Web Desc
Molecular Basis for Chromatin Modifications and Epigenetic Phenomena
Organizer(s): Peter Fraser, Sepideh Khorasanizadeh and Asifa Akhtar
Date: April 07 - 12, 2008
Location: Snowmass Resort, Snowmass, CO, USA
Supported by the Director's Fund
Summary of Meeting:
Many chromatin modifications and structures are surprisingly dynamic, yet are involved in initiating and heritably maintaining distinct gene expression patterns that direct and preserve cellular identities. The molecules that target and regulate these modifications and how they influence—and may be influenced by—higher-order chromatin structures, nuclear organization, and various nuclear processes, are areas of intense interest and excitement. This meeting will examine the latest discoveries surrounding the molecular basis of chromatin modifications and explore their connections to various biological processes and epigenetic phenomena such as dosage compensation, imprinting, heterochromatin formation and gene expression in differentiation, development and disease. The goal is to promote a more integrated picture of the molecular interrelationships between chromatin structure and function that exercise the hidden regulatory information in the genomes of complex organisms.
Scholarship Deadline: December 7 2007
Discounted Abstract Deadline: December 7 2007
Abstract Deadline: January 10 2008
Discounted Registration Deadline: February 7 2008
We gratefully acknowledge additional support for this conference from:
CellCentric Ltd.Integrated DNA TechnologiesMarch of Dimes Foundation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
BioMed Central Ltd
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, April 07 | 3:00PM - 7:30PM
Registration
Room: 1st Floor Foyer


Monday, April 07 | 6:30PM - 7:30PM
Refreshments
Room: 1st Floor Foyer


Monday, April 07 | 7:30PM - 8:30PM
Keynote Address
Room: Anderson Room

Speaker 1 of 2
* Peter Fraser, Florida State University, USA
Introduction

Monday, April 07 | 7:30PM - 8:30PM
Keynote Address
Room: Anderson Room

Speaker 2 of 2
Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
INO80 Chromatin Remodeling Complex at Breaks, Forks and Promoters: A Multitude of Functions

Tuesday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Hoaglund/Erickson/ Carrol/Sinclair


Tuesday, April 08 | 8:00AM - 11:15AM
Post-Translational Modifications of Histones
Room: Anderson Room

Speaker 1 of 6
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany

Tuesday, April 08 | 8:00AM - 11:15AM
Post-Translational Modifications of Histones
Room: Anderson Room

Speaker 2 of 6
Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Role of Histone Methylation in Germ Cell Development and Stem Cell Pluripotency

Tuesday, April 08 | 8:00AM - 11:15AM
Post-Translational Modifications of Histones
Room: Anderson Room

Speaker 3 of 6
Kristian Helin, University of Copenhagen and Memorial Sloan Kettering Cancer Center, Denmark
Epigenetic Control and the Development of Cancer

Tuesday, April 08 | 8:00AM - 11:15AM
Post-Translational Modifications of Histones
Room: Anderson Room

Speaker 4 of 6
Zhibin Wang, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Combinatorial Patterns of Histone Acetylations and Methylations in the Human Genome

Tuesday, April 08 | 8:00AM - 11:15AM
Post-Translational Modifications of Histones
Room: Anderson Room

Speaker 5 of 6
Craig L. Peterson, University of Massachusetts Medical School, USA
Histone Modifications and Chromatin Structure

Tuesday, April 08 | 8:00AM - 11:15AM
Post-Translational Modifications of Histones
Room: Anderson Room

Speaker 6 of 6
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Short Talk: H2AZ is Enriched at Polycomb Group Protein Target Regions in ES Cells and is Required for Proper Execution of Developmental Programs

Tuesday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Hoaglund/Erickson/ Carrol/Sinclair


Tuesday, April 08 | 11:00AM - 1:00PM
Poster Setup
Room: Hoaglund/Erickson/ Carrol/Sinclair


Tuesday, April 08 | 11:00AM - 11:00AM
On Own for Lunch


Tuesday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Hoaglund/Erickson/ Carrol/Sinclair


Tuesday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Hoaglund/Erickson/ Carrol/Sinclair


Tuesday, April 08 | 5:00PM - 7:00PM
Atomic Structures of Chromatin Protein Complexes
Room: Anderson Room

Speaker 1 of 5
Vidya Subramanian, Massachusetts Institute of Technology, USA
Histone Chaperones: Structure, Function, and Regulation

Tuesday, April 08 | 5:00PM - 7:00PM
Atomic Structures of Chromatin Protein Complexes
Room: Anderson Room

Speaker 2 of 5
Masami Horikoshi, University of Tokyo, Japan
Short Talk: From Histone Modification to Nuclesome Disassembly

Tuesday, April 08 | 5:00PM - 7:00PM
Atomic Structures of Chromatin Protein Complexes
Room: Anderson Room

Speaker 3 of 5
Ji-Joon Song, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Structural Basis of Histone H4 Recognition by p55

Tuesday, April 08 | 5:00PM - 7:00PM
Atomic Structures of Chromatin Protein Complexes
Room: Anderson Room

Speaker 4 of 5
* Sepideh Khorasanizadeh, Sanford Burnham Prebys Medical Discovery Institute, USA
Multiple Roles for Chromodomains in Epigenetic Regulation

Tuesday, April 08 | 5:00PM - 7:00PM
Atomic Structures of Chromatin Protein Complexes
Room: Anderson Room

Speaker 5 of 5
Natalie Nady, Pfizer, USA
Short Talk: Reading the Histone Code by MBT Domains – Structural Insights into MEthyl Mark Recognition

Tuesday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hoaglund/Erickson/ Carrol/Sinclair


Tuesday, April 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 1 of 7
* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Histone Replacement Dynamics

Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 2 of 7
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Slicing, Spreading and Copying Heterochromatin with RNAi

Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 3 of 7
Sevinc Ercan, University of North Carolina, USA
Short Talk: Dynamic and Bimodal Binding of the C. elegans Dosage Compensation Complex

Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 4 of 7
Andrea Schäfer, German Cancer Research Center, Germany
Short Talk: Molecular Mechanism of Active DNA Demethylation

Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 5 of 7
Jessica K. Tyler, Weill Cornell Medicine, USA
Chaperoning Histones

Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 6 of 7
Jonathan Widom, Northwestern University, USA
The Genomic Code for Nucleosome Positioning

Wednesday, April 09 | 8:00AM - 11:15AM
Chromatin Dynamics
Room: Anderson Room

Speaker 7 of 7
Raul A. Urrutia, Mayo Clinic Rochester, USA
Subcodes within the Histone Code

Wednesday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 11:15AM - 1:00PM
Poster Setup
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 5:00PM - 7:00PM
Stem Cell Chromatin Dynamics
Room: Anderson Room

Speaker 1 of 6
* Wolf Reik, Babraham Institute, UK

Wednesday, April 09 | 5:00PM - 7:00PM
Stem Cell Chromatin Dynamics
Room: Anderson Room

Speaker 2 of 6
Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development

Wednesday, April 09 | 5:00PM - 7:00PM
Stem Cell Chromatin Dynamics
Room: Anderson Room

Speaker 3 of 6
Bradley E. Bernstein, Massachusetts General Hospital, USA
Chromatin Landscapes of Pluripotent and Lineage-Committed Cells

Wednesday, April 09 | 5:00PM - 7:00PM
Stem Cell Chromatin Dynamics
Room: Anderson Room

Speaker 4 of 6
Neil Brockdorff, University of Oxford, UK
Chromatin Regulation by H2A Ubiquitylation

Wednesday, April 09 | 5:00PM - 7:00PM
Stem Cell Chromatin Dynamics
Room: Anderson Room

Speaker 5 of 6
Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Short Talk: Genome-scale DNA Methylation Maps of Pluripotent and Differentiated Cells

Wednesday, April 09 | 5:00PM - 7:00PM
Stem Cell Chromatin Dynamics
Room: Anderson Room

Speaker 6 of 6
Laurie A. Boyer, Massachusetts Institute of Technology, USA
Short Talk: H2AZ is Enriched at Polycomb Group Protein Target Regions in ES Cells and is Required for Proper Execution of Developmental Programs


Wednesday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hoaglund/Erickson/ Carrol/Sinclair


Wednesday, April 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 7:00AM - 8:00AM
Poster Setup
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 1 of 7
* Craig L. Peterson, University of Massachusetts Medical School, USA

Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 2 of 7
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Transposon-Derived Proteins

Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 3 of 7
Francis Stewart, Technische Universitaet Dresden, Germany
The Histone Methyltransferase, Mll2, is only Essential in a Brief Window during Development and for the Germ Lineage

Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 4 of 7
Rebecca A. Mosher, University of Arizona, USA
Short Talk: PolIVb Influences RNA-Directed DNA Methylation and Demethylation Independently of its Role in siRNA Biogenesis

Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 5 of 7
Jürg Müller, Max Planck Institute of Biochemistry, Germany
Transcriptional Control by the Polycomb System

Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 6 of 7
Kai Ge, NIDDK, National Institutes of Health, USA
Isolation of Histone H3K4 Methyltransferase Complexes that Associate with a Histone H3K27 Demethylase

Thursday, April 10 | 8:00AM - 11:15AM
Epigenetics and Chromatin Modification Mechanisms
Room: Anderson Room

Speaker 7 of 7
Matthew Gamble, Albert Einstein College of Medicine, USA
Short Talk: The Histone Variant MacroH2A1 Occupies Large Chromatin Domains and Positively Regulates Genes on Autosomes

Thursday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 11:15AM - 12:15PM
Lunch
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 12:00PM - 2:30PM
Poster Session 3
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 1 of 7
* Janine Arts, Ortho Biotech Oncology Research and Development (J&J), Belgium

Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 2 of 7
Scott A. Armstrong, Dana-Farber Cancer Institute, USA
H3K79 Methylation Abnormalities Define Murine and Human MLL-AF4 Leukemias

Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 3 of 7
Tuncay Baubec, Friedrich Miescher Institute, Switzerland
Zebularine is a Potent Inhibitor of Plant DNA Methylation

Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 4 of 7
Donghang Cheng, MD Anderson Cancer Center, USA
Arginine Methyltransferases as Novel Theraputic Targets for Breast Cancer

Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 5 of 7
Vibhor Gupta, Jawaharlal Nehru University, India
Profiling the Epigenetic and Transcriptional Effects of Histone Deacetylase Inhibitors

Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 6 of 7
Joan Oliva Vilana, LA Biomed, USA
Spontanous Formation of Tumors in Drug Primed DDC Mice: An Epigenetic Phenomena

Thursday, April 10 | 2:30PM - 4:30PM
Workshop: Chromatin as a Drug Target
Room: Anderson Room

Speaker 7 of 7
Pedro Vladimir Pena, University of Colorado Health Sciences Center, USA
Molecular Mechanism of Histone H3K4Me3 Recognition by Plant Homeodomain of ING1 and the Effects of Cancer Specific Mutations

Thursday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Hoaglund/Erickson/ Carrol/Sinclair


Thursday, April 10 | 5:00PM - 7:00PM
Large Scale Epigenetic Control
Room: Anderson Room

Speaker 1 of 5
* Anne C. Ferguson-Smith, University of Cambridge, UK

Thursday, April 10 | 5:00PM - 7:00PM
Large Scale Epigenetic Control
Room: Anderson Room

Speaker 2 of 5
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Dosage Compensation and Chromatin Regulation

Thursday, April 10 | 5:00PM - 7:00PM
Large Scale Epigenetic Control
Room: Anderson Room

Speaker 3 of 5
Edith Heard, European Molecular Biology Laboratory, Germany
Nuclear and Chromatin Dynamics during X-Chromosome Inactivation

Thursday, April 10 | 5:00PM - 7:00PM
Large Scale Epigenetic Control
Room: Anderson Room

Speaker 4 of 5
Wolf Reik, Babraham Institute, UK
Epigenetic Regulation of Lineage Commitment and Pluripotency in the Mammalian Embryo

Thursday, April 10 | 5:00PM - 7:00PM
Large Scale Epigenetic Control
Room: Anderson Room

Speaker 5 of 5
Mareike Puschendorf, Friedrich Miescher Institute, Switzerland
Short Talk: PRC1 and Suv39h Specify Parental Asymmetry at Constitutive Heterochromatin in Early Mouse Embryos

Thursday, April 10 | 7:00PM - 7:00PM
On Own for Dinner


Friday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: Hoaglund/Erickson/ Carrol/Sinclair


Friday, April 11 | 8:00AM - 11:00AM
Nuclear and Chromosome Dynamics
Room: Anderson Room

Speaker 1 of 6
* Edith Heard, European Molecular Biology Laboratory, Germany

Friday, April 11 | 8:00AM - 11:00AM
Nuclear and Chromosome Dynamics
Room: Anderson Room

Speaker 2 of 6
Peter Fraser, Florida State University, USA
3D Transcription Networks

Friday, April 11 | 8:00AM - 11:00AM
Nuclear and Chromosome Dynamics
Room: Anderson Room

Speaker 3 of 6
Yijun Ruan, The Jackson Laboratory for Genomic Medicine, USA
A Whole Genome View of Long-Range Chromatin Interactions in Transcription Regulation

Friday, April 11 | 8:00AM - 11:00AM
Nuclear and Chromosome Dynamics
Room: Anderson Room

Speaker 4 of 6
Michael R. Hübner, Cold Spring Harbor Laboratory, USA
Short Talk: Dynamic Analysis and Induction of Polycomb Bodies at a Specific Genetic Locus

Friday, April 11 | 8:00AM - 11:00AM
Nuclear and Chromosome Dynamics
Room: Anderson Room

Speaker 5 of 6
Vicki L. Chandler, Minerva Schools at Keck Graduate Institute, USA
Interchromosomal Transfer of Epigenetic Information

Friday, April 11 | 8:00AM - 11:00AM
Nuclear and Chromosome Dynamics
Room: Anderson Room

Speaker 6 of 6
Anton Krumm, University of Washington Medical Center, USA
Short Talk: Role of Cohesion in Interphase Chromatin

Friday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Hoaglund/Erickson/ Carrol/Sinclair


Friday, April 11 | 11:00AM - 11:00AM
On Own for Lunch


Friday, April 11 | 4:30PM - 5:00PM
Coffee Available
Room: Hoaglund/Erickson/ Carrol/Sinclair


Friday, April 11 | 5:00PM - 7:00PM
Epigenomics and Disease
Room: Anderson Room

Speaker 1 of 5
* Peter Fraser, Florida State University, USA

Friday, April 11 | 5:00PM - 7:00PM
Epigenomics and Disease
Room: Anderson Room

Speaker 2 of 5
Robert J. Sims, Constellation Pharmaceuticals, USA
Mechanisms of Epigenetic Signaling

Friday, April 11 | 5:00PM - 7:00PM
Epigenomics and Disease
Room: Anderson Room

Speaker 3 of 5
Janine Arts, Ortho Biotech Oncology Research and Development (J&J), Belgium
Chromatin as a Drug Target

Friday, April 11 | 5:00PM - 7:00PM
Epigenomics and Disease
Room: Anderson Room

Speaker 4 of 5
Anne C. Ferguson-Smith, University of Cambridge, UK
The Establishment and Maintenance of Genomic Methylation Imprints

Friday, April 11 | 5:00PM - 7:00PM
Epigenomics and Disease
Room: Anderson Room

Speaker 5 of 5
Nathan R. Rose, University of Oxford, UK
Short Talk: Structural and Mechanistic Studies on the JMJD2 Histone Demethylases

Friday, April 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Hoaglund/Erickson/ Carrol/Sinclair


Friday, April 11 | 8:00PM - 11:00PM
Entertainment
Room: Hoaglund/Erickson/ Carrol/ Sinclair


Friday, April 11 | 8:00PM - 11:00PM
Cash Bar
Room: Hoaglund/Erickson/ Carrol/ Sinclair


Saturday, April 12 | 10:25AM - 10:25AM
Departure


*Session Chair.