Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Understanding the Function of Human Genome Variation (2016K1)
Complex Traits: Genomics and Computational Approaches (2012B5)

Web Desc
Complex Traits: Biologic and Therapeutic Insights Organizer(s): Trudy F.C. Mackay, Lon Cardon and David R. Cox Date: February 29 - March 05, 2008 Location: Eldorado Hotel & Spa, Santa Fe, NM, USA Supported by the Director's Fund Summary of Meeting: Most phenotypic variation in populations, including variation in susceptibility to common human diseases, is attributable to segregating alleles of multiple genes, whose expression is dependent on the environment. Rapidly increasing knowledge about variation in genome sequence and gene expression will facilitate understanding the relationships of genotype to complex phenotypes and the evolutionary mechanisms shaping variation for complex traits, in humans and model organisms. Major questions to be solved regarding the genetic architecture of complex traits include the following: (1) the relative prevalence of common and rare variants; (2) whether causal variation is typically regulatory or structural; (3) how many segregating alleles affect any given trait and their pleiotropic effects on other traits; and (4) the extent to which allelic effects depend on other segregating alleles and the environment. This meeting aims to address these questions by bringing together investigators from population and quantitative genetics, genomics, and with expertise in model systems and humans. Scholarship Deadline: October 30 2007 Discounted Abstract Deadline: October 30 2007 Abstract Deadline: November 29 2007 Discounted Registration Deadline: December 31 2007 We gratefully acknowledge additional support for this conference from: We gratefully acknowledge the generous grant for this conference provided by: National Human Genome Research Institute (NHGRI) Grant No. 1R13HG004585-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Complex Traits: Biologic and Therapeutic Insights

Organizer(s): Trudy F.C. Mackay, Lon Cardon and David R. Cox

Date: February 29 - March 05, 2008
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA

Supported by the Director's Fund

Summary of Meeting:

Most phenotypic variation in populations, including variation in susceptibility to common human diseases, is attributable to segregating alleles of multiple genes, whose expression is dependent on the environment. Rapidly increasing knowledge about variation in genome sequence and gene expression will facilitate understanding the relationships of genotype to complex phenotypes and the evolutionary mechanisms shaping variation for complex traits, in humans and model organisms. Major questions to be solved regarding the genetic architecture of complex traits include the following: (1) the relative prevalence of common and rare variants; (2) whether causal variation is typically regulatory or structural; (3) how many segregating alleles affect any given trait and their pleiotropic effects on other traits; and (4) the extent to which allelic effects depend on other segregating alleles and the environment. This meeting aims to address these questions by bringing together investigators from population and quantitative genetics, genomics, and with expertise in model systems and humans.

Scholarship Deadline: October 30 2007

Discounted Abstract Deadline: October 30 2007

Abstract Deadline: November 29 2007

Discounted Registration Deadline: December 31 2007

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge the generous grant for this conference provided by:

National Human Genome Research Institute (NHGRI)
Grant No. 1R13HG004585-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Friday, February 29 \| 3:00PM - 7:30PM Registration Room: Zia Concourse
Friday, February 29 \| 6:30PM - 7:30PM Refreshments Room: Sunset Room
Friday, February 29 \| 7:30PM - 8:30PM Keynote Address Room: Anasazi Ballroom Speaker 1 of 2 * Trudy F.C. Mackay, North Carolina State University, USA
Friday, February 29 \| 7:30PM - 8:30PM Keynote Address Room: Anasazi Ballroom Speaker 2 of 2 Michael Lynch, Indiana University, USA Spontaneous Mutation, Complex Traits and Evolution
Saturday, March 01 \| 7:00AM - 8:00AM Breakfast Room: Eldorado Court
Saturday, March 01 \| 8:00AM - 11:00AM The Spectrum of Genetic Variation Room: Anasazi Ballroom Speaker 1 of 5 Charles H. Langley, University of California, Davis, USA Polymorphism and Divergence across the Drosophila melanogaster Genome
Saturday, March 01 \| 8:00AM - 11:00AM The Spectrum of Genetic Variation Room: Anasazi Ballroom Speaker 2 of 5 Detlef Weigel, Max Planck Institute for Developmental Biology, Germany Whole-Genome Variation and its Impact on Reproductive Isolation in Arabidopsis thaliana
Saturday, March 01 \| 8:00AM - 11:00AM The Spectrum of Genetic Variation Room: Anasazi Ballroom Speaker 3 of 5 Eleazar Eskin, University of Calfornia, Los Angeles, USA A Sequence-Based Variation Map of 8.27 million SNPs in Inbred Mouse Strains
Saturday, March 01 \| 8:00AM - 11:00AM The Spectrum of Genetic Variation Room: Anasazi Ballroom Speaker 4 of 5 * Peter Donnelly, University of Oxford and Genomics plc, UK Human Genetic Variation and Disease Susceptibility
Saturday, March 01 \| 8:00AM - 11:00AM The Spectrum of Genetic Variation Room: Anasazi Ballroom Speaker 5 of 5 Richard M. Durbin, Wellcome Trust Sanger Institute, UK Short Talk: Whole Genome Sequence Variation in 70 Saccharomyces Strains
Saturday, March 01 \| 9:20AM - 9:40AM Coffee Break Room: Zia Concourse
Saturday, March 01 \| 11:00AM - 1:00PM Poster Setup Room: Sunset Room
Saturday, March 01 \| 1:00PM - 10:00PM Poster Viewing Room: Sunset Room
Saturday, March 01 \| 4:30PM - 5:00PM Coffee Available Room: Zia Concourse
Saturday, March 01 \| 5:00PM - 7:00PM Genetic Variation and Evolution Room: Anasazi Ballroom Speaker 1 of 4 Adam Eyre-Walker, University of Sussex, UK Inferring the Effects of Mutations from DNA Sequence Data
Saturday, March 01 \| 5:00PM - 7:00PM Genetic Variation and Evolution Room: Anasazi Ballroom Speaker 2 of 4 Daniel L. Hartl, Harvard University, USA Therapeutic Insights from Yeast: Plasticity, Pleiotropy, and Mutability in the Transcriptome
Saturday, March 01 \| 5:00PM - 7:00PM Genetic Variation and Evolution Room: Anasazi Ballroom Speaker 3 of 4 * Sarah A. Tishkoff, University of Pennsylvania, USA Genotypic and Phenotypic Variation in Africa
Saturday, March 01 \| 5:00PM - 7:00PM Genetic Variation and Evolution Room: Anasazi Ballroom Speaker 4 of 4 James P. Noonan, Yale University School of Medicine, USA Short Talk: Functional Insights into the Role of Gene Regulatory Change in Human Evolution
Saturday, March 01 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Eldorado Court/Sunset Room
Saturday, March 01 \| 7:30PM - 10:00PM Poster Session 1 Room: Sunset Room
Sunday, March 02 \| 7:00AM - 8:00AM Breakfast Room: Eldorado Court
Sunday, March 02 \| 8:00AM - 11:00AM The Genetic Architecture of Gene Expression Room: Anasazi Ballroom Speaker 1 of 5 Ritsert C. Jansen, University of Groningen, Netherlands Statistical Challenges for Genetical Genomics
Sunday, March 02 \| 8:00AM - 11:00AM The Genetic Architecture of Gene Expression Room: Anasazi Ballroom Speaker 2 of 5 * Leonid Kruglyak, Princeton University, USA Genetic Architecture of Gene Expression in Yeast
Sunday, March 02 \| 8:00AM - 11:00AM The Genetic Architecture of Gene Expression Room: Anasazi Ballroom Speaker 3 of 5 Eric Schadt, Mount Sinai School of Medicine, USA Mapping the Genetic Architecture of Gene Expression in Mouse and Human Populations
Sunday, March 02 \| 8:00AM - 11:00AM The Genetic Architecture of Gene Expression Room: Anasazi Ballroom Speaker 4 of 5 Vivian Cheung, University of Michigan, USA Genetics of Natural Variation in Human Gene Expression
Sunday, March 02 \| 8:00AM - 11:00AM The Genetic Architecture of Gene Expression Room: Anasazi Ballroom Speaker 5 of 5 Jan Veldink, University Medical Center Utrecht, Netherlands Short Talk: Differential Expression of Gene Networks in Peripheral Blood of Sporadic Amyotrophic Lateral Sclerosis (ALS) Patients Reveals Molecular Heterogeneity of the Disease
Sunday, March 02 \| 9:20AM - 9:40AM Coffee Break Room: Zia Concourse
Sunday, March 02 \| 11:00AM - 1:00PM Poster Setup Room: Sunset Room
Sunday, March 02 \| 1:00PM - 10:00PM Poster Viewing Room: Sunset Room
Sunday, March 02 \| 1:30PM - 2:30PM Editor's Roundtable Room: Anasazi Ballroom
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 1 of 9 * Trudy F.C. Mackay, North Carolina State University, USA
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 2 of 9 Michael N. Weedon, Peninsula Medical School, UK Genome Wide Association Analysis Identifies 20 loci that Influence Adult Height
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 3 of 9 Laurens Basten Snoek, Wageningen University and Research Centre, Netherlands The Genetic Architecture of Life-History Variation
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 4 of 9 Cristen J. Willer, University of Michigan, USA Genome-Wide Association Scans Identify Novel Loci That Influence Lipid Levels and Risk of Coronary Artery Disease
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 5 of 9 Michael Olivier, Medical College of Wisconsin, USA Complete Dissection of a QTL Identifies Five Novel Genes Responsible for Altered Lipid Levels in the Metabolic Syndrome
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 6 of 9 Hyun Seok Kim, Yonsei University College of Medicine, South Korea A Systematic Screen for Genes Contributing to Quantitative Traits in Yeast using Quantitative non-Complementation
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 7 of 9 Yi Jia, Iowa State University, USA Genetic Control of the Transcription of Natural Antisense Transcripts (NATs) in Maize
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 8 of 9 Yurii Aulchenko, Novosibirsk State University, Russia Comparison of Methods for Genome-Wide Quantitative Trait Association Analysis in Related Individuals
Sunday, March 02 \| 2:30PM - 4:30PM Workshop: Short Talks Selected from Abstracts Room: Anasazi Ballroom Speaker 9 of 9 Ana-Teresa Maia, CRUK-Cambridge Research Institute, UK New Approach to Study Susceptibility to Breast Cancer: Allelic Variation of Gene Expression Analysis
Sunday, March 02 \| 4:30PM - 5:00PM Coffee Available Room: Zia Concourse
Sunday, March 02 \| 5:00PM - 7:00PM The Genetic Architecture of Complex Traits: Lessons from Mod el Organisms Room: Anasazi Ballroom Speaker 1 of 4 * Trudy F.C. Mackay, North Carolina State University, USA Genetic Analysis of Complex Traits in Drosophila
Sunday, March 02 \| 5:00PM - 7:00PM The Genetic Architecture of Complex Traits: Lessons from Mod el Organisms Room: Anasazi Ballroom Speaker 2 of 4 Ronald W. Davis, Stanford University, USA Chemical and Complex Genetics in Yeast
Sunday, March 02 \| 5:00PM - 7:00PM The Genetic Architecture of Complex Traits: Lessons from Mod el Organisms Room: Anasazi Ballroom Speaker 3 of 4 Beverly Paigen, The Jackson Laboratory, USA Genetic Dissection of Mouse Complex Traits
Sunday, March 02 \| 5:00PM - 7:00PM The Genetic Architecture of Complex Traits: Lessons from Mod el Organisms Room: Anasazi Ballroom Speaker 4 of 4 Bart M.G. Smits, University of Wisconsin - Madison, USA Short Talk: Characterization of Mcs5a, a non-Coding Breast Cancer Susceptibility Locus
Sunday, March 02 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Eldorado Court/Sunset Room
Sunday, March 02 \| 7:30PM - 10:00PM Poster Session 2 Room: Sunset Room
Monday, March 03 \| 7:00AM - 8:00AM Breakfast Room: Eldorado Court
Monday, March 03 \| 8:00AM - 11:00AM Human Complex Traits: Progress and Prospects Room: Anasazi Ballroom Speaker 1 of 4 P. Eline Slagboom, Leiden University, Netherlands Genetic and Biomarker Studies for Human Longevity
Monday, March 03 \| 8:00AM - 11:00AM Human Complex Traits: Progress and Prospects Room: Anasazi Ballroom Speaker 2 of 4 * Carole Ober, University of Chicago, USA Genome-Wide Association Studies in a Founder Population
Monday, March 03 \| 8:00AM - 11:00AM Human Complex Traits: Progress and Prospects Room: Anasazi Ballroom Speaker 3 of 4 Gilles Thomas, NCI - National Institutes of Health, USA Genome-Wide Association Studies in Breast and Prostate Cancer: Cancer Genetic Markers of Susceptibility (CGEMS).
Monday, March 03 \| 8:00AM - 11:00AM Human Complex Traits: Progress and Prospects Room: Anasazi Ballroom Speaker 4 of 4 Adnan Derti, Harvard Medical School, USA Short Talk: Assessing Excess Epistasis Among Functionally Related Human Genes
Monday, March 03 \| 9:20AM - 9:40AM Coffee Break Room: Zia Concourse
Monday, March 03 \| 4:30PM - 5:00PM Coffee Available Room: Zia Concourse
Monday, March 03 \| 5:00PM - 6:40PM Whole Genome Association Studies Room: Anasazi Ballroom Speaker 1 of 4 * David R. Cox, Perlegen Sciences, Inc., USA Common Human DNA Variation and Complex Human Traits: Success Stories
Monday, March 03 \| 5:00PM - 6:40PM Whole Genome Association Studies Room: Anasazi Ballroom Speaker 2 of 4 Teri A. Manolio, National Human Genome Research Institute, USA Collaboration and Data Sharing in the Genetic Association Information Network
Monday, March 03 \| 5:00PM - 6:40PM Whole Genome Association Studies Room: Anasazi Ballroom Speaker 3 of 4 Richard Spielman, University of Pennsylvania, USA Short Talk: Monozygotic Twins Reveal Germ-line Contribution to Allelic Expression Differences
Monday, March 03 \| 5:00PM - 6:40PM Whole Genome Association Studies Room: Anasazi Ballroom Speaker 4 of 4 Minerva M. Carrasquillo, Mayo Clinic, USA Short Talk: Genome-Wide Association Scan for Late Onset Alzheimer’s Disease (LOAD)
Monday, March 03 \| 6:40PM - 7:15PM Roundtable: Whole Genome Scans in Non-Academic Medicine Room: Anasazi Ballroom Speaker 1 of 2 * David R. Cox, Perlegen Sciences, Inc., USA
Monday, March 03 \| 6:40PM - 7:15PM Roundtable: Whole Genome Scans in Non-Academic Medicine Room: Anasazi Ballroom Speaker 2 of 2 Kári Stefánsson, deCode Genetics, Iceland Prospects for Whole Genome Analysis for Individualized Medicine in the Real World
Monday, March 03 \| 7:00PM - 7:00PM On Own for Dinner
Tuesday, March 04 \| 7:00AM - 8:00AM Breakfast Room: Eldorado Court
Tuesday, March 04 \| 8:00AM - 11:00AM Behavioral Genetics and Genomics Room: Anasazi Ballroom Speaker 1 of 5 * Robert R.H. Anholt, North Carolina State University, USA Genetic Architecture of Complex Behavior in Drosophila
Tuesday, March 04 \| 8:00AM - 11:00AM Behavioral Genetics and Genomics Room: Anasazi Ballroom Speaker 2 of 5 Emmanuel Mignot, Stanford University School of Medicine, USA Molecular Studies in Narcolepsy and Hypersomnia
Tuesday, March 04 \| 8:00AM - 11:00AM Behavioral Genetics and Genomics Room: Anasazi Ballroom Speaker 3 of 5 Kári Stefánsson, deCode Genetics, Iceland Genetic of Common Diseases
Tuesday, March 04 \| 8:00AM - 11:00AM Behavioral Genetics and Genomics Room: Anasazi Ballroom Speaker 4 of 5 Hans A. Hofmann, University of Texas at Austin, USA Genes, Hormones and Brains: A Genomic Analysis of Social Behavior
Tuesday, March 04 \| 8:00AM - 11:00AM Behavioral Genetics and Genomics Room: Anasazi Ballroom Speaker 5 of 5 Susan T. Harbison, North Carolina State University, USA Short Talk: Identification of Co-Regulated Genetic Networks Contributing to Naturally Occurring Genetic Variation in Drosophila Sleep
Tuesday, March 04 \| 9:20AM - 9:40AM Coffee Break Room: Zia Concourse
Tuesday, March 04 \| 4:30PM - 5:00PM Coffee Available Room: Zia Concourse
Tuesday, March 04 \| 5:00PM - 7:00PM Epigenetics and Genomic Rearrangement Room: Anasazi Ballroom Speaker 1 of 5 * James R. Lupski, Baylor College of Medicine, USA Genomic Rearrangements and Gene Copy Number Variation as a Cause for Complex Traits
Tuesday, March 04 \| 5:00PM - 7:00PM Epigenetics and Genomic Rearrangement Room: Anasazi Ballroom Speaker 2 of 5 Andrew Chess, Massachusetts General Hospital, USA Epigenetic Mechanisms of Gene Regulationand Their Impact on Complex Traits
Tuesday, March 04 \| 5:00PM - 7:00PM Epigenetics and Genomic Rearrangement Room: Anasazi Ballroom Speaker 3 of 5 Iuliana Ionita, Harvard University, USA Short Talk: On the Analysis of Copy-Number Variations (CNVs) in Genome-Wide Association Studies: A Translation of the Family-Based Association Test (FBAT) Approach
Tuesday, March 04 \| 5:00PM - 7:00PM Epigenetics and Genomic Rearrangement Room: Anasazi Ballroom Speaker 4 of 5 Dana C. Crawford, Case Western Reserve University, USA Short Talk: APOA1/C3/A4/A5 Gene Cluster SNPs and their Interaction with Dietary Intake are Associated with Triglyceride Levels in the Third National Health and Nutrition Examination Survey
Tuesday, March 04 \| 5:00PM - 7:00PM Epigenetics and Genomic Rearrangement Room: Anasazi Ballroom Speaker 5 of 5 Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA Short Talk: On the Complexity of the Growth Phenotype
Tuesday, March 04 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Eldorado Court/Sunset Room
Tuesday, March 04 \| 8:00PM - 11:00PM Entertainment Room: Eldorado Court/Sunset Room
Tuesday, March 04 \| 8:00PM - 11:00PM Cash Bar Room: Eldorado Court/Sunset Room
Wednesday, March 05 \| 10:25AM - 10:25AM Departure *Session Chair.