Web Desc
Cell Biology of Virus Entry, Replication and Pathogenesis
Organizer(s): Robert W. Doms, Beth Levine, Herbert (Skip) W. Virgin IV, and Robert A. Lamb
Date: April 13 - 18, 2008
Location: Fairmont Empress Victoria / Victoria Conference Centre, Victoria, BC, Canada
Supported by the Director's Fund
Summary of Meeting:
Advances in structural biology have provided great insight into virus entry and assembly. The increasing use of whole genome screens, such as RNAi screens, has greatly accelerated the discovery of host factors needed for virus replication. Mechanisms underlying innate immunity and how viruses evade immune responses continue to be identified and provide fascinating insights into viral pathogenesis. Putting everything together to understand viral pathogenesis remains a central goal in this field. This meeting brings together experts on all facets of viral life cycles to develop insights into how viruses cause disease, and how this may be prevented.
Scholarship Deadline: December 13 2007
Discounted Abstract Deadline: December 13 2007
Abstract Deadline: January 14 2008
Discounted Registration Deadline: February 13 2008
We gratefully acknowledge additional support for this conference from:
Burroughs Wellcome Fund
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13AI078578-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 5U13AI60000-05
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, April 13 | 3:00PM - 7:30PM
Registration
Room: Victoria Conference Center-Level 2


Sunday, April 13 | 6:30PM - 7:30PM
Refreshments
Room: Victoria Conference Center- Level 2


Sunday, April 13 | 7:30PM - 8:30PM
Keynote Address
Room: Salon A

Speaker 1 of 1
Bernard Moss, National Institutes of Health, USA
Through the Looking Glass: Stratagems of a Cytoplasmic DNA Virus

Monday, April 14 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court / Crystal Ballroom


Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 1 of 7
* Robert A. Lamb, Northwestern University, USA

Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 2 of 7
Stephen C. Harrison, Harvard Medical School, USA
Molecular Mechanisms of Non-Enveloped Viral Entry

Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 3 of 7
Margaret Kielian, Albert Einstein College of Medicine, USA
Virus-Membrane Fusion: Mechanisms and Inhibition of Class II Fusion Proteins.

Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 4 of 7
Yves Gaudin, CNRS, France
Structural Studies on the Vesicular Stomatitis Glycoprotein G: Membrane Fusion Revisited

Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 5 of 7
Ari Helenius, ETH Zurich, Switzerland
New Pathways of Virus Entry

Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 6 of 7
Jeffrey E. Lee, The Scripps Research Institute, USA
Short Talk: Crystal Structure of the Trimeric, Prefusion Ebola Virus Glycoprotein in Complex with an Antibody from a Human Survivor

Monday, April 14 | 8:00AM - 11:15AM
Viral Structure and Entry
Room: Salon A

Speaker 7 of 7
Karin Stiasny, Medical University of Vienna, Austria
Short Talk: Dissection of the Flavivirus Membrane Fusion Pathway

Monday, April 14 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center-Level 2


Monday, April 14 | 11:15AM - 1:00PM
Poster Setup
Room: Salon B


Monday, April 14 | 11:15AM - 11:15AM
On Own for Lunch


Monday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon B


Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 1 of 9
* Robert W. Doms, University of Pennsylvania School of Medicine, USA

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 2 of 9
Nicky E. Martin, University of Oxford, UK
Novel Role for beta 1 Integrin Revealed by Studies of Ebola Virus Entry: Regulation of Cathepsin Activity


Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 3 of 9
Mei Lin Z. Bissonnette, Northwestern University, USA
Residues in the Outer Leaflet of the Transmembrane Domain of the Parainfluenza Virus 5 Fusion Protein are Critical for Membrane Fusion

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 4 of 9
Rahel Byland, University Children Hospital Zurich, Switzerland
Epstein-Barr Virus Binding to Epithelial Cells Triggers Signalling Cascades Crucial for Virus Entry

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 5 of 9
Henrik Garoff, Karolinska Institute, Sweden
Turning of the Receptor Binding Domains Opens up the Env of Moloney Murine Leukemia Virus for Membrane Fusion

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 6 of 9
Michael J. Root, Thomas Jefferson University, USA
Asymmetry in HIV-1 Inactivation Following Inhibitor Binding to gp41

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 7 of 9
Peter J.M. Rottier, Utrecht University, Netherlands
Refolding of the Spike Fusion Protein during Coronavirus Entry Involves Progression through Distinct Conformational Stages

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 8 of 9
Judith M. White, University of Virginia Health Sciences Center, USA
Novel Role for beta 1 Integrin Revealed by Studies of Integrins in Ebola Virus Entry: Regulation of Cathepsin L Activity

Monday, April 14 | 2:30PM - 4:30PM
Workshop 1: Viral Structure and Entry
Room: Salon A

Speaker 9 of 9
Kristen M. Guglielmi, Vanderbilt University, USA
Structural and Mutational Analysis of Reovirus Attachment Protein sigma 1 Binding to Junctional Adhesion Molecule-A

Monday, April 14 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center-Level 2


Monday, April 14 | 5:00PM - 7:00PM
Viral Entry
Room: Salon A

Speaker 1 of 4
* James M. Cunningham, Brigham and Women's Hospital, USA
Cysteine Cathepsins are Host Factors for Filovirus Infection

Monday, April 14 | 5:00PM - 7:00PM
Viral Entry
Room: Salon A

Speaker 2 of 4
Carolyn B. Coyne, University of Pittsburgh, USA
Breaking Barriers: How Enteroviruses Enter Polarized Cell Monolayers

Monday, April 14 | 5:00PM - 7:00PM
Viral Entry
Room: Salon A

Speaker 3 of 4
Michael Farzan, The Scripps Research Institute, USA
Receptors, Entry Proteins, and Viral Zoonoses



Monday, April 14 | 5:00PM - 7:00PM
Viral Entry
Room: Salon A

Speaker 4 of 4
Michael S. Kay, University of Utah School of Medicine, USA
Short Talk: Potent D-peptide Inhibitors of HIV-1 Entry

Monday, April 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon B


Monday, April 14 | 7:30PM - 10:00PM
Poster Session 1
Room: Salon B


Tuesday, April 15 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court / Crystal Ballroom


Tuesday, April 15 | 8:00AM - 11:15AM
Viral Movement and Trafficking
Room: Salon A

Speaker 1 of 6
Urs F. Greber, University of Zürich, Switzerland
Entry and Cytoplasmic Transport of Human Adenoviruses

Tuesday, April 15 | 8:00AM - 11:15AM
Viral Movement and Trafficking
Room: Salon A

Speaker 2 of 6
* Lynn W. Enquist, Princeton University, USA
Trans-Neuronal Spread of Alpha Herpesvirus Infection

Tuesday, April 15 | 8:00AM - 11:15AM
Viral Movement and Trafficking
Room: Salon A

Speaker 3 of 6
Michael Way, Cancer Research UK, UK
Rho-mDia Signalling Regulates Microtubule Dynamics and Cortical Actin during Vaccinia Virus Infection

Tuesday, April 15 | 8:00AM - 11:15AM
Viral Movement and Trafficking
Room: Salon A

Speaker 4 of 6
Walther Mothes, Yale University School of Medicine, USA
Cell-to-Cell Transmission of Viruses

Tuesday, April 15 | 8:00AM - 11:15AM
Viral Movement and Trafficking
Room: Salon A

Speaker 5 of 6
Benjamin K. Chen, Mount Sinai School of Medicine, USA
Short Talk: Live Imaging of the HIV Virological Synapse

Tuesday, April 15 | 8:00AM - 11:15AM
Viral Movement and Trafficking
Room: Salon A

Speaker 6 of 6
Sarah Cohen, University of British Columbia, Canada
Short Talk: Nuclear Import of Parvovirus

Tuesday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center-Level 2


Tuesday, April 15 | 11:15AM - 1:00PM
Poster Setup
Room: Salon B


Tuesday, April 15 | 11:15AM - 11:15AM
On Own for Lunch


Tuesday, April 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Salon B


Tuesday, April 15 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center-Level 2


Tuesday, April 15 | 5:00PM - 7:00PM
Cellular Genes and Virus Infection
Room: Salon A

Speaker 1 of 4
* Michael H. Malim, King's College London, UK
APOBEC Proteins and Intrinsic Resistance to HIV Infection

Tuesday, April 15 | 5:00PM - 7:00PM
Cellular Genes and Virus Infection
Room: Salon A

Speaker 2 of 4
Sara R. Cherry, University of Pennsylvania, USA
Identification of Host Factors Involved in Viral Replication

Tuesday, April 15 | 5:00PM - 7:00PM
Cellular Genes and Virus Infection
Room: Salon A

Speaker 3 of 4
Jonathan P. Stoye, Francis Crick Institute, UK
Studies of Restriction Factor-Retrovirus Interactions

Tuesday, April 15 | 5:00PM - 7:00PM
Cellular Genes and Virus Infection
Room: Salon A

Speaker 4 of 4
Sonia Jiménez-Baranda, National Center of Biotechnology, Spain
Short Talk: Filamin A (ABP280) Coordinates Actin Cytoskeleton Remodeling Required for HIV-1 Infection

Tuesday, April 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Salon B


Tuesday, April 15 | 7:30PM - 10:00PM
Poster Session 2
Room: Salon B


Wednesday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court / Crystal Ballroom


Wednesday, April 16 | 7:00AM - 8:00AM
Poster Setup
Room: Salon B


Wednesday, April 16 | 8:00AM - 11:15AM
Viral Assembly and Release
Room: Salon A

Speaker 1 of 6
* Jaisri R. Lingappa, University of Washington, USA
Targeting Viral-Host Interactions during Assembly: From Cell-Free Systems to Novel Antiviral Drugs

Wednesday, April 16 | 8:00AM - 11:15AM
Viral Assembly and Release
Room: Salon A

Speaker 2 of 6
Paul D. Bieniasz, Rockefeller University, USA
Retrovirus Assembly and Release

Wednesday, April 16 | 8:00AM - 11:15AM
Viral Assembly and Release
Room: Salon A

Speaker 3 of 6
Wesley I. Sundquist, University of Utah School of Medicine, USA
Virus Assembly and Host Cell Pathways

Wednesday, April 16 | 8:00AM - 11:15AM
Viral Assembly and Release
Room: Salon A

Speaker 4 of 6
Robert A. Lamb, Northwestern University, USA
Requirements for Influenza Virus-like Particle Assembly and Budding

Wednesday, April 16 | 8:00AM - 11:15AM
Viral Assembly and Release
Room: Salon A

Speaker 5 of 6
Nathan Zauberman, Weizmann Institute of Science, Israel
Short Talk: Distinct DNA Exit and Packaging Portals in the Virus
Acanthamoeba Polyphaga Mimivirus


Wednesday, April 16 | 8:00AM - 11:15AM
Viral Assembly and Release
Room: Salon A

Speaker 6 of 6
Berend Jan Bosch, Utrecht University, Netherlands
Short Talk: On the Structure of Coronaviruses: Cryotomography of House Hepatitis Virus


Wednesday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center-Level 2


Wednesday, April 16 | 11:15AM - 12:15PM
Lunch
Room: Salon B


Wednesday, April 16 | 12:00PM - 2:30PM
Poster Session 3
Room: Salon B


Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 1 of 8
* Herbert (Skip) W. Virgin, Vir Biotechnology, USA

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 2 of 8
Thomas E. Morrison, University of North Carolina, Chapel Hill, USA
A Critical Role for the Host Complement System in Ross River Virus-Induced Inflammatory Disease

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 3 of 8
Michelle M. Arnold, National Institutes of Health, USA
Suppression of the Innate Immune Response by NSP1 during Rotavirus Infection

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 4 of 8
Javier Guillermo Magadán, NICHD, National Institutes of Health, USA
The HIV-1 Vpu Accessory Protein Hijacks the p97-Ufd1-Npl4 Endoplasmic Reticulum-Associated Degradation Pathway to Mediate Down-Regulation of CD4 Receptor Molecules

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 5 of 8
Beatriz M.A. Fontoura, University of Texas Southwestern Medical Center, USA
Identification of Small Molecules that Antagonize the Inhibition of Gene Expression by NS1 Protein of Influenza A Virus and Attenuate Viral-mediated Cell Death

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 6 of 8
Annukka Aida Rose Antar, Johns Hopkins School of Medicine, USA
Junctional Adhesion Molecule-A is Required for Efficient Hematogenous Dissemination of Reovirus

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 7 of 8
Grzegorz Sarek, Institute of Biomedicine, Biomedicum Helsinki, Finland
Nucleophosmin is a Novel Regulator of KSHV Replication via Functional Interactions with Viral Cyclin and LANA

Wednesday, April 16 | 2:30PM - 4:30PM
Workshop 2: Viral Pathogenesis and Immunity
Room: Salon A

Speaker 8 of 8
Tyler M. Sharp, Baylor College of Medicine, USA
Norwalk Virus Nonstructural Protein p22 Recruits COPII Vesicles via a Novel ER Exit Signal to Induce Golgi Disassembly

Wednesday, April 16 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center-Level 2


Wednesday, April 16 | 5:00PM - 7:00PM
Viral Replication
Room: Salon A

Speaker 1 of 4
Donald E. Ganem, Novartis Institutes for BioMedical Research, USA
MicroRNAs and the Biology of KSHV

Wednesday, April 16 | 5:00PM - 7:00PM
Viral Replication
Room: Salon A

Speaker 2 of 4
Peter Sarnow, Stanford University School of Medicine, USA
Control of Hepatitis C Virus RNA Replication by microRNAs

Wednesday, April 16 | 5:00PM - 7:00PM
Viral Replication
Room: Salon A

Speaker 3 of 4
* Paula Traktman, Medical College of Wisconsin, USA
Poxviruses - What Does it Take to Replicate DNA in the Cytoplasm?

Wednesday, April 16 | 5:00PM - 7:00PM
Viral Replication
Room: Salon A

Speaker 4 of 4
Samson A. Chow, University of California, Los Angeles, USA
Short Talk: Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer

Wednesday, April 16 | 7:00PM - 7:00PM
On Own for Dinner


Thursday, April 17 | 7:00AM - 8:00AM
Breakfast
Room: Palm Court / Crystal Ballroom


Thursday, April 17 | 8:00AM - 11:00AM
Viral Disease and Pathogenesis
Room: Salon A

Speaker 1 of 4
Ted C. Pierson, NIAID, National Institutes of Health, USA
The Stoichiometry of Antibody-Mediated Neutralization of West Nile Virus Infection: Factors that Govern Antibody Potency

Thursday, April 17 | 8:00AM - 11:00AM
Viral Disease and Pathogenesis
Room: Salon A

Speaker 2 of 4
Michael S. Diamond, Washington University School of Medicine, USA
The Critical Role of C1q in Modulating Antibody Neutralization and Enhancement of West Nile Virus Infection

Thursday, April 17 | 8:00AM - 11:00AM
Viral Disease and Pathogenesis
Room: Salon A

Speaker 3 of 4
* Susan R. Ross, University of Pennsylvania, USA
Mouse Mammary Tumor Virus's Interaction with the Innate Immune System

Thursday, April 17 | 8:00AM - 11:00AM
Viral Disease and Pathogenesis
Room: Salon A

Speaker 4 of 4
Grant McFadden, University of Florida, USA
Molecular Mechanisms of Poxvirus Immune Evasion and Tropism

Thursday, April 17 | 9:20AM - 9:40AM
Coffee Break
Room: Victoria Conference Center-Level 2


Thursday, April 17 | 11:00AM - 11:00AM
On Own for Lunch


Thursday, April 17 | 4:30PM - 5:00PM
Coffee Available
Room: Victoria Conference Center-Level 2


Thursday, April 17 | 5:00PM - 7:00PM
Immune Evasion and Subversion of Host Defense
Room: Salon A

Speaker 1 of 5
* Beth Levine, University of Texas Southwestern Medical Center, USA

Thursday, April 17 | 5:00PM - 7:00PM
Immune Evasion and Subversion of Host Defense
Room: Salon A

Speaker 2 of 5
Laurent Coscoy, University of California, Berkeley, USA
Immune Subversion by KSHV

Thursday, April 17 | 5:00PM - 7:00PM
Immune Evasion and Subversion of Host Defense
Room: Salon A

Speaker 3 of 5
Jae U. Jung, Keck School of Medicine of University of Southern California, USA
Induction and Evasion of the Type I Interferon Response by Viruses

Thursday, April 17 | 5:00PM - 7:00PM
Immune Evasion and Subversion of Host Defense
Room: Salon A

Speaker 4 of 5
Matthew L. Albert, Genentech, Inc., USA
The Immune Pathogenesis of Chikungunya Infection

Thursday, April 17 | 5:00PM - 7:00PM
Immune Evasion and Subversion of Host Defense
Room: Salon A

Speaker 5 of 5
Gary Thomas, Oregon Health & Science University, USA
Short Talk: HIV-1 Nef Binds PACS-2 to Assembly a Multi-Kinase Cascade that Triggers MHC-I Downregulation

Thursday, April 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Palm Court / Crystal Ballroom


Thursday, April 17 | 8:00PM - 11:00PM
Entertainment
Room: Palm Court / Crystal Ballroom


Thursday, April 17 | 8:00PM - 11:00PM
Cash Bar
Room: Palm Court / Crystal Ballroom


Friday, April 18 | 10:25AM - 10:25AM
Departure


*Session Chair.