Web Desc
Regulatory Mechanisms in Eukaryotic Transcription
Organizer(s): Kevin Struhl and John T. Lis
Date: February 03 - 08, 2008
Location: Keystone Resort, Keystone, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Transcriptional regulatory mechanisms are central to many biological phenomena such as cell growth, development of multicellular organisms, response to environmental conditions, and disease. Critical subject areas to be address include (1) detailed structure-function analysis of the basic transcription machinery, (2) how transcriptional co-activators connect gene-specific activator proteins to the basic machinery, (3) the mechanism of transcriptional elongation and its coupling to mRNA processing, (4) the role of chromatin structure in transcriptional mechanisms, (5) the role of nuclear organization, (6) transcriptional silencing mechanisms including the involvement of RNAi, (7) various long-range effects on transcriptional activity, and (8) genome-wide and other functional genomic approaches. These research areas are interconnected at many levels, from detailed mechanistic issues to important biological phenomena. A major goal of the meeting is to provide an avenue for participants to learn about the latest conceptual and technical advances in eukaryotic transcription regulation.
Scholarship Deadline: October 4 2007
Discounted Abstract Deadline: October 4 2007
Abstract Deadline: November 2 2007
Discounted Registration Deadline: December 4 2007
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA130251-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 03 | 3:00PM - 7:30PM
Registration
Room: Longs Peak Foyer


Sunday, February 03 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Sunday, February 03 | 7:30PM - 8:30PM
Keynote Address
Room: Longs Peak

Speaker 1 of 1
Robert G. Roeder, Rockefeller University, USA
Function of Diverse Coactivators in Transcriptional Regulation

Monday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Monday, February 04 | 8:00AM - 11:00AM
Basic Transcriptional Mechanisms
Room: Longs Peak

Speaker 1 of 6
* Stephen Buratowski, Harvard Medical School, USA

Monday, February 04 | 8:00AM - 11:00AM
Basic Transcriptional Mechanisms
Room: Longs Peak

Speaker 2 of 6
Steven Hahn, Fred Hutchinson Cancer Research Center, USA
Mechanisms of RNA Polymerase II Transcription Initiation and Activation

Monday, February 04 | 8:00AM - 11:00AM
Basic Transcriptional Mechanisms
Room: Longs Peak

Speaker 3 of 6
Karen Adelman, Harvard Medical School, USA
RNA Polymerase is Poised for Rapid Activation Across the Genome

Monday, February 04 | 8:00AM - 11:00AM
Basic Transcriptional Mechanisms
Room: Longs Peak

Speaker 4 of 6
James A. Goodrich, University of Colorado, USA
Regulation of the Early Steps of Transcription by ncRNAs

Monday, February 04 | 8:00AM - 11:00AM
Basic Transcriptional Mechanisms
Room: Longs Peak

Speaker 5 of 6
Michael Meisterernst, Institute of Molecular Tumor Biology, Germany
Short Talk: A Dynamic Model for Control of Transcription by General RNA Polymerase II Transcription Cofactors

Monday, February 04 | 8:00AM - 11:00AM
Basic Transcriptional Mechanisms
Room: Longs Peak

Speaker 6 of 6
Tamar Juven-Gershon, Bar-Ilan University, Israel
Short Talk: The Importance of the Downstream Core Promoter Element (DPE) in the Development of the Animal Body Plan

Monday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, February 04 | 11:00AM - 1:00PM
Poster Setup
Room: Grays Peak 1-3


Monday, February 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak 1-3


Monday, February 04 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Monday, February 04 | 5:00PM - 7:00PM
Transcriptional Co-Activators
Room: Longs Peak

Speaker 1 of 6
* Joan W. Conaway, Stowers Institute for Medical Research, USA

Monday, February 04 | 5:00PM - 7:00PM
Transcriptional Co-Activators
Room: Longs Peak

Speaker 2 of 6
Kevin Struhl, Harvard Medical School, USA
Molecular Understanding of Epigenetics

Monday, February 04 | 5:00PM - 7:00PM
Transcriptional Co-Activators
Room: Longs Peak

Speaker 3 of 6
Laszlo Tora, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
TBP and TBP2 (TRF3) Involved in Transcriptional Events Regulated by Oogenesis and Early Embryogenesis

Monday, February 04 | 5:00PM - 7:00PM
Transcriptional Co-Activators
Room: Longs Peak

Speaker 4 of 6
Arnold J. Berk, University of California, Los Angeles, USA
Short Talk: Adenovirus Small e1a Drives Cell Cycling by Globally Re-Localizing Chromatin Modifying Complexes

Monday, February 04 | 5:00PM - 7:00PM
Transcriptional Co-Activators
Room: Longs Peak

Speaker 5 of 6
Marc Timmers, University Medical Centre Utrecht, Netherlands
Short Talk: TFIID and Chromatin Modification

Monday, February 04 | 5:00PM - 7:00PM
Transcriptional Co-Activators
Room: Longs Peak

Speaker 6 of 6
Laurie A. Stargell, Colorado State University, USA
Short Talk: Spn1 Regulates Chromatin-Remodeling Complexes during Transcriptional Activation by RNA Pol II

Monday, February 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Monday, February 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays Peak 1-3


Tuesday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Tuesday, February 05 | 8:00AM - 11:00AM
Transcriptional Elongation and Coupling to mRNA Processing
Room: Longs Peak

Speaker 1 of 6
* Shelley L. Berger, University of Pennsylvania, USA

Tuesday, February 05 | 8:00AM - 11:00AM
Transcriptional Elongation and Coupling to mRNA Processing
Room: Longs Peak

Speaker 2 of 6
Stephen Buratowski, Harvard Medical School, USA
Suppression of Cryptic Transcription by Two CTD-Dependent Mechanisms

Tuesday, February 05 | 8:00AM - 11:00AM
Transcriptional Elongation and Coupling to mRNA Processing
Room: Longs Peak

Speaker 3 of 6
Joan W. Conaway, Stowers Institute for Medical Research, USA
Regulation of DUB Uch37 by the INO80 Complex and by the 19S Proteasome

Tuesday, February 05 | 8:00AM - 11:00AM
Transcriptional Elongation and Coupling to mRNA Processing
Room: Longs Peak

Speaker 4 of 6
Nicholas J. Proudfoot, University of Oxford, UK
Mechanism of Pre-mRNA 3’ End Formation: Interconnections with Gene Structure and Mitosis

Tuesday, February 05 | 8:00AM - 11:00AM
Transcriptional Elongation and Coupling to mRNA Processing
Room: Longs Peak

Speaker 5 of 6
Nevan J. Krogan, University of California, San Francisco, USA
Functional Insights on Transcriptional Regulation from Genetic and Protein-Protein Interaction Maps

Tuesday, February 05 | 8:00AM - 11:00AM
Transcriptional Elongation and Coupling to mRNA Processing
Room: Longs Peak

Speaker 6 of 6
David H. Price, University of Iowa, USA
Short Talk: The Termination Factor TTF2 is Involved in Mammalian Transcription-Coupled Repair

Tuesday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 05 | 11:00AM - 1:00PM
Poster Setup
Room: Grays Peak 1-3


Tuesday, February 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak 1-3


Tuesday, February 05 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Tuesday, February 05 | 5:00PM - 7:15PM
Role of Chromatin in Transcriptional Mechanisms
Room: Longs Peak

Speaker 1 of 6
* Bing Ren, Ludwig Institute for Cancer Research, USA

Tuesday, February 05 | 5:00PM - 7:15PM
Role of Chromatin in Transcriptional Mechanisms
Room: Longs Peak

Speaker 2 of 6
Shelley L. Berger, University of Pennsylvania, USA
Post-Transcriptional Modifications of Histone H4 in Gametogenesis and Aging

Tuesday, February 05 | 5:00PM - 7:15PM
Role of Chromatin in Transcriptional Mechanisms
Room: Longs Peak

Speaker 3 of 6
Robert J. Sims, Constellation Pharmaceuticals, USA
The CTD of RNA Pol II is Regulated by Site-Specific Methylation

Tuesday, February 05 | 5:00PM - 7:15PM
Role of Chromatin in Transcriptional Mechanisms
Room: Longs Peak

Speaker 4 of 6
Jerry L. Workman, Stowers Institute for Medical Research, USA
Chromatin-Modifying Complexes and Histone Variants

Tuesday, February 05 | 5:00PM - 7:15PM
Role of Chromatin in Transcriptional Mechanisms
Room: Longs Peak

Speaker 5 of 6
Masami Horikoshi, University of Tokyo, Japan
Short Talk: From Histone Modification to Nuclesome Disassembly

Tuesday, February 05 | 5:00PM - 7:15PM
Role of Chromatin in Transcriptional Mechanisms
Room: Longs Peak

Speaker 6 of 6
François Robert, Institut de Recherches Cliniques de Montreal, Canada
Short Talk: Human H2A.Z Modulates Early Events in the Process of Transcription and is Required for Estrogen Receptor Signaling

Tuesday, February 05 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Tuesday, February 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays Peak 1-3


Wednesday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Wednesday, February 06 | 8:00AM - 11:00AM
Nuclear Organization and Transcription
Room: Longs Peak

Speaker 1 of 6
* Peter B. Becker, University of Munich, Germany

Wednesday, February 06 | 8:00AM - 11:00AM
Nuclear Organization and Transcription
Room: Longs Peak

Speaker 2 of 6
Gordon L. Hager, NCI, National Institutes of Health, USA
Transcription Factor Dynamics and Global Chromatin Structure

Wednesday, February 06 | 8:00AM - 11:00AM
Nuclear Organization and Transcription
Room: Longs Peak

Speaker 3 of 6
Robert H. Singer, Albert Einstein College of Medicine, USA
Modeling the Synthesis and Behavior of mRNA

Wednesday, February 06 | 8:00AM - 11:00AM
Nuclear Organization and Transcription
Room: Longs Peak

Speaker 4 of 6
John T. Lis, Cornell University, USA
The Dynamics of Transcription Factors and Chromatin at Specific Loci upon Gene Activation

Wednesday, February 06 | 8:00AM - 11:00AM
Nuclear Organization and Transcription
Room: Longs Peak

Speaker 5 of 6
Michael Hampsey, Robert Wood Johnson Medical School, UMDNJ, USA
Short Talk: DNA Loops in RNA Polymerase II Transcription

Wednesday, February 06 | 8:00AM - 11:00AM
Nuclear Organization and Transcription
Room: Longs Peak

Speaker 6 of 6
Benoit Coulombe, Institut de recherches cliniques de Montréal, Canada
Short Talk: Proteomics Survey Identifies Novel Regulatory Factors That Target the Elongation Factor P-TEFb and RNA Polymerase II

Wednesday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Wednesday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Grays Peak 1-3


Wednesday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays Peak 1-3


Wednesday, February 06 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Wednesday, February 06 | 5:00PM - 7:00PM
Transcriptional Silencing
Room: Longs Peak

Speaker 1 of 4
* Barbara J. Meyer, University of California, Berkeley, USA

Wednesday, February 06 | 5:00PM - 7:00PM
Transcriptional Silencing
Room: Longs Peak

Speaker 2 of 4
Danesh Moazed, Harvard Medical School, USA
Role of Histone Modifications and Non-Coding RNA in Heterochromatin Assembly

Wednesday, February 06 | 5:00PM - 7:00PM
Transcriptional Silencing
Room: Longs Peak

Speaker 3 of 4
Michael R. Green, University of Massachusetts Medical Center, USA
Oncogene-Directed Epigenetic Silencing

Wednesday, February 06 | 5:00PM - 7:00PM
Transcriptional Silencing
Room: Longs Peak

Speaker 4 of 4
Min Gyu Lee, University of Texas MD Anderson Cancer Center, USA
Short Talk: Crosstalk between H3K27 Demethylation and H3K4 Methylation for Gene Activation

Wednesday, February 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Wednesday, February 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays Peak 1-3


Thursday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak 1-3


Thursday, February 07 | 8:00AM - 11:00AM
Long-Range Effects
Room: Longs Peak

Speaker 1 of 5
* Richard A. Young, Whitehead Institute for Biomedical Research, USA

Thursday, February 07 | 8:00AM - 11:00AM
Long-Range Effects
Room: Longs Peak

Speaker 2 of 5
Job Dekker, University of Massachusetts Medical School, USA
Spatial Organization of Chromatin and Long-Range Gene Regulation

Thursday, February 07 | 8:00AM - 11:00AM
Long-Range Effects
Room: Longs Peak

Speaker 3 of 5
Edith Heard, European Molecular Biology Laboratory, Germany
Cis and Trans Regulation during X Inactivation

Thursday, February 07 | 8:00AM - 11:00AM
Long-Range Effects
Room: Longs Peak

Speaker 4 of 5
Barbara J. Meyer, University of California, Berkeley, USA
X-Chromosome-Wide Repression through Dosage Compensation

Thursday, February 07 | 8:00AM - 11:00AM
Long-Range Effects
Room: Longs Peak

Speaker 5 of 5
Peter B. Becker, University of Munich, Germany
Dosage Compensation in Fruit Flies: Making the X a Special Chromosome

Thursday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Thursday, February 07 | 4:30PM - 5:00PM
Coffee Available
Room: Longs Peak Foyer


Thursday, February 07 | 5:00PM - 7:00PM
Global Approaches
Room: Longs Peak

Speaker 1 of 5
* Danesh Moazed, Harvard Medical School, USA

Thursday, February 07 | 5:00PM - 7:00PM
Global Approaches
Room: Longs Peak

Speaker 2 of 5
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Regulatory Circuitry of Human Embryonic Stem Cells

Thursday, February 07 | 5:00PM - 7:00PM
Global Approaches
Room: Longs Peak

Speaker 3 of 5
Bing Ren, Ludwig Institute for Cancer Research, USA
Differential Roles of Promoters, Enhancers and Insulators in Cell-Type Specific Gene Expression

Thursday, February 07 | 5:00PM - 7:00PM
Global Approaches
Room: Longs Peak

Speaker 4 of 5
Michael P. Snyder, Stanford University School of Medicine, USA
Mapping Regulatory Networks in Yeast and Humans

Thursday, February 07 | 5:00PM - 7:00PM
Global Approaches
Room: Longs Peak

Speaker 5 of 5
Chia-Lin Wei, Genome Institute of Singapore, Singapore
Short Talk: Global Mapping of Chromatin Interactions and Transcription Networks Mediated by Pluripotent TFs in ES Cells

Thursday, February 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Grays Peak 1-3


Thursday, February 07 | 8:00PM - 11:00PM
Entertainment
Room: Grays Peak 1-3


Thursday, February 07 | 8:00PM - 11:00PM
Cash Bar
Room: Grays Peak 1-3


Friday, February 08 | 10:25AM - 10:25AM
Departure


*Session Chair.