Web Desc
Biomarker Discovery, Validation and Applications
Organizer(s): Mark S. Boguski and Jean-Jacques Garaud
Date: February 03 - 08, 2008
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Conceptually, biomarkers are emerging as a new organizing principle for translational research involving multidisciplinary and parallel activities in basic research, technology development and clinical application. The primary reason for this is that the concept encompasses a broad swath of potential roles in human disease including prevention, diagnosis, prognosis, patient stratification and the pharmacodynamic and pharmacokinetic properties of drugs as well as their efficacies and toxicities. This meeting attempts to bring together scientists, technologists and research physicians to focus attention on key challenges and highlight synergies among groups working in different but overlapping areas. The meeting will address major trends in the field from macromolecular analytics to clinical imaging and overall strategies for biomarker development and applications.
Scholarship Deadline: October 3 2007
Discounted Abstract Deadline: October 3 2007
Abstract Deadline: November 1 2007
Discounted Registration Deadline: December 3 2007
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Applied Biosystems

Merck & Co., Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA132374-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 03 | 3:00PM - 7:30PM
Registration
Room: Pre-Function


Sunday, February 03 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain / Lake

Speaker 1 of 1
Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
A Systems Approach to Drug Development and Implementation


Monday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, February 04 | 8:00AM - 11:00AM
New Strategies for Biomarker Discovery and Use
Room: Mountain / Lake

Speaker 1 of 3
Michael Gillette, Broad Institute, USA
The Long and Winding Road: Discovery, Verification and Validation of Protein Biomarkers

Monday, February 04 | 8:00AM - 11:00AM
New Strategies for Biomarker Discovery and Use
Room: Mountain / Lake

Speaker 2 of 3
* Mark S. Boguski, Harvard Medical School, USA
Proteomics, Systems Biology and Knowledge-Mining in Drug and Biomarker Discovery

Monday, February 04 | 8:00AM - 11:00AM
New Strategies for Biomarker Discovery and Use
Room: Mountain / Lake

Speaker 3 of 3
Christoph W. Turck, Max Planck Institute of Psychiatry, Germany
The Quest for Mood Disorder Biomarkers

Monday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, February 04 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Monday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Monday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, February 04 | 5:00PM - 7:00PM
Biomarker Qualification
Room: Mountain / Lake

Speaker 1 of 3
Michael L. Bittner, Tgen, USA
Genomic Classification: The Epistemological Wall

Monday, February 04 | 5:00PM - 7:00PM
Biomarker Qualification
Room: Mountain / Lake

Speaker 2 of 3
David F. Ransohoff, University of North Carolina at Chapel Hill, USA
Improving Efficiency and Reliability of Evaluations of Biomarkers for Cancer: Status in 2008

Monday, February 04 | 5:00PM - 7:00PM
Biomarker Qualification
Room: Mountain / Lake

Speaker 3 of 3
* Christie L. Hunter, AB SCIEX, USA
Novel Strategy Involving Peptide MRM-based Assays and Chemistry for Targeted Quantitation of Biomarkers in Plasma

Monday, February 04 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, February 04 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room


Monday, February 04 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Tuesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, February 05 | 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake

Speaker 1 of 4
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Proteomic Mapping of Vascular Biomarkers to Image Antibody Penetration into Single Organs and Solid Tumors

Tuesday, February 05 | 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake

Speaker 2 of 4
Maria Bobadilla, F. Hoffmann-La Roche Ltd., Switzerland
Systems Biology of the Pancreatic beta Cells: A Novel Paradigm for Biomarker Discovery in Type 2 Diabetes

Tuesday, February 05 | 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake

Speaker 3 of 4
Mitchell Albert, Harvard Medical School, USA
Pulmonary Imaging: From Structural to Functional with Hyperpolarized 3He MRI

Tuesday, February 05 | 8:00AM - 11:00AM
Imaging Biomarkers 1
Room: Mountain / Lake

Speaker 4 of 4
* Perry F. Renshaw, University of Utah, USA
Imaging’s Role in Advancement in Psychiatric Disease Management and Therapy Development

Tuesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, February 05 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Tuesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Tuesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, February 05 | 5:00PM - 5:40PM
Genomic Strategies
Room: Mountain / Lake

Speaker 1 of 2
* Perry F. Renshaw, University of Utah, USA

Tuesday, February 05 | 5:00PM - 5:40PM
Genomic Strategies
Room: Mountain / Lake

Speaker 2 of 2
* Joseph R. Nevins, Duke University Medical Center, USA
Genomic Strategies for Personalized Cancer Therapy

Tuesday, February 05 | 5:40PM - 7:00PM
Imaging Biomarkers 2
Room: Mountain / Lake

Speaker 1 of 2
Gary J. Kelloff, National Cancer Institute, National Institutes of Health, USA
OBQI: Project Overview and Objectives (Science and Medical Perspective)

Tuesday, February 05 | 5:40PM - 7:00PM
Imaging Biomarkers 2
Room: Mountain / Lake

Speaker 2 of 2
Jonathan H. Gillard, University of Cambridge, UK
Tracking Inflammation in Atherosclerotic Plaques: Latest Clinical Results

Tuesday, February 05 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, February 05 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room


Tuesday, February 05 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Wednesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, February 06 | 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake

Speaker 1 of 4
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Analysis of Disease Signatures in Gene Expression Profiles from Peripheral Blood Leukocytes

Wednesday, February 06 | 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake

Speaker 2 of 4
Joachim L. Schultze, LIMES Institute, University of Bonn, Germany
Applying Genome-Wide High Throughput Technologies to Clinical Biomarker Development

Wednesday, February 06 | 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake

Speaker 3 of 4
Shannon Neeley, Ut M. D. Anderson Cancer Center, USA

Wednesday, February 06 | 8:00AM - 11:00AM
Multiplex Biomarkers and System Response Profiles
Room: Mountain / Lake

Speaker 4 of 4
Jay W. Heinecke, University of Washington School of Medicine, USA
Mass Spectrometric Approaches for Identifying Inflammatory Pathways that Generate Dysfunctional HDL in Humans

Wednesday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Wednesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Wednesday, February 06 | 5:00PM - 7:00PM
New Technologies
Room: Mountain / Lake

Speaker 1 of 3
Peter W. Laird, Van Andel Research Institute, USA
DNA Methylation Biomarkers as Cancer Biomarkers

Wednesday, February 06 | 5:00PM - 7:00PM
New Technologies
Room: Mountain / Lake

Speaker 2 of 3
* Ruth Birner-Gruenberger, Medical University of Graz, Austria
Activity-Based Proteomics: Enzymatic Activity Profiling in Complex Proteomes

Wednesday, February 06 | 5:00PM - 7:00PM
New Technologies
Room: Mountain / Lake

Speaker 3 of 3
Keith O. Elliston, Genstruct Inc., USA
Identifying Mechanistic Biomarkers using Causal Modeling Powered by Molecular Profiling

Wednesday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Granhall


Wednesday, February 06 | 7:30PM - 8:30PM
Dinner
Room: Granhall


Thursday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, February 07 | 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake

Speaker 1 of 4
* Jean-Jacques Garaud, F. Hoffmann-La Roche Ltd, Switzerland
Efficacy Biomarkers in Early Clinical Development

Thursday, February 07 | 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake

Speaker 2 of 4
Richard Levine, National Institutes of Child Health and Human Development, USA
An Excess of Circulating Anti-Angiogenic Factors: Final Common Pathway to the Maternal Hypertensive Syndrome of Preeclampsia

Thursday, February 07 | 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake

Speaker 3 of 4
Rick Baehner, Genomic Health, Inc., USA
Development and Clinical Use of Oncotype DX TM, a Multigene Test that Facilitates Treatment Decisions in Early Breast Cancer

Thursday, February 07 | 8:00AM - 11:00AM
Translational Medicine and the Critical Path 1
Room: Mountain / Lake

Speaker 4 of 4
Paul Delmar, Switzerland
Title to be Determined

Thursday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Thursday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Thursday, February 07 | 5:00PM - 7:00PM
Translational Medicine and the Critical Path 2
Room: Mountain / Lake

Speaker 1 of 3
Maryellen de Mars, Critical Path Institute, USA
Genetic Markers and Diagnostics: Progress towards Personalized Warfarin Therapy

Thursday, February 07 | 5:00PM - 7:00PM
Translational Medicine and the Critical Path 2
Room: Mountain / Lake

Speaker 2 of 3
* Denis Hochstrasser, University Hospital of Geneva, Switzerland
Clinical Practice & Biomarker Proteomic Discovery

Thursday, February 07 | 5:00PM - 7:00PM
Translational Medicine and the Critical Path 2
Room: Mountain / Lake

Speaker 3 of 3
Frank D. Sistare, Merck Research Laboratories, USA
Biomarkers of Drug-induced Kidney Injury: Moving with Histopathology and Molecular Signatures Toward an Advanced Accessible Safety Biomarker Toolbox

Thursday, February 07 | 7:00PM - 8:00PM
Social Hour
Room: Bay Room


Thursday, February 07 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Thursday, February 07 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Friday, February 08 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.