Web Desc
Complex Traits: Biologic and Therapeutic Insights
Organizer(s): Trudy F.C. Mackay, Lon Cardon and David R. Cox
Date: February 29 - March 05, 2008
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by the Director's Fund
Summary of Meeting:
Most phenotypic variation in populations, including variation in susceptibility to common human diseases, is attributable to segregating alleles of multiple genes, whose expression is dependent on the environment. Rapidly increasing knowledge about variation in genome sequence and gene expression will facilitate understanding the relationships of genotype to complex phenotypes and the evolutionary mechanisms shaping variation for complex traits, in humans and model organisms. Major questions to be solved regarding the genetic architecture of complex traits include the following: (1) the relative prevalence of common and rare variants; (2) whether causal variation is typically regulatory or structural; (3) how many segregating alleles affect any given trait and their pleiotropic effects on other traits; and (4) the extent to which allelic effects depend on other segregating alleles and the environment. This meeting aims to address these questions by bringing together investigators from population and quantitative genetics, genomics, and with expertise in model systems and humans.
Scholarship Deadline: October 30 2007
Discounted Abstract Deadline: October 30 2007
Abstract Deadline: November 29 2007
Discounted Registration Deadline: December 31 2007
We gratefully acknowledge additional support for this conference from:
Integrated DNA Technologies
We gratefully acknowledge the generous grant for this conference provided by:

National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG004585-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, February 29 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Friday, February 29 | 6:30PM - 7:30PM
Refreshments
Room: Sunset Room


Friday, February 29 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 2
* Trudy F.C. Mackay, North Carolina State University, USA

Friday, February 29 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 2
Michael Lynch, Indiana University, USA
Spontaneous Mutation, Complex Traits and Evolution

Saturday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, March 01 | 8:00AM - 11:00AM
The Spectrum of Genetic Variation
Room: Anasazi Ballroom

Speaker 1 of 5
Charles H. Langley, University of California, Davis, USA
Polymorphism and Divergence across the Drosophila melanogaster Genome

Saturday, March 01 | 8:00AM - 11:00AM
The Spectrum of Genetic Variation
Room: Anasazi Ballroom

Speaker 2 of 5
Detlef Weigel, Max Planck Institute for Developmental Biology, Germany
Whole-Genome Variation and its Impact on Reproductive Isolation in Arabidopsis thaliana

Saturday, March 01 | 8:00AM - 11:00AM
The Spectrum of Genetic Variation
Room: Anasazi Ballroom

Speaker 3 of 5
Eleazar Eskin, University of Calfornia, Los Angeles, USA
A Sequence-Based Variation Map of 8.27 million SNPs in Inbred Mouse Strains

Saturday, March 01 | 8:00AM - 11:00AM
The Spectrum of Genetic Variation
Room: Anasazi Ballroom

Speaker 4 of 5
* Peter Donnelly, University of Oxford and Genomics plc, UK
Human Genetic Variation and Disease Susceptibility

Saturday, March 01 | 8:00AM - 11:00AM
The Spectrum of Genetic Variation
Room: Anasazi Ballroom

Speaker 5 of 5
Richard M. Durbin, Wellcome Trust Sanger Institute, UK
Short Talk: Whole Genome Sequence Variation in 70 Saccharomyces Strains

Saturday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Saturday, March 01 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Saturday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Saturday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Saturday, March 01 | 5:00PM - 7:00PM
Genetic Variation and Evolution
Room: Anasazi Ballroom

Speaker 1 of 4
Adam Eyre-Walker, University of Sussex, UK
Inferring the Effects of Mutations from DNA Sequence Data

Saturday, March 01 | 5:00PM - 7:00PM
Genetic Variation and Evolution
Room: Anasazi Ballroom

Speaker 2 of 4
Daniel L. Hartl, Harvard University, USA
Therapeutic Insights from Yeast: Plasticity, Pleiotropy, and Mutability in the Transcriptome

Saturday, March 01 | 5:00PM - 7:00PM
Genetic Variation and Evolution
Room: Anasazi Ballroom

Speaker 3 of 4
* Sarah A. Tishkoff, University of Pennsylvania, USA
Genotypic and Phenotypic Variation in Africa

Saturday, March 01 | 5:00PM - 7:00PM
Genetic Variation and Evolution
Room: Anasazi Ballroom

Speaker 4 of 4
James P. Noonan, Yale University School of Medicine, USA
Short Talk: Functional Insights into the Role of Gene Regulatory Change in Human Evolution

Saturday, March 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Saturday, March 01 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Sunday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, March 02 | 8:00AM - 11:00AM
The Genetic Architecture of Gene Expression
Room: Anasazi Ballroom

Speaker 1 of 5
Ritsert C. Jansen, University of Groningen, Netherlands
Statistical Challenges for Genetical Genomics

Sunday, March 02 | 8:00AM - 11:00AM
The Genetic Architecture of Gene Expression
Room: Anasazi Ballroom

Speaker 2 of 5
* Leonid Kruglyak, Princeton University, USA
Genetic Architecture of Gene Expression in Yeast

Sunday, March 02 | 8:00AM - 11:00AM
The Genetic Architecture of Gene Expression
Room: Anasazi Ballroom

Speaker 3 of 5
Eric Schadt, Mount Sinai School of Medicine, USA
Mapping the Genetic Architecture of Gene Expression in Mouse and Human Populations

Sunday, March 02 | 8:00AM - 11:00AM
The Genetic Architecture of Gene Expression
Room: Anasazi Ballroom

Speaker 4 of 5
Vivian Cheung, University of Michigan, USA
Genetics of Natural Variation in Human Gene Expression

Sunday, March 02 | 8:00AM - 11:00AM
The Genetic Architecture of Gene Expression
Room: Anasazi Ballroom

Speaker 5 of 5
Jan Veldink, University Medical Center Utrecht, Netherlands
Short Talk: Differential Expression of Gene Networks in Peripheral Blood of Sporadic Amyotrophic Lateral Sclerosis (ALS) Patients Reveals Molecular Heterogeneity of the Disease

Sunday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Sunday, March 02 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Sunday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Sunday, March 02 | 1:30PM - 2:30PM
Editor's Roundtable
Room: Anasazi Ballroom


Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 1 of 9
* Trudy F.C. Mackay, North Carolina State University, USA

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 2 of 9
Michael N. Weedon, Peninsula Medical School, UK
Genome Wide Association Analysis Identifies 20 loci that Influence Adult Height

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 3 of 9
Laurens Basten Snoek, Wageningen University and Research Centre, Netherlands
The Genetic Architecture of Life-History Variation

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 4 of 9
Cristen J. Willer, University of Michigan, USA
Genome-Wide Association Scans Identify Novel Loci That Influence Lipid Levels and Risk of Coronary Artery Disease

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 5 of 9
Michael Olivier, Medical College of Wisconsin, USA
Complete Dissection of a QTL Identifies Five Novel Genes Responsible for Altered Lipid Levels in the Metabolic Syndrome

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 6 of 9
Hyun Seok Kim, Yonsei University College of Medicine, South Korea
A Systematic Screen for Genes Contributing to Quantitative Traits in Yeast using Quantitative non-Complementation

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 7 of 9
Yi Jia, Iowa State University, USA
Genetic Control of the Transcription of Natural Antisense Transcripts (NATs) in Maize

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 8 of 9
Yurii Aulchenko, Novosibirsk State University, Russia
Comparison of Methods for Genome-Wide Quantitative Trait Association Analysis in Related Individuals

Sunday, March 02 | 2:30PM - 4:30PM
Workshop: Short Talks Selected from Abstracts
Room: Anasazi Ballroom

Speaker 9 of 9
Ana-Teresa Maia, CRUK-Cambridge Research Institute, UK
New Approach to Study Susceptibility to Breast Cancer: Allelic Variation of Gene Expression Analysis

Sunday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Sunday, March 02 | 5:00PM - 7:00PM
The Genetic Architecture of Complex Traits: Lessons from Mod
el Organisms

Room: Anasazi Ballroom

Speaker 1 of 4
* Trudy F.C. Mackay, North Carolina State University, USA
Genetic Analysis of Complex Traits in Drosophila

Sunday, March 02 | 5:00PM - 7:00PM
The Genetic Architecture of Complex Traits: Lessons from Mod
el Organisms

Room: Anasazi Ballroom

Speaker 2 of 4
Ronald W. Davis, Stanford University, USA
Chemical and Complex Genetics in Yeast

Sunday, March 02 | 5:00PM - 7:00PM
The Genetic Architecture of Complex Traits: Lessons from Mod
el Organisms

Room: Anasazi Ballroom

Speaker 3 of 4
Beverly Paigen, The Jackson Laboratory, USA
Genetic Dissection of Mouse Complex Traits

Sunday, March 02 | 5:00PM - 7:00PM
The Genetic Architecture of Complex Traits: Lessons from Mod
el Organisms

Room: Anasazi Ballroom

Speaker 4 of 4
Bart M.G. Smits, University of Wisconsin - Madison, USA
Short Talk: Characterization of Mcs5a, a non-Coding Breast Cancer Susceptibility Locus

Sunday, March 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Sunday, March 02 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Monday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, March 03 | 8:00AM - 11:00AM
Human Complex Traits: Progress and Prospects
Room: Anasazi Ballroom

Speaker 1 of 4
P. Eline Slagboom, Leiden University, Netherlands
Genetic and Biomarker Studies for Human Longevity

Monday, March 03 | 8:00AM - 11:00AM
Human Complex Traits: Progress and Prospects
Room: Anasazi Ballroom

Speaker 2 of 4
* Carole Ober, University of Chicago, USA
Genome-Wide Association Studies in a Founder Population

Monday, March 03 | 8:00AM - 11:00AM
Human Complex Traits: Progress and Prospects
Room: Anasazi Ballroom

Speaker 3 of 4
Gilles Thomas, NCI - National Institutes of Health, USA
Genome-Wide Association Studies in Breast and Prostate Cancer: Cancer Genetic Markers of Susceptibility (CGEMS).

Monday, March 03 | 8:00AM - 11:00AM
Human Complex Traits: Progress and Prospects
Room: Anasazi Ballroom

Speaker 4 of 4
Adnan Derti, Harvard Medical School, USA
Short Talk: Assessing Excess Epistasis Among Functionally Related Human Genes

Monday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Monday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Monday, March 03 | 5:00PM - 6:40PM
Whole Genome Association Studies
Room: Anasazi Ballroom

Speaker 1 of 4
* David R. Cox, Perlegen Sciences, Inc., USA
Common Human DNA Variation and Complex Human Traits: Success Stories

Monday, March 03 | 5:00PM - 6:40PM
Whole Genome Association Studies
Room: Anasazi Ballroom

Speaker 2 of 4
Teri A. Manolio, National Human Genome Research Institute, USA
Collaboration and Data Sharing in the Genetic Association Information Network

Monday, March 03 | 5:00PM - 6:40PM
Whole Genome Association Studies
Room: Anasazi Ballroom

Speaker 3 of 4
Richard Spielman, University of Pennsylvania, USA
Short Talk: Monozygotic Twins Reveal Germ-line Contribution to Allelic Expression Differences

Monday, March 03 | 5:00PM - 6:40PM
Whole Genome Association Studies
Room: Anasazi Ballroom

Speaker 4 of 4
Minerva M. Carrasquillo, Mayo Clinic, USA
Short Talk: Genome-Wide Association Scan for Late Onset Alzheimer’s Disease (LOAD)

Monday, March 03 | 6:40PM - 7:15PM
Roundtable: Whole Genome Scans in Non-Academic Medicine
Room: Anasazi Ballroom

Speaker 1 of 2
* David R. Cox, Perlegen Sciences, Inc., USA

Monday, March 03 | 6:40PM - 7:15PM
Roundtable: Whole Genome Scans in Non-Academic Medicine
Room: Anasazi Ballroom

Speaker 2 of 2
Kári Stefánsson, deCode Genetics, Iceland
Prospects for Whole Genome Analysis for Individualized Medicine in the Real World

Monday, March 03 | 7:00PM - 7:00PM
On Own for Dinner


Tuesday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Tuesday, March 04 | 8:00AM - 11:00AM
Behavioral Genetics and Genomics
Room: Anasazi Ballroom

Speaker 1 of 5
* Robert R.H. Anholt, North Carolina State University, USA
Genetic Architecture of Complex Behavior in Drosophila

Tuesday, March 04 | 8:00AM - 11:00AM
Behavioral Genetics and Genomics
Room: Anasazi Ballroom

Speaker 2 of 5
Emmanuel Mignot, Stanford University School of Medicine, USA
Molecular Studies in Narcolepsy and Hypersomnia

Tuesday, March 04 | 8:00AM - 11:00AM
Behavioral Genetics and Genomics
Room: Anasazi Ballroom

Speaker 3 of 5
Kári Stefánsson, deCode Genetics, Iceland
Genetic of Common Diseases

Tuesday, March 04 | 8:00AM - 11:00AM
Behavioral Genetics and Genomics
Room: Anasazi Ballroom

Speaker 4 of 5
Hans A. Hofmann, University of Texas at Austin, USA
Genes, Hormones and Brains: A Genomic Analysis of Social Behavior

Tuesday, March 04 | 8:00AM - 11:00AM
Behavioral Genetics and Genomics
Room: Anasazi Ballroom

Speaker 5 of 5
Susan T. Harbison, North Carolina State University, USA
Short Talk: Identification of Co-Regulated Genetic Networks Contributing to Naturally Occurring Genetic Variation in Drosophila Sleep

Tuesday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Tuesday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Tuesday, March 04 | 5:00PM - 7:00PM
Epigenetics and Genomic Rearrangement
Room: Anasazi Ballroom

Speaker 1 of 5
* James R. Lupski, Baylor College of Medicine, USA
Genomic Rearrangements and Gene Copy Number Variation as a Cause for Complex Traits

Tuesday, March 04 | 5:00PM - 7:00PM
Epigenetics and Genomic Rearrangement
Room: Anasazi Ballroom

Speaker 2 of 5
Andrew Chess, Massachusetts General Hospital, USA
Epigenetic Mechanisms of Gene Regulationand Their Impact on Complex Traits

Tuesday, March 04 | 5:00PM - 7:00PM
Epigenetics and Genomic Rearrangement
Room: Anasazi Ballroom

Speaker 3 of 5
Iuliana Ionita, Harvard University, USA
Short Talk: On the Analysis of Copy-Number Variations (CNVs) in Genome-Wide Association Studies: A Translation of the Family-Based Association Test (FBAT) Approach

Tuesday, March 04 | 5:00PM - 7:00PM
Epigenetics and Genomic Rearrangement
Room: Anasazi Ballroom

Speaker 4 of 5
Dana C. Crawford, Case Western Reserve University, USA
Short Talk: APOA1/C3/A4/A5 Gene Cluster SNPs and their Interaction with Dietary Intake are Associated with Triglyceride Levels in the Third National Health and Nutrition Examination Survey

Tuesday, March 04 | 5:00PM - 7:00PM
Epigenetics and Genomic Rearrangement
Room: Anasazi Ballroom

Speaker 5 of 5
Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA
Short Talk: On the Complexity of the Growth Phenotype

Tuesday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Tuesday, March 04 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Tuesday, March 04 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Wednesday, March 05 | 10:25AM - 10:25AM
Departure


*Session Chair.