Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Pathways of Neurodevelopmental Disorders (2015C8)
Toward Defining the Pathophysiology of Autistic Behavior (2010Z4)
Synapses: Formation, Function and Misfunction (2010Z3)
Epigenetic Basis of Neurodevelopmental Disorders (2009X2)

Web Desc
Towards Identifying the Pathophysiology of Autistic Syndromes Organizer(s): Joseph Piven and Pat Levitt Date: February 24 - 28, 2008 Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA Supported by the Director's Fund Summary of Meeting: Autism is a common and highly heritable, neurodevelopmental disorder defined by the co-occurrence of three characteristic, behavioral features: (1) deficits in social interactions, (2) abnormalities in verbal and non-verbal communication, and (3) highly restricted interests and repetitive behaviors. The developmental etiology and specific pathogenetic mechanisms underlying autism are unknown, but the pathophysiology that underlies a small subset of etiologically-defined, rarer neurodevelopmental disorders, thought to be associated with autism and autistic behaviors—e.g., Fragile X Syndrome, tuberous sclerosis, Smith-Lemli-Opitz Syndrome and Rett Syndrome—have been well-described, yet there is disproportionately little research on these conditions as models for understanding autism. Accumulating data suggest that an underlying pathophysiology in the development of brain connectivity may be the point of convergence across all of these disorders. This conference brings together a unique group of clinical and basic scientists to examine what is known about the genetic and neurobiological underpinnings of this subset of disorders as a starting point for identifying the pathophysiological basis of autism. Scholarship Deadline: October 24 2007 Discounted Abstract Deadline: October 24 2007 Abstract Deadline: November 26 2007 Discounted Registration Deadline: December 26 2007 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: We gratefully acknowledge the generous grant for this conference provided by: National Institute of Mental Health (NIMH) Grant No. 1R13MH082458-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Towards Identifying the Pathophysiology of Autistic Syndromes

Organizer(s): Joseph Piven and Pat Levitt

Date: February 24 - 28, 2008
Location: Hilton Santa Fe Historic Plaza Hotel, Santa Fe, NM, USA

Supported by the Director's Fund

Summary of Meeting:

Autism is a common and highly heritable, neurodevelopmental disorder defined by the co-occurrence of three characteristic, behavioral features: (1) deficits in social interactions, (2) abnormalities in verbal and non-verbal communication, and (3) highly restricted interests and repetitive behaviors. The developmental etiology and specific pathogenetic mechanisms underlying autism are unknown, but the pathophysiology that underlies a small subset of etiologically-defined, rarer neurodevelopmental disorders, thought to be associated with autism and autistic behaviors—e.g., Fragile X Syndrome, tuberous sclerosis, Smith-Lemli-Opitz Syndrome and Rett Syndrome—have been well-described, yet there is disproportionately little research on these conditions as models for understanding autism. Accumulating data suggest that an underlying pathophysiology in the development of brain connectivity may be the point of convergence across all of these disorders. This conference brings together a unique group of clinical and basic scientists to examine what is known about the genetic and neurobiological underpinnings of this subset of disorders as a starting point for identifying the pathophysiological basis of autism.

Scholarship Deadline: October 24 2007

Discounted Abstract Deadline: October 24 2007

Abstract Deadline: November 26 2007

Discounted Registration Deadline: December 26 2007

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13MH082458-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Sunday, February 24 \| 3:00PM - 7:30PM Registration Room: Promenade
Sunday, February 24 \| 6:30PM - 7:30PM Refreshments Room: Promenade
Sunday, February 24 \| 7:30PM - 8:30PM Keynote Address Room: Mesa A-B Speaker 1 of 1 Patrick Bolton, King's College, London, UK Overview of the Medical Condition Associated with the Autistic Phenotype (Rett, FXS, SLO, TSC)
Monday, February 25 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Monday, February 25 \| 8:00AM - 11:00AM Autism Overview Room: Mesa A-B Speaker 6 of 6 Joseph Piven, University of North Carolina at Chapel Hill, USA Brain-Behavior Relationships in Early Development of Autism
Monday, February 25 \| 8:00AM - 11:00AM Autism Overview Room: Mesa A-B Speaker 5 of 6 Mark H. Lewis, University of Florida, USA The Pathophysiology of Repetitive Behavior
Monday, February 25 \| 8:00AM - 11:00AM Autism Overview Room: Mesa A-B Speaker 4 of 6 David Amaral, University of California, Davis, USA Neurobiological Studies in Autism
Monday, February 25 \| 8:00AM - 11:00AM Autism Overview Room: Mesa A-B Speaker 3 of 6 Daniel H. Geschwind, University of California, Los Angeles, USA Tackling Genetic Complexity in Autism
Monday, February 25 \| 8:00AM - 11:00AM Autism Overview Room: Mesa A-B Speaker 2 of 6 Geraldine Dawson, Duke University Medical Center, USA The Syndrome of Autism: Early Patterns of Behavioral Symptoms, Brain Dysfunction, and Clinical Course
Monday, February 25 \| 8:00AM - 11:00AM Autism Overview Room: Mesa A-B Speaker 1 of 6 * Pat Levitt, Keck School of Medicine, USA
Monday, February 25 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Monday, February 25 \| 11:00AM - 1:00PM Poster Setup Room: Ortiz
Monday, February 25 \| 1:00PM - 10:00PM Poster Viewing Room: Ortiz
Monday, February 25 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Monday, February 25 \| 5:00PM - 7:00PM Neurocutaneous Disorders Room: Mesa A-B Speaker 4 of 4 Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA The P13 Kinase Pathway and Mouse Models of Autism
Monday, February 25 \| 5:00PM - 7:00PM Neurocutaneous Disorders Room: Mesa A-B Speaker 3 of 4 Kevin Ess, Vanderbilt University, USA Neurobiology of Tuberous Sclerosis Complex
Monday, February 25 \| 5:00PM - 7:00PM Neurocutaneous Disorders Room: Mesa A-B Speaker 2 of 4 Alcino J. Silva, University of California, Los Angeles, USA Memory and How it Fails: Unraveling Mechanisms and Finding Cures for Cognitive Disorders
Monday, February 25 \| 5:00PM - 7:00PM Neurocutaneous Disorders Room: Mesa A-B Speaker 1 of 4 * Daniel H. Geschwind, University of California, Los Angeles, USA
Monday, February 25 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Ortiz
Monday, February 25 \| 7:30PM - 10:00PM Poster Session 1 Room: Ortiz
Tuesday, February 26 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Tuesday, February 26 \| 8:00AM - 11:00AM Fragile X Syndrome Room: Mesa A-B Speaker 3 of 6 David L. Nelson, Baylor College of Medicine, USA Modeling Modifiers in Fragile X Syndrome
Tuesday, February 26 \| 8:00AM - 11:00AM Fragile X Syndrome Room: Mesa A-B Speaker 2 of 6 Declan G. Murphy, King's College London, UK An Overview of Brain and Behavioral Phenotypes in FXS
Tuesday, February 26 \| 8:00AM - 11:00AM Fragile X Syndrome Room: Mesa A-B Speaker 1 of 6 * Joseph Piven, University of North Carolina at Chapel Hill, USA
Tuesday, February 26 \| 8:00AM - 11:00AM Fragile X Syndrome Room: Mesa A-B Speaker 4 of 6 William T. Greenough, University of Illinois at Urbana-Champaign, USA Neurobiology of FXS
Tuesday, February 26 \| 8:00AM - 11:00AM Fragile X Syndrome Room: Mesa A-B Speaker 5 of 6 Gul Dolen, Johns Hopkins University, USA Correction of Fragile X in Mice
Tuesday, February 26 \| 8:00AM - 11:00AM Fragile X Syndrome Room: Mesa A-B Speaker 6 of 6 Jacqueline J. Blundell, University of Texas Southwestern Medical Center, USA Short Talk: A Potential Mouse Model of Non-syndromic Autism: Disease-Linked Point Mutation in Neuroligin-3 Produces Autism-Like Behavior in Mice
Tuesday, February 26 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Tuesday, February 26 \| 11:00AM - 1:00PM Poster Setup Room: Ortiz
Tuesday, February 26 \| 1:00PM - 10:00PM Poster Viewing Room: Ortiz
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop: Epigenetics Room: Mesa A-B Speaker 1 of 5 * David L. Nelson, Baylor College of Medicine, USA
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop: Epigenetics Room: Mesa A-B Speaker 2 of 5 Yi Eve Sun, University of California, Los Angeles, USA Title to be Determined
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop: Epigenetics Room: Mesa A-B Speaker 3 of 5 Arthur L. Beaudet, Baylor College of Medicine, USA Distinct Genetic and Epigenetic Approaches to the Etiology of Autism Independent of Genetic Linkage and Association
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop: Epigenetics Room: Mesa A-B Speaker 4 of 5 Jonathan Sebat, University of California, San Diego, USA Analysis of Genome Copy Number Variation in Autism Spectrum Disorders
Tuesday, February 26 \| 2:30PM - 4:30PM Workshop: Epigenetics Room: Mesa A-B Speaker 5 of 5 Marylyn D. Ritchie, Pennsylvania State University, USA Epistasis Modeling
Tuesday, February 26 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Tuesday, February 26 \| 5:00PM - 5:50PM Rett Syndrome Room: Mesa A-B Speaker 1 of 3 * Declan G. Murphy, King's College London, UK
Tuesday, February 26 \| 5:00PM - 5:50PM Rett Syndrome Room: Mesa A-B Speaker 2 of 3 Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA Deciphering the Neurobiology of Rett Syndrome
Tuesday, February 26 \| 5:00PM - 5:50PM Rett Syndrome Room: Mesa A-B Speaker 3 of 3 Sarika U. Peters, Baylor College of Medicine, USA Short Talk: An Emerging Behavioral Phenotype in Female Carriers with MECP2 Duplications: Implications for the Broad Autism Phenotype
Tuesday, February 26 \| 5:50PM - 7:00PM Smith Lemli Opitz Syndrome Room: Mesa A-B Speaker 1 of 2 Forbes D. Porter, National Institutes of Health and Human Development, USA Smith-Lemli-Opitz Syndrome: Mouse Models, Pathophysiology, and Treatment
Tuesday, February 26 \| 5:50PM - 7:00PM Smith Lemli Opitz Syndrome Room: Mesa A-B Speaker 2 of 2 Elaine Tierney, Kennedy Krieger Institute, USA Smith-Lemli-Opitz Syndrome: Clinical Trials, Autism Interface
Tuesday, February 26 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Ortiz
Tuesday, February 26 \| 7:30PM - 10:00PM Poster Session 2 Room: Ortiz
Wednesday, February 27 \| 7:00AM - 8:00AM Breakfast Room: Chamisa
Wednesday, February 27 \| 8:00AM - 11:00AM Signaling Systems Room: Mesa A-B Speaker 1 of 6 * Michael E. Greenberg, Harvard Medical School, USA
Wednesday, February 27 \| 8:00AM - 11:00AM Signaling Systems Room: Mesa A-B Speaker 2 of 6 Randy Blakely, Florida Atlantic University, USA Rare Opportunities for Progress in Autism: Serotonin and Serotonin Transporters from Mouse to Man
Wednesday, February 27 \| 8:00AM - 11:00AM Signaling Systems Room: Mesa A-B Speaker 3 of 6 Pat Levitt, Keck School of Medicine, USA Convergent Evidence of C-Met Tyrosine Kinase Receptor Involvement In Forebrain Development and Autism Spectrum Disorder
Wednesday, February 27 \| 8:00AM - 11:00AM Signaling Systems Room: Mesa A-B Speaker 4 of 6 Takao K. Hensch, Harvard University, USA Excitatory-Inhibitory Balance in Neuronal Circuit Development
Wednesday, February 27 \| 8:00AM - 11:00AM Signaling Systems Room: Mesa A-B Speaker 5 of 6 Lisa M. Boulanger, Princeton University, USA Regulation of Glutamatergic Synaptic Transmission and Synaptic Plasticity by MHC Class I
Wednesday, February 27 \| 8:00AM - 11:00AM Signaling Systems Room: Mesa A-B Speaker 6 of 6 Toru Takumi, RIKEN Center for Brain Science Institute, Japan Short Talk: The Mouse Model for Human 15q11-13 Duplication Displays Autistic Behaviour
Wednesday, February 27 \| 9:20AM - 9:40AM Coffee Break Room: Promenade
Wednesday, February 27 \| 4:30PM - 5:00PM Coffee Available Room: Promenade
Wednesday, February 27 \| 5:00PM - 6:15PM Mechanism of Synapse Development Room: Mesa A-B Speaker 1 of 3 * Takao K. Hensch, Harvard University, USA
Wednesday, February 27 \| 5:00PM - 6:15PM Mechanism of Synapse Development Room: Mesa A-B Speaker 2 of 3 Michael E. Greenberg, Harvard Medical School, USA Activity-Dependent Synapse Formation and Elimination, Role of MEF2
Wednesday, February 27 \| 5:00PM - 6:15PM Mechanism of Synapse Development Room: Mesa A-B Speaker 3 of 3 Beth Stevens, Boston Children's Hospital, Harvard Medical School, USA How are CNS Synapses Eliminated?
Wednesday, February 27 \| 6:15PM - 7:00PM Discussion Panel: Toward Identifying the Pathophysiology of Autism Room: Mesa A-B
Wednesday, February 27 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Ortiz
Wednesday, February 27 \| 8:00PM - 11:00PM Entertainment Room: Ortiz
Wednesday, February 27 \| 8:00PM - 11:00PM Cash Bar Room: Ortiz
Thursday, February 28 \| 10:25AM - 10:25AM Departure *Session Chair.