Web Desc
Towards Identifying the Pathophysiology of Autistic Syndromes
Organizer(s): Joseph Piven and Pat Levitt
Date: February 24 - 28, 2008
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA
Supported by the Director's Fund
Summary of Meeting:
Autism is a common and highly heritable, neurodevelopmental disorder defined by the co-occurrence of three characteristic, behavioral features: (1) deficits in social interactions, (2) abnormalities in verbal and non-verbal communication, and (3) highly restricted interests and repetitive behaviors. The developmental etiology and specific pathogenetic mechanisms underlying autism are unknown, but the pathophysiology that underlies a small subset of etiologically-defined, rarer neurodevelopmental disorders, thought to be associated with autism and autistic behaviors—e.g., Fragile X Syndrome, tuberous sclerosis, Smith-Lemli-Opitz Syndrome and Rett Syndrome—have been well-described, yet there is disproportionately little research on these conditions as models for understanding autism. Accumulating data suggest that an underlying pathophysiology in the development of brain connectivity may be the point of convergence across all of these disorders. This conference brings together a unique group of clinical and basic scientists to examine what is known about the genetic and neurobiological underpinnings of this subset of disorders as a starting point for identifying the pathophysiological basis of autism.
Scholarship Deadline: October 24 2007
Discounted Abstract Deadline: October 24 2007
Abstract Deadline: November 26 2007
Discounted Registration Deadline: December 26 2007
We gratefully acknowledge additional support for this conference from:
International Rett Syndrome Foundation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Organization for Autism Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13MH082458-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 24 | 3:00PM - 7:30PM
Registration
Room: Promenade


Sunday, February 24 | 6:30PM - 7:30PM
Refreshments
Room: Promenade


Sunday, February 24 | 7:30PM - 8:30PM
Keynote Address
Room: Mesa A-B

Speaker 1 of 1
Patrick Bolton, King's College, London, UK
Overview of the Medical Condition Associated with the Autistic Phenotype (Rett, FXS, SLO, TSC)

Monday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Monday, February 25 | 8:00AM - 11:00AM
Autism Overview
Room: Mesa A-B

Speaker 6 of 6
Joseph Piven, University of North Carolina at Chapel Hill, USA
Brain-Behavior Relationships in Early Development of Autism

Monday, February 25 | 8:00AM - 11:00AM
Autism Overview
Room: Mesa A-B

Speaker 5 of 6
Mark H. Lewis, University of Florida, USA
The Pathophysiology of Repetitive Behavior

Monday, February 25 | 8:00AM - 11:00AM
Autism Overview
Room: Mesa A-B

Speaker 4 of 6
David Amaral, University of California, Davis, USA
Neurobiological Studies in Autism

Monday, February 25 | 8:00AM - 11:00AM
Autism Overview
Room: Mesa A-B

Speaker 3 of 6
Daniel H. Geschwind, University of California, Los Angeles, USA
Tackling Genetic Complexity in Autism

Monday, February 25 | 8:00AM - 11:00AM
Autism Overview
Room: Mesa A-B

Speaker 2 of 6
Geraldine Dawson, Duke University Medical Center, USA
The Syndrome of Autism: Early Patterns of Behavioral Symptoms, Brain Dysfunction, and Clinical Course

Monday, February 25 | 8:00AM - 11:00AM
Autism Overview
Room: Mesa A-B

Speaker 1 of 6
* Pat Levitt, Keck School of Medicine, USA

Monday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Monday, February 25 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Monday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Monday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Monday, February 25 | 5:00PM - 7:00PM
Neurocutaneous Disorders
Room: Mesa A-B

Speaker 4 of 4
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
The P13 Kinase Pathway and Mouse Models of Autism

Monday, February 25 | 5:00PM - 7:00PM
Neurocutaneous Disorders
Room: Mesa A-B

Speaker 3 of 4
Kevin Ess, Vanderbilt University, USA
Neurobiology of Tuberous Sclerosis Complex

Monday, February 25 | 5:00PM - 7:00PM
Neurocutaneous Disorders
Room: Mesa A-B

Speaker 2 of 4
Alcino J. Silva, University of California, Los Angeles, USA
Memory and How it Fails: Unraveling Mechanisms and Finding Cures for Cognitive Disorders

Monday, February 25 | 5:00PM - 7:00PM
Neurocutaneous Disorders
Room: Mesa A-B

Speaker 1 of 4
* Daniel H. Geschwind, University of California, Los Angeles, USA

Monday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz


Monday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Ortiz


Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Tuesday, February 26 | 8:00AM - 11:00AM
Fragile X Syndrome
Room: Mesa A-B

Speaker 3 of 6
David L. Nelson, Baylor College of Medicine, USA
Modeling Modifiers in Fragile X Syndrome

Tuesday, February 26 | 8:00AM - 11:00AM
Fragile X Syndrome
Room: Mesa A-B

Speaker 2 of 6
Declan G. Murphy, King's College London, UK
An Overview of Brain and Behavioral Phenotypes in FXS

Tuesday, February 26 | 8:00AM - 11:00AM
Fragile X Syndrome
Room: Mesa A-B

Speaker 1 of 6
* Joseph Piven, University of North Carolina at Chapel Hill, USA

Tuesday, February 26 | 8:00AM - 11:00AM
Fragile X Syndrome
Room: Mesa A-B

Speaker 4 of 6
William T. Greenough, University of Illinois at Urbana-Champaign, USA
Neurobiology of FXS

Tuesday, February 26 | 8:00AM - 11:00AM
Fragile X Syndrome
Room: Mesa A-B

Speaker 5 of 6
Gul Dolen, Johns Hopkins University, USA
Correction of Fragile X in Mice

Tuesday, February 26 | 8:00AM - 11:00AM
Fragile X Syndrome
Room: Mesa A-B

Speaker 6 of 6
Jacqueline J. Blundell, University of Texas Southwestern Medical Center, USA
Short Talk: A Potential Mouse Model of Non-syndromic Autism: Disease-Linked Point Mutation in Neuroligin-3 Produces Autism-Like Behavior in Mice

Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Tuesday, February 26 | 11:00AM - 1:00PM
Poster Setup
Room: Ortiz


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Ortiz


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop: Epigenetics
Room: Mesa A-B

Speaker 1 of 5
* David L. Nelson, Baylor College of Medicine, USA

Tuesday, February 26 | 2:30PM - 4:30PM
Workshop: Epigenetics
Room: Mesa A-B

Speaker 2 of 5
Yi Eve Sun, University of California, Los Angeles, USA
Title to be Determined

Tuesday, February 26 | 2:30PM - 4:30PM
Workshop: Epigenetics
Room: Mesa A-B

Speaker 3 of 5
Arthur L. Beaudet, Baylor College of Medicine, USA
Distinct Genetic and Epigenetic Approaches to the Etiology of Autism Independent of Genetic Linkage and Association


Tuesday, February 26 | 2:30PM - 4:30PM
Workshop: Epigenetics
Room: Mesa A-B

Speaker 4 of 5
Jonathan Sebat, University of California, San Diego, USA
Analysis of Genome Copy Number Variation in Autism Spectrum Disorders

Tuesday, February 26 | 2:30PM - 4:30PM
Workshop: Epigenetics
Room: Mesa A-B

Speaker 5 of 5
Marylyn D. Ritchie, Pennsylvania State University, USA
Epistasis Modeling

Tuesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Tuesday, February 26 | 5:00PM - 5:50PM
Rett Syndrome
Room: Mesa A-B

Speaker 1 of 3
* Declan G. Murphy, King's College London, UK

Tuesday, February 26 | 5:00PM - 5:50PM
Rett Syndrome
Room: Mesa A-B

Speaker 2 of 3
Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Deciphering the Neurobiology of Rett Syndrome

Tuesday, February 26 | 5:00PM - 5:50PM
Rett Syndrome
Room: Mesa A-B

Speaker 3 of 3
Sarika U. Peters, Baylor College of Medicine, USA
Short Talk: An Emerging Behavioral Phenotype in Female Carriers with MECP2 Duplications: Implications for the Broad Autism Phenotype

Tuesday, February 26 | 5:50PM - 7:00PM
Smith Lemli Opitz Syndrome
Room: Mesa A-B

Speaker 1 of 2
Forbes D. Porter, National Institutes of Health and Human Development, USA
Smith-Lemli-Opitz Syndrome: Mouse Models, Pathophysiology, and Treatment

Tuesday, February 26 | 5:50PM - 7:00PM
Smith Lemli Opitz Syndrome
Room: Mesa A-B

Speaker 2 of 2
Elaine Tierney, Kennedy Krieger Institute, USA
Smith-Lemli-Opitz Syndrome: Clinical Trials, Autism Interface

Tuesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz


Tuesday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Ortiz


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Chamisa


Wednesday, February 27 | 8:00AM - 11:00AM
Signaling Systems
Room: Mesa A-B

Speaker 1 of 6
* Michael E. Greenberg, Harvard Medical School, USA

Wednesday, February 27 | 8:00AM - 11:00AM
Signaling Systems
Room: Mesa A-B

Speaker 2 of 6
Randy Blakely, Florida Atlantic University, USA
Rare Opportunities for Progress in Autism: Serotonin and Serotonin Transporters from Mouse to Man

Wednesday, February 27 | 8:00AM - 11:00AM
Signaling Systems
Room: Mesa A-B

Speaker 3 of 6
Pat Levitt, Keck School of Medicine, USA
Convergent Evidence of C-Met Tyrosine Kinase Receptor Involvement In Forebrain Development and Autism Spectrum Disorder

Wednesday, February 27 | 8:00AM - 11:00AM
Signaling Systems
Room: Mesa A-B

Speaker 4 of 6
Takao K. Hensch, Harvard University, USA
Excitatory-Inhibitory Balance in Neuronal Circuit Development

Wednesday, February 27 | 8:00AM - 11:00AM
Signaling Systems
Room: Mesa A-B

Speaker 5 of 6
Lisa M. Boulanger, Princeton University, USA
Regulation of Glutamatergic Synaptic Transmission and Synaptic Plasticity by MHC Class I

Wednesday, February 27 | 8:00AM - 11:00AM
Signaling Systems
Room: Mesa A-B

Speaker 6 of 6
Toru Takumi, RIKEN Center for Brain Science Institute, Japan
Short Talk: The Mouse Model for Human 15q11-13 Duplication Displays Autistic Behaviour

Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Promenade


Wednesday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Promenade


Wednesday, February 27 | 5:00PM - 6:15PM
Mechanism of Synapse Development
Room: Mesa A-B

Speaker 1 of 3
* Takao K. Hensch, Harvard University, USA

Wednesday, February 27 | 5:00PM - 6:15PM
Mechanism of Synapse Development
Room: Mesa A-B

Speaker 2 of 3
Michael E. Greenberg, Harvard Medical School, USA
Activity-Dependent Synapse Formation and Elimination, Role of MEF2

Wednesday, February 27 | 5:00PM - 6:15PM
Mechanism of Synapse Development
Room: Mesa A-B

Speaker 3 of 3
Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA
How are CNS Synapses Eliminated?

Wednesday, February 27 | 6:15PM - 7:00PM
Discussion Panel: Toward Identifying the Pathophysiology of
Autism
Room: Mesa A-B


Wednesday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Ortiz


Wednesday, February 27 | 8:00PM - 11:00PM
Entertainment
Room: Ortiz


Wednesday, February 27 | 8:00PM - 11:00PM
Cash Bar
Room: Ortiz


Thursday, February 28 | 10:25AM - 10:25AM
Departure


*Session Chair.