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This meeting took place in the past. Here is a list of meetings that are related:
Stem Cells and Reprogramming (2014Z4)
Stem Cell Regulation in Homeostasis and Disease (2013B7)
The Life of a Stem Cell: From Birth to Death (2012C3)
Stem Cells in Development, Tissue Homeostasis and Disease (2011B3)
Stem Cell Differentiation and Dedifferentiation (2010B4)
Stem Cell Niche Interactions (2009D5)
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Web Desc
Tumor Suppressors and Stem Cell Biology
Organizer(s): Sean J. Morrison and Alejandro Sánchez Alvarado
Date: February 24 - 29, 2008
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Director's Fund
For important information on the coronavirus, please
click here
Summary of Meeting:
Stem cells play key roles in the development, maintenance, and reproduction of all known multicellular organisms. Stem cells operate in a wide variety of biological contexts from homeostasis to regeneration and must be subject to complex and robust regulation. Recent evidence suggests that tumor suppressor mechanisms, originally discovered for their ability to inhibit tumorigenesis, also play widespread roles in the physiological regulation of stem cells. Tumor suppressors play critical roles in the regulation of tissue homeostasis, stem cell self-renewal, regeneration, and aging. This reveals mechanistic links between the regulation of stem cells, and the regulation of cancer cells that could potentially be exploited to target cancer and to enhance regeneration. The dual roles of these mechanisms in stem cell and cancer biology illuminate the evolved balance between the promotion of regeneration and the suppression of cancer.
Scholarship Deadline: October 24 2007
Discounted Abstract Deadline: October 24 2007
Abstract Deadline: November 26 2007
Discounted Registration Deadline: December 26 2007
We gratefully acknowledge additional support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
National Cancer Institute (NCI)
Grant No. 1R13CA132459-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
Program
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Sunday, February 24
| 3:00PM - 7:30PM
Registration
Room: BC Foyer
Sunday, February 24
| 6:30PM - 7:30PM
Refreshments
Room: BC Foyer
Sunday, February 24
| 7:30PM - 8:30PM
Keynote Address
Room: British Columbia Ballroom
Speaker 1 of 1
Charles J. Sherr
, St. Jude Children's Research Hospital, USA
Tumor Suppressors (RB, p53 INK4 genes, & ARF): On the Road to Immortality
Monday, February 25
| 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom
Monday, February 25
| 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom
Speaker 1 of 6
Andrea I. McClatchey
, Massachusetts General Hospital, USA
Membrane Organization in Tissue Homeostasis and Tumorigenesis
Monday, February 25
| 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom
Speaker 2 of 6
Gad Shaulsky
, Baylor College of Medicine, USA
Cell Competition, Stem Cells and the Evolution of Sociality
Monday, February 25
| 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom
Speaker 3 of 6
Yukiko M. Yamashita
, University of Michigan, Ann Arbor, USA
Asymmetric Stem Cell Division during Tissue Homeostasis and Aging
Monday, February 25
| 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom
Speaker 4 of 6
*
Alejandro Sánchez Alvarado
, Stowers Institute for Medical Research/HHMI, USA
Stem Cells and their Regulation in the Planarian Schmidtea Mediterranea
Monday, February 25
| 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom
Speaker 5 of 6
Bret Pearson
, University of Utah, USA
Short Talk: Adult Stem Cells and Tumorigenesis in the Freshwater Planarian
Monday, February 25
| 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom
Speaker 6 of 6
Junlin Qi
, University of Washington, Seattle, USA
Short Talk: microRNA-195 Regulates Human Embryonic Stem Cell Division
Monday, February 25
| 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer
Monday, February 25
| 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom
Monday, February 25
| 11:15AM - 11:15AM
On Own for Lunch
Monday, February 25
| 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom
Monday, February 25
| 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer
Monday, February 25
| 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom
Speaker 1 of 5
Megan F. Cole
, Massachusetts Institute of Technology, USA
Connecting Signaling to the Core Regulatory Circuitry of Embryonic Stem Cells
Monday, February 25
| 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom
Speaker 2 of 5
Patrick M.P. Viatour
, Stanford University, USA
Short Talk: Hematopoietic Stem Cell Quiescence is maintained by Compound Contributions of the Retinoblastoma Gene Family
Monday, February 25
| 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom
Speaker 3 of 5
Valerie M. Renault
, Stanford Medical School - Stanford University, USA
Short Talk: The Role of FoxO Transcription Factors in the Maintenance of Neural Stem Cells during Aging
Monday, February 25
| 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom
Speaker 4 of 5
Iannis Aifantis
, New York University School of Medicine, USA
Short Talk: The E3 Ligase Fbw7, a T-ALL Tumor Suppressor, is a Novel Regulator of Hematopoietic Stem Cell Self-Renewal
Monday, February 25
| 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom
Speaker 5 of 5
Emmanuelle Passegué
, Columbia University, USA
Short Talk: Regulation of Hematopoietic Stem Cell Functions by JunB
Monday, February 25
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
Monday, February 25
| 7:30PM - 10:00PM
Poster Session 1
Tuesday, February 26
| 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom
Tuesday, February 26
| 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s
Room: British Columbia Ballroom
Speaker 1 of 6
Ruth Lehmann
, New York University, USA
The Niche and Germline Homeostasis
Tuesday, February 26
| 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s
Room: British Columbia Ballroom
Speaker 2 of 6
*
David T. Scadden
, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cell Niche
Tuesday, February 26
| 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s
Room: British Columbia Ballroom
Speaker 3 of 6
Judith E. Kimble
, University of Wisconsin, Madison, USA
Germline Stem Cells and their Niche in C. elegans
Tuesday, February 26
| 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s
Room: British Columbia Ballroom
Speaker 4 of 6
Linheng Li
, Stowers Institute for Medical Research, USA
Stem Cells, Niches, and Zones
Tuesday, February 26
| 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s
Room: British Columbia Ballroom
Speaker 5 of 6
Maria Sol Flaherty
, New York University School of Medicine, USA
Short Talk: A Novel BTB-Domain Protein Regulates Stem Cell Self-Renewal Downstream of JAK/STAT Signaling in the Drosophila Testis
Tuesday, February 26
| 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s
Room: British Columbia Ballroom
Speaker 6 of 6
Vivienne I. Rebel
, University of Texas Health Science Center, USA
Short Talk: CBP+/- Mice Develop Myelodysplasia and Hhypersensitivity to gamma Radiation with Age
Tuesday, February 26
| 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer
Tuesday, February 26
| 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom
Tuesday, February 26
| 11:15AM - 11:15AM
On Own for Lunch
Tuesday, February 26
| 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom
Tuesday, February 26
| 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer
Tuesday, February 26
| 5:00PM - 7:00PM
Physiological Function of Tumor Suppressors
Room: British Columbia Ballroom
Speaker 1 of 3
*
Scott W. Lowe
, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in Vivo
Tuesday, February 26
| 5:00PM - 7:00PM
Physiological Function of Tumor Suppressors
Room: British Columbia Ballroom
Speaker 2 of 3
Tian Xu
, Yale University School of Medicine, USA
Immune Response of Blood Cells to Tumors in Drosophila
Tuesday, February 26
| 5:00PM - 7:00PM
Physiological Function of Tumor Suppressors
Room: British Columbia Ballroom
Speaker 3 of 3
Ihor R. Lemischka
, Icahn School of Medicine at Mount Sinai, USA
Mechanisms Regulating Stem Cell Fate
Tuesday, February 26
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
Tuesday, February 26
| 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom
Wednesday, February 27
| 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom
Wednesday, February 27
| 7:00AM - 8:00AM
Poster Setup
Room: Pacific Ballroom
Wednesday, February 27
| 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom
Speaker 1 of 6
* Stuart H. Orkin
, Dana-Farber Cancer Institute, USA
Lineage Determination in the Hematopoietic System
Wednesday, February 27
| 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom
Speaker 2 of 6
Guy Sauvageau
, IRIC/Université de Montréal, Canada
Bmi1 Integrates Multiple Pathways in Hematopoietic Stem Cell Regulation
Wednesday, February 27
| 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom
Speaker 3 of 6
Cheng-Yu Lee
, University of Michigan, USA
Regulation of Neuroblast Self-Renewal in Drosophila
Wednesday, February 27
| 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom
Speaker 4 of 6
Fiona Doetsch
, University of Basel, Switzerland
MicroRNA Regulation of Adult Neural Stem Cells
Wednesday, February 27
| 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom
Speaker 5 of 6
Janel E. Le Belle
, University of California, Los Angeles, USA
Short Talk: Deletion and Inactivation of the Tumor Suppressors TSC and PTEN Influence Neural Stem Cell Self-Renewal and Neurogenesis
Wednesday, February 27
| 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom
Speaker 6 of 6
Susumu Goyama
, University of Tokyo, Japan
Short Talk: Evi-1 is a Critical Regulator for Hematopoietic Stem Cells and Leukemic Cells
Wednesday, February 27
| 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer
Wednesday, February 27
| 10:00AM - 10:00AM
On Own for Dinner
Wednesday, February 27
| 11:15AM - 12:15PM
Lunch
Room: Pacific Ballroom
Wednesday, February 27
| 12:00PM - 2:30PM
Poster Session 3
Room: Pacific Ballroom
Wednesday, February 27
| 2:30PM - 3:00PM
Coffee Available
Room: Pacific Foyer
Wednesday, February 27
| 3:00PM - 5:00PM
Stem Cells and Cancer
Room: Pacific Ballroom
Speaker 1 of 3
Luis F. Parada
, Memorial Sloan Kettering Cancer Center, USA
Title to be Determined
Wednesday, February 27
| 3:00PM - 5:00PM
Stem Cells and Cancer
Room: Pacific Ballroom
Speaker 2 of 3
John E. Dick
, Princess Margaret Cancer Centre, Canada
Modeling the Human Leukemogenic Process
Wednesday, February 27
| 3:00PM - 5:00PM
Stem Cells and Cancer
Room: Pacific Ballroom
Speaker 3 of 3
*
Sean J. Morrison
, University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal Versus Cancer Cell Proliferation
Thursday, February 28
| 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom
Thursday, February 28
| 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom
Speaker 1 of 6
Peter W. Reddien
, Whitehead Institute, USA
Identification of Regeneration and Stem Cell Regulatory Genes in Planaria
Thursday, February 28
| 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom
Speaker 2 of 6
Amy J. Wagers
, Harvard University, USA
Regulation and Function of Skeletal Muscle Stem Cells
Thursday, February 28
| 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom
Speaker 3 of 6
Leanne Jones
, University of California, Los Angeles, USA
Aging-Related Changes to Stem Cells and the Stem Cell Niche
Thursday, February 28
| 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom
Speaker 4 of 6
* Irving L. Weissman
, Stanford University, USA
Stem Cells and the Origin of Self/Non-Self Recognition
Thursday, February 28
| 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom
Speaker 5 of 6
Michael A. Dyer
, HHMI/St. Jude Children's Research Hospital, USA
Short Talk: The Role of the Rb Family in Retinal Development and Retinoblastoma
Thursday, February 28
| 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom
Speaker 6 of 6
Christine Karlsson
, Lund University, Sweden
Short Talk: Defining Regulators of Hematopoietic Stem Cell Self-Renewal using RNA Interference in High-throughput Genetic Screens
Thursday, February 28
| 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer
Thursday, February 28
| 11:00AM - 11:00AM
On Own for Lunch
Thursday, February 28
| 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer
Thursday, February 28
| 5:00PM - 7:00PM
Stem Cells and Aging
Room: British Columbia Ballroom
Speaker 1 of 3
*
Norman E. Sharpless
, NCI, National Institutes of Health, USA
Tumor Suppressors and Aging
Thursday, February 28
| 5:00PM - 7:00PM
Stem Cells and Aging
Room: British Columbia Ballroom
Speaker 2 of 3
Heinrich Jasper
, Genentech, Inc., USA
Stress Signaling, Stem Cells and Aging
Thursday, February 28
| 5:00PM - 7:00PM
Stem Cells and Aging
Room: British Columbia Ballroom
Speaker 3 of 3
Thomas A. Rando
, Stanford University School of Medicine, USA
Wnt Signaling Alters Stem Cell Fate in Aged Tissue
Thursday, February 28
| 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom
Thursday, February 28
| 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom
Thursday, February 28
| 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom
Friday, February 29
| 10:21AM - 10:21AM
Departure
*Session Chair
†Invited, not yet responded.
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