Web Desc
Molecular Evolution as a Driving Force in Infectious Diseases
Organizer(s): Jeffery K. Taubenberger, Edward C. Holmes and Thomas S. Whittam
Date: April 08 - 13, 2008
Location: Beaver Run Resort, Breckenridge, CO, USA
Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Infectious diseases have been a key driving force in evolution, both of the hosts and the pathogens. The era of genomics has made it possible to evaluate both infectious agents and their hosts at the genomic level. The evolutionary dynamics of viruses, bacteria and parasites, in their adaptive evolution to changes in host response or adaptation to new hosts is enormously complex. The burden of infectious diseases on people and domestic animals is staggering. We are only now beginning to achieve an understanding of how infectious organisms cause disease and how the complex patterns of immune response generated by their infections mitigate it. By bringing together experts in the evolution of viruses, bacteria and parasites, plus those studying host adaptation and evolution of the immune response, we hope that this meeting will stimulate further interaction between widely disparate lines of investigation.
Global Health Travel Award Deadline: November 12 2007
Scholarship Deadline: December 10 2007
Discounted Abstract Deadline: December 10 2007
Abstract Deadline: January 14 2008
Discounted Registration Deadline: February 11 2008
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome Fund
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI078558-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5U13AI60000-05
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 08 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, April 08 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, April 08 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 2
* Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA

Tuesday, April 08 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 4-5

Speaker 2 of 2
David J. Weatherall, University of Oxford, John Radcliffe Hospital, UK
The Role of Genetic Variation in Susceptibility to Malaria in Human Evolution: Was Haldane Right?

Wednesday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Wednesday, April 09 | 8:00AM - 11:15AM
RNA Viruses I
Room: Peak 5

Speaker 1 of 6
Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA
The Evolutionary Dynamics of Influenza A Viruses

Wednesday, April 09 | 8:00AM - 11:15AM
RNA Viruses I
Room: Peak 5

Speaker 2 of 6
* Edward C. Holmes, University of Sydney, Australia
The Molecular Evolution and Phylodynamics of Dengue Virus


Wednesday, April 09 | 8:00AM - 11:15AM
RNA Viruses I
Room: Peak 5

Speaker 3 of 6
Oliver G. Pybus, University of Oxford, UK
Integrating Evolutionary and Epidemiological Dynamics: HIV and the Hepatitis C Virus

Wednesday, April 09 | 8:00AM - 11:15AM
RNA Viruses I
Room: Peak 5

Speaker 4 of 6
Paul A. Rota, Centers for Disease Control, USA
Molecular Epidemiology of Measles and Mumps Viruses

Wednesday, April 09 | 8:00AM - 11:15AM
RNA Viruses I
Room: Peak 5

Speaker 5 of 6
Philippe Lemey, Katholieke Universiteit Leuven, Belgium
Short Talk: Tracing Virus Migration Using Bayesian Phylogeographic Inference

Wednesday, April 09 | 8:00AM - 11:15AM
RNA Viruses I
Room: Peak 5

Speaker 6 of 6
Naomi Lynne Forrester, University of Texas Medical Branch, USA
Short Talk: Use of Phylogenetic Analysis to Reveal the Evolution, Epidemiology and Origin of Rabbit Haemorrhagic Disease Virus

Wednesday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, April 09 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-4


Wednesday, April 09 | 11:15AM - 11:15AM
On Own for Lunch


Wednesday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-4


Wednesday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, April 09 | 5:00PM - 7:00PM
RNA Viruses II
Room: Peak 5

Speaker 1 of 5
* Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA

Wednesday, April 09 | 5:00PM - 7:00PM
RNA Viruses II
Room: Peak 5

Speaker 2 of 5
Kathryn V. Holmes, University of Colorado School of Medicine, USA
Coronaviruses and Host Adaptation

Wednesday, April 09 | 5:00PM - 7:00PM
RNA Viruses II
Room: Peak 5

Speaker 3 of 5
Alan D.T. Barrett, University of Texas Medical Branch, USA
Introduction of West Nile Virus into North America: Of Humans, Birds, Mosquitoes and Mice

Wednesday, April 09 | 5:00PM - 7:00PM
RNA Viruses II
Room: Peak 5

Speaker 4 of 5
Michael G. Katze, University of Washington, USA
Functional Genomics will Save the World from Killer Viruses (but it Better Happen Soon!)

Wednesday, April 09 | 5:00PM - 7:00PM
RNA Viruses II
Room: Peak 5

Speaker 5 of 5
Chung-Chau Hon, University of Hong Kong, Hong Kong
Short Talk: Evidence of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus

Wednesday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Wednesday, April 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-4


Thursday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Thursday, April 10 | 7:00AM - 8:00AM
Poster Setup
Room: Peaks 1-4


Thursday, April 10 | 8:00AM - 11:15AM
DNA Viruses
Room: Peak 5

Speaker 1 of 5
Elliot J. Lefkowitz, University of Alabama at Birmingham, USA
Gene Acquisition and Gene Loss as Controlling Events in Poxvirus Speciation and Pathogenesis

Thursday, April 10 | 8:00AM - 11:15AM
DNA Viruses
Room: Peak 5

Speaker 2 of 5
* Colin R. Parrish, Cornell University, USA
Variation and Evolution of Parvoviruses and the Controls of Host Ranges

Thursday, April 10 | 8:00AM - 11:15AM
DNA Viruses
Room: Peak 5

Speaker 3 of 5
Thomas F. Schulz, Medizinische Hochschule Hannover, Germany
Functional Diversification of a Terminal Membrane Protein during Rhadinoviral Evolution

Thursday, April 10 | 8:00AM - 11:15AM
DNA Viruses
Room: Peak 5

Speaker 4 of 5
Mary R. Odom, University of Alabama, Birmingham, USA
Short Talk: Poxvirus Gene Evolution: The Contribution of Gene Capture from the Host

Thursday, April 10 | 8:00AM - 11:15AM
DNA Viruses
Room: Peak 5

Speaker 5 of 5
Edgar E. Sevilla-Reyes, Instituto Nacional de Enfermedades Respiratorias, Mexico
Short Talk: The Dynamic Gene Content of Human Cytomegalovirus

Thursday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 10 | 11:15AM - 12:00PM
Lunch
Room: Peaks 1-4


Thursday, April 10 | 12:00PM - 2:30PM
Poster Session 2
Room: Peaks 1-4


Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 1 of 9
* Edward C. Holmes, University of Sydney, Australia

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 2 of 9
Nels C. Elde, University of Utah, USA
Adaptive Evolution of Protein Kinase R Defeats a Substrate Mimic Encoded by Poxviruses

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 3 of 9
Willem M. van Ballegooijen, National Institute of Public Health and the Environment, Netherlands
DNA of Hepatitis B Virus Reveals Impact of Vaccination

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 4 of 9
Elodie Ghedin, New York University, USA
Intra-Host Diversity and Evolutionary Dynamics of Influenza Virus

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 5 of 9
Ma Luo, University of Manitoba, Canada
Rapid Selection for HLA alleles that Protect against HIV-1 Infection Correlates Significantly to the Declining Incidence of HIV-1 in an East African Sex Worker Population

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 6 of 9
Molly Ohainle, Fred Hutchinson Cancer Research Center, USA
The Conserved Anti-Retroelemement Activity of APOBEC3H was Independently Lost Twice in Recent Human Evolution

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 7 of 9
Bouke C. de Jong, Institute of Tropical Medicine, Antwerp, Belgium
Mycobacterium Africanum: First to Arrive in West Africa?

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 8 of 9
Joel O. Wertheim, University of Arizona, USA
Dating the Origin of SIV from Sooty Mangabey using a Relaxed Molecular Clock

Thursday, April 10 | 2:30PM - 4:30PM
Workshop
Room: Peaks 4-5

Speaker 9 of 9
Tsan Yuk (Tommy) Lam, University of Hong Kong, China
Transmission Dynamics of Natural Reassortant H5N1 Influenza Viruses in Indonesia

Thursday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, April 10 | 5:00PM - 7:00PM
Retroviruses
Room: Peak 5

Speaker 1 of 4
Beatrice H. Hahn, University of Pennsylvania, USA
Origins of HIV-1 and Adaptation to its Human Host

Thursday, April 10 | 5:00PM - 7:00PM
Retroviruses
Room: Peak 5

Speaker 2 of 4
John V. Moran, University of Michigan Medical School, USA
Studies of a Human Transposable Element

Thursday, April 10 | 5:00PM - 7:00PM
Retroviruses
Room: Peak 5

Speaker 3 of 4
* Nathan D. Wolfe, University of California, Los Angeles, USA
Cross-Species Transmission and Establishment of Novel Human Retroviruses

Thursday, April 10 | 5:00PM - 7:00PM
Retroviruses
Room: Peak 5

Speaker 4 of 4
Christine L. Clouser, University of Minnesota, USA
Short Talk: Exploiting the Mutation Rate of HIV

Thursday, April 10 | 7:00PM - 7:00PM
On Own for Dinner


Friday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Friday, April 11 | 8:00AM - 11:00AM
Bacteria I
Room: Peak 5

Speaker 1 of 6
Eun Chung Park, NIAID, USA
Short Talk

Friday, April 11 | 8:00AM - 11:00AM
Bacteria I
Room: Peak 5

Speaker 2 of 6
David Alland, Rutgers University, New Jersey Medical School, USA
Evaluating the Evolution of Drug Resistance in Mycobacterium Tuberculosis

Friday, April 11 | 8:00AM - 11:00AM
Bacteria I
Room: Peak 5

Speaker 3 of 6
M. Cristina Gutiérrez Perez, Institut Pasteur, France
Mycobacterium tuberculosis and other Mycobacteria: Rethinking Tuberculosis in the Light of Evolution

Friday, April 11 | 8:00AM - 11:00AM
Bacteria I
Room: Peak 5

Speaker 4 of 6
* Bruce R. Levin, Emory University, USA
The Evolution, Rate and Population Genetics of Recombination in Bacteria with a Particular Focus on Transformation: An Opinionated Rant

Friday, April 11 | 8:00AM - 11:00AM
Bacteria I
Room: Peak 5

Speaker 5 of 6
Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: A Multilocus Sequence Analysis of Mycobacterium tuberculosis

Friday, April 11 | 8:00AM - 11:00AM
Bacteria I
Room: Peak 5

Speaker 6 of 6
Anne M. Buboltz, Pennsylvania State University, USA
Short Talk: Replacement of Adenylate Cyclase Toxin in a Prominent Lineage of Bordetella bronchiseptica

Friday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 11 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-4


Friday, April 11 | 11:15AM - 11:15AM
On Own for Lunch


Friday, April 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-4


Friday, April 11 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, April 11 | 5:00PM - 7:00PM
Bacteria II
Room: Peak 5

Speaker 1 of 4
* James M. Musser, Methodist Hospital Research Institute, USA
Evolution of Virulence in Group A Streptococcus, the Flesh-Eater

Friday, April 11 | 5:00PM - 7:00PM
Bacteria II
Room: Peak 5

Speaker 2 of 4
Nancy A. Moran, University of Texas at Austin, USA
The Evolutionary Genomics of Bacterial Symbionts in Insects

Friday, April 11 | 5:00PM - 7:00PM
Bacteria II
Room: Peak 5

Speaker 3 of 4
Mark Achtman, University College Cork, Ireland
Helicobacter pylori

Friday, April 11 | 5:00PM - 7:00PM
Bacteria II
Room: Peak 5

Speaker 4 of 4
Martin Antonio, Medical Research Council Laboratories, Gambia
Short Talk: Enhanced Invasiveness of ST618 Streptococcus pneumoniae Serotype 1 Clone from The Gambia, West Africa

Friday, April 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Friday, April 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 1-4


Saturday, April 12 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 1-4


Saturday, April 12 | 8:00AM - 11:00AM
Parasites and Host Evolution I
Room: Peak 5

Speaker 1 of 5
Mark Achtman, University College Cork, Ireland
Salmonela Thypi and Versinia Pestis

Saturday, April 12 | 8:00AM - 11:00AM
Parasites and Host Evolution I
Room: Peak 5

Speaker 2 of 5
Wendy Gibson, University of Bristol, UK
Evolution of the Pathogenic Trypanosomes

Saturday, April 12 | 8:00AM - 11:00AM
Parasites and Host Evolution I
Room: Peak 5

Speaker 3 of 5
* Peter Parham, Stanford University, USA
Host Evolution: Interactions between Polymorphic Human Receptors and Ligands that Influence Immune Defense and Reproduction

Saturday, April 12 | 8:00AM - 11:00AM
Parasites and Host Evolution I
Room: Peak 5

Speaker 4 of 5
Peter Sarnow, Stanford University School of Medicine, USA
Host Evolution: Evolution of microRNA miR-122 to Aid in Hepatitis C Virus Replication

Saturday, April 12 | 8:00AM - 11:00AM
Parasites and Host Evolution I
Room: Peak 5

Speaker 5 of 5
Jenny Tan, Genome Institute of Singapore, Singapore
Short Talk: Elevated Levels of Common Nonsynonymous Variants in the Human Macrophage Receptor Gene, EMR1, Result from Balancing Selection

Saturday, April 12 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 12 | 11:00AM - 11:00AM
On Own for Lunch


Saturday, April 12 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, April 12 | 5:00PM - 7:00PM
Parasites and Host Evolution II
Room: Peak 5

Speaker 1 of 4
* Martin F. Flajnik, University of Maryland, USA
Evolution of Adaptive Immunity

Saturday, April 12 | 5:00PM - 7:00PM
Parasites and Host Evolution II
Room: Peak 5

Speaker 2 of 4
Richard Carter, University of Edinburgh, UK
Plasmodium vivax: Where in the World has it Been?

Saturday, April 12 | 5:00PM - 7:00PM
Parasites and Host Evolution II
Room: Peak 5

Speaker 3 of 4
Sunetra Gupta, University of Oxford, UK
Transmission Dynamics and Evolution of the Influenza Virus

Saturday, April 12 | 5:00PM - 7:00PM
Parasites and Host Evolution II
Room: Peak 5

Speaker 4 of 4
Sara L. Sawyer, University of Texas at Austin, USA
Short Talk: Evolution of the Anti-Retroviral TRIM5 and Related Genes

Saturday, April 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-4


Saturday, April 12 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-4


Saturday, April 12 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-4


Sunday, April 13 | 10:25AM - 10:25AM
Departure


*Session Chair.