Web Desc
Lymphocyte Activation and Signaling
Organizer(s): André Veillette and Michel C. Nussenzweig
Date: February 03 - 08, 2008
Location: Snowbird Resort, Snowbird, UT, USA
Supported by the Director's Fund
Summary of Meeting:
The differentiation and activation of immune cells, including lymphocytes, is tightly controlled by a wide array of signaling molecules. These include receptors sensing external stimuli; kinases and phosphatases controlling the initiation of intracellular biochemical signals; adaptor molecules linking receptors to intracellular effectors; and transcription factors and other genomic modifiers regulating gene expression and structure. Over the past fifteen years, there has been a marked increase in our understanding of the roles and the regulation of these various molecules in a normal immune response. Recently, several of these components have been linked to human diseases such as auto-immunity, immunodeficiencies and lymphoid malignancies. In this symposium, we bring together distinguished researchers working at the cutting edge of immune cell signaling. These scientists will report on their most recent findings and provide a clear picture of where the field is going. The impact of their research findings on a better understanding and, possibly, better treatments of human diseases will be discussed. In particular, this meeting will highlight how immune cells can sense external stimuli and, through intracellular signal transduction cascades, mediate proper biological responses. It will also emphasize the impact of this knowledge on significant clinical problems such as auto-immunity, immunodeficiencies, tumor immunity, transplantation and infectious diseases.
Scholarship Deadline: October 3 2007
Discounted Abstract Deadline: October 3 2007
Abstract Deadline: November 2 2007
Discounted Registration Deadline: December 4 2007
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI075650-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5U13AI60000-05
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, February 03 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Sunday, February 03 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Lobby


Sunday, February 03 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Frederick W. Alt, Boston Children's Hospital, USA
Molecular Mechanisms Controlling Antigen Receptor Genes

Monday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, February 04 | 8:00AM - 11:00AM
Transcriptional Regulation of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 1 of 5
* Steven L. Reiner, Columbia University, USA
Specifying the T Cell Fates Required for Immunity

Monday, February 04 | 8:00AM - 11:00AM
Transcriptional Regulation of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 2 of 5
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Transcriptional Programs in T Cell Activation

Monday, February 04 | 8:00AM - 11:00AM
Transcriptional Regulation of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 3 of 5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Calcium-Regulation Transcription in Lymphocyte Activation

Monday, February 04 | 8:00AM - 11:00AM
Transcriptional Regulation of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 4 of 5
Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of RORgammat in Development and Homeostasis of the Immune System

Monday, February 04 | 8:00AM - 11:00AM
Transcriptional Regulation of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 5 of 5
MacLean C. Sellars, IGBMC, France
Short Talk: Ikaros Controls Immunoglobulin Class Switch Recombination

Monday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Monday, February 04 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 1 of 8
* Anjana Rao, La Jolla Institute for Allergy and Immunology, USA

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 2 of 8
Jayanta Chaudhuri, Memorial Sloan Kettering Cancer Center, USA
Regulation of the Immunoglobulin Gene Diversification Enzyme AID

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 3 of 8
Velizar Stefanov Shivarov, Kyoto University Graduate School of Medicine, Japan
ssDNA Deamination Activity of AID is not Required for Class Switch Recombination

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 4 of 8
Heike Schmidlin, Academic Medical Center, University of Amsterdam, Netherlands
The Ets Factor Spi-B Inhibits Human Plasma Cell Differentiation

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 5 of 8
Hiroaki Kaku, Western Michigan University Homer Stryker M.D. School of Medicine, USA
FAIM, a New Germinal Center Gene, Is Involved in CD40-Mediated B Cell Activation

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 6 of 8
Frank Xiao-Feng Qin, University of Texas MD Anderson Cancer Center, USA
Antagonistic Cross-Regulation between Th1/Th2 Effector and Foxp3+ Regulatory T Cell Differentiation Pathways

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 7 of 8
Lisa C. Osborne, University of Pennsylvania, USA
Impaired T Cell Function and CD8 Memory Maintenance in a Novel IL-7Ralpha Knock-in Mouse

Monday, February 04 | 2:30PM - 4:30PM
Workshop 1: Transcriptional and Post-Transcriptional Control
of Lymphocyte Activation and Differentiation
Room: Ballroom 2-3

Speaker 8 of 8
Andy L. Johnson, Cell Press, USA
Anarchin: A Novel Gene Necessary for T Cell Development

Monday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Monday, February 04 | 5:00PM - 7:00PM
DNA Modifications in Lymphocyte Activation and Transformatio
n

Room: Ballroom 2-3

Speaker 1 of 4
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Switching on Chromosome Translocations

Monday, February 04 | 5:00PM - 7:00PM
DNA Modifications in Lymphocyte Activation and Transformatio
n

Room: Ballroom 2-3

Speaker 2 of 4
* Gerald R. Crabtree, Stanford University, USA
Mapping and Modeling a Genetic Circuit of Lymphocyte Signaling

Monday, February 04 | 5:00PM - 7:00PM
DNA Modifications in Lymphocyte Activation and Transformatio
n

Room: Ballroom 2-3

Speaker 3 of 4
Alexander Tarakhovsky, Rockefeller University, USA
Histone Mimicry by a Histone Methyltransferase

Monday, February 04 | 5:00PM - 7:00PM
DNA Modifications in Lymphocyte Activation and Transformatio
n

Room: Ballroom 2-3

Speaker 4 of 4
John David Colgan, University of Iowa, USA
Short Talk: The Justy Mutation Identifies a Novel and Essential Regulator of Mouse B Cell Development

Monday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, February 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, February 05 | 8:00AM - 11:15AM
Immunoreceptor Signaling
Room: Ballroom 2-3

Speaker 1 of 6
Arthur Weiss, University of California, San Francisco, USA
Structural Insights into ZAP-70 Regulation and TCR Signaling

Tuesday, February 05 | 8:00AM - 11:15AM
Immunoreceptor Signaling
Room: Ballroom 2-3

Speaker 2 of 6
Lawrence E. Samelson, National Institutes of Health, USA
Signaling at the T Cell Antigen Receptor

Tuesday, February 05 | 8:00AM - 11:15AM
Immunoreceptor Signaling
Room: Ballroom 2-3

Speaker 3 of 6
* Michael Reth, Albert-Ludwigs University Freiburg, Germany
Amplification of Syk Activity at the B Cell Antigen Receptor

Tuesday, February 05 | 8:00AM - 11:15AM
Immunoreceptor Signaling
Room: Ballroom 2-3

Speaker 4 of 6
Andrey S. Shaw, Genentech, Inc., USA
Immunological Synapse and Polarity in T Lymphocytes

Tuesday, February 05 | 8:00AM - 11:15AM
Immunoreceptor Signaling
Room: Ballroom 2-3

Speaker 5 of 6
Nicholas R. J. Gascoigne, National University of Singapore and Scripps Research, Singapore
Short Talk: The Role of Endogenous pMHC and CD8 in T Cell Antigen Recognition

Tuesday, February 05 | 8:00AM - 11:15AM
Immunoreceptor Signaling
Room: Ballroom 2-3

Speaker 6 of 6
Leslie E. Silberstein, Children's Hospital Boston, USA
Short Talk: Role of Focal Adhesion Kinase (FAK) in progenitor B Cell Proliferation and Localization in the Bone Marrow Microenvironment

Tuesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Tuesday, February 05 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Tuesday, February 05 | 5:00PM - 7:00PM
Imaging Lymphocyte Activation and Differentation
Room: Ballroom 2-3

Speaker 1 of 4
* Ellen A. Robey, University of California, Berkeley, USA
Imaging the Dynamic Behavior of T Cells and Thymocytes in Tissues

Tuesday, February 05 | 5:00PM - 7:00PM
Imaging Lymphocyte Activation and Differentation
Room: Ballroom 2-3

Speaker 2 of 4
Ronald N. Germain, NIAID, National Institutes of Health, USA
Dynamic Intravital Visualization of Multi-Cellular Immune Communication in Lymph Nodes and Tissues

Tuesday, February 05 | 5:00PM - 7:00PM
Imaging Lymphocyte Activation and Differentation
Room: Ballroom 2-3

Speaker 3 of 4
Facundo D. Batista, Massachusetts Institute of Technology and Harvard University, USA
Initiation of B Cell Activation and Adaptive Immune Response

Tuesday, February 05 | 5:00PM - 7:00PM
Imaging Lymphocyte Activation and Differentation
Room: Ballroom 2-3

Speaker 4 of 4
Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Conduits Mediate Antigen Transport To Follicular Dendritic Cells

Tuesday, February 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, February 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, February 06 | 8:00AM - 11:15AM
Immune Modulation and Inhibition
Room: Ballroom 2-3

Speaker 1 of 6
* Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease

Wednesday, February 06 | 8:00AM - 11:15AM
Immune Modulation and Inhibition
Room: Ballroom 2-3

Speaker 2 of 6
André Veillette, Institut de Recherches Cliniques de Montreal, Canada
SAP Family Adaptors in Immune Regulation

Wednesday, February 06 | 8:00AM - 11:15AM
Immune Modulation and Inhibition
Room: Ballroom 2-3

Speaker 3 of 6
Sylvain Latour, Hopital Necker Enfants-Malades, France
Molecular Basis of X-Linked Lymphoproliferative Disease

Wednesday, February 06 | 8:00AM - 11:15AM
Immune Modulation and Inhibition
Room: Ballroom 2-3

Speaker 4 of 6
Jun O. Liu, Johns Hopkins University School of Medicine, USA
Signaling by Carabin and other Calcium-Regulated Molecules in T Cells

Wednesday, February 06 | 8:00AM - 11:15AM
Immune Modulation and Inhibition
Room: Ballroom 2-3

Speaker 5 of 6
Paula M. Oliver, University of Pennsylvania, USA
Short Talk: Nedd4-Family Ubiquitination Networks and how they Regulate T Cell Function

Wednesday, February 06 | 8:00AM - 11:15AM
Immune Modulation and Inhibition
Room: Ballroom 2-3

Speaker 6 of 6
Wojciech A. Swat, Washington University School of Medicine, USA
Short Talk: Control of T Cell Activation by an ITAM-Signaling Pathway in Dendritic Cells

Wednesday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Wednesday, February 06 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 1 of 8
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 2 of 8
Jerome Delon, Universite Paris Descartes, France
Atypical PKCs Regulate T Lymphocyte Polarity and Scanning Behavior

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 3 of 8
Jung-Hua Yeh, Genentech, Inc, USA
Maintenance of a late Phase of T Cell Cytoskeletal Polarity is Important for Normal T Cell Functions

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 4 of 8
Yeyan Ke, Columbia University, USA
A Novel Negative Regulatory Role of FAK in T Cell Activation and Function

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 5 of 8
Jane Oliaro, Peter MacCallum Cancer Centre, Australia
T Cells Undergo Asymmetric Cell Division – a New Mechanism to Dictate T Cell Fate

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 6 of 8
Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
Conditional mTOR Null Mice Reveal its Central Role in Directing Adaptive Effector Versus Regulatory T Cell Differentiation by Integrating Costimulatory and Cytokine Signals

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 7 of 8
Cindy Ma, Garvan Institute of Medical Research, Australia
Investigating the Mechanisms Adopted by CD4+CXCR5+ T Follicular Helper (TFH) Cells to Provide B Cell Help

Wednesday, February 06 | 2:30PM - 4:30PM
Workshop 2 : Lymphocyte Activation and Co-Stimulation
Room: Ballroom 2-3

Speaker 8 of 8
Andrew J. Gross, University of California, San Francisco, USA
Developmental Acquisition of the Lyn–CD22–SHP-1 Inhibitory Pathway Promotes B Cell Tolerance

Wednesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Wednesday, February 06 | 5:00PM - 7:00PM
Cytoplasmic Effectors of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 1 of 4
Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Adapters in T Cell Activation

Wednesday, February 06 | 5:00PM - 7:00PM
Cytoplasmic Effectors of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 2 of 4
* Tomohiro Kurosaki, Osaka University, Japan
Role of Ras/Erk Pathway in B Lymphocyte Development and Activation

Wednesday, February 06 | 5:00PM - 7:00PM
Cytoplasmic Effectors of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 3 of 4
Michael Karin, University of California, San Diego, USA
NF-kappaB and JNK Signaling in Lymphocyte and Myeloid Cells - Dangerous Liaisons and Interesting Twists

Wednesday, February 06 | 5:00PM - 7:00PM
Cytoplasmic Effectors of Lymphocyte Activation
Room: Ballroom 2-3

Speaker 4 of 4
Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: Role of Rac GTPases and their Exchange Factors in Lymphocyte Development and Activation

Wednesday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, February 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Wasatch/Maybird


Thursday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, February 07 | 8:00AM - 11:00AM
Lymphocyte Regulation and Homing
Room: Ballroom 2-3

Speaker 1 of 5
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Cell-Mediated Control of Immune Mediated Inflammation

Thursday, February 07 | 8:00AM - 11:00AM
Lymphocyte Regulation and Homing
Room: Ballroom 2-3

Speaker 2 of 5
Xin Lin, University of Texas MD Anderson Cancer Center, USA
The Role of CARMA1 in TCR-Induced NF-kappaB and JNK Activation

Thursday, February 07 | 8:00AM - 11:00AM
Lymphocyte Regulation and Homing
Room: Ballroom 2-3

Speaker 3 of 5
* Margot Thome, University of Lausanne, Switzerland
Identification of NF-kappaB-Independent Functions of Bcl10 in Lymphocyte Activation

Thursday, February 07 | 8:00AM - 11:00AM
Lymphocyte Regulation and Homing
Room: Ballroom 2-3

Speaker 4 of 5
Fiona M. Powrie, University of Oxford, UK
Regulatory T Cells and Lymphocyte Homeostasis

Thursday, February 07 | 8:00AM - 11:00AM
Lymphocyte Regulation and Homing
Room: Ballroom 2-3

Speaker 5 of 5
Jeffrey C. Rathmell, Vanderbilt University, USA
Short Talk: Glucose Uptake in Lymphocyte Survival and Disease

Thursday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Thursday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Thursday, February 07 | 5:00PM - 7:00PM
Signaling in Lymphocyte Diseases and their Treatment
Room: Ballroom 2-3

Speaker 1 of 3
* Genevieve de Saint-Basile, INSERM U768, France
Inherited Defects of Lymphocyte Cytotoxic Activity

Thursday, February 07 | 5:00PM - 7:00PM
Signaling in Lymphocyte Diseases and their Treatment
Room: Ballroom 2-3

Speaker 2 of 3
Yoshiyuki Minegishi, University of Tokushima, Japan
Signaling Defects in Hyper-IgE Syndromes

Thursday, February 07 | 5:00PM - 7:00PM
Signaling in Lymphocyte Diseases and their Treatment
Room: Ballroom 2-3

Speaker 3 of 3
Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genetic Mechanisms that Mediate the Loss of Immune Tolerance in Lupus-Prone Mice

Thursday, February 07 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Ballroom 1-2


Thursday, February 07 | 9:00PM - 11:00PM
Entertainment
Room: Ballroom 1-2


Thursday, February 07 | 9:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-2


Friday, February 08 | 10:25AM - 10:25AM
Departure


*Session Chair.