Web Desc
Tolerance in Transplantation and Autoimmunity
Organizer(s): Jeffrey A. Bluestone, Abul K. Abbas, Laurence A. Turka and Diane J. Mathis
Date: January 29 - February 03, 2008
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Novo Nordisk A/S
Summary of Meeting:
The past 40 years has seen enormous progress in the treatment of organ transplantation and autoimmunity. However, with the modern era of immunosuppression, significant problems remain including strikingly higher rates of cardiovascular disease, opportunistic infection, and malignancy. The ability to induce immune tolerance would solve most of these problems. There has been enormous progress in our understanding of the basic processes of both central and peripheral tolerance. Moreover, the development of novel cell surface, soluble and cellular targets has created new therapeutics. The goals of this meeting will be to present cutting edge basic and clinical tolerance research related to transplantation and autoimmunity. Presentations will focus on both advances in basic understanding of immune tolerance, pre-clinical models of disease as well as far-reaching mechanistic studies devoted to the understanding of diseases and therapeutic interventions. The meeting stands out as bringing both basic science and clinical research experts together to explore the major biological pathways of tolerance at the molecular, cellular, pre-clinical and clinical levels. Thus, the meeting will promote critical interchanges between scientists who study these processes and educate students. The long-term objective is to increase our understanding of basic tenets underlying tolerance, to establish new collaborative research projects between basic and clinical researchers and to excite future scientists in this field of study.
Scholarship Deadline: October 1 2007
Discounted Abstract Deadline: October 1 2007
Abstract Deadline: November 1 2007
Discounted Registration Deadline: December 3 2007
We gratefully acknowledge additional support for this conference from:
JDRFNational Multiple Sclerosis SocietyNovo Nordisk A/S
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI075649-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 29 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Tuesday, January 29 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Tuesday, January 29 | 7:30PM - 8:30PM
Keynote Address
Room: Shavano/Torreys

Speaker 1 of 1
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Multiple Steps to Tolerance and Autoimmunity

Wednesday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Wednesday, January 30 | 8:00AM - 11:00AM
Central Tolerance
Room: Shavano/Torreys

Speaker 1 of 4
* Philippa C. Marrack, HHMI/National Jewish Health, USA
How the T Cell Repertoire becomes Peptide and MHC Specific

Wednesday, January 30 | 8:00AM - 11:00AM
Central Tolerance
Room: Shavano/Torreys

Speaker 2 of 4
George S. Eisenbarth, University of Colorado Health Sciences Center, USA
Insulin: Tolerance and Intolerance in Type 1 Diabetes of Man and Mouse

Wednesday, January 30 | 8:00AM - 11:00AM
Central Tolerance
Room: Shavano/Torreys

Speaker 3 of 4
Megan Sykes, Massachusetts General Hospital, USA
Clinical Application of Bone Marrow Transplantation in Organ Transplantation

Wednesday, January 30 | 8:00AM - 11:00AM
Central Tolerance
Room: Shavano/Torreys

Speaker 4 of 4
Mark S. Anderson, University of California, San Francisco, USA
Mechanisms of a Novel Autoimmunity Syndrome caused by a Dominant Mutation in Aire

Wednesday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, January 30 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud


Wednesday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud


Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 1 of 7
* Bruce R. Blazar, University of Minnesota, USA
Role of Indoloeamine 2, 3 Dioxygenase and Regulating Alloresponses

Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 2 of 7
Steve D. Levin, Alpine Immune Sciences, USA
Identification and Characterization of Vsig9 as an Inhibitory Member of the CD28 Family

Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 3 of 7
Elizabeth C. Nowak, Dartmouth Medical School, USA
Specific DC Subsets and Co-Stimulatory/Inhibitory Molecules Regulate Conversion of Naïve CD4+ T Cells to Foxp3+ Regulatory T Cells

Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 4 of 7
Greg M. Delgoffe, University of Pittsburgh, USA
Identification of mTOR as a Central Regulator in Adaptive Effector versus Regulatory T Cell Lineage Development

Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 5 of 7
Girdhari Lal, National Centre for Cell Science, India
Epigenetic Regulation of Foxp3 Expression and Efficient Generation of Regulatory CD4+ T Cells from Peripheral Naïve CD4+CD25- T Cells

Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 6 of 7
Allison L. Bayer, University of Miami School of Medicine, USA
IL-2R and IL-7R Signaling Normally Functions during Thymic Development of CD4+CD25+Foxp3+ Regulatory Cells

Wednesday, January 30 | 2:30PM - 4:30PM
Workshop 1
Room: Shavano/Torreys

Speaker 7 of 7
* Hugh Auchincloss, NIAID/NIH/HHS, USA

Wednesday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Wednesday, January 30 | 5:00PM - 7:00PM
Biochemical Pathways of Tolerance
Room: Shavano/Torreys

Speaker 1 of 3
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Thoughts on Treg and Th17 Differentiation and Function

Wednesday, January 30 | 5:00PM - 7:00PM
Biochemical Pathways of Tolerance
Room: Shavano/Torreys

Speaker 2 of 3
* Diane Mathis, Harvard Medical School, USA
CD4, CD25, Foxp3 and Tregs Regulate Diabetes Progression in NOD Mice

Wednesday, January 30 | 5:00PM - 7:00PM
Biochemical Pathways of Tolerance
Room: Shavano/Torreys

Speaker 3 of 3
Andrew C. Chan, Genentech, Inc., USA
Cellular Polarity in Tcell Biology

Wednesday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Wednesday, January 30 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone/Red Cloud


Thursday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Thursday, January 31 | 8:00AM - 11:00AM
Co-Stimulatory and Inhibitory Receptors and Cytokines
Room: Shavano/Torreys

Speaker 1 of 4
Arlene H. Sharpe, Harvard Medical School, USA
PD-L1:PD-1 and PD-L1:B7-1 Interactions and T Cell Tolerance

Thursday, January 31 | 8:00AM - 11:00AM
Co-Stimulatory and Inhibitory Receptors and Cytokines
Room: Shavano/Torreys

Speaker 2 of 4
Flavio G. Vincenti, University of California, San Francisco, USA
Costimulation Blockade with Belatacept in Renal Transplantation

Thursday, January 31 | 8:00AM - 11:00AM
Co-Stimulatory and Inhibitory Receptors and Cytokines
Room: Shavano/Torreys

Speaker 3 of 4
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
TIM Family of Genes: Role in T Cell Differentiation, Autoimmunity and Tolerance

Thursday, January 31 | 8:00AM - 11:00AM
Co-Stimulatory and Inhibitory Receptors and Cytokines
Room: Shavano/Torreys

Speaker 4 of 4
Christian P. Larsen, Emory University School of Medicine, USA
Determinants of Transplantation Tolerance Induction

Thursday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, January 31 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud


Thursday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud


Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 1 of 8
* Jeffrey L. Browning, Boston University School of Medicine, USA
BioGen/IDEC

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 2 of 8
Paul Anthony Blair, University College London, UK
Suppressive Effect of Regulatory B Cells in Experimental Lupus: Translation to Systemic Lupus Erythematosus

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 3 of 8
Joseph M. Dal Porto, Pfizer, Inc., USA
Immunomodulation of B Cell Activation via Non-Depleting, Therapeutic Intervention of the CD19 Co-Receptor

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 4 of 8
Barbara Metzler, Novartis Institutes for BioMedical Research, Switzerland
Homeostatic Tuning of FoxP3+CD4 T Cell Populations under Continuous Exposure to FTY720

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 5 of 8
Andrew Miller, Apros Therapeutics, Inc., USA
ITPKb is a Negative Regulator of B Cell Tolerance via Inhibition of Store-Operated Calcium Channels

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 6 of 8
Mark R. Rigby, Emory University, USA
Costimulation Antagonists Result in Abortive Activation of Antigen-Stimulated T Cells

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 7 of 8
Anne S. De Groot, EpiVax, Inc., USA
A Novel Model of IVIG Immunosuppression: Activation of Natural Regulatory T cells by IgG-Derived Peptides

Thursday, January 31 | 2:30PM - 4:30PM
Workshop 2: Drug Discovery and Therapeutic Intervention
Room: Shavano/Torreys

Speaker 8 of 8
* David W. Scott, Uniformed Services University of Health Sciences, USA
Peptide-IgG Transduced B Cells that Activated via TLR4 and TLR9 have Opposite Effects on Tolerance Induction

Thursday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Thursday, January 31 | 5:00PM - 7:00PM
Bioinformatics and Biomarkers in Tolerance
Room: Shavano/Torreys

Speaker 1 of 4
* Terry B. Strom, Beth Israel Deaconess Medical Center, USA
Gene Expression Profiling to Study Tolerance

Thursday, January 31 | 5:00PM - 7:00PM
Bioinformatics and Biomarkers in Tolerance
Room: Shavano/Torreys

Speaker 2 of 4
Ken H. Buetow, National Cancer Institute, National Institutes of Health, USA
Enabling the Molecular Medicine Revolution through Network-Centric Biomedicine

Thursday, January 31 | 5:00PM - 7:00PM
Bioinformatics and Biomarkers in Tolerance
Room: Shavano/Torreys

Speaker 3 of 4
David A. Hafler, Yale University School of Medicine, USA
Tolerance in Transplantation and Autoimmunity

Thursday, January 31 | 5:00PM - 7:00PM
Bioinformatics and Biomarkers in Tolerance
Room: Shavano/Torreys

Speaker 4 of 4
Vicki L. Seyfert-Margolis, Food and Drug Administration, USA
Short Talk: New Biomarkers in Immune Tolerance

Thursday, January 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Thursday, January 31 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone/Red Cloud


Friday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Friday, February 01 | 8:00AM - 11:00AM
Regulatory Cells to Control Immunity
Room: Shavano/Torreys

Speaker 1 of 4
* Jeffrey A. Bluestone, University of California, San Francisco, USA
Immune Homeostasis in Autoimmunity

Friday, February 01 | 8:00AM - 11:00AM
Regulatory Cells to Control Immunity
Room: Shavano/Torreys

Speaker 2 of 4
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Cell-Mediated Control of Immune Mediated Inflammation

Friday, February 01 | 8:00AM - 11:00AM
Regulatory Cells to Control Immunity
Room: Shavano/Torreys

Speaker 3 of 4
Herman Waldmann, University of Oxford, UK
How is Infectious Tolerance Generated?

Friday, February 01 | 8:00AM - 11:00AM
Regulatory Cells to Control Immunity
Room: Shavano/Torreys

Speaker 4 of 4
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
In Vitro Expansion and Therapy with Regulatory T Cells

Friday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Friday, February 01 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone/Red Cloud


Friday, February 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone/Red Cloud


Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 1 of 8
* Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
A Dominant Function for Interleukin 27 in Generating Interleukin 10-Producing Anti-Inflammatory T Cells

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 2 of 8
Benoit L. Salomon, University Pierre et Marie Curie, France
CD4+ T Cells Limit their Own-Pathogenicity by Activating Regulatory T Cells

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 3 of 8
Irene Puga, Institut Municipal d'Investigació Mèdica, Spain
Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 4 of 8
Francisco J. Quintana, Harvard Medical School, USA
Control of Foxp3 Expression and Treg Generation by AHR

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 5 of 8
Masahide Tone, University of Pennsylvania, USA
Smad3 and NFAT Cooperate to Induce FoxP3 Expression through its Enhancer

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 6 of 8
Gerald J. Prud'homme, St. Michael's Hospital, Canada
Neuropilin-1 is a Receptor for Latent and Active TGF-beta-1 and Contributes to Regulatory T Cell Activity

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 7 of 8
* Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia
Role of Different Thymic Dendritic Cells in the Development of Thymic Tregs

Friday, February 01 | 2:30PM - 4:30PM
Workshop 3
Room: Shavano/Torreys

Speaker 8 of 8
Qizhi Tang, University of California, San Francisco, USA
Amplification of Autoimmune Response through Induction of Dendritic Cell Maturation in Inflamed Tissues

Friday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Friday, February 01 | 5:00PM - 7:00PM
B Cells in Tolerance and Autoimmunity
Room: Shavano/Torreys

Speaker 1 of 4
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Dissecting the Autoantibody Response

Friday, February 01 | 5:00PM - 7:00PM
B Cells in Tolerance and Autoimmunity
Room: Shavano/Torreys

Speaker 2 of 4
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Activation and Regulation of Autoreactive B Cells: T Cells, Tolls, and Tolerance

Friday, February 01 | 5:00PM - 7:00PM
B Cells in Tolerance and Autoimmunity
Room: Shavano/Torreys

Speaker 3 of 4
John C. Cambier, University of Colorado, USA
Chronic Transduction of Biased Inhibitory Signals Maintains the Antigen Unresponsiveness of Anergic B Cells

Friday, February 01 | 5:00PM - 7:00PM
B Cells in Tolerance and Autoimmunity
Room: Shavano/Torreys

Speaker 4 of 4
E. William St. Clair, Duke University Medical Center, USA
Short Talk: B Cells as Therapeutic Targets for Human Autoimmunity

Friday, February 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Friday, February 01 | 7:30PM - 10:00PM
Poster Session 3
Room: Crestone/Red Cloud


Saturday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Crestone/Red Cloud


Saturday, February 02 | 8:00AM - 11:00AM
Balancing Effector and Regulatory T Cells in Immunity and Di
sease

Room: Shavano/Torreys

Speaker 1 of 5
* Abul K. Abbas, University of California, San Francisco, USA
Development of Autoagressive and Protective T Cell Responses to a Systemic Antigen

Saturday, February 02 | 8:00AM - 11:00AM
Balancing Effector and Regulatory T Cells in Immunity and Di
sease

Room: Shavano/Torreys

Speaker 2 of 5
Brigitta Stockinger, Francis Crick Institute, UK
Context Matters - Regulation of Th17 Responses

Saturday, February 02 | 8:00AM - 11:00AM
Balancing Effector and Regulatory T Cells in Immunity and Di
sease

Room: Shavano/Torreys

Speaker 3 of 5
Kathryn J. Wood, University of Oxford, UK
Transplantation Tolerance in the Clinic

Saturday, February 02 | 8:00AM - 11:00AM
Balancing Effector and Regulatory T Cells in Immunity and Di
sease

Room: Shavano/Torreys

Speaker 4 of 5
Andrew D. Wells, University of Pennsylvania, USA
Short Talk: Foxp3 and Ikaros: Partners in Regulatory T Cell Function

Saturday, February 02 | 8:00AM - 11:00AM
Balancing Effector and Regulatory T Cells in Immunity and Di
sease

Room: Shavano/Torreys

Speaker 5 of 5
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Short Talk: Interleukin-35: A Novel Cytokine that Mediates Regulatory T Cell Function

Saturday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Saturday, February 02 | 5:00PM - 7:00PM
Innate Immunity in Autoimmune Disease, Transplantation and A
llergic Diseases

Room: Shavano/Torreys

Speaker 1 of 4
* Laurence A. Turka, Rheos Medicines, USA
Expression and Function of MyD88 and TLRs on T Cells

Saturday, February 02 | 5:00PM - 7:00PM
Innate Immunity in Autoimmune Disease, Transplantation and A
llergic Diseases

Room: Shavano/Torreys

Speaker 2 of 4
Robert L. Coffman, Dynavax Technologies, USA
TLR Interventions in Allergy

Saturday, February 02 | 5:00PM - 7:00PM
Innate Immunity in Autoimmune Disease, Transplantation and A
llergic Diseases

Room: Shavano/Torreys

Speaker 3 of 4
Alberto Sanchez-Fueyo, Hospital Clinic Barcelona, Spain
Short Talk: Identification of Operationally Tolerant Liver Transplant Recipients

Saturday, February 02 | 5:00PM - 7:00PM
Innate Immunity in Autoimmune Disease, Transplantation and A
llergic Diseases

Room: Shavano/Torreys

Speaker 4 of 4
Wayne W. Hancock, Children's Hospital of Philadelphia, USA
Exploiting Epigenetic Mechanisms to Prevent and Cure Autoimmunity and Transplant Rejection

Saturday, February 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone/Red Cloud


Saturday, February 02 | 8:00PM - 11:00PM
Entertainment
Room: Crestone/Red Cloud


Saturday, February 02 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone/Red Cloud


Sunday, February 03 | 10:25AM - 10:25AM
Departure


*Session Chair.