Web Desc
DNA Replication and Recombination
Organizer(s): Jack D. Griffith, Nancy G. Nossal (in Memoriam), Richard D. Kolodner, Charles S. McHenry and Jerard Hurwitz
Date: February 10 - 15, 2008
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Director's Fund
Summary of Meeting:
The Keystone Symposia “DNA Replication and Recombination” meeting, the longest standing meeting of this multi-decade series continues to meld investigators representing a range of disciplines who otherwise would not have a format for sharing novel approaches and groundbreaking discoveries. This field drives DNA sequencing technology, the design of myriad anti-viral and anti-bacterial drugs, and the development of novel strategies for gene targeting and generation of transgenic animals. Major pivotal questions include (1) the role of condensins in DNA pairing and replication fork movement, (2) mechanisms by which stalled replication forks are recognized and replication is restarted, (3) the role of recombinational mechanisms in the maintenance of telomeres in the absence of telomerase, (4) the architecture of forks and replication origins, and (5) the mechanisms by which fork initiation is timed with the cell cycle. Speakers representing established laboratories will share the podium with young investigators describing genomic, structural, and biochemical approaches to these central questions.
Scholarship Deadline: October 10 2007
Discounted Abstract Deadline: October 10 2007
Abstract Deadline: November 8 2007
Discounted Registration Deadline: December 11 2007
We gratefully acknowledge additional support for this conference from:
Merck & Co., Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 10 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Sunday, February 10 | 6:30PM - 7:30PM
Refreshments
Room: Pavillion


Sunday, February 10 | 7:30PM - 7:40PM
Brief Introduction to the Meeting

Speaker 1 of 1
* Jack D. Griffith, University of North Carolina, Chapel Hill, USA

Sunday, February 10 | 7:40PM - 8:40PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 1
Michael E. O'Donnell, Rockefeller University, USA
Dynamic Mechanisms at the E. coli Replication Fork

Monday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, February 11 | 8:00AM - 11:00AM
Replication Fork Mechanisms
Room: Anasazi Ballroom

Speaker 1 of 4
* Peter M. Burgers, Washington University School of Medicine, USA
Remodeling of the Replication Fork in Response to DNA Damage

Monday, February 11 | 8:00AM - 11:00AM
Replication Fork Mechanisms
Room: Anasazi Ballroom

Speaker 2 of 4
Thomas A. Steitz, Howard Hughes Medical Institute, Yale University, USA
The Macromolecular Replication Machinery: Structural Insights into the Replisome

Monday, February 11 | 8:00AM - 11:00AM
Replication Fork Mechanisms
Room: Anasazi Ballroom

Speaker 3 of 4
Charles S. McHenry, University of Colorado Boulder, USA
Reconstitution of a B. subtilis Rolling Circle DNA Replication System

Monday, February 11 | 8:00AM - 11:00AM
Replication Fork Mechanisms
Room: Anasazi Ballroom

Speaker 4 of 4
Antoine M. van Oijen, University of Wollongong, Australia
Under the Hood of the Replisome: A Single-Molecule View of DNA Replication

Monday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Pavillion


Monday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Pavillion


Monday, February 11 | 11:00AM - 11:00AM
On Own for Lunch


Monday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Pavillion


Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 1 of 8
* Nicholas E. Dixon, University of Wollongong, Australia
A Molecular Mousetrap Determines Polarity in Termination of E. coli DNA Replication

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 2 of 8
Alan C. Leonard, Florida Institute of Technology, USA
Two Growth Rate-Dependent Mechanisms for Pre-Replication Complex Assembly in E. coli

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 3 of 8
Kenji Keyamura, Kyushu University, Japan
A Novel Initiation-Stimulator DiaA Directly Promotes ATP-DnaA-Specific Initiation Complexes in E. coli

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 4 of 8
Smita S. Patel, UMDNJ-RW Johnson Medical School, USA
Coordination of Helicase, Primase, and Polymerase Activities in DNA Replication

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 5 of 8
Samir M. Hamdan, King Abdullah University of Science and Technology, Saudi Arabia
Two Molecular Triggers Reset the Bacteriophage T7 Replisome after Okazaki Fragment Synthesis

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 6 of 8
Isabel Kurth, Rockefeller University, USA
Polymerase Collision Release is Mediated by Loss of Multiple Attachment Points to DNA upon Completing each Okazaki Fragment

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 7 of 8
Erik Johansson, Umeå University, Sweden
The Eukaryotic Leading and Lagging Strand DNA Polymerases are Loaded onto Primer-Ends via Separate Mechanisms but have Comparable Processivity in the Presence of PCNA

Monday, February 11 | 2:30PM - 4:30PM
Workshop 1: Origins and Okazaki Fragments
Room: Anasazi Ballroom

Speaker 8 of 8
Nina Y. Yao, Rockefeller University, USA
Mechanism of PCNA Clamp Opening by Replication Factor C

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 1 of 8
* David J. Sherratt, University of Oxford, UK
Independent positioning and action of replication forks in live Esherichia coli

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 2 of 8
Kiyoshi Mizuuchi, NIDDK, National Institutes of Health, USA
P1 Plasmid Partition: Role of ATP-Dependent ParA Conformational Change and DNA Binding Kinetics in DNA Translocation

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 3 of 8
Shingo Nozaki, Nagoya University Graduate School, Japan
Subcellular Localization of Escherichia coli DnaA, the Initiator of DNA Replication

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 4 of 8
Bhupender Singh, Uppsala University, Sweden
Replication Factories in Live Bacteria (E. coli): Localization for Chromosomal, Viral and Plasmid Replication Sites

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 5 of 8
Amitabh Nimonkar, University of California, USA
Single-Molecule Imaging & Biochemical Analysis of Saccharomyces Cerevisiae Encoded Dmc1 & Tid1/Rdh54 Proteins

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 6 of 8
Constance Nugent, University of California, Riverside, USA
Analysis of Telomere Capping Protein Interactions with Polalpha Subunits

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 7 of 8
Toru Nakamura, University of Illinois at Chicago, USA
Cell Cycle Regulation of Fission Yeast Telomere Proteins

Monday, February 11 | 2:30PM - 4:30PM
Workshop 2: Chromosomes, Telomeres, and Large Scale Organiza
tion
Room: Zia Ballroom

Speaker 8 of 8
Manolis Papamichos-Chronakis, Institut Curie, France
The INO80 Chromatin Remodeling Enzyme Regulates Replisome Function and Stability

Monday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Pavillion


Monday, February 11 | 5:00PM - 7:00PM
Replication and Recombination at Telomeres
Room: Anasazi Ballroom

Speaker 1 of 3
* Jack D. Griffith, University of North Carolina, Chapel Hill, USA
T-Loops and T-Circles in the Replication of Telomeres

Monday, February 11 | 5:00PM - 7:00PM
Replication and Recombination at Telomeres
Room: Anasazi Ballroom

Speaker 2 of 3
Julia Promisel Cooper, NCI, National Institutes of Health, USA
Disentangling Chromosome Ends: The Outcome of Replication Fork Stalling at Telomeres is Dictated by Sumoylation of RecQ Helicase

Monday, February 11 | 5:00PM - 7:00PM
Replication and Recombination at Telomeres
Room: Anasazi Ballroom

Speaker 3 of 3
Susan M. Bailey, Colorado State University, USA
Telomere Dynamics and Premature Aging

Monday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pavillion


Monday, February 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Pavillion


Tuesday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Tuesday, February 12 | 7:00AM - 8:00AM
Poster Setup
Room: Pavillion


Tuesday, February 12 | 8:00AM - 11:00AM
Assembling Initiation Complexes - Replication Origins and Ce
ll Cycle Control

Room: Anasazi Ballroom

Speaker 1 of 4
* Jerard Hurwitz, Memorial Sloan-Kettering Cancer Center, USA
Initiation of Replication

Tuesday, February 12 | 8:00AM - 11:00AM
Assembling Initiation Complexes - Replication Origins and Ce
ll Cycle Control

Room: Anasazi Ballroom

Speaker 2 of 4
Louise T. Chow, University of Alabama at Birmingham, USA
Regulation of Human Papillomavirus DNA Replication

Tuesday, February 12 | 8:00AM - 11:00AM
Assembling Initiation Complexes - Replication Origins and Ce
ll Cycle Control

Room: Anasazi Ballroom

Speaker 3 of 4
Bruce W. Stillman, Cold Spring Harbor Laboratory, USA
Control of the Chromosome Cycle in Human Cells by the Origin Recognition Complex

Tuesday, February 12 | 8:00AM - 11:00AM
Assembling Initiation Complexes - Replication Origins and Ce
ll Cycle Control

Room: Anasazi Ballroom

Speaker 4 of 4
John F.X. Diffley, Francis Crick Institute, UK
Regulation of Replication Origin Activation during the Cell Cycle and in Response to DNA Damage

Tuesday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Pavillion


Tuesday, February 12 | 11:00AM - 12:00PM
Lunch
Room: Pavillion


Tuesday, February 12 | 12:00PM - 2:30PM
Poster Session 2
Room: Pavillion


Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 1 of 8
* Laurie S. Kaguni, Michigan State University, USA
Modular Architecture and Human Disease Alleles of the Mitochondrial Replicative DNA Helicase

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 2 of 8
Amy Marion Branagan, University of Vermont, USA
Intermediates in Gp59-Mediated Helicase Loading at the T4 DNA Replication Fork

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 3 of 8
Ajit Kumar Satapathy, Harvard Medical School, USA
Nucleotide and Metal Cofactor Specificity in Bacteriophage T7 Helicase

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 4 of 8
Whitney Yin, University of Texas, Austin, USA
Crystal Structure of Human Miochondrial DNA Polymerase Holoenzyme

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 5 of 8
Robert A. Sclafani, University of Colorado Denver, USA
Structure-Function Analysis of DNA Binding Domains in Mcm DNA Helicases

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 6 of 8
Matthew L. Bochman, Indiana University, USA
Involvement of an ATP-Dependent “Gate” in MCM2-7 Helicase Activity

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 7 of 8
Megan Davey, University of Western Ontario, Canada
A Ringmaker Mechanism for Loading MCMs onto DNA

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 3: Helicases, Mitochondrial Replication
Room: Anasazi Ballroom

Speaker 8 of 8
Jaya G. Yodh, University of Illinois at Urbana-Champaign, USA
Single Molecule Analysis of DNA Unwinding by Human Bloom Helicase

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 1 of 9
* Johannes C. Walter, Harvard Medical School, USA

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 2 of 9
Chrystelle Maric Antoinat, Institut Andre Lwoff, France
X-Shaped Post-Replicative Joint DNA Molecules Contain Ribonucleotides

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 3 of 9
Francesca Storici, Georgia Institute of Technology, USA
RNA-Templated DNA Repair

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 4 of 9
Benedicte Michel, CNRS, France
Ruva Mutants that Resolve Holliday Junctions but do not Revert Replication Forks

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 5 of 9
Kent W. Mouw, Dana-Farber Cancer Institute, USA
Architecture of a Serine Recombinase – DNA Regulatory Complex

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 6 of 9
Yasuto Murayama, Yokohama City University, Japan
Fission Yeast Rhp51 Recombinase Promotes DNA Four-Strand Exchange Reaction in vitro

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 7 of 9
Sapna Das-Bradoo, Northeastern State University, USA
How do Cells Sense DNA Damage “Behind” the Fork?

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 8 of 9
Kristina Trenz, London Research Institute, Clare Hall, UK
Plx1 is Required for Chromosomal DNA Replication under Stressful Conditions

Tuesday, February 12 | 2:30PM - 4:30PM
Workshop 4: Recombination and Repair in Yeast and Prokaryote
s
Room: Zia Ballroom

Speaker 9 of 9
Audrey J. Klingele, Proteovista LLC, USA
Changes in Gene Expression Related to Acquired Resistance to Radiation Damage

Tuesday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Pavillion


Tuesday, February 12 | 5:00PM - 7:00PM
Recombination Mechanisms and Chromosome Pairing
Room: Anasazi Ballroom

Speaker 1 of 3
* Kirill S. Lobachev, Georgia Institute of Technology, USA
Mechanisms of Chromosomal Fragility and Genome Rearrangements Mediated by Unstable Repeats

Tuesday, February 12 | 5:00PM - 7:00PM
Recombination Mechanisms and Chromosome Pairing
Room: Anasazi Ballroom

Speaker 2 of 3
Eric C. Greene, Columbia University, USA
Visualizing DNA Repair Proteins in Action

Tuesday, February 12 | 5:00PM - 7:00PM
Recombination Mechanisms and Chromosome Pairing
Room: Anasazi Ballroom

Speaker 3 of 3
Camilla Sjögren, Karolinska Institutet, Sweden
Sister Chromatid Cohesion in Chromosome Segregation and Repair

Tuesday, February 12 | 7:00PM - 7:00PM
On Own for Dinner


Wednesday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Wednesday, February 13 | 8:00AM - 11:00AM
Architecture of Replication and Recombination Complexes
Room: Anasazi Ballroom

Speaker 1 of 4
* Stephen C. West, Francis Crick Institute, UK
Aprataxin — A Proofreader for Abortive DNA Ligation Events

Wednesday, February 13 | 8:00AM - 11:00AM
Architecture of Replication and Recombination Complexes
Room: Anasazi Ballroom

Speaker 2 of 4
Johannes C. Walter, Harvard Medical School, USA
Mechanism of DNA Interstrand Crosslink Repair

Wednesday, February 13 | 8:00AM - 11:00AM
Architecture of Replication and Recombination Complexes
Room: Anasazi Ballroom

Speaker 3 of 4
Fred Dyda, NIDDK, National Institutes of Health, USA
Molecular Mechanism of Asymmetric DNA Transposition

Wednesday, February 13 | 8:00AM - 11:00AM
Architecture of Replication and Recombination Complexes
Room: Anasazi Ballroom

Speaker 4 of 4
James M. Berger, Johns Hopkins University School of Medicine, USA
Molecular Mechanisms for Initiating DNA Replication

Wednesday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Pavillion


Wednesday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Pavillion


Wednesday, February 13 | 11:00AM - 11:00AM
On Own for Lunch


Wednesday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Pavillion


Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 1 of 9
* Kyungjae Myung, Institute for Basic Science, South Korea

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 2 of 9
Elena Curti, NICHD, National Institutes of Health, USA
Interplay of E. coli Polymerases during Genome Duplication

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 3 of 9
Anne-Marie MacLean McRobbie, University of St Andrews, UK
Understanding the Interplay between Recombinases, Helicases and DNA Binding Proteins during Homologous Recombination in Archaea

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 4 of 9
Danielle L. Daee, USA
Functional Consequences of Replicative Polymerase Polymorphisms and Cancer-Associated Mutations Modeled in Yeast

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 5 of 9
Daniel Kane, Tufts University, USA
Usage of DNA Polymerase Eta and Zeta in Homologous Recombination and Repair following DNA Damage in Drosophila

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 6 of 9
Mitch McVey, Tufts University, USA
DNA Polymerase Theta Functions in an Alternative Double-Strand Break Repair Pathway in Drosophila Melanogaster

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 7 of 9
Nilabja Sikdar, National Human Genome Research Institute, USA
Human ELG1 Functions to Repair DNA Damage through its Interaction with PCNA and Polymerase eta

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 8 of 9
Tina M. Albertson, University of Washington, USA
Polymerase Delta and Epsilon Proofreading Act in Parallel Pathways to Suppress Spontaneous Mutation and Cancer in Mice

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 5: New Polymerases
Room: Anasazi Ballroom

Speaker 9 of 9
Garry Dallmann, Venria Bioscience, USA
Identification of Small–Molecule Inhibitors of DNA Polymerase III Holoenzyme

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 1 of 9
* Richard A. Fishel, Ohio State University, USA

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 2 of 9
Guo-Min Li, University of Kentucky, USA
Identification of a Novel Mismatch Repair Stimulating Factor involving RFX

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 3 of 9
Ling Xia, Molecular Medicine and Genetics, USA
The Role of Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 4 of 9
Martin Kupiec, Tel Aviv University, Israel
Elg1 is Required for Genome Stability

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 5 of 9
Renee D. Paulsen, Stanford University, USA
siRNA Screening for Novel Regulators of Genomic Integrity

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 6 of 9
Kirstin Bass, Mount Sinai School of Medicine, USA
Brc1: Coordinating DNA Repair and Replication

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 7 of 9
† Bernard S. Lopez, Institut Gustave Roussy, France
PKBalpha/AKT1 Inhibits Homologous Recombination by Cytoplasmic Retention of BRCA1 and Rad51, Mediated by FOXO1a: Impact in Sporadic Breast Cancer

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 8 of 9
Mark A. Brenneman, Rutgers University, USA
DSS1, a BRCA2-Associated Protein, Regulates Homologous Recombinational Repair in Human Cells

Wednesday, February 13 | 2:30PM - 4:30PM
Workshop 6: Recombination and Repair in Higher Eukaryotes
Room: Zia Ballroom

Speaker 9 of 9
Sandra K. Weller, University of Connecticut School of Medicine, USA
HSV-1 inactivates the ATR pathway during infection by sequestration of ATRIP

Wednesday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Pavillion


Wednesday, February 13 | 5:00PM - 7:00PM
Replication Response to Checkpoints
Room: Anasazi Ballroom

Speaker 1 of 3
* Stephen P. Bell, Massachusetts Institute of Technology, USA
DDK Targets Mcm 2-7 Proteins in the Pre-RC

Wednesday, February 13 | 5:00PM - 7:00PM
Replication Response to Checkpoints
Room: Anasazi Ballroom

Speaker 2 of 3
Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
Pathways Controlling Replication Fork Stability

Wednesday, February 13 | 5:00PM - 7:00PM
Replication Response to Checkpoints
Room: Anasazi Ballroom

Speaker 3 of 3
Karlene A. Cimprich, Stanford University, USA
Mechanisms for Maintaining Genome Stability at the Replication Fork

Wednesday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pavillion


Wednesday, February 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Pavillion


Thursday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Thursday, February 14 | 8:00AM - 11:00AM
Genome Stability and DNA Repair, Alternative Polymerases, DS
B Repair

Room: Anasazi Ballroom

Speaker 1 of 4
* Richard D. Kolodner, Ludwig Institute for Cancer Research, USA
Identification of Pathways that Prevent Genome Instability

Thursday, February 14 | 8:00AM - 11:00AM
Genome Stability and DNA Repair, Alternative Polymerases, DS
B Repair

Room: Anasazi Ballroom

Speaker 2 of 4
Lorena S. Beese, Duke University Medical Center, USA
Human mutS alpha DNA Lesion Recognition Complex

Thursday, February 14 | 8:00AM - 11:00AM
Genome Stability and DNA Repair, Alternative Polymerases, DS
B Repair

Room: Anasazi Ballroom

Speaker 3 of 4
Roger Woodgate, National Institutes of Health, USA
Y-Family Polymerases and Their Role in the Translesion Synthesis of Alkylation Damage

Thursday, February 14 | 8:00AM - 11:00AM
Genome Stability and DNA Repair, Alternative Polymerases, DS
B Repair

Room: Anasazi Ballroom

Speaker 4 of 4
Jan Karlseder, The Salk Institute for Biological Studies, USA
C. elegans Telomeres Contain both G-Strand and C-Strand Overhangs that are Bound by Distinct Telomere-Binding Proteins

Thursday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Pavillion


Thursday, February 14 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 1 of 8
* Xiaojiang S. Chen, University of Southern California, USA
The Hexameric Structure of a DnaB-Family Replicative Helicase and its Functional Interplay with Primase

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 2 of 8
Sharmistha Ghosh, Harvard Medical School, USA
Escherichia Coli Thioredoxin Interacts wiht the Thioredoxin Binding Domain of Bacteriophage T7 DNA Polymerase and with Helicase/Primase at the Replication Fork

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 3 of 8
Iben Bach Bentsen, Aarhus University, Denmark
Identification of Protein Factors Required during Stalled Replication at a Protein-DNA Barrier

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 4 of 8
Hong Yan, Fox Chase Cancer Center, USA
Biochemical Analysis of Replication Fork Stall and Restart at a Defined Lesion in Xenopus Nucleoplasmic Extracts

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 5 of 8
Chiara Indiani, Rockefeller University, USA
Programmed Slowing of the Replication Fork in Response to DNA Damage

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 6 of 8
Kieran Emptage, University of Newcastle, UK
Archaeal Family B DNA Polymerase Stalling, Protection and Interaction with PCNA at Deaminated Bases

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 7 of 8
Yu-Hao Paul Chang, University of Southern California, USA
Crystal Structure of the GINS Complex and Functional Insights into its Role in DNA Replication

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 7: Fork Stalling And Structure of Fork Complexes
Room: Anasazi Ballroom

Speaker 8 of 8
Roxana Georgescu, Rockefeller University, USA
Structure of a Sliding Clamp on DNA

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 1 of 8
* Ronald Chalmers, University of Nottingham Medical School, UK
Base-Flipping Dynamics in V(D)J Recombination

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 2 of 8
Michael G. Chandler, CNRS UMR 5100, France
Transposition of the Novel Insertion Sequence IS608: Biochemistry and Assimilation into the Cell Cycle

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 3 of 8
Hiroshi Nakai, Georgetown University Medical Center, USA
Effect of Translation Factor IF2-2 at the Interface of Recombination and Replication for Bacteriophage MU Transposition

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 4 of 8
Patrick C. Swanson, Creighton University, USA
Evidence for Long Range RAG1/2 Interactions with Coding Sequences in Discrete V(D)J Initiation Complexes Assembled on Coupled Cleavage Substrates

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 5 of 8
Adam G. W. Matthews, Massachusetts Institute of Technology, USA
RAG2 PHD Finger Couples Histone H3 Lysine 4 Trimethylation with V(D)J Recombination

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 6 of 8
Lisa Postow, Rockefeller University, USA
Ubiquitin-Mediated Removal of Ku80 from DNA Breaks

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 7 of 8
John R. Lydeard, Biogen Idec, USA
Break-Induced Replication Requires both the Leading and Lagging Strand Replication Machinery

Thursday, February 14 | 2:30PM - 4:30PM
Workshop 8: VDJ, End Joining and Transposition
Room: Zia Ballroom

Speaker 8 of 8
Jennifer A. Cobb, University of Calgary, Canada
The Mre11 Complex and S Phase: Maintaining the Replisome during Fork Stalling

Thursday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Pavillion


Thursday, February 14 | 5:00PM - 7:00PM
Replication Stalling and Restart
Room: Anasazi Ballroom

Speaker 1 of 3
* Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
Mechanisms of Replication Fork Reactivation

Thursday, February 14 | 5:00PM - 7:00PM
Replication Stalling and Restart
Room: Anasazi Ballroom

Speaker 2 of 3
Karim Labib, University of Dundee, UK
Regulating the Progression of Eukaryotic DNA Replication Forks

Thursday, February 14 | 5:00PM - 7:00PM
Replication Stalling and Restart
Room: Anasazi Ballroom

Speaker 3 of 3
James E. Haber, Brandeis University, USA
Break Induced-Replication and the Recombination Execution Checkpoint

Thursday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pavillion


Thursday, February 14 | 8:00PM - 11:00PM
Entertainment
Room: Pavillion


Thursday, February 14 | 8:00PM - 11:00PM
Cash Bar
Room: Pavillion


Friday, February 15 | 10:25AM - 10:25AM
Departure


*Session Chair.