Web Desc
Genetics and Biochemistry of Sleep
Organizer(s): Amita Sehgal, Jay C. Dunlap and Emmanuel Mignot
Date: March 07 - 12, 2008
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by the Director's Fund
Summary of Meeting:
Sleep is increasingly being recognized as an important area of research that is also relevant for our understanding of other physiological functions. Among recent advances are the identification of genes that contribute to sleep disorders (e.g., narcolepsy, advanced sleep phase syndrome), the development of animal, including invertebrate, model systems for sleep, the discovery of sleep-regulating genes and the demonstration of links between sleep and metabolism. In addition, the serious health consequences of disrupted sleep have been rigorously documented. Major questions now are how the timing and duration of sleep are controlled by the circadian and sleep-promoting homeostatic systems, and what essential functions are served by sleep. The program emphasizes the benefits of a cross-disciplinary approach to address the problems posed above. It also highlights the extent to which sleep impacts other aspects of physiology, and the progress towards understanding the molecular basis of sleep disorders.
Scholarship Deadline: November 7 2007
Discounted Abstract Deadline: November 7 2007
Abstract Deadline: December 5 2007
Discounted Registration Deadline: January 21 2008
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13NS061372-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 07 | 3:00PM - 7:30PM
Registration
Room: Pre Function


Friday, March 07 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain / Lake

Speaker 1 of 1
Allan I. Pack, University of Pennsylvania School of Medicine, USA
Functional Genomic Approaches to the Study of Sleep

Saturday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Saturday, March 08 | 8:00AM - 11:20AM
Control of Sleep and Vigilance by Circadian and Non-Circadia
n Mechanisms

Room: Mountain / Lake

Speaker 1 of 6
* Amita Sehgal, University of Pennsylvania Perelman School of Medicine, USA

Saturday, March 08 | 8:00AM - 11:20AM
Control of Sleep and Vigilance by Circadian and Non-Circadia
n Mechanisms

Room: Mountain / Lake

Speaker 2 of 6
David F. Dinges, University of Pennsylvania School of Medicine, USA
Trait-Like Differential Vulnerability to the Neurobehavioral Effects of Sleep Loss in Humans

Saturday, March 08 | 8:00AM - 11:20AM
Control of Sleep and Vigilance by Circadian and Non-Circadia
n Mechanisms

Room: Mountain / Lake

Speaker 3 of 6
Monique K. LeBourgeois, Brown University, USA
Short Talk: Salivary Dim Light Melatonin Onset (DLMO) and Reported Sleep in Preschool Children

Saturday, March 08 | 8:00AM - 11:20AM
Control of Sleep and Vigilance by Circadian and Non-Circadia
n Mechanisms

Room: Mountain / Lake

Speaker 4 of 6
Clifford B. Saper, Beth Israel Deaconess Medical Center, USA
Inducible Clocks: Living in an Unpredictable World

Saturday, March 08 | 8:00AM - 11:20AM
Control of Sleep and Vigilance by Circadian and Non-Circadia
n Mechanisms

Room: Mountain / Lake

Speaker 5 of 6
Jerry M. Siegel, University of California, Los Angeles, USA
Phylogeny of Sleep

Saturday, March 08 | 8:00AM - 11:20AM
Control of Sleep and Vigilance by Circadian and Non-Circadia
n Mechanisms

Room: Mountain / Lake

Speaker 6 of 6
Ravi Allada, Northwestern University, USA
Neural Circuits Controlling Sleep in Drosophila

Saturday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Saturday, March 08 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Saturday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Saturday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Saturday, March 08 | 5:00PM - 7:00PM
Molecular Mechanisms of the Circadian Clock
Room: Mountain / Lake

Speaker 1 of 3
Michael W. Young, Rockefeller University, USA
Regulation of Period Function and Stability by Doubletime

Saturday, March 08 | 5:00PM - 7:00PM
Molecular Mechanisms of the Circadian Clock
Room: Mountain / Lake

Speaker 2 of 3
Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA
Genetic Analysis of Circadian Rhythms in Mammals

Saturday, March 08 | 5:00PM - 7:00PM
Molecular Mechanisms of the Circadian Clock
Room: Mountain / Lake

Speaker 3 of 3
* Jay C. Dunlap, Dartmouth Medical School, USA
Molecular Mechanisms of the Clock in Neurospora

Saturday, March 08 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Saturday, March 08 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room


Saturday, March 08 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Sunday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Sunday, March 09 | 8:00AM - 11:30AM
Circadian Physiology and Other Sleep-Relevant Physiological
Phenomena

Room: Mountain / Lake

Speaker 1 of 5
Paolo Sassone-Corsi, University of California, Irvine, USA
Signaling to Chromatin and the Circadian Clock

Sunday, March 09 | 8:00AM - 11:30AM
Circadian Physiology and Other Sleep-Relevant Physiological
Phenomena

Room: Mountain / Lake

Speaker 2 of 5
Ueli Schibler, University of Geneva, Switzerland
Control of Circadian Gene Expression and Physiology by Central and Peripheral Clocks

Sunday, March 09 | 8:00AM - 11:30AM
Circadian Physiology and Other Sleep-Relevant Physiological
Phenomena

Room: Mountain / Lake

Speaker 3 of 5
Nicolas Cermakian, Douglas Mental Health University Institute, Canada
Short Talk: Entrainment of Clock Gene Expression in Peripheral Blood Mononuclear Cells Following Simulated Night Shift Work with Light/Darkness Intervention

Sunday, March 09 | 8:00AM - 11:30AM
Circadian Physiology and Other Sleep-Relevant Physiological
Phenomena

Room: Mountain / Lake

Speaker 4 of 5
* Irene Tobler, University of Zurich, Switzerland
Daily Torpor and Use-Dependent Aspects of Sleep

Sunday, March 09 | 8:00AM - 11:30AM
Circadian Physiology and Other Sleep-Relevant Physiological
Phenomena

Room: Mountain / Lake

Speaker 5 of 5
Cheng Chi Lee, University of Texas Health Science Center, USA
A Metabolic Rhythm Regulated by Constant Darkness

Sunday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Sunday, March 09 | 11:00AM - 1:00PM
Poster Setup
Room: Bay Room


Sunday, March 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Sunday, March 09 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Intervention to Treat Sleep Disturba
nces
Room: Mountain

Speaker 1 of 6
Philippe Mourrain, Stanford University, USA
Sleeping with the Fishes, a Concrete Story

Sunday, March 09 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Intervention to Treat Sleep Disturba
nces
Room: Mountain

Speaker 2 of 6
Sonia Ancoli-Israel, University of California, San Diego, USA
Treatment of Sleep Disorders in Older Adults

Sunday, March 09 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Intervention to Treat Sleep Disturba
nces
Room: Mountain

Speaker 3 of 6
* David P. White, Respironics, Inc./Harvard Medical School, USA
Phenotyping in Obstructive Sleep Apnea: Implications for Therapy and Genetic Studies

Sunday, March 09 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Intervention to Treat Sleep Disturba
nces
Room: Mountain

Speaker 4 of 6
John Joseph Renger, Merck Research Laboratories, USA
Leveraging the Genetics of Sleep to Identify Novel Targets for the Treatment of Neurological Disease

Sunday, March 09 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Intervention to Treat Sleep Disturba
nces
Room: Mountain

Speaker 5 of 6
Christine Dugovic, Johnson and Johnson Pharmaceutical Research and Development, USA
New Therapeutic Targets for Sleep-Wake Disorders

Sunday, March 09 | 2:30PM - 4:30PM
Workshop 1: Therapeutic Intervention to Treat Sleep Disturba
nces
Room: Mountain

Speaker 6 of 6
Norio K. Ishida, National Institute of Advanced Industrial Science and Technology (AIST), Japan
PPARalpha Ligand is a New Target for DSPS - From Circadian Clock to Seasonal Clock

Sunday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Sunday, March 09 | 5:00PM - 7:00PM
Neural Basis of Sleep
Room: Mountain / Lake

Speaker 1 of 4
Barbara E. Jones, McGill University, Canada
Neuronal and Chemical Substrates of Sleep-Wake States

Sunday, March 09 | 5:00PM - 7:00PM
Neural Basis of Sleep
Room: Mountain / Lake

Speaker 2 of 4
* Luis de Lecea, Stanford University, USA
Neuropeptides and Sleep

Sunday, March 09 | 5:00PM - 7:00PM
Neural Basis of Sleep
Room: Mountain / Lake

Speaker 3 of 4
Michael M. Rosbash, Brandeis University, USA
Pharmacological Approaches to the Study of Sleep in Drosophila

Sunday, March 09 | 5:00PM - 7:00PM
Neural Basis of Sleep
Room: Mountain / Lake

Speaker 4 of 4
Thomas S. Kilduff, SRI International, USA
Short Talk: Gene Expression during Sleep Deprivation and Recovery Sleep: Global, Regional and Cellular Analyses

Sunday, March 09 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Sunday, March 09 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room


Sunday, March 09 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Monday, March 10 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, March 10 | 8:00AM - 11:30AM
Molecular Analysis of Sleep
Room: Mountain / Lake

Speaker 1 of 4
Chiara Cirelli, University of Wisconsin, Madison, USA
Genetic Screens for Sleep Mutants in Drosophila

Monday, March 10 | 8:00AM - 11:30AM
Molecular Analysis of Sleep
Room: Mountain / Lake

Speaker 2 of 4
* Fred W. Turek, Northwestern University, USA
Genetic Analysis of Sleep in Mammals

Monday, March 10 | 8:00AM - 11:30AM
Molecular Analysis of Sleep
Room: Mountain / Lake

Speaker 3 of 4
Sigrid C. Veasey, University of Pennsylvania School of Medicine, USA
Selective Loss of Catecholaminergic Wake-Active Neurons in a Murine Sleep Apnea Model

Monday, March 10 | 8:00AM - 11:30AM
Molecular Analysis of Sleep
Room: Mountain / Lake

Speaker 4 of 4
Paul Franken, University of Lausanne, Switzerland
Circadian Genes = Sleep Homeostatic Genes = Metabolic Genes?

Monday, March 10 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Monday, March 10 | 2:30PM - 4:30PM
Workshop 2: New Approaches to the Study of Sleep
Room: Mountain

Speaker 1 of 5
Amanda Sorribes, Universidad Autónoma de Madrid, Spain
Statistics of Sleep-Wake Transitions: Drosophila vs Mammals

Monday, March 10 | 2:30PM - 4:30PM
Workshop 2: New Approaches to the Study of Sleep
Room: Mountain

Speaker 2 of 5
Kyunghee Koh, University of Pennsylvania, USA
Severe Reduction of Sleep in Sleepless Mutants

Monday, March 10 | 2:30PM - 4:30PM
Workshop 2: New Approaches to the Study of Sleep
Room: Mountain

Speaker 3 of 5
* David M. Raizen, University of Pennsylvania School of Medicine, USA
Lethargus is a C. Elegans Sleep-like State

Monday, March 10 | 2:30PM - 4:30PM
Workshop 2: New Approaches to the Study of Sleep
Room: Mountain

Speaker 4 of 5
Heather Anne Mitchell, Emory University, USA
Responses of Dopamine beta-Hydroxylase Knockout (Dbh -/-) Mice to Modafinil Support a Dual Noradrenergic-Dopaminergic Mechanism
of Action


Monday, March 10 | 2:30PM - 4:30PM
Workshop 2: New Approaches to the Study of Sleep
Room: Mountain

Speaker 5 of 5
David A. Prober, Harvard University, USA
Hypocretin/Orexin Overexpression Induces an Insomnia-Like Phenotype in Zebrafish

Monday, March 10 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Monday, March 10 | 5:00PM - 7:00PM
Relationship between Sleep and Metabolism
Room: Mountain / Lake

Speaker 1 of 4
* Eve Van Cauter, University of Chicago, USA
Sleep Duration and Quality: Impact on Carbohydrate Metabolism and Appetite Regulation

Monday, March 10 | 5:00PM - 7:00PM
Relationship between Sleep and Metabolism
Room: Mountain / Lake

Speaker 2 of 4
Jason R. Gerstner, University of Wisconsin, USA
And

Monday, March 10 | 5:00PM - 7:00PM
Relationship between Sleep and Metabolism
Room: Mountain / Lake

Speaker 3 of 4
Jerry C.P. Yin, University of Wisconsin-Madison, USA
A Role for Fatty-Acid Binding Proteins in Sleep Homeostasis and Long-Term Memory in Drosophila

Monday, March 10 | 5:00PM - 7:00PM
Relationship between Sleep and Metabolism
Room: Mountain / Lake

Speaker 4 of 4
Masashi Yanagisawa, University of Tsukuba, Japan
Molecular Genetic Dissection of Sleep/Wake Regulation

Monday, March 10 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 11 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 11 | 8:00AM - 11:00AM
Genetic/Genomic Approaches to the Study of Human Sleep Disor
ders

Room: Mountain / Lake

Speaker 1 of 4
* Emmanuel Mignot, Stanford University School of Medicine, USA
Molecular Studies in Narcolepsy and Hypersomnia

Tuesday, March 11 | 8:00AM - 11:00AM
Genetic/Genomic Approaches to the Study of Human Sleep Disor
ders

Room: Mountain / Lake

Speaker 2 of 4
Ying-Hui Fu, University of California, San Francisco, USA
Genetic Analysis of Advanced Sleep Phase Syndrome

Tuesday, March 11 | 8:00AM - 11:00AM
Genetic/Genomic Approaches to the Study of Human Sleep Disor
ders

Room: Mountain / Lake

Speaker 3 of 4
Mehdi Tafti, University of Lausanne, Switzerland
Genetics of Normal and Pathological Sleep in Humans

Tuesday, March 11 | 8:00AM - 11:00AM
Genetic/Genomic Approaches to the Study of Human Sleep Disor
ders

Room: Mountain / Lake

Speaker 4 of 4
Juliane Winkelmann, Helmholtz Zentrum München, Germany
Genetics of Restless Legs Syndrome

Tuesday, March 11 | 9:20AM - 9:40AM
Coffee Break
Room: Pre Function


Tuesday, March 11 | 4:30PM - 5:00PM
Coffee Available
Room: Pre Function


Tuesday, March 11 | 5:00PM - 7:00PM
Role of Sleep in Other Physiological Processes
Room: Mountain / Lake

Speaker 1 of 4
* Giulio Tononi, University of Wisconsin, Madison, USA
Sleep and Synaptic Plasticity

Tuesday, March 11 | 5:00PM - 7:00PM
Role of Sleep in Other Physiological Processes
Room: Mountain / Lake

Speaker 2 of 4
Ted Abel, University of Pennsylvania, USA
The Role of Sleep in Hippocampal Memory Storage and Synaptic Plasticity

Tuesday, March 11 | 5:00PM - 7:00PM
Role of Sleep in Other Physiological Processes
Room: Mountain / Lake

Speaker 3 of 4
Julie A. Williams, University of Medicine and Dentistry of New Jersey, USA
Interaction between Sleep and the Immune Response in Drosophila

Tuesday, March 11 | 5:00PM - 7:00PM
Role of Sleep in Other Physiological Processes
Room: Mountain / Lake

Speaker 4 of 4
Mark R. Opp, University of Michigan, USA
Short Talk: Role of Cytokine-Neurotransmitter Interactions in Sickness-Induced Suppression of REMS

Tuesday, March 11 | 7:00PM - 8:00PM
Social Hour
Room: Bay Room


Tuesday, March 11 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Tuesday, March 11 | 8:00PM - 11:00PM
Entertainment
Room: Granhall


Wednesday, March 12 | 10:25AM - 10:25AM
Departure


*Session Chair.