Web Desc
Signaling Pathways in Cancer and Development
Organizer(s): Juan Carlos Izpisúa Belmonte and Geoffrey M. Wahl
Date: March 24 - 29, 2008
Location: Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA
Supported by the Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Our views of how cancer arises are changing dramatically. While cancer was originally thought to be a cell autonomous process, we now realize that cancers comprise aberrant organs, in which cell:cell, and cell:matrix interactions are critical. Furthermore, it now seems likely that not all cells within a tumor mass are, in fact, tumorigenic. Rather, specialized cells, that resemble tissue stem cells in some of their properties, may be responsible for tumor formation. Finally, the signaling pathways involved in normal development and in cancer have long been known to be similar. Studies over the past several years have given insight into how these pathways work, and how they can be manipulated for therapeutic benefit. Given all these links between cancer formation and development, and the potential applications to new treatment strategies, this conference has been developed to link these two important, rapidly evolving, and exciting areas.
Scholarship Deadline: November 26 2007
Discounted Abstract Deadline: November 26 2007
Abstract Deadline: December 26 2007
Discounted Registration Deadline: January 25 2008
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Genentech, Inc.Merck & Co., Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 24 | 3:00PM - 7:30PM
Registration
Room: Foyer


Monday, March 24 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Monday, March 24 | 7:30PM - 8:30PM
Keynote Address
Room: Storm Peak/Mt. Werner

Speaker 1 of 1
Hans C. Clevers, Hubrecht Institute, Netherlands
The Wnt Target Gene Lgr5, a Marker for Adult Stem Cells in Multiple Tissues

Tuesday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Sunshine/Rainbow/Twilight


Tuesday, March 25 | 8:00AM - 11:00AM
Enabling Technologies and Treatment
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan
Generation of iPS Cells from Adult Human Fibroblasts

Tuesday, March 25 | 8:00AM - 11:00AM
Enabling Technologies and Treatment
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Angel Raya, Center of Regenerative Medicine, Spain
Generation of Patient-Specific iPS Cells

Tuesday, March 25 | 8:00AM - 11:00AM
Enabling Technologies and Treatment
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Marius Wernig, Stanford University, USA
Short Talk: Direct Reprogramming of Mouse Fibroblasts and Therapeutic Applicability

Tuesday, March 25 | 8:00AM - 11:00AM
Enabling Technologies and Treatment
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Christopher L. Murriel, OncoMed Pharmaceuticals, Inc., USA
Short Talk: The use of a Dual Function Single Lentiviral Vector System for Cre/Lox Mediated Gene Recombination and Inducible Gene Silencing in vivo

Tuesday, March 25 | 8:00AM - 11:00AM
Enabling Technologies and Treatment
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Gerald M. Pao, The Salk Institute, USA
Short Talk: Use of Lentiviral Vectors in Human Stem Cell Biology

Tuesday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 25 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Tuesday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Tuesday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, March 25 | 5:00PM - 6:50PM
Wnt Signaling in Development and Cancer
Room: Storm Peak/Mt. Werner

Speaker 1 of 3
* Elaine V. Fuchs, Rockefeller University, USA
Wnt Signaling, Stem Cell Activation and Cancer in Skin

Tuesday, March 25 | 5:00PM - 6:50PM
Wnt Signaling in Development and Cancer
Room: Storm Peak/Mt. Werner

Speaker 2 of 3
Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling during Development and Tissue Regeneration

Tuesday, March 25 | 5:00PM - 6:50PM
Wnt Signaling in Development and Cancer
Room: Storm Peak/Mt. Werner

Speaker 3 of 3
Randall T. Moon, University of Washington School of Medicine, USA
Wnt Signaling during Development and Cancer

Tuesday, March 25 | 6:50PM - 7:30PM
Stem Cells: A Potential Common Link Between Development and
Cancer

Room: Storm Peak/ Mt. Werner

Speaker 1 of 1
Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

Tuesday, March 25 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Sunshine


Tuesday, March 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine


Wednesday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Sunshine/Rainbow/Twilight


Wednesday, March 26 | 8:00AM - 11:00AM
Adult Stem Cells
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Fiona M. Watt, King's College London School of Medicine, UK
Epidermal Stem Cells and Cancer

Wednesday, March 26 | 8:00AM - 11:00AM
Adult Stem Cells
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Genetic Interaction between PGE2 and Wnt Signaling in Stem Cell Formation and Organ Regeneration

Wednesday, March 26 | 8:00AM - 11:00AM
Adult Stem Cells
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Connie J. Eaves, British Columbia Cancer Agency, Canada
Mammary Epithelial Stem Cells

Wednesday, March 26 | 8:00AM - 11:00AM
Adult Stem Cells
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Helen M. Blau, Stanford University, USA
Adult Stem Cell Behavior In Bioengineered Niches

Wednesday, March 26 | 8:00AM - 11:00AM
Adult Stem Cells
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Hao Chang, University of Texas M. D. Anderson Cancer Center, USA
Short Talk: Misregulated beta-catenin signaling causes Sertoli cell tumor development

Wednesday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 26 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Wednesday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Wednesday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 26 | 5:00PM - 7:15PM
Proliferation, Aging and Cancer
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Margaret T. Fuller, Stanford University, USA
Regulation of Proliferation and Differentiation in Adult Stem Cell Lineages

Wednesday, March 26 | 5:00PM - 7:15PM
Proliferation, Aging and Cancer
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Leanne Jones, University of California, Los Angeles, USA
Aging-Related Changes to Stem Cells and the Stem Cell Niche

Wednesday, March 26 | 5:00PM - 7:15PM
Proliferation, Aging and Cancer
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Brigid L. M. Hogan, Duke University Medical Center, USA
Stem/Progenitor Cells in Lung Development, Homeostasis, and Repair

Wednesday, March 26 | 5:00PM - 7:15PM
Proliferation, Aging and Cancer
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Ignacio Flores, Spanish National Cancer Research Centre (CNIO), Spain
Telomerase Regulation and Stem Cell Behavior

Wednesday, March 26 | 5:00PM - 7:15PM
Proliferation, Aging and Cancer
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Tatjana Piotrowski, Stowers Institute for Medical Research, USA
Short Talk: Interactions between beta-Catenin and Fgf Signaling Regulate Directional Migration of Groups of Cells

Wednesday, March 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sunshine


Wednesday, March 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine


Thursday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Sunshine/Rainbow/Twilight


Thursday, March 27 | 8:00AM - 10:50AM
Organogenesis and Cancer
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Catriona H.M. Jamieson, University of California, San Diego, USA
The Molecular Evolution of Leukemia Stem Cells

Thursday, March 27 | 8:00AM - 10:50AM
Organogenesis and Cancer
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Frank McKeon, The Jackson Laboratory for Genomic Medicine and Genome Institute of Singapore, USA
TAp63 and the Female Germline

Thursday, March 27 | 8:00AM - 10:50AM
Organogenesis and Cancer
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Bruce A. Edgar, German Cancer Research Center, Germany
Homeostatic Growth Mediated by Intestinal Stem Cells in Adult Drosophila

Thursday, March 27 | 8:00AM - 10:50AM
Organogenesis and Cancer
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA
The Hippo Signaling Pathway in Organ Size-Control and Cancer

Thursday, March 27 | 8:00AM - 10:50AM
Organogenesis and Cancer
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Nicolas Di-Poi, University of Geneva, Switzerland
Short Talk: Distinct Roles for Hoxd Genes in Metanephric Kidney Development

Thursday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, March 27 | 10:50AM - 11:30AM
Enabling Technologies and Treatment
Room: Storm Peak/Mt. Werner

Speaker 1 of 1
David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Title to be Determined

Thursday, March 27 | 11:30AM - 1:00PM
Poster Setup
Room: Sunshine


Thursday, March 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Thursday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 27 | 5:00PM - 7:15PM
Hedgehog Signaling in Development and Cancer

Speaker 1 of 5
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling during Cancer Growth

Thursday, March 27 | 5:00PM - 7:15PM
Hedgehog Signaling in Development and Cancer

Speaker 2 of 5
* Matthew P. Scott, Stanford University, USA
Communicating with Hedgehogs

Thursday, March 27 | 5:00PM - 7:15PM
Hedgehog Signaling in Development and Cancer

Speaker 3 of 5
Norbert Perrimon, Harvard Medical School, USA
Genetic Analysis of Growth and Homeostasis

Thursday, March 27 | 5:00PM - 7:15PM
Hedgehog Signaling in Development and Cancer

Speaker 4 of 5
William Matsui, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, USA
Short Talk: Hedgehog Signaling, Self-Renewal and Cancer Stem Cells

Thursday, March 27 | 5:00PM - 7:15PM
Hedgehog Signaling in Development and Cancer

Speaker 5 of 5
Uda Ho, Queensland Institute of Medical Research, Australia
Short Talk: Hedgehog Signaling in Lung Development

Thursday, March 27 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Sunshine


Thursday, March 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine


Friday, March 28 | 7:00AM - 8:00AM
Breakfast
Room: Sunshine/Rainbow/Twilight


Friday, March 28 | 8:00AM - 11:00AM
Stem Cell Renewal Mechanisms
Room: Storm Peak/Mt. Werner

Speaker 1 of 5
* Austin Smith, University of Cambridge, UK
The Ground State of Pluripotency

Friday, March 28 | 8:00AM - 11:00AM
Stem Cell Renewal Mechanisms
Room: Storm Peak/Mt. Werner

Speaker 2 of 5
Sheng Ding, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
A Chemical Approach to Pluripotency and Reprogramming

Friday, March 28 | 8:00AM - 11:00AM
Stem Cell Renewal Mechanisms
Room: Storm Peak/Mt. Werner

Speaker 3 of 5
Kathrin Plath, University of California, Los Angeles, USA
In vitro Reprogramming of Human and Murine Somatic Cells to an Embryonic State

Friday, March 28 | 8:00AM - 11:00AM
Stem Cell Renewal Mechanisms
Room: Storm Peak/Mt. Werner

Speaker 4 of 5
Konrad Hochedlinger, Massachusetts General Hospital, USA
Global Epigenetic Reprogramming by Defined Transcription Factors

Friday, March 28 | 8:00AM - 11:00AM
Stem Cell Renewal Mechanisms
Room: Storm Peak/Mt. Werner

Speaker 5 of 5
Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Ronin Is Essential for Embryogenesis and the Pluri-Potency of Mouse ES Cells and Acts Independently of Canonical Pathways

Friday, March 28 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, March 28 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, March 28 | 5:00PM - 7:00PM
Stem Cells: A Potential Common Link Between Development and
Cancer

Room: Storm Peak/ Mt. Werner

Speaker 1 of 4
* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
The Loss of Nf1 Transiently Promotes Self-Renewal but not Tumorigenesis by Neural Crest Stem Cells

Friday, March 28 | 5:00PM - 7:00PM
Stem Cells: A Potential Common Link Between Development and
Cancer

Room: Storm Peak/ Mt. Werner

Speaker 2 of 4
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
The Role of Pro-survival Bcl-2 Family Members in Tumour Development and Sustaining Tumour Growth

Friday, March 28 | 5:00PM - 7:00PM
Stem Cells: A Potential Common Link Between Development and
Cancer

Room: Storm Peak/ Mt. Werner

Speaker 3 of 4
Maikel Peppelenbosch, Erasmus Medical Center, Netherlands

Friday, March 28 | 5:00PM - 7:00PM
Stem Cells: A Potential Common Link Between Development and
Cancer

Room: Storm Peak/ Mt. Werner

Speaker 4 of 4
Louis Vermeulen, CEMM, Netherlands
Short Talk: Single Cell Cloning of Colon Cancer Stem Cells Reveals Multi-Lineage Differentiation Capacity

Friday, March 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Sunshine


Friday, March 28 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine


Friday, March 28 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine


Saturday, March 29 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.