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Web Desc
Translational Regulatory Mechanisms Organizer(s): Nahum Sonenberg, Alan G. Hinnebusch and Joel D. Richter Date: January 28 - February 02, 2008 Location: Coeur d'Alene Resort, Coeur d'Alene, ID, USA Supported by the Director's Fund Summary of Meeting: There are many exciting new findings in the field of translational control. The discovery that microRNAs control 30-40% of the genomes of many organisms underscores the paramount importance of translational control. Other exciting research involves identification of subcellular components (P-bodies and stress granules), which link translational control to mRNA stability, and associate with the microRNA machinery. The 3-D structures of initiation factors and bacterial ribosomes have been obtained, and recent findings implicate translational control in diseases (diabetes, obesity, virus infection) and in learning and memory. A critical shortcoming in microRNA research is the lack of understanding of the molecular mechanism. Another problem is the lack of structures of mammalian ribosomes with and without translation factors. The meeting’s goals are to discuss experimental approaches to understand the mechanisms of microRNA action, the structural basis of translation and its control, the link between translation and mRNA stability and, finally, defects in translation that cause disease. Scholarship Deadline: September 26 2007 Discounted Abstract Deadline: September 26 2007 Abstract Deadline: October 31 2007 Discounted Registration Deadline: November 28 2007 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grant No. 1R13HD056600-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Translational Regulatory Mechanisms

Organizer(s): Nahum Sonenberg, Alan G. Hinnebusch and Joel D. Richter

Date: January 28 - February 02, 2008
Location: Coeur d'Alene Resort, Coeur d'Alene, ID, USA

Supported by the Director's Fund

Summary of Meeting:

There are many exciting new findings in the field of translational control. The discovery that microRNAs control 30-40% of the genomes of many organisms underscores the paramount importance of translational control. Other exciting research involves identification of subcellular components (P-bodies and stress granules), which link translational control to mRNA stability, and associate with the microRNA machinery. The 3-D structures of initiation factors and bacterial ribosomes have been obtained, and recent findings implicate translational control in diseases (diabetes, obesity, virus infection) and in learning and memory. A critical shortcoming in microRNA research is the lack of understanding of the molecular mechanism. Another problem is the lack of structures of mammalian ribosomes with and without translation factors. The meeting’s goals are to discuss experimental approaches to understand the mechanisms of microRNA action, the structural basis of translation and its control, the link between translation and mRNA stability and, finally, defects in translation that cause disease.

Scholarship Deadline: September 26 2007

Discounted Abstract Deadline: September 26 2007

Abstract Deadline: October 31 2007

Discounted Registration Deadline: November 28 2007

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD056600-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, January 28 \| 3:00PM - 7:30PM Registration Room: Conference Center Lobby
Monday, January 28 \| 6:30PM - 7:30PM Refreshments Room: Bay 2
Monday, January 28 \| 7:30PM - 9:30PM Keynote Session Room: Bay 3-4 Speaker 1 of 2 Matthias W. Hentze, European Molecular Biology Laboratory, Germany Translational Control by miRNAs and RNA-Binding Proteins
Monday, January 28 \| 7:30PM - 9:30PM Keynote Session Room: Bay 3-4 Speaker 2 of 2 Robert H. Singer, Albert Einstein College of Medicine, USA Conserved Translational Mechanisms of Localized mRNA
Tuesday, January 29 \| 7:00AM - 8:00AM Breakfast Room: Bay 2
Tuesday, January 29 \| 8:00AM - 11:15AM The Translational Apparatus: Prokaryotes versus Eukaryotes Room: Bays 3-4 Speaker 1 of 5 Venki Ramakrishnan, MRC Laboratory of Molecular Biology, UK Structural Studies on Functional Complexes of the Ribosome
Tuesday, January 29 \| 8:00AM - 11:15AM The Translational Apparatus: Prokaryotes versus Eukaryotes Room: Bays 3-4 Speaker 2 of 5 Ada Yonath, Weizmann Institute of Science, Israel Ribosomal Regulaory Mechanism
Tuesday, January 29 \| 8:00AM - 11:15AM The Translational Apparatus: Prokaryotes versus Eukaryotes Room: Bays 3-4 Speaker 3 of 5 Jennifer A. Doudna, HHMI/University of California, Berkeley, USA Getting the Message: Ribosome Recruitment by Viruses and Cells
Tuesday, January 29 \| 8:00AM - 11:15AM The Translational Apparatus: Prokaryotes versus Eukaryotes Room: Bays 3-4 Speaker 4 of 5 * Rachel Green, Johns Hopkins University School of Medicine, USA Mechanistic Studies of Ribosome Function and Potential Implications for Translational Control
Tuesday, January 29 \| 8:00AM - 11:15AM The Translational Apparatus: Prokaryotes versus Eukaryotes Room: Bays 3-4 Speaker 5 of 5 Alan G. Hinnebusch, National Institutes of Health, USA Functions of eIF1, eIF1A, and 18S rRNA in Preinitation Complex Assembly and AUG Selection
Tuesday, January 29 \| 9:20AM - 9:40AM Coffee Break Room: Conference Center Lobby
Tuesday, January 29 \| 11:15AM - 1:00PM Poster Setup Room: Bay 5-6
Tuesday, January 29 \| 1:00PM - 10:00PM Poster Viewing Room: Bay 5-6
Tuesday, January 29 \| 4:30PM - 5:00PM Coffee Available Room: Conference Center Lobby
Tuesday, January 29 \| 5:00PM - 7:30PM New Insight into Translation Initiation Room: Bays 3-4 Speaker 1 of 6 * Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Tuesday, January 29 \| 5:00PM - 7:30PM New Insight into Translation Initiation Room: Bays 3-4 Speaker 2 of 6 Jon R. Lorsch, Johns Hopkins School of Medicine, USA The Molecular Mechanics of Start Site Recognition by the Eukaryotic Translational Machinery
Tuesday, January 29 \| 5:00PM - 7:30PM New Insight into Translation Initiation Room: Bays 3-4 Speaker 3 of 6 Tatyana V. Pestova, SUNY Downstate Medical Center, USA Assembly of 48S Initiation Complexes on mRNAs with Highly Structured 5’-UTRs
Tuesday, January 29 \| 5:00PM - 7:30PM New Insight into Translation Initiation Room: Bays 3-4 Speaker 4 of 6 Gerhard Wagner, Harvard Medical School, USA Protein Interactions in Eukaryotic Translation Initiation and their Inhibition
Tuesday, January 29 \| 5:00PM - 7:30PM New Insight into Translation Initiation Room: Bays 3-4 Speaker 5 of 6 Richard J. Jackson, University of Cambridge, UK Reinitiation Mechanisms in Mammalian mRNA Translation
Tuesday, January 29 \| 5:00PM - 7:30PM New Insight into Translation Initiation Room: Bays 3-4 Speaker 6 of 6 Assen Marintchev, Harvard Medical School, USA Short Talk: Organization of the eIF4A/4G/4H Complex: from Model to Experiment
Tuesday, January 29 \| 7:30PM - 8:30PM Social Hour with Lite Bites Room: Bay 5-6
Tuesday, January 29 \| 7:30PM - 10:00PM Poster Session 1 Room: Bay 5-6
Wednesday, January 30 \| 7:00AM - 8:00AM Breakfast Room: Bay 2
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 1 of 7 * Robert H. Singer, Albert Einstein College of Medicine, USA
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 2 of 7 Anne Ephrussi, European Molecular Biology Laboratory, Germany oskar RNP Assembly for Coordinated Transport and Translation Control
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 3 of 7 Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany The P-Body Component GW182 is Essential for miRNA-Mediated Gene Silencing
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 4 of 7 Jennifer Darnell, Rockefeller University, USA Crosslinking-IP (CLIP) Identification of Novel Pre- and Post-Synaptic RNA Targets of the Fragile X Mental Retardation Protein, FMRP
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 5 of 7 Jason M. Casolari, Stanford University, USA Short Talk: mRNA Localization and Organization in S. cerevisiae
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 6 of 7 John H. Carson, University of Connecticut Health Center, USA Short Talk: Multiplexed Dendritic Targeting of LTP RNAs by the A2 Pathway
Wednesday, January 30 \| 8:00AM - 11:00AM mRNA Transport and Localization Room: Bays 3-4 Speaker 7 of 7 Alexander F. Palazzo, Harvard Medical School, USA Short Talk: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA
Wednesday, January 30 \| 9:20AM - 9:40AM Coffee Break Room: Conference Center Lobby
Wednesday, January 30 \| 11:00AM - 1:00PM Poster Setup Room: Bay 5-6
Wednesday, January 30 \| 1:00PM - 10:00PM Poster Viewing Room: Bay 5-6
Wednesday, January 30 \| 4:30PM - 5:00PM Coffee Available Room: Conference Center Lobby
Wednesday, January 30 \| 5:00PM - 7:15PM Translational Control of Development Room: Bays 3-4 Speaker 1 of 6 * Matthias W. Hentze, European Molecular Biology Laboratory, Germany
Wednesday, January 30 \| 5:00PM - 7:15PM Translational Control of Development Room: Bays 3-4 Speaker 2 of 6 Robert J. Schneider, New York University School of Medicine, USA eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy
Wednesday, January 30 \| 5:00PM - 7:15PM Translational Control of Development Room: Bays 3-4 Speaker 3 of 6 Joel D. Richter, University of Massachusetts Medical School, USA Translational Control of Cellular Senescence by CPEB
Wednesday, January 30 \| 5:00PM - 7:15PM Translational Control of Development Room: Bays 3-4 Speaker 4 of 6 Howard Lipshitz, University of Toronto, Canada Control of mRNA Translation, Stability and Localization during Early Drosophila Development
Wednesday, January 30 \| 5:00PM - 7:15PM Translational Control of Development Room: Bays 3-4 Speaker 5 of 6 Scott L. Noble, University of Colorado Denver Health Sciences Center, USA Short Talk: P-body/Stress Granule-Like Particles are Regulated and Linked to Maternal mRNA Control during C. Elegans Development
Wednesday, January 30 \| 5:00PM - 7:15PM Translational Control of Development Room: Bays 3-4 Speaker 6 of 6 Robin P. Wharton, Duke University Medical Center, USA Short Talk: RNA Tethering to Explore Mechanisms of Regulation in the Early Drosophila Embryo
Wednesday, January 30 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Bay 5-6
Wednesday, January 30 \| 7:30PM - 10:00PM Poster Session 2 Room: Bay 5-6
Thursday, January 31 \| 7:00AM - 8:00AM Breakfast Room: Bay 2
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 1 of 7 * Joel D. Richter, University of Massachusetts Medical School, USA
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 2 of 7 Eric Klann, New York University, USA Synaptic Plasticity and Memory Phenotypes in Mice with Mutations for Translational Control Proteins
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 3 of 7 Nahum Sonenberg, McGill University, Canada Control of Memory by eIF2
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 4 of 7 Melissa J. Moore, Moderna Therapeutics, USA Interactions between eIF4A and its Accessory Factors eIF4B and eIF4H
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 5 of 7 Jean-Claude Lacaille, Université de Montréal, Canada Short Talk: Staufen1 Regulation of Protein Synthesis-Dependent Long-Term Potentiation and Synaptic Function in Hippocampal Pyramidal Cells
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 6 of 7 Joseph Rayman, Columbia University, USA Short Talk: Functional Studies of a Neuronal Aplysia TIA Ortholog
Thursday, January 31 \| 8:00AM - 11:00AM Translational Control in Learning and Memory Room: Bays 3-4 Speaker 7 of 7 Douglas R. Cavener, Pennsylvania State University, USA Short Talk: PERK is Required to Regulate Different Cellular Functions in the Endocrine and Exocrine Pancreas and Bone
Thursday, January 31 \| 9:20AM - 9:40AM Coffee Break Room: Conference Center Lobby
Thursday, January 31 \| 11:00AM - 1:00PM Poster Setup Room: Bay 5-6
Thursday, January 31 \| 1:00PM - 10:00PM Poster Viewing Room: Bay 5-6
Thursday, January 31 \| 4:30PM - 5:00PM Coffee Available Room: Conference Center Lobby
Thursday, January 31 \| 5:00PM - 7:15PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) I Room: Bays 3-4 Speaker 1 of 6 * Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Thursday, January 31 \| 5:00PM - 7:15PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) I Room: Bays 3-4 Speaker 2 of 6 Allan Jacobson, University of Massachusetts Medical School, USA NMD: mRNA Decay Solves a Translational Problem
Thursday, January 31 \| 5:00PM - 7:15PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) I Room: Bays 3-4 Speaker 3 of 6 Lynne E. Maquat, University of Rochester Medical Center, USA Efficiency of the Pioneer Round of Translation Affects the Cellular Site of Nonsense-Mediated mRNA Decay
Thursday, January 31 \| 5:00PM - 7:15PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) I Room: Bays 3-4 Speaker 4 of 6 Paul J. Anderson, Harvard Medical School, USA A Genomic siRNA Screen Identifies Signaling Pathways Required for the Assembly of Stress Granules and P-Bodies
Thursday, January 31 \| 5:00PM - 7:15PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) I Room: Bays 3-4 Speaker 5 of 6 Oliver Mühlemann, University of Bern, Switzerland Short Talk: Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3’ Untranslated Region
Thursday, January 31 \| 5:00PM - 7:15PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) I Room: Bays 3-4 Speaker 6 of 6 Yuichi Otsuka, Ohio State University, USA Short Talk: 5’ Capping of Endonuclease-Generated mRNA Decay Intermediates by a Cytoplasmic Capping Enzyme Complex
Thursday, January 31 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Bay 5-6
Thursday, January 31 \| 7:30PM - 10:00PM Poster Session 3 Room: Bay 5-6
Friday, February 01 \| 7:00AM - 8:00AM Breakfast Room: Bay 2
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 1 of 7 * Nahum Sonenberg, McGill University, Canada
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 2 of 7 David Ron, University of Cambridge, UK Regulation of Intermediary Metabolism by Endoplasmic Reticulum Stress-Induced Phosphorylation of Translation Initiation Factor 2-alpha
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 3 of 7 Peter Sarnow, Stanford University School of Medicine, USA Subversion of a Liver-Specific microRNA by Hepatitus C Virus
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 4 of 7 Ian J. Mohr, New York University School of Medicine, USA Assembly of Translation Initiation Factor Complexes in Virus-Infected Cells
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 5 of 7 Thomas E. Dever, National Institutes of Health, USA Regulation of the eIF2 Kinase PKR
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 6 of 7 Suzanne Komili, Harvard Medical School, USA Short Talk: Functional Specificity among Duplicated Ribosomal Protein Genes Regulates Gene Expression in Yeast
Friday, February 01 \| 8:00AM - 11:15AM Translational Control and Disease Models Room: Bays 3-4 Speaker 7 of 7 Mauro Costa-Mattioli, Baylor College of Medicine, USA Short Talk: Translational Control of the Innate Immune Response
Friday, February 01 \| 9:20AM - 9:40AM Coffee Break Room: Conference Center Lobby
Friday, February 01 \| 4:30PM - 5:00PM Coffee Available Room: Conference Center Lobby
Friday, February 01 \| 5:00PM - 7:30PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) II Room: Bays 3-4 Speaker 1 of 6 * Paul J. Anderson, Harvard Medical School, USA
Friday, February 01 \| 5:00PM - 7:30PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) II Room: Bays 3-4 Speaker 2 of 6 John Blenis, Weill Cornell Medical College, USA Regulation of Protein Synthesis by mTOR Signaling
Friday, February 01 \| 5:00PM - 7:30PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) II Room: Bays 3-4 Speaker 3 of 6 Joel G. Belasco, New York University School of Medicine, USA Translational Repression, mRNA Decay, and RNA Interference
Friday, February 01 \| 5:00PM - 7:30PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) II Room: Bays 3-4 Speaker 4 of 6 Zissimos Mourelatos, University of Pennsylvania School of Medicine, USA Mammalian microRNAs and piRNAs
Friday, February 01 \| 5:00PM - 7:30PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) II Room: Bays 3-4 Speaker 5 of 6 Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany Short Talk: Large Scale Identification of Translational and Transcriptional miRNA Targets
Friday, February 01 \| 5:00PM - 7:30PM Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod ies) II Room: Bays 3-4 Speaker 6 of 6 Herve Le Hir, CNRS-Centre de Genetique Moleculaire, France Short Talk: The NMD Factors Upf2 and Upf3 Recruit Upf1 to the Exon-Junction Complex and Stimulate its RNA Helicase Activity
Friday, February 01 \| 7:30PM - 8:30PM Social Hour with Lite Bites Room: Bay 5-6
Friday, February 01 \| 8:00PM - 11:00PM Entertainment Room: Bay 5-6
Friday, February 01 \| 8:00PM - 11:00PM Cash Bar Room: Bay 5-6
Saturday, February 02 \| 10:25AM - 10:25AM Departure *Session Chair.