Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
	Long Noncoding RNAs: From Evolution to Function (2015C7)
Long Noncoding RNAs: Marching toward Mechanism (2014B5)
RNA Silencing (2013C7)
Noncoding RNAs in Development and Cancer (2013A7)
Protein-RNA Interactions in Biology and Disease (2012C1)
Gene Silencing by Small RNAs (2012B1)
MicroRNAs and Human Disease (2011J6)
Mechanism and Biology of Silencing (2011C7)
RNA Silencing: Mechanism, Biology and Application (2010A7)
The Biology of RNA Silencing (2009D6)

Web Desc
RNAi, MicroRNA, and Non-Coding RNA Organizer(s): Judy Lieberman and Phillip A. Sharp Date: March 25 - 30, 2008 Location: Whistler Conference Centre, Whistler, BC, Canada Sponsored by Alnylam Pharmaceuticals, Inc., Novartis Institutes for BioMedical Research, and Santaris Pharma A/S Summary of Meeting: RNA interference (RNAi) describes a variety of evolutionarily conserved mechanisms for regulating gene transcription and post-transcriptional events that are important for controlling development and cell proliferation, survival, differentiation and effector functions. RNAi also protects the genome from transposons and viruses. This meeting will explore recent developments in understanding the molecular mechanisms and cell biology of RNA-based post-transcriptional silencing and for maintaining regions of silenced chromatin. It will consider methods to uncover regulatory networks of endogenous microRNAs and their target genes and illustrative examples in a variety of organisms. Recent advances in harnessing RNA interference for genetic screening and therapeutic gene silencing will also be explored. We gratefully acknowledge additional support for this conference from: QIAGEN, Inc. We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Isis Pharmaceuticals, Inc. Mirus Bio LLC We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1R13CA132336-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

RNAi, MicroRNA, and Non-Coding RNA

Organizer(s): Judy Lieberman and Phillip A. Sharp

Date: March 25 - 30, 2008
Location: Whistler Conference Centre, Whistler, BC, Canada

Sponsored by Alnylam Pharmaceuticals, Inc., Novartis Institutes for BioMedical Research, and Santaris Pharma A/S

Summary of Meeting:

RNA interference (RNAi) describes a variety of evolutionarily conserved mechanisms for regulating gene transcription and post-transcriptional events that are important for controlling development and cell proliferation, survival, differentiation and effector functions. RNAi also protects the genome from transposons and viruses. This meeting will explore recent developments in understanding the molecular mechanisms and cell biology of RNA-based post-transcriptional silencing and for maintaining regions of silenced chromatin. It will consider methods to uncover regulatory networks of endogenous microRNAs and their target genes and illustrative examples in a variety of organisms. Recent advances in harnessing RNA interference for genetic screening and therapeutic gene silencing will also be explored.

We gratefully acknowledge additional support for this conference from:

QIAGEN, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Isis Pharmaceuticals, Inc.

Mirus Bio LLC

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA132336-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Tuesday, March 25 \| 3:00PM - 7:30PM Registration Room: Grand Foyer
Tuesday, March 25 \| 6:30PM - 7:30PM Refreshments Room: Grand Foyer
Tuesday, March 25 \| 7:30PM - 9:30PM Keynote Session Room: Sea to Sky Ballroom BC Speaker 1 of 4 * Judy Lieberman, Harvard University, USA and
Tuesday, March 25 \| 7:30PM - 9:30PM Keynote Session Room: Sea to Sky Ballroom BC Speaker 2 of 4 * Phillip A. Sharp, Massachusetts Institute of Technology, USA Introductions
Tuesday, March 25 \| 7:30PM - 9:30PM Keynote Session Room: Sea to Sky Ballroom BC Speaker 3 of 4 Craig C. Mello, University of Massachusetts Medical School, USA Small RNA Pathways and Germline in C. elegans
Tuesday, March 25 \| 7:30PM - 9:30PM Keynote Session Room: Sea to Sky Ballroom BC Speaker 4 of 4 Gregory J. Hannon, University of Cambridge, UK Conserved Roles of Small RNAs in Genome Defense
Wednesday, March 26 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky Ballroom A, Lower Level
Wednesday, March 26 \| 8:00AM - 11:00AM MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 1 of 5 David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA MicroRNAs and their Targets
Wednesday, March 26 \| 8:00AM - 11:00AM MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 2 of 5 Carlo M. Croce, Ohio State University, USA MicroRNA Genes and Cancer
Wednesday, March 26 \| 8:00AM - 11:00AM MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 3 of 5 Eric N. Olson, University of Texas Southwestern Medical Center, USA microRNAs Control of Muscle Development and Disease
Wednesday, March 26 \| 8:00AM - 11:00AM MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 4 of 5 * V. Narry Kim, Institute for Basic Science, South Korea lin 28-Mediated Terminal Uridylation of pre-let-7
Wednesday, March 26 \| 8:00AM - 11:00AM MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 5 of 5 Joel G. Belasco, New York University School of Medicine, USA Short Talk: Importance of Translational Repression and non-Nucleolytic Ago Isoforms for on-Target RNA Interference
Wednesday, March 26 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Wednesday, March 26 \| 11:00AM - 1:00PM Poster Setup Room: Sea to Sky Ballroom A, Foyer
Wednesday, March 26 \| 11:00AM - 11:00AM On Own for Lunch
Wednesday, March 26 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky Ballroom A, Foyer
Wednesday, March 26 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 1 of 7 * Victor R. Ambros, University of Massachusetts, USA
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 2 of 7 Stephen M. Cohen, Institute of Molecular and Cell Biology, Singapore MicroRNA Functions
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 3 of 7 Oliver Hobert, Columbia University, USA The Regulatory Architecture of a miRNA-Controlled 3'UTR
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 4 of 7 Molly C. Hammell, Cold Spring Harbor Laboratory, USA Short Talk: mirWIP: microRNA Target Prediction Based on miRNP Enriched Transcripts
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 5 of 7 Marcelo A. German, Dow AgroSciences, USA Short Talk: Global Identification of miRNA-Target RNA Pairs by Parallel Analysis of RNA Ends (PARE)
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 6 of 7 Eric C. Lai, Sloan Kettering Institute, USA Short Talk: Biogenesis and Function of Hairpin RNAs
Wednesday, March 26 \| 5:00PM - 7:15PM MicroRNAs and Their Targets (Plants and Invertebrates). Ses sion Supported by Regulus Therapeutics Room: Sea to Sky Ballroom BC Speaker 7 of 7 Alla Grishok, Columbia University Medical Center, USA Short Talk: Targets of Endogenous RNAi Processes in C. elegans
Wednesday, March 26 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Sea to Sky Ballroom A, Foyer
Wednesday, March 26 \| 7:30PM - 10:00PM Poster Session 1 Room: Sea to Sky Ballroom A, Foyer
Thursday, March 27 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky Ballroom A, Lower Level
Thursday, March 27 \| 8:00AM - 11:15AM RNA Interference: Regulation of Transcription Room: Sea to Sky Ballroom BC Speaker 1 of 5 Danesh Moazed, Harvard Medical School, USA Role of Non-Coding RNAs in Heterochromatin Assembly
Thursday, March 27 \| 8:00AM - 11:15AM RNA Interference: Regulation of Transcription Room: Sea to Sky Ballroom BC Speaker 2 of 5 * Marjori Ann Matzke, Institute of Plant and Microbial Biology, Academy Sinica, Taiwan RNA-Directed DNA Methylation in Arabidopsis
Thursday, March 27 \| 8:00AM - 11:15AM RNA Interference: Regulation of Transcription Room: Sea to Sky Ballroom BC Speaker 3 of 5 Alexei A. Aravin, California Institute of Technology, USA Small RNA Pathways in Mouse Germline
Thursday, March 27 \| 8:00AM - 11:15AM RNA Interference: Regulation of Transcription Room: Sea to Sky Ballroom BC Speaker 4 of 5 René F. Ketting, Institute for Molecular Biology, Germany TRF-Like Terminal Transferases affect RNAi and Chromosome Segregation in C. elegans
Thursday, March 27 \| 8:00AM - 11:15AM RNA Interference: Regulation of Transcription Room: Sea to Sky Ballroom BC Speaker 5 of 5 Michel A.J. Georges, University of Leige GIGA Institute B34, Belgium Small RNAs and Imprinting
Thursday, March 27 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Thursday, March 27 \| 11:15AM - 1:00PM Poster Setup Room: Sea to Sky Ballroom A, Foyer
Thursday, March 27 \| 11:15AM - 11:15AM On Own for Lunch
Thursday, March 27 \| 1:00PM - 10:00PM Poster Viewing Room: Sea to Sky Ballroom A, Foyer
Thursday, March 27 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Thursday, March 27 \| 5:00PM - 7:00PM Non-coding RNAs Room: Sea to Sky Ballroom BC Speaker 1 of 4 * Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA Investigations of the Functional Roles of the Pervasive Transcription Observed for Genomes
Thursday, March 27 \| 5:00PM - 7:00PM Non-coding RNAs Room: Sea to Sky Ballroom BC Speaker 2 of 4 Gene W. Yeo, University of California, San Diego, USA Short Talk: Analysis of Small RNAs in Stem Cell Development
Thursday, March 27 \| 5:00PM - 7:00PM Non-coding RNAs Room: Sea to Sky Ballroom BC Speaker 3 of 4 Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA Structural Biology of Riboswitch-Mediated Gene Regulation and Argonaute-Mediated Gene Silencing
Thursday, March 27 \| 5:00PM - 7:00PM Non-coding RNAs Room: Sea to Sky Ballroom BC Speaker 4 of 4 Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany Identifying MicroRNAs and Their Targets
Thursday, March 27 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky Ballroom A, Foyer
Thursday, March 27 \| 7:30PM - 10:00PM Poster Session 2 Room: Sea to Sky Ballroom A, Foyer
Friday, March 28 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky Ballroom A, Lower Level
Friday, March 28 \| 7:00AM - 8:00AM Poster Setup Room: Sea to Sky Ballroom A, Foyer
Friday, March 28 \| 8:00AM - 11:00AM RNA Interference: Newly Emerging Biology Room: Sea to Sky Ballroom BC Speaker 1 of 5 * Phillip D. Zamore, University of Massachusetts Medical School, USA Germline and Somatic Small RNAs
Friday, March 28 \| 8:00AM - 11:00AM RNA Interference: Newly Emerging Biology Room: Sea to Sky Ballroom BC Speaker 2 of 5 Thomas Tuschl, HHMI/Rockefeller University, USA miRNA Profiling and in Situ Hybridization to Examine Their Cell-Type Specific Expression Patterns
Friday, March 28 \| 8:00AM - 11:00AM RNA Interference: Newly Emerging Biology Room: Sea to Sky Ballroom BC Speaker 3 of 5 Haifan Lin, Yale University, USA Epigenetic Function of Piwi and piRNAs
Friday, March 28 \| 8:00AM - 11:00AM RNA Interference: Newly Emerging Biology Room: Sea to Sky Ballroom BC Speaker 4 of 5 Phillip A. Sharp, Massachusetts Institute of Technology, USA miRNA Silencing by Translational Inhibition and mRNA Degradation
Friday, March 28 \| 8:00AM - 11:00AM RNA Interference: Newly Emerging Biology Room: Sea to Sky Ballroom BC Speaker 5 of 5 Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany Short Talk: Mechanism of miRNA-Mediated Gene Silencing
Friday, March 28 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Friday, March 28 \| 11:00AM - 12:00PM Lunch Room: Sea to Sky Ballroom A, Foyer
Friday, March 28 \| 12:00PM - 2:30PM Poster Session 3 Room: Sea to Sky Ballroom A, Foyer
Friday, March 28 \| 2:30PM - 4:30PM Workshop 1: New Approaches to shRNA-Based Screening and Ther apy Room: Sea to Sky Ballroom BC Speaker 1 of 5 David E. Root, Broad Institute, USA Pooled shRNA Screens for Functional Fingerprinting
Friday, March 28 \| 2:30PM - 4:30PM Workshop 1: New Approaches to shRNA-Based Screening and Ther apy Room: Sea to Sky Ballroom BC Speaker 2 of 5 Edward Harlow, Constellation Pharmaceuticals, USA shRNA Screens to Identify Targets for Cancer Drug Development
Friday, March 28 \| 2:30PM - 4:30PM Workshop 1: New Approaches to shRNA-Based Screening and Ther apy Room: Sea to Sky Ballroom BC Speaker 3 of 5 Michael T. Hemann, Massachusetts Institute of Technology, USA In Vivo Screens to Identify Mechanisms of Drug Resistance
Friday, March 28 \| 2:30PM - 4:30PM Workshop 1: New Approaches to shRNA-Based Screening and Ther apy Room: Sea to Sky Ballroom BC Speaker 4 of 5 Mark A. Kay, Stanford University, USA Functional Evidence for Restricting MicroRNA Targets to the 3' Untranslated Region of mRNAs
Friday, March 28 \| 2:30PM - 4:30PM Workshop 1: New Approaches to shRNA-Based Screening and Ther apy Room: Sea to Sky Ballroom BC Speaker 5 of 5 * John J. Rossi, Beckman Research Institute of the City of Hope, USA Applying RNAi for the treatment of HIV infection
Friday, March 28 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Friday, March 28 \| 5:00PM - 7:00PM RNA Interference: Mechanisms and Cell Biology Room: Sea to Sky Ballroom BC Speaker 1 of 4 Matthias W. Hentze, European Molecular Biology Laboratory, Germany Mechanism of Translational Inhibition by miRNAs
Friday, March 28 \| 5:00PM - 7:00PM RNA Interference: Mechanisms and Cell Biology Room: Sea to Sky Ballroom BC Speaker 2 of 4 Carl D. Novina, Dana-Farber Cancer Institute, USA Short Talk: MicroRNA-Targeted mRNAs Contain 40S, but not 60S Components
Friday, March 28 \| 5:00PM - 7:00PM RNA Interference: Mechanisms and Cell Biology Room: Sea to Sky Ballroom BC Speaker 3 of 4 * Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland Role of Dicer in miRNA Pathways and Beyond
Friday, March 28 \| 5:00PM - 7:00PM RNA Interference: Mechanisms and Cell Biology Room: Sea to Sky Ballroom BC Speaker 4 of 4 Jennifer A. Doudna, HHMI/University of California, Berkeley, USA Mechanisms of Small RNA Processing
Friday, March 28 \| 7:00PM - 7:00PM On Own for Dinner
Saturday, March 29 \| 7:00AM - 8:00AM Breakfast Room: Sea to Sky Ballroom A, Lower Level
Saturday, March 29 \| 7:00AM - 8:00AM Poster Setup Room: Sea to Sky Ballroom A, Foyer
Saturday, March 29 \| 8:00AM - 11:00AM RNAi-Based Screening Room: Sea to Sky Ballroom BC Speaker 1 of 4 * Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA The Protein Coding Cofactors of miRNAs and siRNAs
Saturday, March 29 \| 8:00AM - 11:00AM RNAi-Based Screening Room: Sea to Sky Ballroom BC Speaker 2 of 4 Anjana Rao, La Jolla Institute for Allergy and Immunology, USA RNAi Screen for Mammalian Biology and a Bit About Eri-1
Saturday, March 29 \| 8:00AM - 11:00AM RNAi-Based Screening Room: Sea to Sky Ballroom BC Speaker 3 of 4 Reuven Agami, Netherlands Cancer Institute, Netherlands Dead End 1 Blocks microRNA Access to Target mRNA
Saturday, March 29 \| 8:00AM - 11:00AM RNAi-Based Screening Room: Sea to Sky Ballroom BC Speaker 4 of 4 Scott M. Hammond, University of North Carolina at Chapel Hill, USA Regulation of microRNA Biogenesis by Lin-28
Saturday, March 29 \| 9:20AM - 9:40AM Coffee Break Room: Grand Foyer
Saturday, March 29 \| 11:00AM - 12:00PM Lunch Room: Sea to Sky Ballroom A, Foyer
Saturday, March 29 \| 12:00PM - 2:30PM Poster Session 4 Room: Sea to Sky Ballroom A, Foyer
Saturday, March 29 \| 2:30PM - 4:30PM Workshop 2: Translating RNAi Room: Sea to Sky Ballroom BC Speaker 1 of 5 Lee Lim, Sirna/Merck, USA Using Profiling to Study miRNAs
Saturday, March 29 \| 2:30PM - 4:30PM Workshop 2: Translating RNAi Room: Sea to Sky Ballroom BC Speaker 2 of 5 Muthiah Manoharan, Alnylam Pharmaceuticals, Inc., USA Cellular Delivery of siRNAs and Antagomirs Using Chemical Conjugation and Complexation Strategies
Saturday, March 29 \| 2:30PM - 4:30PM Workshop 2: Translating RNAi Room: Sea to Sky Ballroom BC Speaker 3 of 5 * C. Frank Bennett, Ionis Pharmaceuticals, Inc., USA Therapeutic Approaches for Modulating Gene Expression Utilizing Single Stranded Oligonucleotides
Saturday, March 29 \| 2:30PM - 4:30PM Workshop 2: Translating RNAi Room: Sea to Sky Ballroom BC Speaker 4 of 5 David L. Lewis, Arrowhead Research Corporation, USA Dynamic PolyConjugates: A Rationally Designed, Modular Platform for Systemic siRNA Delivery
Saturday, March 29 \| 2:30PM - 4:30PM Workshop 2: Translating RNAi Room: Sea to Sky Ballroom BC Speaker 5 of 5 Fumitaka Takeshita, National Cancer Center Research Institute, Japan Systemic microRNA Therapy for Cancer Metastasis
Saturday, March 29 \| 4:30PM - 5:00PM Coffee Available Room: Grand Foyer
Saturday, March 29 \| 5:00PM - 7:00PM RNAi-Based Therapy Room: Sea to Sky Ballroom BC Speaker 1 of 4 * Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania, USA RNAi and Neurodegenerative Diseases
Saturday, March 29 \| 5:00PM - 7:00PM RNAi-Based Therapy Room: Sea to Sky Ballroom BC Speaker 2 of 4 Judy Lieberman, Harvard University, USA Silent Treatment for Cancer
Saturday, March 29 \| 5:00PM - 7:00PM RNAi-Based Therapy Room: Sea to Sky Ballroom BC Speaker 3 of 4 Markus Stoffel, ETH Zürich, Switzerland Molecular Mechanisms of Cellular Uptake of Cholesterol-Conjugated RNAs
Saturday, March 29 \| 5:00PM - 7:00PM RNAi-Based Therapy Room: Sea to Sky Ballroom BC Speaker 4 of 4 Morten Lindow, Santaris Pharma, Denmark Short Talk: LNA-Mediated microRNA Silencing in non-Human Primates
Saturday, March 29 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Sea to Sky Ballroom A, Foyer
Saturday, March 29 \| 8:00PM - 11:00PM Entertainment Room: Sea to Sky Ballroom A, Foyer
Saturday, March 29 \| 8:00PM - 11:00PM Cash Bar Room: Sea to Sky Ballroom A, Foyer
Sunday, March 30 \| 10:25AM - 10:25AM Departure *Session Chair.