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Web Desc
Biomarker Discovery, Validation and Applications
Organizer(s): Mark S. Boguski and Jean-Jacques Garaud
Date: February 03 - 08, 2008
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Director's Fund
For important information on the coronavirus, please
click here
Summary of Meeting:
Conceptually, biomarkers are emerging as a new organizing principle for translational research involving multidisciplinary and parallel activities in basic research, technology development and clinical application. The primary reason for this is that the concept encompasses a broad swath of potential roles in human disease including prevention, diagnosis, prognosis, patient stratification and the pharmacodynamic and pharmacokinetic properties of drugs as well as their efficacies and toxicities. This meeting attempts to bring together scientists, technologists and research physicians to focus attention on key challenges and highlight synergies among groups working in different but overlapping areas. The meeting will address major trends in the field from macromolecular analytics to clinical imaging and overall strategies for biomarker development and applications.
Scholarship Deadline: October 3 2007
Discounted Abstract Deadline: October 3 2007
Abstract Deadline: November 1 2007
Discounted Registration Deadline: December 3 2007
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
Applied Biosystems
Merck & Co., Inc.
We gratefully acknowledge the generous grant for this conference provided by:
National Cancer Institute (NCI)
Grant No. 1R13CA132374-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
Program
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Sunday, February 03
| 3:00PM - 7:30PM
Registration
Room: Pre-Function
Sunday, February 03
| 7:30PM - 8:30PM
Keynote Address
Room: Mountain / Lake
Speaker 1 of 1
Gordon B. Mills
, University of Texas MD Anderson Cancer Center, USA
A Systems Approach to Drug Development and Implementation
Monday, February 04
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Monday, February 04
| 8:00AM - 11:00AM
New Strategies for Biomarker Discovery and Use
Room: Mountain / Lake
Speaker 1 of 3
Michael Gillette
, Broad Institute, USA
The Long and Winding Road: Discovery, Verification and Validation of Protein Biomarkers
Monday, February 04
| 8:00AM - 11:00AM
New Strategies for Biomarker Discovery and Use
Room: Mountain / Lake
Speaker 2 of 3
*
Mark S. Boguski
, Harvard Medical School, USA
Proteomics, Systems Biology and Knowledge-Mining in Drug and Biomarker Discovery
Monday, February 04
| 8:00AM - 11:00AM
New Strategies for Biomarker Discovery and Use
Room: Mountain / Lake
Speaker 3 of 3
Christoph W. Turck
, Max Planck Institute of Psychiatry, Germany
The Quest for Mood Disorder Biomarkers
Monday, February 04
| 9:20AM - 9:40AM
Coffee Break
Room: Pre Function
Monday, February 04
| 11:00AM - 1:00PM
Poster Setup
Room: Bay Room
Monday, February 04
| 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room
Monday, February 04
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Monday, February 04
| 5:00PM - 7:00PM
Biomarker Qualification
Room: Mountain / Lake
Speaker 1 of 3
Michael L. Bittner
, Tgen, USA
Genomic Classification: The Epistemological Wall
Monday, February 04
| 5:00PM - 7:00PM
Biomarker Qualification
Room: Mountain / Lake
Speaker 2 of 3
David F. Ransohoff
, University of North Carolina at Chapel Hill, USA
Improving Efficiency and Reliability of Evaluations of Biomarkers for Cancer: Status in 2008
Monday, February 04
| 5:00PM - 7:00PM
Biomarker Qualification
Room: Mountain / Lake
Speaker 3 of 3
* Christie L. Hunter
, AB SCIEX, USA
Novel Strategy Involving Peptide MRM-based Assays and Chemistry for Targeted Quantitation of Biomarkers in Plasma
Monday, February 04
| 7:00PM - 8:00PM
Dinner
Room: Granhall
Monday, February 04
| 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room
Monday, February 04
| 8:00PM - 9:00PM
Social Hour
Room: Bay Room
Tuesday, February 05
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Tuesday, February 05
| 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake
Speaker 1 of 4
Jan E. Schnitzer
, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Proteomic Mapping of Vascular Biomarkers to Image Antibody Penetration into Single Organs and Solid Tumors
Tuesday, February 05
| 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake
Speaker 2 of 4
Maria Bobadilla
, F. Hoffmann-La Roche Ltd., Switzerland
Systems Biology of the Pancreatic beta Cells: A Novel Paradigm for Biomarker Discovery in Type 2 Diabetes
Tuesday, February 05
| 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake
Speaker 3 of 4
Mitchell Albert
, Harvard Medical School, USA
Pulmonary Imaging: From Structural to Functional with Hyperpolarized 3He MRI
Tuesday, February 05
| 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake
Speaker 4 of 4
* Perry F. Renshaw
, University of Utah, USA
Imaging’s Role in Advancement in Psychiatric Disease Management and Therapy Development
Tuesday, February 05
| 9:20AM - 9:40AM
Coffee Break
Room: Pre Function
Tuesday, February 05
| 11:00AM - 1:00PM
Poster Setup
Room: Bay Room
Tuesday, February 05
| 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room
Tuesday, February 05
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Tuesday, February 05
| 5:00PM - 5:40PM
Genomic Strategies
Room: Mountain / Lake
Speaker 1 of 2
* Perry F. Renshaw
, University of Utah, USA
Tuesday, February 05
| 5:00PM - 5:40PM
Genomic Strategies
Room: Mountain / Lake
Speaker 2 of 2
* Joseph R. Nevins
, Duke University Medical Center, USA
Genomic Strategies for Personalized Cancer Therapy
Tuesday, February 05
| 5:40PM - 7:00PM
Imaging Biomarkers 2
Room: Mountain / Lake
Speaker 1 of 2
Gary J. Kelloff
, National Cancer Institute, National Institutes of Health, USA
OBQI: Project Overview and Objectives (Science and Medical Perspective)
Tuesday, February 05
| 5:40PM - 7:00PM
Imaging Biomarkers 2
Room: Mountain / Lake
Speaker 2 of 2
Jonathan H. Gillard
, University of Cambridge, UK
Tracking Inflammation in Atherosclerotic Plaques: Latest Clinical Results
Tuesday, February 05
| 7:00PM - 8:00PM
Dinner
Room: Granhall
Tuesday, February 05
| 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room
Tuesday, February 05
| 8:00PM - 9:00PM
Social Hour
Room: Bay Room
Wednesday, February 06
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Wednesday, February 06
| 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake
Speaker 1 of 4
* Jacques F. Banchereau
, The Jackson Laboratory for Genomic Medicine, USA
Analysis of Disease Signatures in Gene Expression Profiles from Peripheral Blood Leukocytes
Wednesday, February 06
| 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake
Speaker 2 of 4
Joachim L. Schultze
, LIMES Institute, University of Bonn, Germany
Applying Genome-Wide High Throughput Technologies to Clinical Biomarker Development
Wednesday, February 06
| 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake
Speaker 3 of 4
Shannon Neeley
, Ut M. D. Anderson Cancer Center, USA
Wednesday, February 06
| 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake
Speaker 4 of 4
Jay W. Heinecke
, University of Washington School of Medicine, USA
Mass Spectrometric Approaches for Identifying Inflammatory Pathways that Generate Dysfunctional HDL in Humans
Wednesday, February 06
| 9:20AM - 9:40AM
Coffee Break
Room: Pre Function
Wednesday, February 06
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Wednesday, February 06
| 5:00PM - 7:00PM
New Technologies
Room: Mountain / Lake
Speaker 1 of 3
Peter W. Laird
, Van Andel Research Institute, USA
DNA Methylation Biomarkers as Cancer Biomarkers
Wednesday, February 06
| 5:00PM - 7:00PM
New Technologies
Room: Mountain / Lake
Speaker 2 of 3
*
Ruth Birner-Gruenberger
, Medical University of Graz, Austria
Activity-Based Proteomics: Enzymatic Activity Profiling in Complex Proteomes
Wednesday, February 06
| 5:00PM - 7:00PM
New Technologies
Room: Mountain / Lake
Speaker 3 of 3
Keith O. Elliston
, Genstruct Inc., USA
Identifying Mechanistic Biomarkers using Causal Modeling Powered by Molecular Profiling
Wednesday, February 06
| 7:00PM - 8:00PM
Social Hour
Room: Granhall
Wednesday, February 06
| 7:30PM - 8:30PM
Dinner
Room: Granhall
Thursday, February 07
| 7:00AM - 8:00AM
Breakfast
Room: Granhall
Thursday, February 07
| 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake
Speaker 1 of 4
* Jean-Jacques Garaud
, F. Hoffmann-La Roche Ltd, Switzerland
Efficacy Biomarkers in Early Clinical Development
Thursday, February 07
| 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake
Speaker 2 of 4
Richard Levine
, National Institutes of Child Health and Human Development, USA
An Excess of Circulating Anti-Angiogenic Factors: Final Common Pathway to the Maternal Hypertensive Syndrome of Preeclampsia
Thursday, February 07
| 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake
Speaker 3 of 4
Rick Baehner
, Genomic Health, Inc., USA
Development and Clinical Use of Oncotype DX TM, a Multigene Test that Facilitates Treatment Decisions in Early Breast Cancer
Thursday, February 07
| 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake
Speaker 4 of 4
Paul Delmar
, Switzerland
Title to be Determined
Thursday, February 07
| 9:20AM - 9:40AM
Coffee Break
Room: Pre Function
Thursday, February 07
| 4:30PM - 5:00PM
Coffee Available
Room: Pre Function
Thursday, February 07
| 5:00PM - 7:00PM
Translational Medicine and the Critical Path 2
Room: Mountain / Lake
Speaker 1 of 3
Maryellen de Mars
, Critical Path Institute, USA
Genetic Markers and Diagnostics: Progress towards Personalized Warfarin Therapy
Thursday, February 07
| 5:00PM - 7:00PM
Translational Medicine and the Critical Path 2
Room: Mountain / Lake
Speaker 2 of 3
*
Denis Hochstrasser
, University Hospital of Geneva, Switzerland
Clinical Practice & Biomarker Proteomic Discovery
Thursday, February 07
| 5:00PM - 7:00PM
Translational Medicine and the Critical Path 2
Room: Mountain / Lake
Speaker 3 of 3
Frank D. Sistare
, Merck Research Laboratories, USA
Biomarkers of Drug-induced Kidney Injury: Moving with Histopathology and Molecular Signatures Toward an Advanced Accessible Safety Biomarker Toolbox
Thursday, February 07
| 7:00PM - 8:00PM
Social Hour
Room: Bay Room
Thursday, February 07
| 8:00PM - 9:00PM
Dinner
Room: Granhall
Thursday, February 07
| 8:00PM - 11:00PM
Entertainment
Room: Granhall
Friday, February 08
| 10:21AM - 10:21AM
Departure
*Session Chair
†Invited, not yet responded.
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