Web Desc
Inflammation, Microenvironment and Cancer
Organizer(s): Michael Karin and Mina J. Bissell
Date: March 30 - April 04, 2008
Location: Snowbird Resort, Snowbird, UT, USA
Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development
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Summary of Meeting:
In recent years it has become increasingly clear that the inflammatory and innate immune system plays a critical role in cancer development and progression. Initial hints for a potential link between infection, inflammation and cancer came from epidemiological studies. However the subsequent proof of a mechanistic link between inflammation and cancer came from studies in mouse models of cancer. Such studies have highlighted the important function of cells of the innate immune system, especially macrophages, in cancer development and progression. In addition such studies provided evidence for the important pro-carcinogenic function of certain inflammatory signal transduction pathways, especially those leading to NF-kappaB activation. However, it is also becoming evident that the adaptive immune system has a considerable impact on tumor development that can be both negative and positive. Undoubtedly, future development of immunotherapeutic approaches to cancer treatment will have to consider all of these factors and manipulate them in a way that will allow more effective tumor elimination. This meeting will consider the different mechanisms and pathways through which inflammation and immunity affect cancer development. In addition, the contribution of other cells in the tumor microenvironments, such as myofibroblasts and cancer stem cells, will be discussed. Presentations will include state-of-the-art animal studies indicating that even potent oncogenes do not lead to cancer without assistance from activated inflammatory cells. In addition to being a fertile area for research and an important source for new ideas in cancer biology, the inflammation and cancer field is likely to provide us with novel therapeutic opportunities. This meeting will therefore be a source of inspiration of basic and translational researchers alike.
Scholarship Deadline: December 4 2007
Discounted Abstract Deadline: December 4 2007
Abstract Deadline: January 2 2008
Discounted Registration Deadline: January 30 2008
We gratefully acknowledge additional support for this conference from:
EntreMed, Inc.Pfizer Global Research & Development
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13CA132250-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, March 30 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Sunday, March 30 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Lobby


Sunday, March 30 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Alberto Mantovani, Humanitas University, Italy
Inflammation and Cancer: An Intrinsic and an Extrinsic Pathway

Monday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Monday, March 31 | 8:00AM - 11:00AM
Innate Immunity and Cancer
Room: Ballroom 2-3

Speaker 1 of 4
* Jürg Tschopp, University of Lausanne, Switzerland
RNA Helicases and HCV

Monday, March 31 | 8:00AM - 11:00AM
Innate Immunity and Cancer
Room: Ballroom 2-3

Speaker 2 of 4
Laurence Zitvogel, Institut Gustave Roussy, France
The Molecular Bases of the Immunogenicity of Cell Death

Monday, March 31 | 8:00AM - 11:00AM
Innate Immunity and Cancer
Room: Ballroom 2-3

Speaker 3 of 4
Vishva M. Dixit, Genentech, Inc., USA
Role of cIAP1/2 in the Non-Canonical NF-kappaB Survival Pathway

Monday, March 31 | 8:00AM - 11:00AM
Innate Immunity and Cancer
Room: Ballroom 2-3

Speaker 4 of 4
Robert D. Schreiber, Washington University School of Medicine, USA
Cancer Immunoediting: Distinct Roles for Innate and Adaptive Immunity in Cancer Control and Promotion

Monday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Monday, March 31 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, March 31 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Monday, March 31 | 5:00PM - 7:00PM
Adaptive Immunity
Room: Ballroom 2-3

Speaker 1 of 4
Martin Oft, ARMO BioSciences, USA
IL-23 Induces Immune Deviation in Tumors

Monday, March 31 | 5:00PM - 7:00PM
Adaptive Immunity
Room: Ballroom 2-3

Speaker 2 of 4
* Hans Schreiber, University of Chicago, USA
Stromal Cross-Presentation and the Destruction of the Tumor Microenvironment by T Cells

Monday, March 31 | 5:00PM - 7:00PM
Adaptive Immunity
Room: Ballroom 2-3

Speaker 3 of 4
George C. Prendergast, Lankenau Institute for Medical Research, USA
Genetics and Therapeutic Correction of Immune Escape in Cancer

Monday, March 31 | 5:00PM - 7:00PM
Adaptive Immunity
Room: Ballroom 2-3

Speaker 4 of 4
Matthias Ernst, Olivia Newton-John Cancer Research Institute, Australia
Short Talk: Stat3 and Stat1 Functionally Cooperate in IL-11-Dependent, Inflammation-Associated Gastric Cancer in gp130 Mutant Mice

Monday, March 31 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Monday, March 31 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Tuesday, April 01 | 8:00AM - 11:00AM
Microenvironment
Room: Ballroom 2-3

Speaker 1 of 4
Claire E. Lewis, University of Sheffield Medical School, UK
Activation of the Potent, Pro-Tumour Functions of Macrophages by the Tumour Microenvironment

Tuesday, April 01 | 8:00AM - 11:00AM
Microenvironment
Room: Ballroom 2-3

Speaker 2 of 4
Randall S. Johnson, University of Cambridge, UK
Hypoxia

Tuesday, April 01 | 8:00AM - 11:00AM
Microenvironment
Room: Ballroom 2-3

Speaker 3 of 4
Shahin Rafii, Weill Cornell Medical College, USA
Contribution of Pro-Angiogenic Hematopoietic Cells to Tumor Growth

Tuesday, April 01 | 8:00AM - 11:00AM
Microenvironment
Room: Ballroom 2-3

Speaker 4 of 4
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Control of Cell Deaths in Tumour Microenviroment

Tuesday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Tuesday, April 01 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 01 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Tuesday, April 01 | 5:00PM - 7:00PM
Cytokines and Chemokines
Room: Ballroom 2-3

Speaker 1 of 3
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Targeting Inflammatory Cytokines in the Tumor Microenvironment

Tuesday, April 01 | 5:00PM - 7:00PM
Cytokines and Chemokines
Room: Ballroom 2-3

Speaker 2 of 3
Markus F. Neurath, University Hospital Erlangen, Germany
IL-6 in Chronic Intestinal Inflammation and Colon Cancer

Tuesday, April 01 | 5:00PM - 7:00PM
Cytokines and Chemokines
Room: Ballroom 2-3

Speaker 3 of 3
* Ann Richmond, Vanderbilt University School of Medicine, USA
Chemokines and Cancer Biology

Tuesday, April 01 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Tuesday, April 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Wednesday, April 02 | 8:00AM - 11:00AM
Animal Models
Room: Ballroom 2-3

Speaker 1 of 5
Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas, Spain
Ras Oncogenes, Inflammation and Pancreatic Cancer

Wednesday, April 02 | 8:00AM - 11:00AM
Animal Models
Room: Ballroom 2-3

Speaker 2 of 5
* Dafna Bar-Sagi, New York University School of Medicine, USA
Chronic Inflammation and the Pathogenesis of Pancreatic Cancer

Wednesday, April 02 | 8:00AM - 11:00AM
Animal Models
Room: Ballroom 2-3

Speaker 3 of 5
Lisa M. Coussens, Oregon Health & Science University, USA
Polarized Immune Responses Differentially Regulate Cancer Development

Wednesday, April 02 | 8:00AM - 11:00AM
Animal Models
Room: Ballroom 2-3

Speaker 4 of 5
Eli Pikarsky, Hadassah, Hebrew University Medical Center, Israel
Short Talk: Molecular Mechanisms for Liver Tumor Inhibition by non Steroidal Anti- Inflammatory Drugs

Wednesday, April 02 | 8:00AM - 11:00AM
Animal Models
Room: Ballroom 2-3

Speaker 5 of 5
Michael Karin, University of California, San Diego, USA
Inflammatory Processes in Metastatic Progression

Wednesday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Wednesday, April 02 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, April 02 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Wednesday, April 02 | 5:00PM - 7:00PM
Bacteria Viruses Tissue Injury
Room: Ballroom 2-3

Speaker 1 of 4
James G. Fox, Massachusetts Institute of Technology, USA
Helicobacters, Chronic Inflammation and Cancer

Wednesday, April 02 | 5:00PM - 7:00PM
Bacteria Viruses Tissue Injury
Room: Ballroom 2-3

Speaker 2 of 4
Timothy C. Wang, Columbia University, USA
Gastric Cancer

Wednesday, April 02 | 5:00PM - 7:00PM
Bacteria Viruses Tissue Injury
Room: Ballroom 2-3

Speaker 3 of 4
* Erwin F. Wagner, Spanish National Cancer Research Centre, Spain
AP-1(Fos/Jun) in Inflammation and Cancer Development

Wednesday, April 02 | 5:00PM - 7:00PM
Bacteria Viruses Tissue Injury
Room: Ballroom 2-3

Speaker 4 of 4
Xin-Yuan Fu, National University of Singapore, Singapore
Short Talk: Stats and Inflammation

Wednesday, April 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Wasatch/Maybird


Wednesday, April 02 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Wasatch/Maybird


Thursday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles


Thursday, April 03 | 8:00AM - 11:00AM
Fibroblasts and Stem Cells
Room: Ballroom 2-3

Speaker 1 of 4
Nancy J. Boudreau, NCI, National Institutes of Health, USA
The Role of Microenvironment in Breast Cancer and Mammary Cell Fate

Thursday, April 03 | 8:00AM - 11:00AM
Fibroblasts and Stem Cells
Room: Ballroom 2-3

Speaker 2 of 4
Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Regulation of in Situ to Invasive Carcinoma Transition

Thursday, April 03 | 8:00AM - 11:00AM
Fibroblasts and Stem Cells
Room: Ballroom 2-3

Speaker 3 of 4
Judith Campisi, Buck Institute for Research on Aging, USA
The Pro-Inflammatory and Pro-Carcinogenic Senescent Microenvironment

Thursday, April 03 | 8:00AM - 11:00AM
Fibroblasts and Stem Cells
Room: Ballroom 2-3

Speaker 4 of 4
Harold L. Moses, Vanderbilt University, USA
TGF-beta and Metastasis

Thursday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Lobby & Mezzanine


Thursday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Ballroom Lobby & Mezzanine


Thursday, April 03 | 5:00PM - 7:15PM
Therapeutics
Room: Ballroom 2-3

Speaker 1 of 5
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Targeting Host Stromal Microenvironment in Developing New Cancer Therapies

Thursday, April 03 | 5:00PM - 7:15PM
Therapeutics
Room: Ballroom 2-3

Speaker 2 of 5
Roya Khosravi-Far, Harvard Medical School, Beth Israel Deaconess Medical Center, USA
A Novel Connection between the Bcr-Abl and the Forkhead Family of Tumor Suppressors

Thursday, April 03 | 5:00PM - 7:15PM
Therapeutics
Room: Ballroom 2-3

Speaker 3 of 5
* David A. Cheresh, University of California, San Diego, USA
Raf Kinase as Target for Tumor Growth and Angiogenesis

Thursday, April 03 | 5:00PM - 7:15PM
Therapeutics
Room: Ballroom 2-3

Speaker 4 of 5
Douglas Hanahan, ISREC, Switzerland
Short Talk: Distinctive Pro-Angiogenic Roles by Cancer-Associated Fibroblasts and Inflammatory Macrophages in the Neoplasctic Cell Enveronment.

Thursday, April 03 | 5:00PM - 7:15PM
Therapeutics
Room: Ballroom 2-3

Speaker 5 of 5
George C. Prendergast, Lankenau Institute for Medical Research, USA
Genetics and Therapeutic Correction of Immune Escape in Cancer

Thursday, April 03 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Ballroom 2-3


Thursday, April 03 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Thursday, April 03 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, April 04 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.