Web Desc
Wnt/beta-Catenin Signaling in Development and Disease
Organizer(s): Joanna L. Groden and Randall T. Moon
Date: February 17 - 22, 2008
Location: Keystone Resort, Keystone, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Current research has shown that the Wnt signaling pathways are vital in the regulation of growth and differentiation in many diverse organisms and cell types. From their importance in the development of the fly wing and the specification of the vertebrate embryonic axis, their roles in cancer susceptibility to their functions in stem cell biology, to their roles in cell movement and planar cell polarity, these pathways control numerous key processes. This meeting will provide a platform to review the latest research on the functions and mechanisms of action of beta-catenin dependent and independent Wnt/Frizzled signaling pathways in a variety of organisms, tissue systems, and disease contexts. Finally, this meeting will continue to be a major platform for announcing advances in the discovery of small molecule modulators that might serve as leads for drug development.
Scholarship Deadline: October 17 2007
Discounted Abstract Deadline: October 17 2007
Abstract Deadline: November 15 2007
Discounted Registration Deadline: December 17 2007
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.March of Dimes FoundationThe Company of Biologists Ltd
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD057682-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 17 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Sunday, February 17 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Sunday, February 17 | 7:30PM - 8:30PM
Keynote Address
Room: Red Cloud/Shavano

Speaker 1 of 1
Thomas A. Rando, Stanford University School of Medicine, USA
Control of Muscle Stem Cell Fate by Wnt Signaling

Monday, February 18 | 7:00AM - 8:00AM
Breakfast
Room: Crestone


Monday, February 18 | 8:00AM - 11:00AM
Pathway Components I
Room: Red Cloud/Shavano

Speaker 1 of 5
Bill Arthur, Rosetta Inpharmatics-Merck & Co., Inc., USA
Screening the Wnt Pathway Using RNAi

Monday, February 18 | 8:00AM - 11:00AM
Pathway Components I
Room: Red Cloud/Shavano

Speaker 2 of 5
Mien-Chie Hung, University of Texas MD Anderson Cancer Center, USA
Strategies for Therapeutic Targeting GSK-3beta and Erk

Monday, February 18 | 8:00AM - 11:00AM
Pathway Components I
Room: Red Cloud/Shavano

Speaker 3 of 5
* Inke S. Näthke, University of Dundee, UK
The APC Protein in Cell Adhesion, Migration, and Division

Monday, February 18 | 8:00AM - 11:00AM
Pathway Components I
Room: Red Cloud/Shavano

Speaker 4 of 5
Kristi L. Neufeld, University of Kansas, USA
Nuclear and Cytoplasmic Localization of the APC Tumor Suppressor

Monday, February 18 | 8:00AM - 11:00AM
Pathway Components I
Room: Red Cloud/Shavano

Speaker 5 of 5
Ken-Ichi Takemaru, Stony Brook University, USA
Short Talk: Nuclear-Cytoplasmic Shuttling of Chibby Regulates Subcellular Localization of beta-Catenin

Monday, February 18 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, February 18 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone


Monday, February 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone


Monday, February 18 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, February 18 | 5:00PM - 7:15PM
Pathway Components II
Room: Red Cloud/Shavano

Speaker 1 of 5
* Michael Ben Major, Washington University, USA

Monday, February 18 | 5:00PM - 7:15PM
Pathway Components II
Room: Red Cloud/Shavano

Speaker 2 of 5
Christopher J. Phiel, University of Colorado Denver, USA
In Vivo Functions of GSK-3 Isoforms

Monday, February 18 | 5:00PM - 7:15PM
Pathway Components II
Room: Red Cloud/Shavano

Speaker 3 of 5
Hsien-yu Wang, Stony Brook University, USA
Inositol Pentakisphosphate Mediates Wnt/beta-Catenin Signaling

Monday, February 18 | 5:00PM - 7:15PM
Pathway Components II
Room: Red Cloud/Shavano

Speaker 4 of 5
Xinhua Lin, Cincinnati Children's Hospital Medical Center, USA
The Retromer Complex is Involved in Wnt Secretion by Controlling Retrograde Transport of Wntless from Endosomes to Trans Golgi Network

Monday, February 18 | 5:00PM - 7:15PM
Pathway Components II
Room: Red Cloud/Shavano

Speaker 5 of 5
Aaron M. Zorn, Cincinnati Children's Hospital Medical Center, USA
Sox Proteins Regulate Beta-catenin/Tcf Activity

Monday, February 18 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Crestone


Monday, February 18 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone


Tuesday, February 19 | 7:00AM - 8:00AM
Breakfast
Room: Crestone


Tuesday, February 19 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Red Cloud/Shavano

Speaker 1 of 5
* Janet Heasman, Cincinnati Children's Research Foundation, USA
The Role of the Wnt Antagonist Dickkopf-1 in Patterning the Axis of the Xenopus Laevis Embryo

Tuesday, February 19 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Red Cloud/Shavano

Speaker 2 of 5
Edward E. Morrisey, University of Pennsylvania, USA
Novel Roles for Wnt Signaling in Lung and Cardiac Development

Tuesday, February 19 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Red Cloud/Shavano

Speaker 3 of 5
Diane C. Slusarski, University of Iowa, USA
Wnt/Calcium Signaling in Zebrafish Morphogenesis: Cues for Laterality and Polarity

Tuesday, February 19 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Red Cloud/Shavano

Speaker 4 of 5
Christian P. Petersen, Northwestern University, USA
Short Talk: smed beta catenin-1 is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

Tuesday, February 19 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Red Cloud/Shavano

Speaker 5 of 5
Woo-Yang Kim, University of North Carolina, USA
Short Talk: Glycogen Synthase Kinase-3s are Required for Mouse Brain Development

Tuesday, February 19 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, February 19 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone


Tuesday, February 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone


Tuesday, February 19 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, February 19 | 5:00PM - 7:00PM
Wnt Signaling in Stem Cells and Regeneration
Room: Red Cloud/Shavano

Speaker 1 of 4
Gary D. Hammer, University of Michigan, USA
Wnt/beta-Catenin Signaling in Adrenocortical Stem/Progenitor Cells: Implications for Adrenocortical Carcinoma

Tuesday, February 19 | 5:00PM - 7:00PM
Wnt Signaling in Stem Cells and Regeneration
Room: Red Cloud/Shavano

Speaker 2 of 4
* Randall T. Moon, University of Washington School of Medicine, USA
WNT Signaling in Zebrafish Regeneration

Tuesday, February 19 | 5:00PM - 7:00PM
Wnt Signaling in Stem Cells and Regeneration
Room: Red Cloud/Shavano

Speaker 3 of 4
Sarah E. Millar, University of Pennsylvania, USA
Title to be Determined

Tuesday, February 19 | 5:00PM - 7:00PM
Wnt Signaling in Stem Cells and Regeneration
Room: Red Cloud/Shavano

Speaker 4 of 4
Nick Barker, Institute of Medical Biology, Singapore
Short Talk: LGR5 Marks Stem Cells in Multiple Adult Tissues

Tuesday, February 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone


Tuesday, February 19 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone


Wednesday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Crestone


Wednesday, February 20 | 8:00AM - 11:00AM
Interactions of Wnt with Other Signaling Pathways
Room: Red Cloud/Shavano

Speaker 1 of 6
* Barry M. Gumbiner, University of Virginia School of Medicine, USA
Cadherin and Beta-Catenin Signaling Interactions

Wednesday, February 20 | 8:00AM - 11:00AM
Interactions of Wnt with Other Signaling Pathways
Room: Red Cloud/Shavano

Speaker 2 of 6
Stephen Carl Ekker, Mayo Clinic, USA
Wnt5 Signaling in Organogenesis and Human Craniofacial Development

Wednesday, February 20 | 8:00AM - 11:00AM
Interactions of Wnt with Other Signaling Pathways
Room: Red Cloud/Shavano

Speaker 3 of 6
Marek Mlodzik, Mount Sinai School of Medicine, USA
Wnt/Fz-Planar Cell Polarity (PCP) Signaling: Signaling Specificity, Regulation, and Interactions with Other Pathways

Wednesday, February 20 | 8:00AM - 11:00AM
Interactions of Wnt with Other Signaling Pathways
Room: Red Cloud/Shavano

Speaker 4 of 6
Lena Al-Harthi, Rush University, USA
Lithium Inhibits HIV Replication in Peripheral Blood Mononuclear Cells (PBMCs) by Activating the beta-catenin

Wednesday, February 20 | 8:00AM - 11:00AM
Interactions of Wnt with Other Signaling Pathways
Room: Red Cloud/Shavano

Speaker 5 of 6
Wolfram Goessling, Brigham and Women's Hospital-Harvard Medical School, USA
and

Wednesday, February 20 | 8:00AM - 11:00AM
Interactions of Wnt with Other Signaling Pathways
Room: Red Cloud/Shavano

Speaker 6 of 6
Trista E. North, Beth Israel Deaconess Medical Center, USA
Short Talk: Genetic Interaction between PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

Wednesday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, February 20 | 11:00AM - 1:00PM
Poster Setup
Room: Crestone


Wednesday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone


Wednesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Wednesday, February 20 | 5:00PM - 7:00PM
Wnt Regulation of Gene Expression
Room: Red Cloud/Shavano

Speaker 1 of 4
* Marian Waterman, University of California, Irvine, USA
LEF/TCF Control of Gene Expression

Wednesday, February 20 | 5:00PM - 7:00PM
Wnt Regulation of Gene Expression
Room: Red Cloud/Shavano

Speaker 2 of 4
Katherine A. Jones, The Salk Institute, USA
Control of H3K4 Trimethylation at Wnt-induced genes

Wednesday, February 20 | 5:00PM - 7:00PM
Wnt Regulation of Gene Expression
Room: Red Cloud/Shavano

Speaker 3 of 4
Mariann Bienz, MRC Laboratory of Molecular Biology, UK
The Role of the Pygopus-BCL9 Complex in TCF-mediated Transcription

Wednesday, February 20 | 5:00PM - 7:00PM
Wnt Regulation of Gene Expression
Room: Red Cloud/Shavano

Speaker 4 of 4
Timothy A. Blauwkamp, University of Michigan, USA
Short Talk: Novel TCF Binding Sites Specify Transcriptional
Repression by Wnt Signaling


Wednesday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone


Wednesday, February 20 | 7:30PM - 10:00PM
Poster Session 3
Room: Crestone


Thursday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Crestone


Thursday, February 21 | 8:00AM - 11:00AM
Wnt Signaling in Cancer
Room: Red Cloud/Shavano

Speaker 1 of 5
* Joanna L. Groden, Ohio State University, USA

Thursday, February 21 | 8:00AM - 11:00AM
Wnt Signaling in Cancer
Room: Red Cloud/Shavano

Speaker 2 of 5
Sylvie Robine, Institut Curie, France
RAS Pathway Synergy with wnt Signaling in in vivo Models of Cancer

Thursday, February 21 | 8:00AM - 11:00AM
Wnt Signaling in Cancer
Room: Red Cloud/Shavano

Speaker 3 of 5
Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
Naked1 and Naked2, Mammalian Orthologs of Naked Cuticle, are Differentially Regulated in Colorectal Cancer

Thursday, February 21 | 8:00AM - 11:00AM
Wnt Signaling in Cancer
Room: Red Cloud/Shavano

Speaker 4 of 5
Michael Ben Major, Washington University, USA
Proteomic Dissection of the Wnt/beta-Catenin Signal Transduction Pathway

Thursday, February 21 | 8:00AM - 11:00AM
Wnt Signaling in Cancer
Room: Red Cloud/Shavano

Speaker 5 of 5
Matthias Ernst, Olivia Newton-John Cancer Research Institute, Australia
Short Talk: Enforced Expression of DNA Methyltransferase 3a Enhances Polyposis in ApcMin/+ Mice by Transcriptional Silencing of Sfrp5

Thursday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Thursday, February 21 | 5:00PM - 7:00PM
Pharmacological Modulation of Wnt Signaling
Room: Red Cloud/Shavano

Speaker 1 of 4
Caterina A.M. La Porta, University of Milan, Italy
Cancer Stem Cells and Therapeutic Perspectives

Thursday, February 21 | 5:00PM - 7:00PM
Pharmacological Modulation of Wnt Signaling
Room: Red Cloud/Shavano

Speaker 2 of 4
Elena Brin, Ambrx, USA
Short Talk: Selective Apoptosis Induction in Wnt-Deregulated Cancer Cells

Thursday, February 21 | 5:00PM - 7:00PM
Pharmacological Modulation of Wnt Signaling
Room: Red Cloud/Shavano

Speaker 3 of 4
† Thomas Andersson, Swedish University of Agricultural Sciences, Sweden
Short Talk: Foxy-5, A WNT-5-Derived Hexapeptide

Thursday, February 21 | 5:00PM - 7:00PM
Pharmacological Modulation of Wnt Signaling
Room: Red Cloud/Shavano

Speaker 4 of 4
* Trevor Clive Dale, Cardiff University, UK
Cell Based Screening for Inhibitors of the Wnt Signaling Pathway

Thursday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Crestone


Thursday, February 21 | 8:00PM - 11:00PM
Entertainment
Room: Crestone


Thursday, February 21 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone


Friday, February 22 | 10:25AM - 10:25AM
Departure


*Session Chair.