Web Desc
Translational Regulatory Mechanisms
Organizer(s): Nahum Sonenberg, Alan G. Hinnebusch and Joel D. Richter
Date: January 28 - February 02, 2008
Location: Coeur d'Alene Resort, Coeur d'Alene, ID, USA
Supported by the Director's Fund
Summary of Meeting:
There are many exciting new findings in the field of translational control. The discovery that microRNAs control 30-40% of the genomes of many organisms underscores the paramount importance of translational control. Other exciting research involves identification of subcellular components (P-bodies and stress granules), which link translational control to mRNA stability, and associate with the microRNA machinery. The 3-D structures of initiation factors and bacterial ribosomes have been obtained, and recent findings implicate translational control in diseases (diabetes, obesity, virus infection) and in learning and memory. A critical shortcoming in microRNA research is the lack of understanding of the molecular mechanism. Another problem is the lack of structures of mammalian ribosomes with and without translation factors. The meeting’s goals are to discuss experimental approaches to understand the mechanisms of microRNA action, the structural basis of translation and its control, the link between translation and mRNA stability and, finally, defects in translation that cause disease.
Scholarship Deadline: September 26 2007
Discounted Abstract Deadline: September 26 2007
Abstract Deadline: October 31 2007
Discounted Registration Deadline: November 28 2007
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Integrated DNA Technologies
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD056600-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 28 | 3:00PM - 7:30PM
Registration
Room: Conference Center Lobby


Monday, January 28 | 6:30PM - 7:30PM
Refreshments
Room: Bay 2


Monday, January 28 | 7:30PM - 9:30PM
Keynote Session
Room: Bay 3-4

Speaker 1 of 2
Matthias W. Hentze, European Molecular Biology Laboratory, Germany
Translational Control by miRNAs and RNA-Binding Proteins

Monday, January 28 | 7:30PM - 9:30PM
Keynote Session
Room: Bay 3-4

Speaker 2 of 2
Robert H. Singer, Albert Einstein College of Medicine, USA
Conserved Translational Mechanisms of Localized mRNA

Tuesday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Bay 2


Tuesday, January 29 | 8:00AM - 11:15AM
The Translational Apparatus: Prokaryotes versus Eukaryotes
Room: Bays 3-4

Speaker 1 of 5
Venki Ramakrishnan, MRC Laboratory of Molecular Biology, UK
Structural Studies on Functional Complexes of the Ribosome

Tuesday, January 29 | 8:00AM - 11:15AM
The Translational Apparatus: Prokaryotes versus Eukaryotes
Room: Bays 3-4

Speaker 2 of 5
Ada Yonath, Weizmann Institute of Science, Israel
Ribosomal Regulaory Mechanism

Tuesday, January 29 | 8:00AM - 11:15AM
The Translational Apparatus: Prokaryotes versus Eukaryotes
Room: Bays 3-4

Speaker 3 of 5
Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
Getting the Message: Ribosome Recruitment by Viruses and Cells

Tuesday, January 29 | 8:00AM - 11:15AM
The Translational Apparatus: Prokaryotes versus Eukaryotes
Room: Bays 3-4

Speaker 4 of 5
* Rachel Green, Johns Hopkins University School of Medicine, USA
Mechanistic Studies of Ribosome Function and Potential Implications for Translational Control

Tuesday, January 29 | 8:00AM - 11:15AM
The Translational Apparatus: Prokaryotes versus Eukaryotes
Room: Bays 3-4

Speaker 5 of 5
Alan G. Hinnebusch, National Institutes of Health, USA
Functions of eIF1, eIF1A, and 18S rRNA in Preinitation Complex Assembly and AUG Selection

Tuesday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Tuesday, January 29 | 11:15AM - 1:00PM
Poster Setup
Room: Bay 5-6


Tuesday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Tuesday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: Conference Center Lobby


Tuesday, January 29 | 5:00PM - 7:30PM
New Insight into Translation Initiation
Room: Bays 3-4

Speaker 1 of 6
* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Tuesday, January 29 | 5:00PM - 7:30PM
New Insight into Translation Initiation
Room: Bays 3-4

Speaker 2 of 6
Jon R. Lorsch, Johns Hopkins School of Medicine, USA
The Molecular Mechanics of Start Site Recognition by the Eukaryotic Translational Machinery

Tuesday, January 29 | 5:00PM - 7:30PM
New Insight into Translation Initiation
Room: Bays 3-4

Speaker 3 of 6
Tatyana V. Pestova, SUNY Downstate Medical Center, USA
Assembly of 48S Initiation Complexes on mRNAs with Highly Structured 5’-UTRs


Tuesday, January 29 | 5:00PM - 7:30PM
New Insight into Translation Initiation
Room: Bays 3-4

Speaker 4 of 6
Gerhard Wagner, Harvard Medical School, USA
Protein Interactions in Eukaryotic Translation Initiation and their Inhibition

Tuesday, January 29 | 5:00PM - 7:30PM
New Insight into Translation Initiation
Room: Bays 3-4

Speaker 5 of 6
Richard J. Jackson, University of Cambridge, UK
Reinitiation Mechanisms in Mammalian mRNA Translation

Tuesday, January 29 | 5:00PM - 7:30PM
New Insight into Translation Initiation
Room: Bays 3-4

Speaker 6 of 6
Assen Marintchev, Harvard Medical School, USA
Short Talk: Organization of the eIF4A/4G/4H Complex: from Model to Experiment

Tuesday, January 29 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Bay 5-6


Tuesday, January 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay 5-6


Wednesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Bay 2


Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 1 of 7
* Robert H. Singer, Albert Einstein College of Medicine, USA

Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 2 of 7
Anne Ephrussi, European Molecular Biology Laboratory, Germany
oskar RNP Assembly for Coordinated Transport and Translation Control

Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 3 of 7
Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
The P-Body Component GW182 is Essential for miRNA-Mediated Gene Silencing

Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 4 of 7
Jennifer Darnell, Rockefeller University, USA
Crosslinking-IP (CLIP) Identification of Novel Pre- and Post-Synaptic RNA Targets of the Fragile X Mental Retardation Protein, FMRP

Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 5 of 7
Jason M. Casolari, Stanford University, USA
Short Talk: mRNA Localization and Organization in S. cerevisiae

Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 6 of 7
John H. Carson, University of Connecticut Health Center, USA
Short Talk: Multiplexed Dendritic Targeting of LTP RNAs by the A2 Pathway

Wednesday, January 30 | 8:00AM - 11:00AM
mRNA Transport and Localization
Room: Bays 3-4

Speaker 7 of 7
Alexander F. Palazzo, Harvard Medical School, USA
Short Talk: The Signal Sequence Coding Region Promotes Nuclear Export of mRNA

Wednesday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Wednesday, January 30 | 11:00AM - 1:00PM
Poster Setup
Room: Bay 5-6


Wednesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Wednesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Conference Center Lobby


Wednesday, January 30 | 5:00PM - 7:15PM
Translational Control of Development
Room: Bays 3-4

Speaker 1 of 6
* Matthias W. Hentze, European Molecular Biology Laboratory, Germany

Wednesday, January 30 | 5:00PM - 7:15PM
Translational Control of Development
Room: Bays 3-4

Speaker 2 of 6
Robert J. Schneider, New York University School of Medicine, USA
eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy

Wednesday, January 30 | 5:00PM - 7:15PM
Translational Control of Development
Room: Bays 3-4

Speaker 3 of 6
Joel D. Richter, University of Massachusetts Medical School, USA
Translational Control of Cellular Senescence by CPEB

Wednesday, January 30 | 5:00PM - 7:15PM
Translational Control of Development
Room: Bays 3-4

Speaker 4 of 6
Howard Lipshitz, University of Toronto, Canada
Control of mRNA Translation, Stability and Localization during Early Drosophila Development

Wednesday, January 30 | 5:00PM - 7:15PM
Translational Control of Development
Room: Bays 3-4

Speaker 5 of 6
Scott L. Noble, University of Colorado Denver Health Sciences Center, USA
Short Talk: P-body/Stress Granule-Like Particles are Regulated and Linked to Maternal mRNA Control during C. Elegans Development

Wednesday, January 30 | 5:00PM - 7:15PM
Translational Control of Development
Room: Bays 3-4

Speaker 6 of 6
Robin P. Wharton, Duke University Medical Center, USA
Short Talk: RNA Tethering to Explore Mechanisms of Regulation in the Early Drosophila Embryo

Wednesday, January 30 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Bay 5-6


Wednesday, January 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay 5-6


Thursday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Bay 2


Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 1 of 7
* Joel D. Richter, University of Massachusetts Medical School, USA

Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 2 of 7
Eric Klann, New York University, USA
Synaptic Plasticity and Memory Phenotypes in Mice with Mutations for Translational Control Proteins

Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 3 of 7
Nahum Sonenberg, McGill University, Canada
Control of Memory by eIF2

Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 4 of 7
Melissa J. Moore, Moderna Therapeutics, USA
Interactions between eIF4A and its Accessory Factors eIF4B and eIF4H

Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 5 of 7
Jean-Claude Lacaille, Université de Montréal, Canada
Short Talk: Staufen1 Regulation of Protein Synthesis-Dependent Long-Term Potentiation and Synaptic Function in Hippocampal Pyramidal Cells

Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 6 of 7
Joseph Rayman, Columbia University, USA
Short Talk: Functional Studies of a Neuronal Aplysia TIA Ortholog

Thursday, January 31 | 8:00AM - 11:00AM
Translational Control in Learning and Memory
Room: Bays 3-4

Speaker 7 of 7
Douglas R. Cavener, Pennsylvania State University, USA
Short Talk: PERK is Required to Regulate Different Cellular Functions in the Endocrine and Exocrine Pancreas and Bone

Thursday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Thursday, January 31 | 11:00AM - 1:00PM
Poster Setup
Room: Bay 5-6


Thursday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Thursday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Conference Center Lobby


Thursday, January 31 | 5:00PM - 7:15PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) I

Room: Bays 3-4

Speaker 1 of 6
* Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany

Thursday, January 31 | 5:00PM - 7:15PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) I

Room: Bays 3-4

Speaker 2 of 6
Allan Jacobson, University of Massachusetts Medical School, USA
NMD: mRNA Decay Solves a Translational Problem

Thursday, January 31 | 5:00PM - 7:15PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) I

Room: Bays 3-4

Speaker 3 of 6
Lynne E. Maquat, University of Rochester Medical Center, USA
Efficiency of the Pioneer Round of Translation Affects the Cellular Site of Nonsense-Mediated mRNA Decay

Thursday, January 31 | 5:00PM - 7:15PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) I

Room: Bays 3-4

Speaker 4 of 6
Paul J. Anderson, Harvard Medical School, USA
A Genomic siRNA Screen Identifies Signaling Pathways Required for the Assembly of Stress Granules and P-Bodies

Thursday, January 31 | 5:00PM - 7:15PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) I

Room: Bays 3-4

Speaker 5 of 6
Oliver Mühlemann, University of Bern, Switzerland
Short Talk: Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3’ Untranslated Region

Thursday, January 31 | 5:00PM - 7:15PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) I

Room: Bays 3-4

Speaker 6 of 6
Yuichi Otsuka, Ohio State University, USA
Short Talk: 5’ Capping of Endonuclease-Generated mRNA Decay Intermediates by a Cytoplasmic Capping Enzyme Complex

Thursday, January 31 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Bay 5-6


Thursday, January 31 | 7:30PM - 10:00PM
Poster Session 3
Room: Bay 5-6


Friday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Bay 2


Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 1 of 7
* Nahum Sonenberg, McGill University, Canada

Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 2 of 7
David Ron, University of Cambridge, UK
Regulation of Intermediary Metabolism by Endoplasmic Reticulum Stress-Induced Phosphorylation of Translation Initiation Factor 2-alpha

Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 3 of 7
Peter Sarnow, Stanford University School of Medicine, USA
Subversion of a Liver-Specific microRNA by Hepatitus C Virus

Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 4 of 7
Ian J. Mohr, New York University School of Medicine, USA
Assembly of Translation Initiation Factor Complexes in Virus-Infected Cells

Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 5 of 7
Thomas E. Dever, National Institutes of Health, USA
Regulation of the eIF2 Kinase PKR

Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 6 of 7
Suzanne Komili, Harvard Medical School, USA
Short Talk: Functional Specificity among Duplicated Ribosomal Protein Genes Regulates Gene Expression in Yeast

Friday, February 01 | 8:00AM - 11:15AM
Translational Control and Disease Models
Room: Bays 3-4

Speaker 7 of 7
Mauro Costa-Mattioli, Baylor College of Medicine, USA
Short Talk: Translational Control of the Innate Immune Response

Friday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Friday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Conference Center Lobby


Friday, February 01 | 5:00PM - 7:30PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) II

Room: Bays 3-4

Speaker 1 of 6
* Paul J. Anderson, Harvard Medical School, USA

Friday, February 01 | 5:00PM - 7:30PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) II

Room: Bays 3-4

Speaker 2 of 6
John Blenis, Weill Cornell Medical College, USA
Regulation of Protein Synthesis by mTOR Signaling

Friday, February 01 | 5:00PM - 7:30PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) II

Room: Bays 3-4

Speaker 3 of 6
Joel G. Belasco, New York University School of Medicine, USA
Translational Repression, mRNA Decay, and RNA Interference

Friday, February 01 | 5:00PM - 7:30PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) II

Room: Bays 3-4

Speaker 4 of 6
Zissimos Mourelatos, University of Pennsylvania School of Medicine, USA
Mammalian microRNAs and piRNAs

Friday, February 01 | 5:00PM - 7:30PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) II

Room: Bays 3-4

Speaker 5 of 6
Matthias Selbach, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Large Scale Identification of Translational and Transcriptional miRNA Targets

Friday, February 01 | 5:00PM - 7:30PM
Coupling of Translation to mRNA Stability (miRNA, NMD, p-Bod
ies) II

Room: Bays 3-4

Speaker 6 of 6
Herve Le Hir, CNRS-Centre de Genetique Moleculaire, France
Short Talk: The NMD Factors Upf2 and Upf3 Recruit Upf1 to the Exon-Junction Complex and Stimulate its RNA Helicase Activity

Friday, February 01 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Bay 5-6


Friday, February 01 | 8:00PM - 11:00PM
Entertainment
Room: Bay 5-6


Friday, February 01 | 8:00PM - 11:00PM
Cash Bar
Room: Bay 5-6


Saturday, February 02 | 10:25AM - 10:25AM
Departure


*Session Chair.