Web Desc
Tumor Suppressors and Stem Cell Biology
Organizer(s): Sean J. Morrison and Alejandro Sánchez Alvarado
Date: February 24 - 29, 2008
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Stem cells play key roles in the development, maintenance, and reproduction of all known multicellular organisms. Stem cells operate in a wide variety of biological contexts from homeostasis to regeneration and must be subject to complex and robust regulation. Recent evidence suggests that tumor suppressor mechanisms, originally discovered for their ability to inhibit tumorigenesis, also play widespread roles in the physiological regulation of stem cells. Tumor suppressors play critical roles in the regulation of tissue homeostasis, stem cell self-renewal, regeneration, and aging. This reveals mechanistic links between the regulation of stem cells, and the regulation of cancer cells that could potentially be exploited to target cancer and to enhance regeneration. The dual roles of these mechanisms in stem cell and cancer biology illuminate the evolved balance between the promotion of regeneration and the suppression of cancer.
Scholarship Deadline: October 24 2007
Discounted Abstract Deadline: October 24 2007
Abstract Deadline: November 26 2007
Discounted Registration Deadline: December 26 2007
We gratefully acknowledge additional support for this conference from:
Merck & Co., Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA132459-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 24 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Sunday, February 24 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Sunday, February 24 | 7:30PM - 8:30PM
Keynote Address
Room: British Columbia Ballroom

Speaker 1 of 1
Charles J. Sherr, St. Jude Children's Research Hospital, USA
Tumor Suppressors (RB, p53 INK4 genes, & ARF): On the Road to Immortality

Monday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Monday, February 25 | 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom

Speaker 1 of 6
Andrea I. McClatchey, Massachusetts General Hospital, USA
Membrane Organization in Tissue Homeostasis and Tumorigenesis

Monday, February 25 | 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom

Speaker 2 of 6
Gad Shaulsky, Baylor College of Medicine, USA
Cell Competition, Stem Cells and the Evolution of Sociality

Monday, February 25 | 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom

Speaker 3 of 6
Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Asymmetric Stem Cell Division during Tissue Homeostasis and Aging

Monday, February 25 | 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom

Speaker 4 of 6
* Alejandro Sánchez Alvarado, Stowers Institute for Medical Research/HHMI, USA
Stem Cells and their Regulation in the Planarian Schmidtea Mediterranea

Monday, February 25 | 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom

Speaker 5 of 6
Bret Pearson, University of Utah, USA
Short Talk: Adult Stem Cells and Tumorigenesis in the Freshwater Planarian

Monday, February 25 | 8:00AM - 11:15AM
Tumor Suppressors and the Evolution of Stem Cells
Room: British Columbia Ballroom

Speaker 6 of 6
Junlin Qi, University of Washington, Seattle, USA
Short Talk: microRNA-195 Regulates Human Embryonic Stem Cell Division

Monday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Monday, February 25 | 11:15AM - 11:15AM
On Own for Lunch


Monday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Monday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, February 25 | 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom

Speaker 1 of 5
Megan F. Cole, Massachusetts Institute of Technology, USA
Connecting Signaling to the Core Regulatory Circuitry of Embryonic Stem Cells

Monday, February 25 | 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom

Speaker 2 of 5
Patrick M.P. Viatour, Stanford University, USA
Short Talk: Hematopoietic Stem Cell Quiescence is maintained by Compound Contributions of the Retinoblastoma Gene Family

Monday, February 25 | 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom

Speaker 3 of 5
Valerie M. Renault, Stanford Medical School - Stanford University, USA
Short Talk: The Role of FoxO Transcription Factors in the Maintenance of Neural Stem Cells during Aging

Monday, February 25 | 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom

Speaker 4 of 5
Iannis Aifantis, New York University School of Medicine, USA
Short Talk: The E3 Ligase Fbw7, a T-ALL Tumor Suppressor, is a Novel Regulator of Hematopoietic Stem Cell Self-Renewal

Monday, February 25 | 5:00PM - 7:00PM
Epigenetic Regulation of Stem Cells
Room: British Columbia Ballroom

Speaker 5 of 5
Emmanuelle Passegué, Columbia University, USA
Short Talk: Regulation of Hematopoietic Stem Cell Functions by JunB

Monday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Monday, February 25 | 7:30PM - 10:00PM
Poster Session 1


Tuesday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Tuesday, February 26 | 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s

Room: British Columbia Ballroom

Speaker 1 of 6
Ruth Lehmann, New York University, USA
The Niche and Germline Homeostasis

Tuesday, February 26 | 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s

Room: British Columbia Ballroom

Speaker 2 of 6
* David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cell Niche

Tuesday, February 26 | 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s

Room: British Columbia Ballroom

Speaker 3 of 6
Judith E. Kimble, University of Wisconsin, Madison, USA
Germline Stem Cells and their Niche in C. elegans

Tuesday, February 26 | 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s

Room: British Columbia Ballroom

Speaker 4 of 6
Linheng Li, Stowers Institute for Medical Research, USA
Stem Cells, Niches, and Zones

Tuesday, February 26 | 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s

Room: British Columbia Ballroom

Speaker 5 of 6
Maria Sol Flaherty, New York University School of Medicine, USA
Short Talk: A Novel BTB-Domain Protein Regulates Stem Cell Self-Renewal Downstream of JAK/STAT Signaling in the Drosophila Testis

Tuesday, February 26 | 8:00AM - 11:15AM
Tumor Suppressors and the Environmental Control of Stem Cell
s

Room: British Columbia Ballroom

Speaker 6 of 6
Vivienne I. Rebel, University of Texas Health Science Center, USA
Short Talk: CBP+/- Mice Develop Myelodysplasia and Hhypersensitivity to gamma Radiation with Age

Tuesday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Tuesday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Tuesday, February 26 | 11:15AM - 11:15AM
On Own for Lunch


Tuesday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Tuesday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Tuesday, February 26 | 5:00PM - 7:00PM
Physiological Function of Tumor Suppressors
Room: British Columbia Ballroom

Speaker 1 of 3
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Dissecting Tumor Suppressor Gene Networks in Vivo

Tuesday, February 26 | 5:00PM - 7:00PM
Physiological Function of Tumor Suppressors
Room: British Columbia Ballroom

Speaker 2 of 3
Tian Xu, Yale University School of Medicine, USA
Immune Response of Blood Cells to Tumors in Drosophila

Tuesday, February 26 | 5:00PM - 7:00PM
Physiological Function of Tumor Suppressors
Room: British Columbia Ballroom

Speaker 3 of 3
Ihor R. Lemischka, Icahn School of Medicine at Mount Sinai, USA
Mechanisms Regulating Stem Cell Fate

Tuesday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Tuesday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Wednesday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Wednesday, February 27 | 7:00AM - 8:00AM
Poster Setup
Room: Pacific Ballroom


Wednesday, February 27 | 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom

Speaker 1 of 6
* Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Lineage Determination in the Hematopoietic System

Wednesday, February 27 | 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom

Speaker 2 of 6
Guy Sauvageau, IRIC/Université de Montréal, Canada
Bmi1 Integrates Multiple Pathways in Hematopoietic Stem Cell Regulation

Wednesday, February 27 | 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom

Speaker 3 of 6
Cheng-Yu Lee, University of Michigan, USA
Regulation of Neuroblast Self-Renewal in Drosophila

Wednesday, February 27 | 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom

Speaker 4 of 6
Fiona Doetsch, University of Basel, Switzerland
MicroRNA Regulation of Adult Neural Stem Cells

Wednesday, February 27 | 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom

Speaker 5 of 6
Janel E. Le Belle, University of California, Los Angeles, USA
Short Talk: Deletion and Inactivation of the Tumor Suppressors TSC and PTEN Influence Neural Stem Cell Self-Renewal and Neurogenesis

Wednesday, February 27 | 8:00AM - 11:15AM
Stem Cell Self-Renewal
Room: British Columbia Ballroom

Speaker 6 of 6
Susumu Goyama, University of Tokyo, Japan
Short Talk: Evi-1 is a Critical Regulator for Hematopoietic Stem Cells and Leukemic Cells

Wednesday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, February 27 | 10:00AM - 10:00AM
On Own for Dinner


Wednesday, February 27 | 11:15AM - 12:15PM
Lunch
Room: Pacific Ballroom


Wednesday, February 27 | 12:00PM - 2:30PM
Poster Session 3
Room: Pacific Ballroom


Wednesday, February 27 | 2:30PM - 3:00PM
Coffee Available
Room: Pacific Foyer


Wednesday, February 27 | 3:00PM - 5:00PM
Stem Cells and Cancer
Room: Pacific Ballroom

Speaker 1 of 3
Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Title to be Determined

Wednesday, February 27 | 3:00PM - 5:00PM
Stem Cells and Cancer
Room: Pacific Ballroom

Speaker 2 of 3
John E. Dick, Princess Margaret Cancer Centre, Canada
Modeling the Human Leukemogenic Process

Wednesday, February 27 | 3:00PM - 5:00PM
Stem Cells and Cancer
Room: Pacific Ballroom

Speaker 3 of 3
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal Versus Cancer Cell Proliferation


Thursday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Thursday, February 28 | 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom

Speaker 1 of 6
Peter W. Reddien, Whitehead Institute, USA
Identification of Regeneration and Stem Cell Regulatory Genes in Planaria

Thursday, February 28 | 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom

Speaker 2 of 6
Amy J. Wagers, Harvard University, USA
Regulation and Function of Skeletal Muscle Stem Cells

Thursday, February 28 | 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom

Speaker 3 of 6
Leanne Jones, University of California, Los Angeles, USA
Aging-Related Changes to Stem Cells and the Stem Cell Niche

Thursday, February 28 | 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom

Speaker 4 of 6
* Irving L. Weissman, Stanford University, USA
Stem Cells and the Origin of Self/Non-Self Recognition

Thursday, February 28 | 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom

Speaker 5 of 6
Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA
Short Talk: The Role of the Rb Family in Retinal Development and Retinoblastoma

Thursday, February 28 | 8:00AM - 11:00AM
Tumor Suppressors and Regeneration
Room: British Columbia Ballroom

Speaker 6 of 6
Christine Karlsson, Lund University, Sweden
Short Talk: Defining Regulators of Hematopoietic Stem Cell Self-Renewal using RNA Interference in High-throughput Genetic Screens

Thursday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Thursday, February 28 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Thursday, February 28 | 5:00PM - 7:00PM
Stem Cells and Aging
Room: British Columbia Ballroom

Speaker 1 of 3
* Norman E. Sharpless, NCI, National Institutes of Health, USA
Tumor Suppressors and Aging

Thursday, February 28 | 5:00PM - 7:00PM
Stem Cells and Aging
Room: British Columbia Ballroom

Speaker 2 of 3
Heinrich Jasper, Genentech, Inc., USA
Stress Signaling, Stem Cells and Aging

Thursday, February 28 | 5:00PM - 7:00PM
Stem Cells and Aging
Room: British Columbia Ballroom

Speaker 3 of 3
Thomas A. Rando, Stanford University School of Medicine, USA
Wnt Signaling Alters Stem Cell Fate in Aged Tissue

Thursday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Thursday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Thursday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Friday, February 29 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.