Web Desc
TGF-ß Family in Homeostasis and Disease
Organizer(s): Joan Massagué, Liliana Attisano and Alexander F. Schier
Date: February 03 - 08, 2008
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Director's Fund
Summary of Meeting:
As a set of cytokines with a powerful signal transduction system and the ability to regulate a large number of critical genes and functions, the TGF-ß family controls cell fate and behavior in every stage of embryonic development and every tissue in the adult. Recently identified components and connections of this pathway provide new insights into how cells read TGF-ß signals under normal conditions and mishandle these signals in various diseases. By focusing on these topics, this meeting will provide an update on the TGF-ß system, its role in physiology and pathogenesis, and its promise as a drug target in cancer and other disorders.
Scholarship Deadline: October 2 2007
Discounted Abstract Deadline: October 3 2007
Abstract Deadline: November 2 2007
Discounted Registration Deadline: December 4 2007
We gratefully acknowledge additional support for this conference from:

Anita Roberts Memorial Fund
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA130244-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 03 | 3:00PM - 7:30PM
Registration
Room: North End of Concourse


Sunday, February 03 | 6:30PM - 7:30PM
Refreshments
Room: Sunset Room


Sunday, February 03 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 2
* Joan Massagué, Memorial Sloan Kettering Cancer Center, USA

Sunday, February 03 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 2
Edward M. De Robertis, Howard Hughes Medical Institute and University of California, USA
Integrating D-V and A-P Signals by BMP and Wnt via Smad1/Mad phosphorylations in Xenopus and Drosophila Embryos

Monday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Lobby Lounge


Monday, February 04 | 8:00AM - 11:15AM
Signaling System I
Room: Anasazi Ballroom

Speaker 1 of 6
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
High Throughput Mapping Interactomes in Mammalian Systems

Monday, February 04 | 8:00AM - 11:15AM
Signaling System I
Room: Anasazi Ballroom

Speaker 2 of 6
Elizabeth J. Robertson, University of Oxford, UK
High Throughput Mapping Interactomes in Mammalian Systems

Monday, February 04 | 8:00AM - 11:15AM
Signaling System I
Room: Anasazi Ballroom

Speaker 3 of 6
* Alexander F. Schier, University of Basel, Switzerland
Regulation of TGF-beta Signaling by microRNAs

Monday, February 04 | 8:00AM - 11:15AM
Signaling System I
Room: Anasazi Ballroom

Speaker 4 of 6
Andrew P. Hinck, University of Texas Health Science Center, USA
Cooperative Assembly of TGF-beta and BMP Signaling Complexes is Mediated by Disparate Mechanisms and Distinct Modes of Receptor Binding

Monday, February 04 | 8:00AM - 11:15AM
Signaling System I
Room: Anasazi Ballroom

Speaker 5 of 6
Lan Xu, University of Massachusetts Medical School, USA
Short Talk: Whole-genome RNAi Screening Identifies Msk as a Nuclear Import Factor for Activated Smads

Monday, February 04 | 8:00AM - 11:15AM
Signaling System I
Room: Anasazi Ballroom

Speaker 6 of 6
Katerina Pardali, AstraZeneca, Sweden
Short Talk: Monitoring the Dynamics of Smad Complex Formation Using Proximity Ligation

Monday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Devargas Concourse


Monday, February 04 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room


Monday, February 04 | 11:15AM - 11:15AM
On Own for Lunch


Monday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Monday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Devargas Concourse


Monday, February 04 | 5:00PM - 7:00PM
Signaling System II
Room: Anasazi Ballroom

Speaker 1 of 4
Xin-Hua Feng, Baylor College of Medicine, USA
Phospho-Control of SMAD Signaling

Monday, February 04 | 5:00PM - 7:00PM
Signaling System II
Room: Anasazi Ballroom

Speaker 2 of 4
Caroline S. Hill, Francis Crick Institute, UK
The Role of the E3 Ubiquitin Ligase, Arkadia in TGF-beta Signaling

Monday, February 04 | 5:00PM - 7:00PM
Signaling System II
Room: Anasazi Ballroom

Speaker 3 of 4
* Liliana Attisano, University of Toronto, Canada
A Genome-Wide Approach to Identify Smad/Foxh1 Targets during Early Mouse Development

Monday, February 04 | 5:00PM - 7:00PM
Signaling System II
Room: Anasazi Ballroom

Speaker 4 of 4
Gareth Inman, Beatson Institute for Cancer Research, UK
Short Talk: Carm1 is a Smad Cofactor that Links TGF-beta Signaling to Gene Activation, Motility and Growth Arrest

Monday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, February 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Tuesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Lobby Lounge


Tuesday, February 05 | 7:00AM - 8:00AM
Poster Setup
Room: Sunset Room


Tuesday, February 05 | 8:00AM - 11:15AM
Cancer I
Room: Anasazi Ballroom

Speaker 1 of 5
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
TGF-beta Primes Breast Tumors for Lung Metastasis through Angiopoietin-Like 4

Tuesday, February 05 | 8:00AM - 11:15AM
Cancer I
Room: Anasazi Ballroom

Speaker 2 of 5
* Lalage M. Wakefield, NCI, National Institutes of Health, USA
Death by a Thousand Cuts: Suppression of Metastasis by Anti-TGF-beta Antibody Therapy

Tuesday, February 05 | 8:00AM - 11:15AM
Cancer I
Room: Anasazi Ballroom

Speaker 3 of 5
Jonathan M. Yingling, Idera Pharmaceuticals, Inc., USA
TGF-beta Inhibitors

Tuesday, February 05 | 8:00AM - 11:15AM
Cancer I
Room: Anasazi Ballroom

Speaker 4 of 5
Akiyoshi Komuro, University of Tokyo, Japan
Short Talk: Deletion of TGF-beta Signaling in Diffuse-Type Gastric Cancer Cells Promotes Tumor Progression in vivo via Alteration of Tumor Microenvironment

Tuesday, February 05 | 8:00AM - 11:15AM
Cancer I
Room: Anasazi Ballroom

Speaker 5 of 5
Veronica R. Placencio, Vanderbilt University, USA
Short Talk: Stromal TGF-ß Signaling Mediates Prostatic Response to Androgen Ablation by Paracrine Wnt Activity

Tuesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Devargas Concourse


Tuesday, February 05 | 11:15AM - 12:15PM
Lunch
Room: Lobby Lounge


Tuesday, February 05 | 12:00PM - 2:30PM
Poster Session 2
Room: Sunset Room


Tuesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Devargas Concourse


Tuesday, February 05 | 5:00PM - 7:00PM
Signaling System III
Room: Anasazi Ballroom

Speaker 1 of 4
Lilach Gilboa, Weizmann Institute of Science, Israel
How to Organize an Organ: Gonadogenesis and Germ Line Stem Cell Establishment in Drosophila melanogaster

Tuesday, February 05 | 5:00PM - 7:00PM
Signaling System III
Room: Anasazi Ballroom

Speaker 2 of 4
* Elaine V. Fuchs, Rockefeller University, USA
Stem Cell Quiescence and Tissue Homeostasis in the Skin

Tuesday, February 05 | 5:00PM - 7:00PM
Signaling System III
Room: Anasazi Ballroom

Speaker 3 of 4
Michael B. O'Connor, University of Minnesota, Twin Cities, USA
Modulating BMP Mophogen Activity in the Drosophila Embryo and the Pupal Wing

Tuesday, February 05 | 5:00PM - 7:00PM
Signaling System III
Room: Anasazi Ballroom

Speaker 4 of 4
David Wotton, University of Virginia, USA
Short Talk: Tgif Function is Required for Gastrulation

Tuesday, February 05 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Lobby Lounge


Wednesday, February 06 | 8:00AM - 11:00AM
Connective Tissue
Room: Anasazi Ballroom

Speaker 1 of 6
* Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, Blade Therapeutics, USA
Marfan Syndrome: From Molecules to Medicines

Wednesday, February 06 | 8:00AM - 11:00AM
Connective Tissue
Room: Anasazi Ballroom

Speaker 2 of 6
Bart Loeys, University of Antwerp, Belgium
TGFbeta and Connective Tissue Disorders: An Intimate Interplay

Wednesday, February 06 | 8:00AM - 11:00AM
Connective Tissue
Room: Anasazi Ballroom

Speaker 3 of 6
Edward B. Leof, Mayo Clinic, USA
Regulation of Cell Type-Specific TGF-beta Signaling by the Coordinate Action of Erbin and the NF2 Tumor Suppressor Merlin

Wednesday, February 06 | 8:00AM - 11:00AM
Connective Tissue
Room: Anasazi Ballroom

Speaker 4 of 6
Kelsa Teeters, University of Hawaii, USA
Short Talk: Dysregulation of the Immune Response Associated with Allergen Challenge in Caveolin-1 Deficient Mice

Wednesday, February 06 | 8:00AM - 11:00AM
Connective Tissue
Room: Anasazi Ballroom

Speaker 5 of 6
Marene Landström, Rudbeck Laboratory, Sweden
Short Talk: The TGF-beta Type I Receptor Engages TRAF6 and Lys63-Dependent Ubiquitination of TAK1 to Activate a Specific Smad-Independent Pathway

Wednesday, February 06 | 8:00AM - 11:00AM
Connective Tissue
Room: Anasazi Ballroom

Speaker 6 of 6
Gerard C. Blobe, Duke University, USA
Short Talk: Role of the Tumor Suppressor TbetaRIII in Regulating Directional Migration during Epithelial and Cancer Cell Migration

Wednesday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Devargas Concourse


Wednesday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Wednesday, February 06 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Wednesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Devargas Concourse


Wednesday, February 06 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Anasazi Ballroom

Speaker 1 of 4
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Regulatory T Cells, TGF-beta and Immune Suppression

Wednesday, February 06 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Anasazi Ballroom

Speaker 2 of 4
Christoph Becker, Friedrich Alexander University of Erlangen-Nürnberg, Germany
TGF-beta Dependent T Cell Differentiation in Colitis

Wednesday, February 06 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Anasazi Ballroom

Speaker 3 of 4
Rachael Watson, University of Florida, USA
Short Talk: A Model of Arthrofibrosis Using Intra-articular Gene Delivery of TGF-beta1

Wednesday, February 06 | 5:00PM - 7:00PM
Immunity and Inflammation
Room: Anasazi Ballroom

Speaker 4 of 4
Hiroaki Ikushima, University of Tokyo, Japan
Short Talk: An Id-Like Molecule, HHM, is a Synexpression Group-Restricted Regulator of TGF-beta Signaling through Modulation of the Interaction of Smads with Transcription Factors

Wednesday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Wednesday, February 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room


Thursday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Lobby Lounge


Thursday, February 07 | 8:00AM - 11:15AM
Cancer II
Room: Anasazi Ballroom

Speaker 1 of 6
Nabeel Bardeesy, Massachusetts General Hospital, USA
TGFbeta Signaling in Pancreatic Cancer

Thursday, February 07 | 8:00AM - 11:15AM
Cancer II
Room: Anasazi Ballroom

Speaker 2 of 6
Joan Seoane, Vall d'Hebron Institute of Oncology, Spain
The Oncogenic Role of TGF-beta in Glioma

Thursday, February 07 | 8:00AM - 11:15AM
Cancer II
Room: Anasazi Ballroom

Speaker 3 of 6
Theresa A. Guise, Indiana University, USA
Transforming Growth Factor Beta (TGFbeta): Role in Bone Metastases due to Breast Cancer, Prostate Cancer and Melanoma

Thursday, February 07 | 8:00AM - 11:15AM
Cancer II
Room: Anasazi Ballroom

Speaker 4 of 6
* Kunxin Luo, University of California, Berkeley, USA
SnoN, TGF-beta Signaling and Regulation of Cell Growth

Thursday, February 07 | 8:00AM - 11:15AM
Cancer II
Room: Anasazi Ballroom

Speaker 5 of 6
Sophia Bornstein, Oregon Health & Science University, USA
Short Talk: Deletion of Smad4 Leads to Head and Neck Squamous Cell Carcinoma Formation through Increased Genomic Instability and Inflammation

Thursday, February 07 | 8:00AM - 11:15AM
Cancer II
Room: Anasazi Ballroom

Speaker 6 of 6
Piotr Jachimczak, RealTVac, Germany
Short Talk: Inhibition of TGF-beta2 with Antisense Oligonucleotide AP 12009 in Recurrent or Refractory High-Grade Glioma: Results of a Phase IIb study

Thursday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Devargas Concourse


Thursday, February 07 | 11:15AM - 11:15AM
On Own for Lunch


Thursday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Devargas Concourse


Thursday, February 07 | 5:00PM - 6:30PM
Musculoskeletal
Room: Anasazi Ballroom

Speaker 1 of 2
Rik Derynck, University of California, San Francisco, USA
Non-Smad Signaling in the TGF-beta Response

Thursday, February 07 | 5:00PM - 6:30PM
Musculoskeletal
Room: Anasazi Ballroom

Speaker 2 of 2
* Xiao-Fan Wang, Duke University Medical Center, USA
Extracellular Matrix Protein TGFBI/ßIg-h3 Promotes Metastasis of Colon Cancer by Enhancing Cell Extravasation

Thursday, February 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Thursday, February 07 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Thursday, February 07 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Friday, February 08 | 10:25AM - 10:25AM
Departure


*Session Chair.