Web Desc
Pathological and Physiological Regulation of Cardiac Hypertrophy
Organizer(s): Leslie A. Leinwand and Eric N. Olson
Date: January 13 - 18, 2008
Location: Copper Mountain Resort, Copper Mountain, Colorado, USA
Sponsored by Novartis Institutes for BioMedical Research
For important information on the coronavirus, please click here
Summary of Meeting:
Heart disease remains a leading cause of death and constitutes a complex array of disorders. This meeting will explore new areas of research on how the heart adapts to a wide variety of stimuli including exercise, diet, and genetic background. In the post-genome era, it is now possible to contemplate new heart disease therapies such as through tissue engineering, and stem cell and molecular therapies. The role of microRNAs in regulating cardiac development and disease is an exciting new field of study. We will also consider understanding the mechanisms that animals in nature use to regulate their hearts during hibernation and fasting and feeding.
Scholarship Deadline: September 14 2007
Discounted Abstract Deadline: September 14 2007
Abstract Deadline: October 17 2007
Discounted Registration Deadline: November 13 2007
We gratefully acknowledge additional support for this conference from:
American Heart AssociationBoehringer Ingelheim Pharmaceuticals, Inc.Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Cytokinetics, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13HL091551-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 13 | 3:00PM - 7:30PM
Registration
Room: Kokopelli's


Sunday, January 13 | 6:30PM - 7:30PM
Refreshments
Room: Kokopelli's


Sunday, January 13 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn A

Speaker 1 of 1
James A. Spudich, Stanford University, USA
How do Myosins Really Work?

Monday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Monday, January 14 | 8:00AM - 11:00AM
MicroRNAs in Cardiac Development and Disease
Room: Bighorn A

Speaker 1 of 6
* Eric N. Olson, University of Texas Southwestern Medical Center, USA

Monday, January 14 | 8:00AM - 11:00AM
MicroRNAs in Cardiac Development and Disease
Room: Bighorn A

Speaker 2 of 6
Deepak Srivastava, Gladstone Institutes, USA
MicroRNA Regulation of Cardiac Cell Fate, Morphogenesis and Maintenance

Monday, January 14 | 8:00AM - 11:00AM
MicroRNAs in Cardiac Development and Disease
Room: Bighorn A

Speaker 3 of 6
Eva van Rooij, Hubrecht Institute, Netherlands
Stress Responsive microRNAs and their Control of Cardiac Disease

Monday, January 14 | 8:00AM - 11:00AM
MicroRNAs in Cardiac Development and Disease
Room: Bighorn A

Speaker 4 of 6
Michel A.J. Georges, University of Leige GIGA Institute B34, Belgium
Uncovering Roles for miRNAs in Shaping Phenotypic Variability in Domestic Animals

Monday, January 14 | 8:00AM - 11:00AM
MicroRNAs in Cardiac Development and Disease
Room: Bighorn A

Speaker 5 of 6
Minoru Omi, Tohoku University, Japan
Short Talk: miR-21 is Required for Heart Valve Formation in Zebrafish

Monday, January 14 | 8:00AM - 11:00AM
MicroRNAs in Cardiac Development and Disease
Room: Bighorn A

Speaker 6 of 6
Prakash K. Rao, Novartis Institute for Biomedical Research, USA
Short Talk: The Role of MicroRNAs in Muscle Maintenance

Monday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, January 14 | 11:00AM - 1:00PM
Poster Setup
Room: Big Horn C


Monday, January 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Big Horn C


Monday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Monday, January 14 | 5:00PM - 7:00PM
Cardiac Remodeling
Room: Bighorn A

Speaker 1 of 4
* Robert J. Schwartz, Texas A&M University, USA
Serum Response Factor

Monday, January 14 | 5:00PM - 7:00PM
Cardiac Remodeling
Room: Bighorn A

Speaker 2 of 4
Eric N. Olson, University of Texas Southwestern Medical Center, USA
The Myomir Network

Monday, January 14 | 5:00PM - 7:00PM
Cardiac Remodeling
Room: Bighorn A

Speaker 3 of 4
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Unexpected Role for T-type Calcium entry in regulating Cardiac Growth

Monday, January 14 | 5:00PM - 7:00PM
Cardiac Remodeling
Room: Bighorn A

Speaker 4 of 4
Michael D. Schneider, Imperial College London, UK
Cardiac Specification in Embryonic Stem CellsCardiac Specification in Embryonic Stem Cells

Monday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Monday, January 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Big Horn C


Tuesday, January 15 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Tuesday, January 15 | 8:00AM - 11:00AM
Hibernating and Feeding: What We Can Learn from Nature about
Maintenance of Cardiac and Skeletal Muscle Mass

Room: Bighorn A

Speaker 1 of 4
* Nadia A. Rosenthal, The Jackson Laboratory, USA

Tuesday, January 15 | 8:00AM - 11:00AM
Hibernating and Feeding: What We Can Learn from Nature about
Maintenance of Cardiac and Skeletal Muscle Mass

Room: Bighorn A

Speaker 2 of 4
Stephen M. Secor, University of Alabama, USA
The Python Heart: Extreme Regulation of Form and Function

Tuesday, January 15 | 8:00AM - 11:00AM
Hibernating and Feeding: What We Can Learn from Nature about
Maintenance of Cardiac and Skeletal Muscle Mass

Room: Bighorn A

Speaker 3 of 4
Thomas G. Marr, Hiberna Corporation, USA
Profound Mammalian Hibernation

Tuesday, January 15 | 8:00AM - 11:00AM
Hibernating and Feeding: What We Can Learn from Nature about
Maintenance of Cardiac and Skeletal Muscle Mass

Room: Bighorn A

Speaker 4 of 4
Nadia A. Rosenthal, The Jackson Laboratory, USA
The Role of IGF1 in Maintaining Muscle Mass in Heart Failure

Tuesday, January 15 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, January 15 | 11:00AM - 1:00PM
Poster Setup
Room: Big Horn C


Tuesday, January 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Big Horn C


Tuesday, January 15 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Tuesday, January 15 | 5:00PM - 7:00PM
The Effects of Heart Disease on Skeletal Muscle
Room: Bighorn A

Speaker 1 of 4
* Elizabeth M. McNally, Northwestern University, USA

Tuesday, January 15 | 5:00PM - 7:00PM
The Effects of Heart Disease on Skeletal Muscle
Room: Bighorn A

Speaker 2 of 4
Daniel P. Kelly, University of Pennsylvania, USA
PGC-1 Coactivators in Heart and Skeletal Muscle

Tuesday, January 15 | 5:00PM - 7:00PM
The Effects of Heart Disease on Skeletal Muscle
Room: Bighorn A

Speaker 3 of 4
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Remodeling of the RyR1 Channel Complex Causes Impaired Exercise Capacity in Heart Failure

Tuesday, January 15 | 5:00PM - 7:00PM
The Effects of Heart Disease on Skeletal Muscle
Room: Bighorn A

Speaker 4 of 4
Steven R. Houser, Temple University School of Medicine, USA
Differing Viewpoints on RyR and Heart Failure

Tuesday, January 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Tuesday, January 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Big Horn C


Wednesday, January 16 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Wednesday, January 16 | 8:00AM - 11:00AM
Modifiers of Heart Disease
Room: Bighorn A

Speaker 1 of 4
Leslie A. Leinwand, University of Colorado Boulder, USA
A Tale of Two Diets: Diet Affects the Heart

Wednesday, January 16 | 8:00AM - 11:00AM
Modifiers of Heart Disease
Room: Bighorn A

Speaker 2 of 4
* Christine E. Seidman, Harvard Medical School, USA
Mechanistic Insight through Deep Transcriptional Profiling

Wednesday, January 16 | 8:00AM - 11:00AM
Modifiers of Heart Disease
Room: Bighorn A

Speaker 3 of 4
Joseph H. Nadeau, Maine Medical Center Research Institute, USA
Genetic Architecture of Complex Traits in Chromosome Substitution Strains

Wednesday, January 16 | 8:00AM - 11:00AM
Modifiers of Heart Disease
Room: Bighorn A

Speaker 4 of 4
Da-Zhi Wang, Children's Hospital Boston, USA
miRNAs that Regulate Cardiac Development and Function

Wednesday, January 16 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Wednesday, January 16 | 11:00AM - 1:00PM
Poster Setup
Room: Big Horn C


Wednesday, January 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Big Horn C


Wednesday, January 16 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Wednesday, January 16 | 5:00PM - 7:00PM
Is Blocking Pathologic Hypertrophy a Good Therapeutic Strate
gy?

Room: Bighorn A

Speaker 1 of 4
* Michael R. Bristow, University of Colorado Anschutz Medical Campus, USA
Maladaptive Remodeling of the Human Left Ventricle as a Therapeutic Target

Wednesday, January 16 | 5:00PM - 7:00PM
Is Blocking Pathologic Hypertrophy a Good Therapeutic Strate
gy?

Room: Bighorn A

Speaker 2 of 4
Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Pathologic Hypertrophy – an Unfolding Story

Wednesday, January 16 | 5:00PM - 7:00PM
Is Blocking Pathologic Hypertrophy a Good Therapeutic Strate
gy?

Room: Bighorn A

Speaker 3 of 4
Fady Malik, Cytokinetics Inc., USA
Can Small Molecules Improve Cardiac Performance?

Wednesday, January 16 | 5:00PM - 7:00PM
Is Blocking Pathologic Hypertrophy a Good Therapeutic Strate
gy?

Room: Bighorn A

Speaker 4 of 4
Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Short Talk: Cardiomyocyte Autophagy in the Pathogenesis of Heart Failure

Wednesday, January 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Wednesday, January 16 | 7:30PM - 10:00PM
Poster Session 3
Room: Big Horn C


Thursday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Kokopelli's


Thursday, January 17 | 8:00AM - 11:00AM
Stem Cells and Gene Therapy: The Ongoing Debate
Room: Bighorn A

Speaker 1 of 5
* Daniel P. Kelly, University of Pennsylvania, USA

Thursday, January 17 | 8:00AM - 11:00AM
Stem Cells and Gene Therapy: The Ongoing Debate
Room: Bighorn A

Speaker 2 of 5
Yuh-Shin Chang, Massachusetts General Hospital, USA
A Stretch-Activated Survival Pathway in Heart Progenitors and Their Progeny Mediates by the ER/SR Transcription Factor Creb3L2

Thursday, January 17 | 8:00AM - 11:00AM
Stem Cells and Gene Therapy: The Ongoing Debate
Room: Bighorn A

Speaker 3 of 5
Elizabeth M. McNally, Northwestern University, USA
Regeneration and Repair in Skeletal Muscle

Thursday, January 17 | 8:00AM - 11:00AM
Stem Cells and Gene Therapy: The Ongoing Debate
Room: Bighorn A

Speaker 4 of 5
Ulrich Martin, Hannover Medical School, Germany
Short Talk: Cardiac Differentiation of Induced Pluripotent Stem (iPS) Cells

Thursday, January 17 | 8:00AM - 11:00AM
Stem Cells and Gene Therapy: The Ongoing Debate
Room: Bighorn A

Speaker 5 of 5
Jay W. Schneider, University of Texas Southwestern Medical Center, USA
Short Talk: Small Molecules that Promote Fate and Myocardial Repair

Thursday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Thursday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Kokopelli's


Thursday, January 17 | 5:00PM - 7:00PM
Tissue Engineering of Valves and Hearts
Room: Bighorn A

Speaker 1 of 4
* Leslie A. Leinwand, University of Colorado Boulder, USA

Thursday, January 17 | 5:00PM - 7:00PM
Tissue Engineering of Valves and Hearts
Room: Bighorn A

Speaker 2 of 4
Kristi S. Anseth, HHMI/University of Colorado, USA
Hydrogel Niches for 3D Culture of Valvular Interstitial Cells: Approaches to Valve Regeneration

Thursday, January 17 | 5:00PM - 7:00PM
Tissue Engineering of Valves and Hearts
Room: Bighorn A

Speaker 3 of 4
Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
A Functional Construct of Myocardium for Drug Screening and Target Validation

Thursday, January 17 | 5:00PM - 7:00PM
Tissue Engineering of Valves and Hearts
Room: Bighorn A

Speaker 4 of 4
Doris A. Taylor, Texas Heart Institute, USA
Cells for Cure of CVD: Science or Science Fiction?

Thursday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Kokopelli's


Thursday, January 17 | 8:00PM - 11:00PM
Entertainment
Room: Bighorn C


Thursday, January 17 | 8:00PM - 11:00PM
Cash Bar
Room: Bighorn C


Friday, January 18 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.