental DynamicsMarch of Dimes Foundation
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD057650-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 3:00PM - 7:30PM
Registration
Room: Matterhorn Foyer


Sunday, January 13 | 6:30PM - 7:30PM
Refreshments
Room: Matterhorn Foyer


Sunday, January 13 | 7:30PM - 8:30PM
Keynote Session
Room: Matterhorn Ballroom

Speaker 1 of 1
Myles Brown, Dana-Farber Cancer Institute, USA
Connecting Forkhead Factors and Nuclear Receptors to the Genome

Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's Restaurant


Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 1 of 7
* Jane Mellor, University of Oxford, UK

Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 2 of 7
Susan E. Mango, Harvard University, USA
Making and Shaping the Foregut in C. elegans

Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 3 of 7
Peter L. J. de Keizer, UMC Utrecht, Netherlands
Short Talk: The Peptidyl-Isomerase Pin1 Regulates p27kip1 Expression through Inhibition of FOXO Transcription Factors

Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 4 of 7
Deborah J. Andrew, Johns Hopkins University, USA
The Role of the Fox A Protein Fkh in the Drosophila Salivary Gland

Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 5 of 7
Sven Enerbäck, University of Gothenburg, Sweden
A Conserved Foxi1 Regulated Genetic Circuit Operates in the Ear, Kidney and Epididymis

Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 6 of 7
Siew-Lan Ang, National Institute for Medical Research, UK
Short Talk: Foxa1 and Foxa2 Regulate Midbrain Dopaminergic Neuron Development in a Dosage-Dependent Manner

Monday, January 14 | 8:00AM - 11:15AM
Development and Transcription Networks I
Room: Matterhorn Ballroom

Speaker 7 of 7
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
The Foxa Genes in the Endocrine Pancreas

Monday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Davos Break area


Monday, January 14 | 11:15AM - 1:00PM
Poster Set Up for Sessions 1 & 2
Room: Davos/ Grindelwald


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Davos/ Grindelwald


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Davos Break area


Monday, January 14 | 5:00PM - 7:00PM
Chromatin Remodeling and Transcription
Room: Matterhorn Ballroom

Speaker 1 of 5
* Susan E. Mango, Harvard University, USA

Monday, January 14 | 5:00PM - 7:00PM
Chromatin Remodeling and Transcription
Room: Matterhorn Ballroom

Speaker 2 of 5
Jane Mellor, University of Oxford, UK
Yeast Fkh1 and Fkh2 Factors and Chromatin Remodeling


Monday, January 14 | 5:00PM - 7:00PM
Chromatin Remodeling and Transcription
Room: Matterhorn Ballroom

Speaker 3 of 5
Lisa Ann Cirillo, Medical College of Wisconsin, USA
Chromatin Binding and Perturbation by FoxO1

Monday, January 14 | 5:00PM - 7:00PM
Chromatin Remodeling and Transcription
Room: Matterhorn Ballroom

Speaker 4 of 5
David Stillman, University of Utah, USA
Short Talk: Yeast Fkh1 and Fkh2 Proteins Recruit the Sin3 HDAC to Promoters and Can Block Activation By Promoter Bound Factors

Monday, January 14 | 5:00PM - 7:00PM
Chromatin Remodeling and Transcription
Room: Matterhorn Ballroom

Speaker 5 of 5
Kenneth S. Zaret, University of Pennsylvania, USA
Distinctive Chromatin Binding and Scanning Properties of Fox Factors

Monday, January 14 | 7:00PM - 7:15PM
Discussion About the Creation of New Web Resources for Fox F
actors

Room: Matterhorn Ballroom

Speaker 1 of 1
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA

Monday, January 14 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Davos/ Grindelwald


Monday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Davos/ Grindelwald


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's Restaurant


Tuesday, January 15 | 8:00AM - 11:00AM
Metabolism and Signaling
Room: Matterhorn Ballroom

Speaker 1 of 6
* Deborah J. Andrew, Johns Hopkins University, USA

Tuesday, January 15 | 8:00AM - 11:00AM
Metabolism and Signaling
Room: Matterhorn Ballroom

Speaker 2 of 6
Heidi Tissenbaum, University of Massachusetts Medical School, USA
Complex Regulation by C. elegans FOXO/Daf-16

Tuesday, January 15 | 8:00AM - 11:00AM
Metabolism and Signaling
Room: Matterhorn Ballroom

Speaker 3 of 6
Hyun Jung Park, University of Illinois at Chicago, USA
Short Talk: Cell Cycle Regulation of the Forkhead Box M1 (FoxM1) Transcription Factor

Tuesday, January 15 | 8:00AM - 11:00AM
Metabolism and Signaling
Room: Matterhorn Ballroom

Speaker 4 of 6
Andrew G. Dillin, University of California, Berkeley, USA
Pha4/Foxa, Diet Restriction, and Longevity


Tuesday, January 15 | 8:00AM - 11:00AM
Metabolism and Signaling
Room: Matterhorn Ballroom

Speaker 5 of 6
Andrei L. Gartel, University of Illinois, USA
Short Talk: Thiazole Antibiotics that Inhibit FoxM1 are Potential Anticancer Drugs

Tuesday, January 15 | 8:00AM - 11:00AM
Metabolism and Signaling
Room: Matterhorn Ballroom

Speaker 6 of 6
Ronald D. McKay, Lieber Institute for Brain Development, USA
Foxa2, Dopamine Neurons, and Parkinson's Disease

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Davos Break area


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Davos/ Grindelwald


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Davos Break area


Tuesday, January 15 | 5:00PM - 7:00PM
Structure and Evolution of Winged Helix Proteins
Room: Matterhorn Ballroom

Speaker 1 of 5
* Michelle C. Barton, University of Texas MD Anderson Cancer Center, USA

Tuesday, January 15 | 5:00PM - 7:00PM
Structure and Evolution of Winged Helix Proteins
Room: Matterhorn Ballroom

Speaker 2 of 5
Paola Oliveri, University College London, UK
Fox Genes in Regulatory Networks for Embryo Development and Evolution

Tuesday, January 15 | 5:00PM - 7:00PM
Structure and Evolution of Winged Helix Proteins
Room: Matterhorn Ballroom

Speaker 3 of 5
Lin Chen, University of Southern California, USA
Structural Insights into the Potential Role of FOXP Proteins in the Epigenetic Control of Chromatin Structure

Tuesday, January 15 | 5:00PM - 7:00PM
Structure and Evolution of Winged Helix Proteins
Room: Matterhorn Ballroom

Speaker 4 of 5
Xiubei Liao, University of Illinois at Chicago, USA
Folding Stage Dependent Interactions Between HNF-6 and FoxD3 Hint at a Complicated Network in Transcriptional Regulation

Tuesday, January 15 | 5:00PM - 7:00PM
Structure and Evolution of Winged Helix Proteins
Room: Matterhorn Ballroom

Speaker 5 of 5
Michael Brent, Wistar Institute, USA
Short Talk: Structure and Regulation of Human FoxO1 Transcription Factor

Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Davos/ Grindelwald


Tuesday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Davos/ Grindelwald


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Schneitter's Restaurant


Wednesday, January 16 | 8:00AM - 11:00AM
The Fox Genes in Human Disease
Room: Matterhorn Ballroom

Speaker 1 of 6
* Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA

Wednesday, January 16 | 8:00AM - 11:00AM
The Fox Genes in Human Disease
Room: Matterhorn Ballroom

Speaker 2 of 6
H. Phillip Koeffler, Cedars-Sinai Medical Center, USA
FOXA1 and BRCA1 in Breast Cancer

Wednesday, January 16 | 8:00AM - 11:00AM
The Fox Genes in Human Disease
Room: Matterhorn Ballroom

Speaker 3 of 6
Michael A. Walter, University of Alberta, Canada
FOXC1 in Axenfeld-Rieger-Syndrome and Glaucoma

Wednesday, January 16 | 8:00AM - 11:00AM
The Fox Genes in Human Disease
Room: Matterhorn Ballroom

Speaker 4 of 6
Constance Scharff, Max Planck Institute for Molecular Genetics, Germany
Foxp2 in Learned Avian Vocalizations

Wednesday, January 16 | 8:00AM - 11:00AM
The Fox Genes in Human Disease
Room: Matterhorn Ballroom

Speaker 5 of 6
Ping Hu, University of California, Berkeley, USA
Short Talk: A Dual Activator Mechanism Directs Myoblast Specific MyoD Transcription

Wednesday, January 16 | 8:00AM - 11:00AM
The Fox Genes in Human Disease
Room: Matterhorn Ballroom

Speaker 6 of 6
Simon E. Fisher, Oxford University, UK
Neurogenetic Pathways Regulated by FOXP2, a Gene Involved in Speech and Language

Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Davos Break area


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Davos Break area


Wednesday, January 16 | 6:00PM - 7:00PM
Development II
Room: Matterhorn Ballroom

Speaker 1 of 3
* Kenneth S. Zaret, University of Pennsylvania, USA

Wednesday, January 16 | 6:00PM - 7:00PM
Development II
Room: Matterhorn Ballroom

Speaker 2 of 3
Michelle C. Barton, University of Texas MD Anderson Cancer Center, USA
Temporal Orchestration of Chromatin Regulation by Foxa1, TGFß and p53

Wednesday, January 16 | 6:00PM - 7:00PM
Development II
Room: Matterhorn Ballroom

Speaker 3 of 3
Peter Carlsson, Göteborg University, Sweden
FoxF Genes in Murine Embryonic Development

Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Davos/ Grindelwald


Wednesday, January 16 | 8:00PM - 11:00PM
Entertainment
Room: Davos/ Grindelwald


Wednesday, January 16 | 8:00PM - 11:00PM
Cash Bar
Room: Davos/ Grindelwald


Thursday, January 17 | 10:25AM - 10:25AM
Departure


*Session Chair.