Web Desc
Cancer Genomics and Epigenomics
Organizer(s): Andrew P. Feinberg, Greg J. Hannon and Rolf Ohlsson
Date: February 19 - 24, 2008
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
In the “post-genome” era, in which the human DNA sequence is available, as are those of many animal models, cancer genetics is being transformed both by the access to this sequence and by the technology that the genome project facilitated. It is now clear that many genetic changes occur in tumors, including mutations and copy number changes, as well as an even larger number of epigenetic alterations, such as altered DNA methylation, chromatin modification, and loss of genomic imprinting. High-throughput genomic and epigenomic approaches are now available, but are also being developed to assess the scope of these genomic/epigenomic changes. There is also a deeper evolution of our understanding that the genome and epigenome may be intrinsically disrupted in tumors, for example by palindrome formation and whole-band methylation. These advances raise several major questions, including: • Which genetic and epigenetic changes play a causal role in tumor initiation and progression? • What is the genetic and epigenetic basis of cancer predisposition? • Is there large scale disruption of the cancer genome and epigenome and how does this arise? • And how can we exploit advances in cancer genomics and epigenomics? • What are the cutting edge technologies that will advance the sensitivity of detection of subpopulations such as cancer stem cells? This symposium will explore the technological developments, large scale alterations, and gene-specific changes emerging in the genome-wide approach to cancer, as well as the implications of these discoveries for cancer prevention and therapy.
Scholarship Deadline: October 19 2007
Discounted Abstract Deadline: October 19 2007
Abstract Deadline: November 19 2007
Discounted Registration Deadline: December 19 2007
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Affymetrix, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA132471-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 19 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, February 19 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Tuesday, February 19 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 2
* Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA

Tuesday, February 19 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 2 of 2
Janet D. Rowley, University of Chicago, USA
The Hidden Side of Leukemia Gene Expression

Wednesday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, February 20 | 8:00AM - 11:00AM
High Throughput Genome, Epigenome, and Cell Biology Approach
es (Technology)

Room: Chamisa Ballroom 1

Speaker 1 of 5
Stephan Beck, University College London, UK
High-Throughput Approaches for DNA Methylation Profiling

Wednesday, February 20 | 8:00AM - 11:00AM
High Throughput Genome, Epigenome, and Cell Biology Approach
es (Technology)

Room: Chamisa Ballroom 1

Speaker 2 of 5
John A. Stamatoyannopoulos, Altius Institute for Biomedical Sciences, USA
High Throughput Chromatin Analysis

Wednesday, February 20 | 8:00AM - 11:00AM
High Throughput Genome, Epigenome, and Cell Biology Approach
es (Technology)

Room: Chamisa Ballroom 1

Speaker 3 of 5
* Rolf Ohlsson, Karolinska Institute, Sweden
Chromosomal Networks: New Perspectives of Cancer Epigenomics

Wednesday, February 20 | 8:00AM - 11:00AM
High Throughput Genome, Epigenome, and Cell Biology Approach
es (Technology)

Room: Chamisa Ballroom 1

Speaker 4 of 5
Jeffrey A. Jeddeloh, Roche NimbleGen, USA
Short Talk: Sequence Capture: A Microarray Strategy for Genomic Selection Coupled to High-Throughput Sequencing Facilitates Genetic and Epigenetic Characterization upon Individual Alleles

Wednesday, February 20 | 8:00AM - 11:00AM
High Throughput Genome, Epigenome, and Cell Biology Approach
es (Technology)

Room: Chamisa Ballroom 1

Speaker 5 of 5
Christoph Bock, Austrian Academy of Sciences, Austria
Short Talk: Powerful and User-Friendly Bioinformatic Methods for Cancer Epigenomics

Wednesday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, February 20 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, February 20 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, February 20 | 5:00PM - 6:45PM
High Throughput Sequencing of the Tumor Genome
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Richard Myers, Stanford University School of Medicine, USA

Wednesday, February 20 | 5:00PM - 6:45PM
High Throughput Sequencing of the Tumor Genome
Room: Chamisa Ballroom 1

Speaker 2 of 4
Matthew L. Meyerson, Dana-Farber Cancer Institute, USA
Genomic Alterations in Human Cancers

Wednesday, February 20 | 5:00PM - 6:45PM
High Throughput Sequencing of the Tumor Genome
Room: Chamisa Ballroom 1

Speaker 3 of 4
Aleksandar Milosavljevic, Baylor College of Medicine, USA
Short-Read Sequencing Applications

Wednesday, February 20 | 5:00PM - 6:45PM
High Throughput Sequencing of the Tumor Genome
Room: Chamisa Ballroom 1

Speaker 4 of 4
Heidi Greulich, Broad Institute of MIT and Harvard, USA
Cancer Genome Sequencing

Wednesday, February 20 | 6:45PM - 7:00PM
Open Discussion of Sequencing Methods
Room: Chamisa Ballroom 1


Wednesday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, February 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, February 21 | 8:00AM - 11:00AM
Chromosome Abnormalities
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Donna G. Albertson, University of California, San Francisco, USA
Causes and Consequences of Genomic Instability in Cancer

Thursday, February 21 | 8:00AM - 11:00AM
Chromosome Abnormalities
Room: Chamisa Ballroom 1

Speaker 2 of 4
Michael H. Wigler, Cold Spring Harbor Laboratory, USA
Variation in Gene Copy Number and Methylation in Human Cancer

Thursday, February 21 | 8:00AM - 11:00AM
Chromosome Abnormalities
Room: Chamisa Ballroom 1

Speaker 3 of 4
Scott J. Diede, Fred Hutchinson Cancer Research Center, USA
DNA Palindrome Formation is Nonrandomly Distributed and Associated with Gene Amplification in Cancer

Thursday, February 21 | 8:00AM - 11:00AM
Chromosome Abnormalities
Room: Chamisa Ballroom 1

Speaker 4 of 4
Shinya Toyokuni, Kyoto University Graduate School of Medicine, Japan
Short Talk: Chronic Oxidative Stress as a Cause of Genomic Amplification

Thursday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, February 21 | 5:00PM - 7:00PM
Integrative Genomics
Room: Chamisa Ballroom 1

Speaker 1 of 2
Edison T. Liu, The Jackson Laboratory, USA
Systems Integration in Genomic Medicine

Thursday, February 21 | 5:00PM - 7:00PM
Integrative Genomics
Room: Chamisa Ballroom 1

Speaker 2 of 2
* Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Lessons Learned from Pervasive Transcription: Possible Reasons and Mechanisms

Thursday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, February 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 22 | 8:00AM - 11:30AM
Chromatin
Room: Chamisa Ballroom 1

Speaker 1 of 6
Peter Fraser, Florida State University, USA
Transcription and Genome Organization

Friday, February 22 | 8:00AM - 11:30AM
Chromatin
Room: Chamisa Ballroom 1

Speaker 2 of 6
* Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
Large Scale Chromosomal Interactions at the c-Myc Locus Regulated by SATB1

Friday, February 22 | 8:00AM - 11:30AM
Chromatin
Room: Chamisa Ballroom 1

Speaker 3 of 6
Bradley E. Bernstein, Massachusetts General Hospital, USA
Sequencing the Mammalian Epigenome

Friday, February 22 | 8:00AM - 11:30AM
Chromatin
Room: Chamisa Ballroom 1

Speaker 4 of 6
Agate Noer, University of Oslo, Norway
Short Talk: Modifications of Histone H3 Associated with Senescence and Differentiation of Human Adipose Stem Cells

Friday, February 22 | 8:00AM - 11:30AM
Chromatin
Room: Chamisa Ballroom 1

Speaker 5 of 6
Melissa J. Fullwood, Nanyang Technological University, Singapore
Short Talk: Whole Genome Chromatin Interaction Analysis using Paired End diTag Sequencing

Friday, February 22 | 8:00AM - 11:30AM
Chromatin
Room: Chamisa Ballroom 1

Speaker 6 of 6
Anderly C. Chueh, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Defining Neocentromere Identity: Role of L1 Retroelements in the Epigenetic Formation of Ectopic Centromere Chromatin

Friday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, February 22 | 5:00PM - 7:15PM
RNA and Functional Screening
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Gregory J. Hannon, University of Cambridge, UK
Focal Re-Seqencing: A Comparison of Capture Platforms

Friday, February 22 | 5:00PM - 7:15PM
RNA and Functional Screening
Room: Chamisa Ballroom 1

Speaker 2 of 6
Yaniv Erlich, Cold Spring Harbor Laboratory, USA
Short Talk: Improving Solexa Base Calling

Friday, February 22 | 5:00PM - 7:15PM
RNA and Functional Screening
Room: Chamisa Ballroom 1

Speaker 3 of 6
René Bernards, Netherlands Cancer Institute, Netherlands
Biomarkers of Resistance to Cancer Therapy Discovered Through Functional Genetic Screens.

Friday, February 22 | 5:00PM - 7:15PM
RNA and Functional Screening
Room: Chamisa Ballroom 1

Speaker 4 of 6
Lili Milani, University of Tartu, Estonia
Short Talk: Allele-Specific Analysis of Gene Expression in Childhood Acute Leukemia by Genome Wide SNP Genotyping

Friday, February 22 | 5:00PM - 7:15PM
RNA and Functional Screening
Room: Chamisa Ballroom 1

Speaker 5 of 6
Sohail F. Tavazoie, Rockefeller University, USA
Short Talk: Endogenous Human MicroRNAs that Suppress Breast Cancer Metastasis

Friday, February 22 | 5:00PM - 7:15PM
RNA and Functional Screening
Room: Chamisa Ballroom 1

Speaker 6 of 6
Milan G. Chheda, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: High Throughput RNAi Screen to Identify Genes Required for Stem Cell Phenotype of Glioblastoma Tumor Initiating Cells

Friday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetics and Epigenomics of Cancer Etiology

Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 2 of 7
Tim H.-M. Huang, Ohio State University, USA
Finding and Defining Causes of Epigenetic Gene Silencing in Cancer

Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 3 of 7
Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Epigenetically Defined Heterogeneity in Normal and Neoplastic Breast Epithelium

Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 4 of 7
Susan J. Clark, Garvan Institute of Medical Research, Australia
DNA Methylation Clusters

Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 5 of 7
Alayne L. Brown, Stanford University, USA
Short Talk: Genome-Wide DNA Methylation Profiling of DNMT-Mutant Cells

Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 6 of 7
Peter L. Molloy, CSIRO, Australia
Short Talk: Hypomethylation of Different Repeat Families in Colorectal Cancer

Saturday, February 23 | 8:00AM - 11:30AM
Epigenomics
Room: Chamisa Ballroom 1

Speaker 7 of 7
Kevin L. Gunderson, Illumina, Inc., USA
Short Talk: Infinium® Methylation Profiling of over 27,000 CpG Sites from CCDS Gene Promoters

Saturday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, February 23 | 5:00PM - 7:00PM
Translational Genomics
Room: Chamisa Ballroom 1

Speaker 1 of 3
Siavash K. Kurdistani, University of California, Los Angeles, USA
Epigenetic Reprogramming for Oncogenic Transformation

Saturday, February 23 | 5:00PM - 7:00PM
Translational Genomics
Room: Chamisa Ballroom 1

Speaker 2 of 3
* Tomas Ekström, Karolinska Institutet, Sweden
Human Cytomegalovirus and its Association with Epigenetic Alterations

Saturday, February 23 | 5:00PM - 7:00PM
Translational Genomics
Room: Chamisa Ballroom 1

Speaker 3 of 3
Jesse S. Boehm, Broad Institute, USA
Short Talk: Integrating Functional and Structural Cancer Genomics to Identify Drug Targets

Saturday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, February 23 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, February 23 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, February 24 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.