Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
TGF-ß in Immunity, Inflammation and Cancer (2017A3)
TGF-beta in Immune Responses: From Bench to Bedside (2011A2)

Web Desc
TGF-ß Family in Homeostasis and Disease Organizer(s): Joan Massagué, Liliana Attisano and Alexander F. Schier Date: February 03 - 08, 2008 Location: Eldorado Hotel & Spa, Santa Fe, NM, USA Supported by the Director's Fund Summary of Meeting: As a set of cytokines with a powerful signal transduction system and the ability to regulate a large number of critical genes and functions, the TGF-ß family controls cell fate and behavior in every stage of embryonic development and every tissue in the adult. Recently identified components and connections of this pathway provide new insights into how cells read TGF-ß signals under normal conditions and mishandle these signals in various diseases. By focusing on these topics, this meeting will provide an update on the TGF-ß system, its role in physiology and pathogenesis, and its promise as a drug target in cancer and other disorders. Scholarship Deadline: October 2 2007 Discounted Abstract Deadline: October 3 2007 Abstract Deadline: November 2 2007 Discounted Registration Deadline: December 4 2007 We gratefully acknowledge additional support for this conference from: Anita Roberts Memorial Fund We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA130244-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

TGF-ß Family in Homeostasis and Disease

Organizer(s): Joan Massagué, Liliana Attisano and Alexander F. Schier

Date: February 03 - 08, 2008
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA

Supported by the Director's Fund

Summary of Meeting:

As a set of cytokines with a powerful signal transduction system and the ability to regulate a large number of critical genes and functions, the TGF-ß family controls cell fate and behavior in every stage of embryonic development and every tissue in the adult. Recently identified components and connections of this pathway provide new insights into how cells read TGF-ß signals under normal conditions and mishandle these signals in various diseases. By focusing on these topics, this meeting will provide an update on the TGF-ß system, its role in physiology and pathogenesis, and its promise as a drug target in cancer and other disorders.

Scholarship Deadline: October 2 2007

Discounted Abstract Deadline: October 3 2007

Abstract Deadline: November 2 2007

Discounted Registration Deadline: December 4 2007

We gratefully acknowledge additional support for this conference from:

Anita Roberts Memorial Fund

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA130244-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 03 \| 3:00PM - 7:30PM Registration Room: North End of Concourse
Sunday, February 03 \| 6:30PM - 7:30PM Refreshments Room: Sunset Room
Sunday, February 03 \| 7:30PM - 8:30PM Keynote Address Room: Anasazi Ballroom Speaker 1 of 2 * Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Sunday, February 03 \| 7:30PM - 8:30PM Keynote Address Room: Anasazi Ballroom Speaker 2 of 2 Edward M. De Robertis, Howard Hughes Medical Institute and University of California, USA Integrating D-V and A-P Signals by BMP and Wnt via Smad1/Mad phosphorylations in Xenopus and Drosophila Embryos
Monday, February 04 \| 7:00AM - 8:00AM Breakfast Room: Lobby Lounge
Monday, February 04 \| 8:00AM - 11:15AM Signaling System I Room: Anasazi Ballroom Speaker 1 of 6 Jeffrey L. Wrana, Mount Sinai Hospital, Canada High Throughput Mapping Interactomes in Mammalian Systems
Monday, February 04 \| 8:00AM - 11:15AM Signaling System I Room: Anasazi Ballroom Speaker 2 of 6 Elizabeth J. Robertson, University of Oxford, UK High Throughput Mapping Interactomes in Mammalian Systems
Monday, February 04 \| 8:00AM - 11:15AM Signaling System I Room: Anasazi Ballroom Speaker 3 of 6 * Alexander F. Schier, University of Basel, Switzerland Regulation of TGF-beta Signaling by microRNAs
Monday, February 04 \| 8:00AM - 11:15AM Signaling System I Room: Anasazi Ballroom Speaker 4 of 6 Andrew P. Hinck, University of Texas Health Science Center, USA Cooperative Assembly of TGF-beta and BMP Signaling Complexes is Mediated by Disparate Mechanisms and Distinct Modes of Receptor Binding
Monday, February 04 \| 8:00AM - 11:15AM Signaling System I Room: Anasazi Ballroom Speaker 5 of 6 Lan Xu, University of Massachusetts Medical School, USA Short Talk: Whole-genome RNAi Screening Identifies Msk as a Nuclear Import Factor for Activated Smads
Monday, February 04 \| 8:00AM - 11:15AM Signaling System I Room: Anasazi Ballroom Speaker 6 of 6 Katerina Pardali, AstraZeneca, Sweden Short Talk: Monitoring the Dynamics of Smad Complex Formation Using Proximity Ligation
Monday, February 04 \| 9:20AM - 9:40AM Coffee Break Room: Devargas Concourse
Monday, February 04 \| 11:15AM - 1:00PM Poster Setup Room: Sunset Room
Monday, February 04 \| 11:15AM - 11:15AM On Own for Lunch
Monday, February 04 \| 1:00PM - 10:00PM Poster Viewing Room: Sunset Room
Monday, February 04 \| 4:30PM - 5:00PM Coffee Available Room: Devargas Concourse
Monday, February 04 \| 5:00PM - 7:00PM Signaling System II Room: Anasazi Ballroom Speaker 1 of 4 Xin-Hua Feng, Baylor College of Medicine, USA Phospho-Control of SMAD Signaling
Monday, February 04 \| 5:00PM - 7:00PM Signaling System II Room: Anasazi Ballroom Speaker 2 of 4 Caroline S. Hill, Francis Crick Institute, UK The Role of the E3 Ubiquitin Ligase, Arkadia in TGF-beta Signaling
Monday, February 04 \| 5:00PM - 7:00PM Signaling System II Room: Anasazi Ballroom Speaker 3 of 4 * Liliana Attisano, University of Toronto, Canada A Genome-Wide Approach to Identify Smad/Foxh1 Targets during Early Mouse Development
Monday, February 04 \| 5:00PM - 7:00PM Signaling System II Room: Anasazi Ballroom Speaker 4 of 4 Gareth Inman, Beatson Institute for Cancer Research, UK Short Talk: Carm1 is a Smad Cofactor that Links TGF-beta Signaling to Gene Activation, Motility and Growth Arrest
Monday, February 04 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Eldorado Court/Sunset Room
Monday, February 04 \| 7:30PM - 10:00PM Poster Session 1 Room: Sunset Room
Tuesday, February 05 \| 7:00AM - 8:00AM Breakfast Room: Lobby Lounge
Tuesday, February 05 \| 7:00AM - 8:00AM Poster Setup Room: Sunset Room
Tuesday, February 05 \| 8:00AM - 11:15AM Cancer I Room: Anasazi Ballroom Speaker 1 of 5 Joan Massagué, Memorial Sloan Kettering Cancer Center, USA TGF-beta Primes Breast Tumors for Lung Metastasis through Angiopoietin-Like 4
Tuesday, February 05 \| 8:00AM - 11:15AM Cancer I Room: Anasazi Ballroom Speaker 2 of 5 * Lalage M. Wakefield, NCI, National Institutes of Health, USA Death by a Thousand Cuts: Suppression of Metastasis by Anti-TGF-beta Antibody Therapy
Tuesday, February 05 \| 8:00AM - 11:15AM Cancer I Room: Anasazi Ballroom Speaker 3 of 5 Jonathan M. Yingling, Idera Pharmaceuticals, Inc., USA TGF-beta Inhibitors
Tuesday, February 05 \| 8:00AM - 11:15AM Cancer I Room: Anasazi Ballroom Speaker 4 of 5 Akiyoshi Komuro, University of Tokyo, Japan Short Talk: Deletion of TGF-beta Signaling in Diffuse-Type Gastric Cancer Cells Promotes Tumor Progression in vivo via Alteration of Tumor Microenvironment
Tuesday, February 05 \| 8:00AM - 11:15AM Cancer I Room: Anasazi Ballroom Speaker 5 of 5 Veronica R. Placencio, Vanderbilt University, USA Short Talk: Stromal TGF-ß Signaling Mediates Prostatic Response to Androgen Ablation by Paracrine Wnt Activity
Tuesday, February 05 \| 9:20AM - 9:40AM Coffee Break Room: Devargas Concourse
Tuesday, February 05 \| 11:15AM - 12:15PM Lunch Room: Lobby Lounge
Tuesday, February 05 \| 12:00PM - 2:30PM Poster Session 2 Room: Sunset Room
Tuesday, February 05 \| 4:30PM - 5:00PM Coffee Available Room: Devargas Concourse
Tuesday, February 05 \| 5:00PM - 7:00PM Signaling System III Room: Anasazi Ballroom Speaker 1 of 4 Lilach Gilboa, Weizmann Institute of Science, Israel How to Organize an Organ: Gonadogenesis and Germ Line Stem Cell Establishment in Drosophila melanogaster
Tuesday, February 05 \| 5:00PM - 7:00PM Signaling System III Room: Anasazi Ballroom Speaker 2 of 4 * Elaine V. Fuchs, Rockefeller University, USA Stem Cell Quiescence and Tissue Homeostasis in the Skin
Tuesday, February 05 \| 5:00PM - 7:00PM Signaling System III Room: Anasazi Ballroom Speaker 3 of 4 Michael B. O'Connor, University of Minnesota, Twin Cities, USA Modulating BMP Mophogen Activity in the Drosophila Embryo and the Pupal Wing
Tuesday, February 05 \| 5:00PM - 7:00PM Signaling System III Room: Anasazi Ballroom Speaker 4 of 4 David Wotton, University of Virginia, USA Short Talk: Tgif Function is Required for Gastrulation
Tuesday, February 05 \| 7:00PM - 7:00PM On Own for Dinner
Wednesday, February 06 \| 7:00AM - 8:00AM Breakfast Room: Lobby Lounge
Wednesday, February 06 \| 8:00AM - 11:00AM Connective Tissue Room: Anasazi Ballroom Speaker 1 of 6 * Harry (Hal) C. Dietz, Johns Hopkins University School of Medicine, Blade Therapeutics, USA Marfan Syndrome: From Molecules to Medicines
Wednesday, February 06 \| 8:00AM - 11:00AM Connective Tissue Room: Anasazi Ballroom Speaker 2 of 6 Bart Loeys, University of Antwerp, Belgium TGFbeta and Connective Tissue Disorders: An Intimate Interplay
Wednesday, February 06 \| 8:00AM - 11:00AM Connective Tissue Room: Anasazi Ballroom Speaker 3 of 6 Edward B. Leof, Mayo Clinic, USA Regulation of Cell Type-Specific TGF-beta Signaling by the Coordinate Action of Erbin and the NF2 Tumor Suppressor Merlin
Wednesday, February 06 \| 8:00AM - 11:00AM Connective Tissue Room: Anasazi Ballroom Speaker 4 of 6 Kelsa Teeters, University of Hawaii, USA Short Talk: Dysregulation of the Immune Response Associated with Allergen Challenge in Caveolin-1 Deficient Mice
Wednesday, February 06 \| 8:00AM - 11:00AM Connective Tissue Room: Anasazi Ballroom Speaker 5 of 6 Marene Landström, Rudbeck Laboratory, Sweden Short Talk: The TGF-beta Type I Receptor Engages TRAF6 and Lys63-Dependent Ubiquitination of TAK1 to Activate a Specific Smad-Independent Pathway
Wednesday, February 06 \| 8:00AM - 11:00AM Connective Tissue Room: Anasazi Ballroom Speaker 6 of 6 Gerard C. Blobe, Duke University, USA Short Talk: Role of the Tumor Suppressor TbetaRIII in Regulating Directional Migration during Epithelial and Cancer Cell Migration
Wednesday, February 06 \| 9:20AM - 9:40AM Coffee Break Room: Devargas Concourse
Wednesday, February 06 \| 11:00AM - 1:00PM Poster Setup Room: Sunset Room
Wednesday, February 06 \| 11:00AM - 11:00AM On Own for Lunch
Wednesday, February 06 \| 1:00PM - 10:00PM Poster Viewing Room: Sunset Room
Wednesday, February 06 \| 4:30PM - 5:00PM Coffee Available Room: Devargas Concourse
Wednesday, February 06 \| 5:00PM - 7:00PM Immunity and Inflammation Room: Anasazi Ballroom Speaker 1 of 4 * Richard A. Flavell, HHMI/Yale University School of Medicine, USA Regulatory T Cells, TGF-beta and Immune Suppression
Wednesday, February 06 \| 5:00PM - 7:00PM Immunity and Inflammation Room: Anasazi Ballroom Speaker 2 of 4 Christoph Becker, Friedrich Alexander University of Erlangen-Nürnberg, Germany TGF-beta Dependent T Cell Differentiation in Colitis
Wednesday, February 06 \| 5:00PM - 7:00PM Immunity and Inflammation Room: Anasazi Ballroom Speaker 3 of 4 Rachael Watson, University of Florida, USA Short Talk: A Model of Arthrofibrosis Using Intra-articular Gene Delivery of TGF-beta1
Wednesday, February 06 \| 5:00PM - 7:00PM Immunity and Inflammation Room: Anasazi Ballroom Speaker 4 of 4 Hiroaki Ikushima, University of Tokyo, Japan Short Talk: An Id-Like Molecule, HHM, is a Synexpression Group-Restricted Regulator of TGF-beta Signaling through Modulation of the Interaction of Smads with Transcription Factors
Wednesday, February 06 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Eldorado Court/Sunset Room
Wednesday, February 06 \| 7:30PM - 10:00PM Poster Session 3 Room: Sunset Room
Thursday, February 07 \| 7:00AM - 8:00AM Breakfast Room: Lobby Lounge
Thursday, February 07 \| 8:00AM - 11:15AM Cancer II Room: Anasazi Ballroom Speaker 1 of 6 Nabeel Bardeesy, Massachusetts General Hospital, USA TGFbeta Signaling in Pancreatic Cancer
Thursday, February 07 \| 8:00AM - 11:15AM Cancer II Room: Anasazi Ballroom Speaker 2 of 6 Joan Seoane, Vall d'Hebron Institute of Oncology, Spain The Oncogenic Role of TGF-beta in Glioma
Thursday, February 07 \| 8:00AM - 11:15AM Cancer II Room: Anasazi Ballroom Speaker 3 of 6 Theresa A. Guise, Indiana University, USA Transforming Growth Factor Beta (TGFbeta): Role in Bone Metastases due to Breast Cancer, Prostate Cancer and Melanoma
Thursday, February 07 \| 8:00AM - 11:15AM Cancer II Room: Anasazi Ballroom Speaker 4 of 6 * Kunxin Luo, University of California, Berkeley, USA SnoN, TGF-beta Signaling and Regulation of Cell Growth
Thursday, February 07 \| 8:00AM - 11:15AM Cancer II Room: Anasazi Ballroom Speaker 5 of 6 Sophia Bornstein, Oregon Health & Science University, USA Short Talk: Deletion of Smad4 Leads to Head and Neck Squamous Cell Carcinoma Formation through Increased Genomic Instability and Inflammation
Thursday, February 07 \| 8:00AM - 11:15AM Cancer II Room: Anasazi Ballroom Speaker 6 of 6 Piotr Jachimczak, RealTVac, Germany Short Talk: Inhibition of TGF-beta2 with Antisense Oligonucleotide AP 12009 in Recurrent or Refractory High-Grade Glioma: Results of a Phase IIb study
Thursday, February 07 \| 9:20AM - 9:40AM Coffee Break Room: Devargas Concourse
Thursday, February 07 \| 11:15AM - 11:15AM On Own for Lunch
Thursday, February 07 \| 4:30PM - 5:00PM Coffee Available Room: Devargas Concourse
Thursday, February 07 \| 5:00PM - 6:30PM Musculoskeletal Room: Anasazi Ballroom Speaker 1 of 2 Rik Derynck, University of California, San Francisco, USA Non-Smad Signaling in the TGF-beta Response
Thursday, February 07 \| 5:00PM - 6:30PM Musculoskeletal Room: Anasazi Ballroom Speaker 2 of 2 * Xiao-Fan Wang, Duke University Medical Center, USA Extracellular Matrix Protein TGFBI/ßIg-h3 Promotes Metastasis of Colon Cancer by Enhancing Cell Extravasation
Thursday, February 07 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Eldorado Court/Sunset Room
Thursday, February 07 \| 8:00PM - 11:00PM Entertainment Room: Eldorado Court/Sunset Room
Thursday, February 07 \| 8:00PM - 11:00PM Cash Bar Room: Eldorado Court/Sunset Room
Friday, February 08 \| 10:25AM - 10:25AM Departure *Session Chair.