Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Signal Dynamics and Signal Integration in Development and Disease (2019J4)
Developmental Pathways and Cancer: Wnt, Notch and Hedgehog (2014J7)

Web Desc
Wnt/beta-Catenin Signaling in Development and Disease Organizer(s): Joanna L. Groden and Randall T. Moon Date: February 17 - 22, 2008 Location: Keystone Resort, Keystone, CO, USA Supported by the Director's Fund Summary of Meeting: Current research has shown that the Wnt signaling pathways are vital in the regulation of growth and differentiation in many diverse organisms and cell types. From their importance in the development of the fly wing and the specification of the vertebrate embryonic axis, their roles in cancer susceptibility to their functions in stem cell biology, to their roles in cell movement and planar cell polarity, these pathways control numerous key processes. This meeting will provide a platform to review the latest research on the functions and mechanisms of action of beta-catenin dependent and independent Wnt/Frizzled signaling pathways in a variety of organisms, tissue systems, and disease contexts. Finally, this meeting will continue to be a major platform for announcing advances in the discovery of small molecule modulators that might serve as leads for drug development. Scholarship Deadline: October 17 2007 Discounted Abstract Deadline: October 17 2007 Abstract Deadline: November 15 2007 Discounted Registration Deadline: December 17 2007 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Grant No. 1R13HD057682-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Wnt/beta-Catenin Signaling in Development and Disease

Organizer(s): Joanna L. Groden and Randall T. Moon

Date: February 17 - 22, 2008
Location: Keystone Resort, Keystone, CO, USA

Supported by the Director's Fund

Summary of Meeting:

Current research has shown that the Wnt signaling pathways are vital in the regulation of growth and differentiation in many diverse organisms and cell types. From their importance in the development of the fly wing and the specification of the vertebrate embryonic axis, their roles in cancer susceptibility to their functions in stem cell biology, to their roles in cell movement and planar cell polarity, these pathways control numerous key processes. This meeting will provide a platform to review the latest research on the functions and mechanisms of action of beta-catenin dependent and independent Wnt/Frizzled signaling pathways in a variety of organisms, tissue systems, and disease contexts. Finally, this meeting will continue to be a major platform for announcing advances in the discovery of small molecule modulators that might serve as leads for drug development.

Scholarship Deadline: October 17 2007

Discounted Abstract Deadline: October 17 2007

Abstract Deadline: November 15 2007

Discounted Registration Deadline: December 17 2007

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13HD057682-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 17 \| 3:00PM - 7:30PM Registration Room: Shavano Peak Foyer
Sunday, February 17 \| 6:30PM - 7:30PM Refreshments Room: Shavano Peak Foyer
Sunday, February 17 \| 7:30PM - 8:30PM Keynote Address Room: Red Cloud/Shavano Speaker 1 of 1 Thomas A. Rando, Stanford University School of Medicine, USA Control of Muscle Stem Cell Fate by Wnt Signaling
Monday, February 18 \| 7:00AM - 8:00AM Breakfast Room: Crestone
Monday, February 18 \| 8:00AM - 11:00AM Pathway Components I Room: Red Cloud/Shavano Speaker 1 of 5 Bill Arthur, Rosetta Inpharmatics-Merck & Co., Inc., USA Screening the Wnt Pathway Using RNAi
Monday, February 18 \| 8:00AM - 11:00AM Pathway Components I Room: Red Cloud/Shavano Speaker 2 of 5 Mien-Chie Hung, University of Texas MD Anderson Cancer Center, USA Strategies for Therapeutic Targeting GSK-3beta and Erk
Monday, February 18 \| 8:00AM - 11:00AM Pathway Components I Room: Red Cloud/Shavano Speaker 3 of 5 * Inke S. Näthke, University of Dundee, UK The APC Protein in Cell Adhesion, Migration, and Division
Monday, February 18 \| 8:00AM - 11:00AM Pathway Components I Room: Red Cloud/Shavano Speaker 4 of 5 Kristi L. Neufeld, University of Kansas, USA Nuclear and Cytoplasmic Localization of the APC Tumor Suppressor
Monday, February 18 \| 8:00AM - 11:00AM Pathway Components I Room: Red Cloud/Shavano Speaker 5 of 5 Ken-Ichi Takemaru, Stony Brook University, USA Short Talk: Nuclear-Cytoplasmic Shuttling of Chibby Regulates Subcellular Localization of beta-Catenin
Monday, February 18 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Monday, February 18 \| 11:00AM - 1:00PM Poster Setup Room: Crestone
Monday, February 18 \| 1:00PM - 10:00PM Poster Viewing Room: Crestone
Monday, February 18 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Monday, February 18 \| 5:00PM - 7:15PM Pathway Components II Room: Red Cloud/Shavano Speaker 1 of 5 * Michael Ben Major, Washington University, USA
Monday, February 18 \| 5:00PM - 7:15PM Pathway Components II Room: Red Cloud/Shavano Speaker 2 of 5 Christopher J. Phiel, University of Colorado Denver, USA In Vivo Functions of GSK-3 Isoforms
Monday, February 18 \| 5:00PM - 7:15PM Pathway Components II Room: Red Cloud/Shavano Speaker 3 of 5 Hsien-yu Wang, Stony Brook University, USA Inositol Pentakisphosphate Mediates Wnt/beta-Catenin Signaling
Monday, February 18 \| 5:00PM - 7:15PM Pathway Components II Room: Red Cloud/Shavano Speaker 4 of 5 Xinhua Lin, Cincinnati Children's Hospital Medical Center, USA The Retromer Complex is Involved in Wnt Secretion by Controlling Retrograde Transport of Wntless from Endosomes to Trans Golgi Network
Monday, February 18 \| 5:00PM - 7:15PM Pathway Components II Room: Red Cloud/Shavano Speaker 5 of 5 Aaron M. Zorn, Cincinnati Children's Hospital Medical Center, USA Sox Proteins Regulate Beta-catenin/Tcf Activity
Monday, February 18 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Crestone
Monday, February 18 \| 7:30PM - 10:00PM Poster Session 1 Room: Crestone
Tuesday, February 19 \| 7:00AM - 8:00AM Breakfast Room: Crestone
Tuesday, February 19 \| 8:00AM - 11:00AM Wnt Signaling in Development Room: Red Cloud/Shavano Speaker 1 of 5 * Janet Heasman, Cincinnati Children's Research Foundation, USA The Role of the Wnt Antagonist Dickkopf-1 in Patterning the Axis of the Xenopus Laevis Embryo
Tuesday, February 19 \| 8:00AM - 11:00AM Wnt Signaling in Development Room: Red Cloud/Shavano Speaker 2 of 5 Edward E. Morrisey, University of Pennsylvania, USA Novel Roles for Wnt Signaling in Lung and Cardiac Development
Tuesday, February 19 \| 8:00AM - 11:00AM Wnt Signaling in Development Room: Red Cloud/Shavano Speaker 3 of 5 Diane C. Slusarski, University of Iowa, USA Wnt/Calcium Signaling in Zebrafish Morphogenesis: Cues for Laterality and Polarity
Tuesday, February 19 \| 8:00AM - 11:00AM Wnt Signaling in Development Room: Red Cloud/Shavano Speaker 4 of 5 Christian P. Petersen, Northwestern University, USA Short Talk: smed beta catenin-1 is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
Tuesday, February 19 \| 8:00AM - 11:00AM Wnt Signaling in Development Room: Red Cloud/Shavano Speaker 5 of 5 Woo-Yang Kim, University of North Carolina, USA Short Talk: Glycogen Synthase Kinase-3s are Required for Mouse Brain Development
Tuesday, February 19 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Tuesday, February 19 \| 11:00AM - 1:00PM Poster Setup Room: Crestone
Tuesday, February 19 \| 1:00PM - 10:00PM Poster Viewing Room: Crestone
Tuesday, February 19 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Tuesday, February 19 \| 5:00PM - 7:00PM Wnt Signaling in Stem Cells and Regeneration Room: Red Cloud/Shavano Speaker 1 of 4 Gary D. Hammer, University of Michigan, USA Wnt/beta-Catenin Signaling in Adrenocortical Stem/Progenitor Cells: Implications for Adrenocortical Carcinoma
Tuesday, February 19 \| 5:00PM - 7:00PM Wnt Signaling in Stem Cells and Regeneration Room: Red Cloud/Shavano Speaker 2 of 4 * Randall T. Moon, University of Washington School of Medicine, USA WNT Signaling in Zebrafish Regeneration
Tuesday, February 19 \| 5:00PM - 7:00PM Wnt Signaling in Stem Cells and Regeneration Room: Red Cloud/Shavano Speaker 3 of 4 Sarah E. Millar, University of Pennsylvania, USA Title to be Determined
Tuesday, February 19 \| 5:00PM - 7:00PM Wnt Signaling in Stem Cells and Regeneration Room: Red Cloud/Shavano Speaker 4 of 4 Nick Barker, Institute of Medical Biology, Singapore Short Talk: LGR5 Marks Stem Cells in Multiple Adult Tissues
Tuesday, February 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Crestone
Tuesday, February 19 \| 7:30PM - 10:00PM Poster Session 2 Room: Crestone
Wednesday, February 20 \| 7:00AM - 8:00AM Breakfast Room: Crestone
Wednesday, February 20 \| 8:00AM - 11:00AM Interactions of Wnt with Other Signaling Pathways Room: Red Cloud/Shavano Speaker 1 of 6 * Barry M. Gumbiner, University of Virginia School of Medicine, USA Cadherin and Beta-Catenin Signaling Interactions
Wednesday, February 20 \| 8:00AM - 11:00AM Interactions of Wnt with Other Signaling Pathways Room: Red Cloud/Shavano Speaker 2 of 6 Stephen Carl Ekker, Mayo Clinic, USA Wnt5 Signaling in Organogenesis and Human Craniofacial Development
Wednesday, February 20 \| 8:00AM - 11:00AM Interactions of Wnt with Other Signaling Pathways Room: Red Cloud/Shavano Speaker 3 of 6 Marek Mlodzik, Mount Sinai School of Medicine, USA Wnt/Fz-Planar Cell Polarity (PCP) Signaling: Signaling Specificity, Regulation, and Interactions with Other Pathways
Wednesday, February 20 \| 8:00AM - 11:00AM Interactions of Wnt with Other Signaling Pathways Room: Red Cloud/Shavano Speaker 4 of 6 Lena Al-Harthi, Rush University, USA Lithium Inhibits HIV Replication in Peripheral Blood Mononuclear Cells (PBMCs) by Activating the beta-catenin
Wednesday, February 20 \| 8:00AM - 11:00AM Interactions of Wnt with Other Signaling Pathways Room: Red Cloud/Shavano Speaker 5 of 6 Wolfram Goessling, Brigham and Women's Hospital-Harvard Medical School, USA and
Wednesday, February 20 \| 8:00AM - 11:00AM Interactions of Wnt with Other Signaling Pathways Room: Red Cloud/Shavano Speaker 6 of 6 Trista E. North, Beth Israel Deaconess Medical Center, USA Short Talk: Genetic Interaction between PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration
Wednesday, February 20 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Wednesday, February 20 \| 11:00AM - 1:00PM Poster Setup Room: Crestone
Wednesday, February 20 \| 1:00PM - 10:00PM Poster Viewing Room: Crestone
Wednesday, February 20 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Wednesday, February 20 \| 5:00PM - 7:00PM Wnt Regulation of Gene Expression Room: Red Cloud/Shavano Speaker 1 of 4 * Marian Waterman, University of California, Irvine, USA LEF/TCF Control of Gene Expression
Wednesday, February 20 \| 5:00PM - 7:00PM Wnt Regulation of Gene Expression Room: Red Cloud/Shavano Speaker 2 of 4 Katherine A. Jones, The Salk Institute, USA Control of H3K4 Trimethylation at Wnt-induced genes
Wednesday, February 20 \| 5:00PM - 7:00PM Wnt Regulation of Gene Expression Room: Red Cloud/Shavano Speaker 3 of 4 Mariann Bienz, MRC Laboratory of Molecular Biology, UK The Role of the Pygopus-BCL9 Complex in TCF-mediated Transcription
Wednesday, February 20 \| 5:00PM - 7:00PM Wnt Regulation of Gene Expression Room: Red Cloud/Shavano Speaker 4 of 4 Timothy A. Blauwkamp, University of Michigan, USA Short Talk: Novel TCF Binding Sites Specify Transcriptional Repression by Wnt Signaling
Wednesday, February 20 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Crestone
Wednesday, February 20 \| 7:30PM - 10:00PM Poster Session 3 Room: Crestone
Thursday, February 21 \| 7:00AM - 8:00AM Breakfast Room: Crestone
Thursday, February 21 \| 8:00AM - 11:00AM Wnt Signaling in Cancer Room: Red Cloud/Shavano Speaker 1 of 5 * Joanna L. Groden, Ohio State University, USA
Thursday, February 21 \| 8:00AM - 11:00AM Wnt Signaling in Cancer Room: Red Cloud/Shavano Speaker 2 of 5 Sylvie Robine, Institut Curie, France RAS Pathway Synergy with wnt Signaling in in vivo Models of Cancer
Thursday, February 21 \| 8:00AM - 11:00AM Wnt Signaling in Cancer Room: Red Cloud/Shavano Speaker 3 of 5 Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA Naked1 and Naked2, Mammalian Orthologs of Naked Cuticle, are Differentially Regulated in Colorectal Cancer
Thursday, February 21 \| 8:00AM - 11:00AM Wnt Signaling in Cancer Room: Red Cloud/Shavano Speaker 4 of 5 Michael Ben Major, Washington University, USA Proteomic Dissection of the Wnt/beta-Catenin Signal Transduction Pathway
Thursday, February 21 \| 8:00AM - 11:00AM Wnt Signaling in Cancer Room: Red Cloud/Shavano Speaker 5 of 5 Matthias Ernst, Olivia Newton-John Cancer Research Institute, Australia Short Talk: Enforced Expression of DNA Methyltransferase 3a Enhances Polyposis in ApcMin/+ Mice by Transcriptional Silencing of Sfrp5
Thursday, February 21 \| 9:20AM - 9:40AM Coffee Break Room: Shavano Peak Foyer
Thursday, February 21 \| 4:30PM - 5:00PM Coffee Available Room: Shavano Peak Foyer
Thursday, February 21 \| 5:00PM - 7:00PM Pharmacological Modulation of Wnt Signaling Room: Red Cloud/Shavano Speaker 1 of 4 Caterina A.M. La Porta, University of Milan, Italy Cancer Stem Cells and Therapeutic Perspectives
Thursday, February 21 \| 5:00PM - 7:00PM Pharmacological Modulation of Wnt Signaling Room: Red Cloud/Shavano Speaker 2 of 4 Elena Brin, Ambrx, USA Short Talk: Selective Apoptosis Induction in Wnt-Deregulated Cancer Cells
Thursday, February 21 \| 5:00PM - 7:00PM Pharmacological Modulation of Wnt Signaling Room: Red Cloud/Shavano Speaker 3 of 4 † Thomas Andersson, Swedish University of Agricultural Sciences, Sweden Short Talk: Foxy-5, A WNT-5-Derived Hexapeptide
Thursday, February 21 \| 5:00PM - 7:00PM Pharmacological Modulation of Wnt Signaling Room: Red Cloud/Shavano Speaker 4 of 4 * Trevor Clive Dale, Cardiff University, UK Cell Based Screening for Inhibitors of the Wnt Signaling Pathway
Thursday, February 21 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Crestone
Thursday, February 21 \| 8:00PM - 11:00PM Entertainment Room: Crestone
Thursday, February 21 \| 8:00PM - 11:00PM Cash Bar Room: Crestone
Friday, February 22 \| 10:25AM - 10:25AM Departure *Session Chair.